Abstract：
OBJECTIVE:Induced endothelin-1 (ET-1) production and decreased nitric oxide synthase (NOS) bioavailability have been found in aneurysmal subarachnoid hemorrhage (SAH). Atorvastatin is recognized to have pleiotropic effects including increasing NOS bioavailability as well as reducing inflammation and oxidative damage other than reducing dyslipidemia. This study is of interest to examine the effect of atorvastatin on ET-1/endothelial nitric oxide synthase (eNOS) in experimental SAH. METHODS:A rodent double-hemorrhage SAH model was employed. Animals were randomly assigned as sham-operated, SAH, vehicle plus SAH, 5 mg/day atorvastatin treatment plus SAH and 5 mg/day atorvastatin precondition plus SAH groups. Administration with atorvastatin (5 mg/day) was initiated 1 week before (precondition) and 24 hr later (treatment). Cerebrospinal fluid samples were collected at 72 hr after second SAH. ET-1 (ELISA) was measured. The basilar arteries (BAs) were harvested and sliced, and their cross-sectional areas were measured. Radiolabeled NOS assay kit was used to detect eNOS. RESULTS:Morphologically, convoluted internal elastic lamina, distorted endothelial cells and myonecrosis of the smooth muscle were predominantly observed in the BA of SAH and vehicle-treated SAH groups, which was not detected in the atorvastatin-preconditioned SAH group or the healthy controls. Significant vasospasm was noted in the vehicle group (lumen potency 64.5%, compared with the sham group, p
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Chang CZ,Wu SC,Lin CL,Hwang SL,Howng SL,Kwan ALdoi
10.1007/s00701-010-0652-3subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1399-406; discussion 1405-6issue
8eissn
0001-6268issn
0942-0940journal_volume
152pub_type
杂志文章abstract：BACKGROUND:To determine its roles in the diagnosis and the systemic evaluation of metastatic brain tumours, whole-body positron emission tomography (PET) using [18F]FDG was performed in 20 consecutive patients. METHODS:All patients were thought to be suffering or needing to be differentiated from metastatic brain tumo...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050161
更新日期：1998-01-01 00:00:00
abstract：:In 12 patients syringomyelia was diagnosed using MRI. The underlying cause was a hindbrain hernia in 8 patients, a posterior fossa cyst in one case, and in 3 patients the underlying cause remained unknown. Syringo-subarachnoid shunting in 8 patients failed to decrease pain and the size of the syrinx, motor lesion and ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Cases of primary spinal epidural Extra-osseous Ewing's sarcoma (EES) are rarely seen and a good prognosis for EES cannot be expected since a high incidence of local recurrence and metastasis frequently occur. We present a case of cervical spinal epidural EES in a 7-year-old girl with long survival after tumour resecti...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-004-0294-4
更新日期：2004-09-01 00:00:00
abstract：:Modern neuro-imaging techniques have significantly increased the accuracy of stereotactic procedures and have thereby generated a renewed interest in guided brain surgery. This paper describes the neuroradiological aspects of stereotaxic target calculation (x-, y-, z- coordinates) using the Riechert-Mundinger (Fisher)...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400713
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:The goal of this study was to investigate the chemokines CCL2, CXCL8, CXCL9 and CXCL10 as markers of the inflammatory responses in chronic subdural hematoma (CSDH). METHODS:Samples of peripheral venous blood and CSDH fluid (obtained during surgery) in 76 adult patients were prospectively analyzed. Chemokine ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-1203-2
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Eloquent area surgery has become safer with the development of intraoperative neurophysiological monitoring and brain mapping techniques. However, the usefulness of intraoperative electric brain stimulation techniques applied to the management and surgical treatment of cavernous malformations in supratentori...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-018-3644-3
更新日期：2018-10-01 00:00:00
abstract：:The authors present a case of cauda equina paraparesis due to compression by tabetic osteo-arthropathy. Diagnosis was confirmed by the typical clinical picture of tabes and by the history of a chancre 53 years earlier. Radiography of the spine showed vertibral osteo-arthropathy. Opaque contrast myelography showed comp...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01774757
更新日期：1978-01-01 00:00:00
abstract：:Intramedullary clear cell meningioma (CCM), which is more aggressive than other meningioma variants, is extremely rare. To date, only one case of such a spinal tumour has been documented. We report the first case of an intramedullary CCM originating in the thoracic region of the spinal cord. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0695-z
