Abstract:
BACKGROUND:Convection-enhanced delivery (CED) is a technique allowing local infusion of therapeutic agents into the central nervous system, circumventing the blood-brain or spinal cord barrier. OBJECTIVE:To evaluate the utility of nimustine hydrochloride (ACNU) CED in controlling tumor progression in an experimental spinal cord glioma model. METHODS:Toxicity studies were performed in 42 rats following the administration of 4 μl of ACNU CED into the mid-thoracic spinal cord at concentrations ranging from 0.1 to 10 mg/ml. Behavioral analyses and histological evaluations were performed to assess ACNU toxicity in the spinal cord. A survival study was performed in 32 rats following the implantation of 9 L cells into the T8 spinal cord. Seven days after the implantation, rats were assigned to four groups: ACNU CED (0.25 mg/ml; n = 8); ACNU intravenous (i.v.) (0.4 mg; n = 8); saline CED (n = 8); saline i.v. (n = 8). Hind limb movements were evaluated daily in all rats for 21 days. Tumor sizes were measured histologically. RESULTS:The maximum tolerated ACNU concentration was 0.25 mg/ml. Preservation of hind limb motor function and tumor growth suppression was observed in the ACNU CED (0.25 mg/ml) and ACNU i.v. groups. Antitumor effects were more prominent in the ACNU CED group especially in behavioral analyses (P < 0.05; log-rank test). CONCLUSIONS:ACNU CED had efficacy in controlling tumor growth and preserving neurological function in an experimental spinal cord tumor model. ACNU CED can be a viable treatment option for spinal cord high-grade glioma.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Ogita S,Endo T,Sugiyama S,Saito R,Inoue T,Sumiyoshi A,Nonaka H,Kawashima R,Sonoda Y,Tominaga Tdoi
10.1007/s00701-017-3123-2subject
Has Abstractpub_date
2017-05-01 00:00:00pages
939-946issue
5eissn
0001-6268issn
0942-0940pii
10.1007/s00701-017-3123-2journal_volume
159pub_type
杂志文章abstract:STUDY DESIGN:This report characterises a 25 year old male patient with a complete burst fracture of the fifth lumbar vertebra with dislocation. He was treated by posterior surgery with transpedicular instrumentation and an expandable cage from the posterior approach. OBJECTIVES:Burst fractures of the fifth lumbar vert...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-0149-5
更新日期:2008-12-01 00:00:00
abstract::This paper is based on a study of sixty cases of cranio-cerebral erosion treated in the Department of Neurosurgery. All India Institute of Medical Sciences, New Delhi during the last 20 years. This constitutes the largest series, so far reported from anywhere. It has provided a unique opportunity to get a comprehensiv...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/BF01400508
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Gamma Knife radiosurgery (GKRS) inverse dose planning is currently far from competing effectively with the quality of dose planning developed by experienced experts. A new inverse planning (IP) method based on « efficient convex optimization algorithms » is proposed, providing high-quality dose plans in real...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04695-x
更新日期:2021-01-05 00:00:00
abstract::Technological developments in neuroendoscopy are leading to an expansion of applications into the realm of microneurosurgical procedures. The new dimension that using an endoscope provides requires insight into different neuroanatomical aspects and a new kind of strategy in planning a microneurosurgical procedure. To ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01417688
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Gamma knife radiosurgery (GKRS) has for the last decades been an established treatment option for patients with small- or medium-sized vestibular schwannomas (VS), although little data is reported on long-term outcome regarding quality of life (QOL) and tumour control in this patient category. The objectiv...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1924-5
更新日期:2014-02-01 00:00:00
abstract::The hypothesis is developed that plateau waves (PW) are caused by an abrupt elevation of postcapillary flow resistance induced by compression of the outlets of the leptomeningeal veins. It is shown by means of a physical model that the main prerequisite for venous outlet compression consists in an elevation of the out...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01407125
更新日期:1981-01-01 00:00:00
abstract::The case report here deals with an intracavernous arterial aneurysm spontaneously developing into a carotid-cavernous fistula. The etiopathology of these fistulas is discussed. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406042
更新日期:1984-01-01 00:00:00
