Abstract：
BACKGROUND:The authors applied a scaffold-free osteogenic three-dimensional (3D) graft made of adipose-derived mesenchymal stem cells (AMSCs) in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). METHODS:Three patients (two patients and one patient with 1 and 2 levels, respectively) with degenerative spondylolisthesis underwent MI-TLIF with 3D graft made of AMSCs. To obtain the AMSCs, fatty tissue was collected from the abdomen by lipoaspiration and differentiated afterwards in our Cell/Tissue bank. Clinical outcomes, including the Oswestry Disability Index (ODI) and visual analog scale (VAS) as well as fusion status were assessed preoperatively and up to 12 months postoperatively. RESULTS:At 12 months, all four operated AMSC levels could be assessed (n = 4). Grade 3 fusion could be confirmed at two levels out of four. Mean VAS score improved from 8.3 to 2 and ODI also improved from 47 to 31%. No donor site complication was observed. The final AMSC osteogenic product was stable, did not rupture with forceps manipulation, and was easily implanted directly into the cage with no marked modification of operating time. CONCLUSIONS:A scaffold-free 3D graft made of AMSCs can be manufactured and used as a promising alternative for spinal fusion procedures. Nevertheless, further studies of a larger series of patients are needed to confirm its effectiveness.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Fomekong E,Dufrane D,Berg BV,André W,Aouassar N,Veriter S,Raftopoulos Cdoi
10.1007/s00701-016-3051-6subject
Has Abstractpub_date
2017-03-01 00:00:00pages
527-536issue
3eissn
0001-6268issn
0942-0940pii
10.1007/s00701-016-3051-6journal_volume
159pub_type
杂志文章abstract：:Two cases of primary extraosseous intradural spinal Ewing's sarcoma are reported with a review of the current literature. This rare neoplasm shares features with cerebral primitive neuroectodermal tumors, complicating a correct diagnosis. Gross total resection seems to be the main treatment, although adjuvant therapie...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-013-1739-4
更新日期：2013-07-01 00:00:00
abstract：:The effectiveness of percutaneous epidural stimulation has been evaluated in 11 patients with multiple sclerosis. Trial stimulation was performed at the thoracic level and lasted for 4 to 10 days. Evaluation was accomplished before the start and at regular intervals during and after the treatment. The scoring systems ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01809178
更新日期：1979-01-01 00:00:00
abstract：:Nine cases of posttraumatic primary brain stem haematoma are described. All cases presented ocular and vegetative symptoms. Hyperextension was regarded as the most likely mechanism of injury. All patients were treated conservatively; half of them with a good outcome. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01428496
更新日期：1995-01-01 00:00:00
abstract：:First described on pre-B leukemia cells, the common acute lymphoblastic leukemia antigen (cALLa) is also expressed on glioma cells in vitro. Its identity to neutral endopeptidase (NEP) (E.C.3.24.11) was corroborated by our finding that cALLa positive glioma cells had NEP activity. To study cALLa/NEP distribution on gl...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401105
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Microsurgical circumferential stripping of intracerebral metastases is often insufficient in achieving local tumor control. Supramarginal resection may improve local tumor control. METHODS:A retrospective analysis was performed for patients who underwent supramarginal resection of a cerebral metastasis by a...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2405-9
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:To illustrate the use of indocyanine green (ICG) video-angiography to confirm abolition of spinal dural arteriovenous fistula (SDAVF) and preserve the normal vascular anatomy intraoperatively. METHODS:A 73-year-old woman presenting with progressive myelopathy was diagnosed with an SDAVF, where the origin of th...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0445-8
更新日期：2010-03-01 00:00:00
abstract：:The authors describe a case of accidental electrocution from a high voltage current in a young worker, who was struck by the electric shock in the mid-occipital region. The case is especially interesting due to the improbability of anyone surviving after receiving a shock of more than 1000 V., and to the development o...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01402395
更新日期：1986-01-01 00:00:00
abstract：:Being motor nerves neurinomas originating from ocular nerves are very rare, unless associated with neurofibromatosis. Authors describe two cases of oculomotor nerve i.e. third nerve, Schwann cell tumours. One of them presented as a cavernous sinus mass in a middle aged lady while the other was a middle aged man with a...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050229
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To define the value of electrically elicited motor evoked potentials (MEP), obtained during the initial phase of the coma, for correct prediction of the post-coma motor status. METHODS:Fifty-two patients were investigated by MEP within 72 hours after onset of the coma. It was the aim to correlate the MEP fin...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050385
更新日期：1999-01-01 00:00:00
abstract：:The facial electromyographic response was monitored intraoperatively in 40 patients with hemifacial spasm who were operated on by microvascular decompression of the facial nerve. All 40 patients showed an abnormal facial electromyographic response (lateral spread response) with a latency of about 10 msec after stimula...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411718
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:The excitotoxic amino acid glutamate is known to aggravate pre-existing neuropathology. Since volatile anesthetics increase plasma amino acid levels, we investigated if the anesthetics isoflurane and propofol increase plasma and cerebrospinal fluid (CSF) glutamate in neurosurgical patients. METHODS:In disce...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0562-y
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Pituitary apoplexy is a rare and life-threatening complication occurring in 0.6-10.5% of all cases of pituitary adenomas. Although the association between pituitary apoplexy and visual dysfunction has been recognized for a long time, the optimal management of this problem still remains controversial. The pur...