abstract::The clinical features of 6 children who are probable sufferers of "unilateral" Moyamoya disease are here reported. They showed angiographic findings which were compatible with those of Moyamoya disease, albeit only on one side. They did not, however, show any basic aetiologic factors. The age of onset, the clinical sy...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808612
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Navigated transcranial magnetic stimulation (nTMS) is increasingly used for preoperative mapping of motor function, and clinical evidence for its benefit for brain tumor patients is accumulating. In respect to language mapping with repetitive nTMS, literature reports have yielded variable results, and it i...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-017-3187-z
更新日期:2017-07-01 00:00:00
abstract::Twenty-one patients with various types of pituitary macroadenomas underwent hypophysectomy at the Chaim Sheba Medical Centre between 1985 to 1987. Intraoperative fine needle aspiration of the tumoural content was attempted prior to tumour excision. Although none of the patients had a history compatible with pituitary ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405275
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Aneurysms associated with brain arteriovenous malformations (bAVMs) influence the natural history of these lesions and pose important therapeutic challenges. However, the epidemiology, natural history, and appropriate management of the aneurysms associated with bAVMs are not completely understood due to the ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,meta分析
doi:10.1007/s00701-016-2957-3
更新日期:2016-11-01 00:00:00
abstract::The long-term outcome in 26 patients following operation of intracranial saccular aneurysms before the age of twenty is presented. The duration of follow-up ranged from 4 to 33 years (mean 14 years). The oldest patient is now 51 years old. 19 patients (73%) made a complete or good recovery with resumption of normal li...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476214
更新日期:1985-01-01 00:00:00
abstract::Intraspinal nerve-sheath tumours are generally slow growing and are diagnosed after causing symptoms such as back pain and progressive neurological symptoms. We present a rare example of multiple schwannomas located in the thoracolumbar spine in a previously asymptomatic patient who developed severe neurological defic...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0239-z
更新日期:2009-06-01 00:00:00
abstract::Event related potential recording and psychometric evaluation of cognitive impairment were carried out on 21 patients with brain tumours, 21 patients with severe head injuries and 24 controls. The tumour and trauma patients who met the psychometric inclusion criteria for dementia, but not the non-demented patients, ha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01812285
更新日期:1986-01-01 00:00:00
abstract::Cerebral developmental venous anomalies (DVAs) are variations of venous vascular anatomy related to an underdevelopment of either the superficial or deep venous emissary system, resulting in a dilated transmedullary vein fed by multiple smaller venous radicles responsible for drainage of normal brain parenchyma. While...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-020-04213-z
更新日期:2020-05-01 00:00:00
abstract::The case is described of a 52 year old patient admitted for acauda equina compression syndrome (flaccid paraplegia of the lower limbs, bilateral lumbar and sciatic pains, urinary incontinence) of rapid onset and due to narrowing of the lumbar canal from tabetic arthropathy. These vertebral manifestations occur in a lo...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405747
更新日期:1976-01-01 00:00:00
abstract::Between 1979 and 1989, 7 patients were admitted, with cerebral arteriovenous malformations (AVM) and associated aneurysms (7% of the AVM patients and 2% of the aneurysm patients admitted during the same period). 6 of these patients were admitted because of an intracranial haemorrhage (in 3 of them the AVM, angiographi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405792
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The COVID19 lockdown has altered the dynamics of living. Its collateral fallout on head injury care has not been studied in detail, especially from low- and middle-income countries, possibly overwhelmed more than developed nations. Here, we analyze the effects of COVID19 restrictions on head injury patients ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-021-04723-4
更新日期:2021-01-21 00:00:00
abstract:BACKGROUND:Torcular meningioma is a rare type of brain tumor with few reports regarding the appropriate resection approach for this disease. In cases without sinus occlusion, surgeons are advised to spare the sinus; however, the sinus may interfere with the visual field. METHOD:Endoscopic supracerebellar infratentoria...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-019-03950-0