journal_title：Acta neurochirurgica
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00701-009-0595-8
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Although the majority of patients with minimal acute subdural hematomas (aSDHs) can be managed conservatively, some require delayed aSDH evacuation due to hematoma enlargement. This study was designed to determine the risk factors associated with delayed hematoma enlargement leading to surgery in patients wi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2151-4
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Multiple intracranial aneurysms (MIAs) are associated with poorer outcomes after rupture than are single intracranial aneurysms (SIAs). Although the risk factors for intracranial aneurysm rupture have been widely investigated, few studies have focused on MIAs. Thus, the present study aimed to determine wheth...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-016-2826-0
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincte...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-018-3494-z
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Accumulating results have disclosed that early brain injury (EBI) may play a major role in the determination of the outcome of aneurysmal subarachnoid hemorrhage (SAH) patients. This study is of interest to examine the efficacy of pitavastatin, a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2399-3
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The wide variety of intraspinal cystic lesions necessitates different elaborate diagnostic procedures to choose the right therapeutic management in symptomatic patients. Based on the case reports of seven patients with symptomatic spinal arachnoid cysts we discuss the aetiology, diagnostic procedures and the...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010170102
更新日期：2001-01-01 00:00:00
abstract：:Traditional clinical outcome measures for the treatment of Parkinson's disease (PD) have focused on motor function and activities of daily living. However, in the past decade there has been a new emphasis on the use of health related quality of life (HRQOL) measures for translating how a patient's response to treatmen...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010070090
更新日期：2000-01-01 00:00:00
abstract：:Recent animal research has provided evidence that brain ischaemia is associated with a shift of energy related metabolites (lactate, adenosine, inosine, and hypoxanthine) and several transmitters from the intracellular to the extracellular fluid (ECF). These chemical changes of the ECF reflect the energy crisis of the...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405420
更新日期：1990-01-01 00:00:00
abstract：:The common method of presentation of intracranial aneurysms is at the time of their rupture (with subarachnoid haemorrhage) or on the occasion of their compression of neighbouring structures. While giant aneurysms may occasionally present with subarachnoid haemorrhage, their more common methods of presentation are due...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400726
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The mechanisms underlying post-extracranial to intracranial (EC-IC) bypass neurocognitive changes are poorly understood. METHODS:Data from 55 patients who underwent a unilateral EC-IC bypass for atherosclerotic internal carotid artery (ICA)/middle cerebral artery (MCA) steno-occlusive disease were retrospec...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2620-4
更新日期：2016-01-01 00:00:00
abstract：:Anterior spinal decompression and fusion was used as the primary treatment for thoracolumbar fractures in eleven patients with neurological deficits. Each patient achieved stability by interbody fusion. Significant progressive kyphosis did not occur. No patients with a complete neurological deficit was improved by ope...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01664845
更新日期：1981-01-01 00:00:00
abstract：:We present a patient with an intracerebral haematoma occurring at a remote site following evacuation of a chronic subdural haematoma. Recurrence of the haematoma, infection, seizure, cerebral edema, tension pneumocephalus and failure of the brain to expand due to cerebro-cranial disproportion are the major complicatio...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-008-1512-2
更新日期：2008-05-01 00:00:00
abstract：:The authors report the results of a study designed to compare the effectiveness of two different types of radiation in patients with acromegaly where surgical therapy had failed to normalize growth hormone (GH). Longterm follow-up after conventional high voltage radiation in 17 patients and proton therapy in 13 patien...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01403492
更新日期：1989-01-01 00:00:00
abstract：:Our understanding of the complexity of genetic abnormalities involved in the tumourigenesis of malignant gliomas is as yet rudimentary. However, we can discern distinctive patterns of loss of genetic material and amplification of chromosomal regions that characterize both the different types of gliomas as well as the ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/BF01411992
更新日期：1997-01-01 00:00:00
abstract：:We present a case of dissection of the extracranial vertebral artery with prominent occipital pain and elements of the lateral medullary syndrome. Arteriography showed a string and pearl sign. Magnetic resonance imaging allowed visualization of an intramural thrombus associated with a narrow vascular lumen. The distal...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401852
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Surgeons often rely on intraoperative electrophysiological monitoring to determine whether decompression is sufficient during microvascular decompression surgery for hemifacial spasms. A new monitoring method is needed when an abnormal muscle response is occasionally not available or is unreliable. This stud...
journal_title：Acta neurochirurgica
pub_type： 临床试验,杂志文章
doi：10.1007/s00701-012-1304-6
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Supratentorial intracerebral haemorrhage (ICH) carries an excessive mortality and morbidity. Although surgical ICH treatment can be life-saving, the indications for surgery in larger cohorts of ICH patients are controversial and not well defined. We hypothesised that surgical indications vary substantially a...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-03853-0
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Brain arteriovenous malformations (AVMs) of the elderly have not received sufficient attention, given the increase in age of individuals in recent years. We therefore designed a retrospective study to clarify features of brain AVMs in this age group in comparison with their counterparts in the general popula...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-004-0346-9
更新日期：2004-10-01 00:00:00
abstract：:Without mortality, 31 patients underwent conservative treatment for traumatic supratentorial acute subdural haematoma (SDH). Later on six of them had the haematoma surgically evacuated mainly because of a deterioration of the Glasgow Coma Scale (GCS) scores. It was found that patients with a midline shift of less than...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02307412
更新日期：1995-01-01 00:00:00