更新日期:2019-08-01 00:00:00
abstract::We present a patient with an intracerebral haematoma occurring at a remote site following evacuation of a chronic subdural haematoma. Recurrence of the haematoma, infection, seizure, cerebral edema, tension pneumocephalus and failure of the brain to expand due to cerebro-cranial disproportion are the major complicatio...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-008-1512-2
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Chronic subdural haematoma (cSDH) is a common disease in neurosurgical practise, especially in elderly patients. This is of growing importance as the number of elderly people in the population is increasing steadily. There are scarce data focussing especially on elderly patients with cSDH. This study intende...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1434-x
更新日期:2012-09-01 00:00:00
abstract::In patients with brain metastasis from lung cancer, we have been able to control local recurrence in approximately 80% of cases. But many of them tend to show brain atrophy with mental deterioration developing a few months after whole brain radiation. To prevent brain atrophy, we have attempted treating patients, whos...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401458
更新日期:1994-01-01 00:00:00
abstract::A case of cauda equina paraganglioma is described; subsequent intracranial and intraspinal metastases occurred after partial resection and adjunctive radiotherapy. Cerebrospinal fluid dissemination is a rare complication of spinal paragangliomas. Factors predictive of this unusual biological behaviour are discussed. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420312
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Aneurysmal subarachnoid haemorrhage (aSAH) is an acute cerebrovascular event with high socioeconomic impact as it tends to affect younger patients. The recent NCEPOD study looking into management of aSAH has recommended that neurovascular units in the United Kingdom should aim to secure cerebral aneurysms wi...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-2746-z
更新日期:2016-05-01 00:00:00
abstract::The authors report their experience with CT scanning ina series of 4 cases of subdural empyema, over a period of 10 months; all the patients were male, aged 16 to 25 years. A review of the literature shows that this disease, in spite of the large variety and efficacy of the available antibiotics, is marked by a signif...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01740084
更新日期:1982-01-01 00:00:00
abstract::An association between fibromuscular dysplasia (FMD) and intracranial aneurysms has been proposed but the occurrence of multiple aneurysms on the trunk of basilar artery (BA) associated with FMD has not been previously reported. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0163-6
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Long-term survival of patients with recurrent gliomas depends on the extent of resection. Thus, the desirability of an intra-operative imaging modality that can augment the resection extension without affecting vital surrounding structures is more than obvious. It was the aim of the present study to evaluate...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0858-6
更新日期:2006-10-01 00:00:00
abstract::This article will look at how one female neurosurgeon in Turkey made her mark in the field. In 1954, Dr. Aysima Altinok began her residency training in neurosurgery at Haydarpaşa Numune Hospital where the first official department of neurosurgery in Turkey had been founded five years earlier. On November 22, 1959, she...
journal_title:Acta neurochirurgica
pub_type: 传,历史文章,杂志文章
doi:10.1007/s00701-007-1252-8
更新日期:2007-01-01 00:00:00
abstract::Too few cases of isolated abducent nerve palsy caused by neurovascular compression syndrome have been reported. We here report on a case of abducent nerve palsy caused by neurovascular compression syndrome that was successfully treated by microvascular decompression (MVD). A 46-year-old male presented with a 6-month h...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-015-2530-5
更新日期:2015-10-01 00:00:00
abstract::Direct and indirect arteriovenous fistulas were applied to the cervical vessels of 19 rats in order to study the haemodynamic parameters of angioma-like, rapid blood flow in small vessels. Flow was measured electromagnetically and intraoperatively using the Doppler sonography, and both methods were compared. Resultant...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403495
更新日期:1989-01-01 00:00:00