更新日期：2006-04-01 00:00:00
abstract：:This experimental study presents the ultrastructure of regenerating sciatic nerve of the rabbit, after transection and immediate end to end anastomosis, using perineural fascicular nerve autograft, in a sterile environment. Twenty-four hours, 1, 2, and 6 weeks after the anastomosis, the treated sciatic nerves were exp...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01456115
更新日期：1987-01-01 00:00:00
abstract：:Radiosurgery is either a primary or an adjunctive management approach used to treat patients with vestibular schwannomas. We sought to determine outcomes measuring the potential benefits against the neurological risks in patients who underwent radiosurgery after previous microsurgical subtotal resection or recurrence ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-002-0950-5
更新日期：2002-07-01 00:00:00
abstract：:The incidence of slit ventricles of shunt treated hydrocephalic children was evaluated in a follow up study of 141 patients. Slit like ventricles on computer tomography was seen in 75 patients (53%). 52 patients (37%) suffered from clinical symptoms corresponding with overdrainage of cerebrospinal fluid. Those 52 pati...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01402318
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:Endoscopic 3rd ventriculostomy has become the method of choice in the management of occlusive hydrocephalus. The treatment is accompanied by significantly less peri-operative complications than the cerebrospinal fluid shunting procedures previously employed. Close surveillance of patients, however, is necessa...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050294
更新日期：1999-01-01 00:00:00
abstract：INTRODUCTION:Radiosurgery (RS) and fractionated radiotherapy (FRT) are part of the therapeutic armamentarium for the management of cavernous sinus meningiomas. We propose a systematic review of the local tumor control and clinical outcomes after monofractionated radiosurgical treatment, including gamma knife radiosurge...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,meta分析
doi：10.1007/s00701-018-3711-9
更新日期：2018-12-01 00:00:00
abstract：:One hundred patients with a verified subarachnoid haemorrhage were studied in a double blind, placebo-controlled trial at a single centre to determine the value and relative risks of tranexamic acid (TXA) in the management of ruptured intracranial aneurysms. The incidence of recurrent haemorrhage between active and pl...
journal_title：Acta neurochirurgica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01402177
更新日期：1990-01-01 00:00:00
abstract：:Changes in vestibulospinal evoked potentials (VsEP) and motor evoked potentials (MEP) were examined in 10 cats before and after two different weight-dropping spinal cord injuries. In six animals somatosensory evoked potentials (SEP) were also monitored. The recordings were done from epidural spinal cord electrodes. Be...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01410530
更新日期：1989-01-01 00:00:00
abstract：:In the current article we review the available English literature by pubmed search engine on the topic of osteochondromas and their location in the cervical spine. The focus is to investigate the location of the lesions in cervical spine and to analyze clinical presentations and symptoms of patients, the aetiology and...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00701-009-0235-3
更新日期：2009-06-01 00:00:00
abstract：:Using magnetic resonance imaging with planes of section tangential to the left or right perietal convexity, we studied the sulcus pattern of the parietal lobes in 50 healthy subjects. The postcentral sulcus and the intraparietal sulcus were easily identified. As a characteristic landmark, and corresponding to postmort...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01411428
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Radiosurgical treatment of brain lesions near motor or language eloquent areas requires careful planning to achieve the optimal balance between effective dose prescription and preservation of function. Navigated brain stimulation (NBS) is the only non-invasive modality that allows the identification of funct...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2079-8
更新日期：2014-06-01 00:00:00
abstract：OBJECT:Parafalcine subdural empyema and those along the superior and inferior surface of the tentorium are rare entities. We present a series of 10 patients where we have attempted to describe the pathophysiology, clinical features, and management of subdural empyema. METHODS:The study group included 10 cases of falco...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0695-5
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Blood blister-like aneurysms (BBAs) pose a significant challenge to neurosurgeons and neuro-interventionalists. These fragile broad-based aneurysms have a propensity to rupture with minimal manipulation during surgical or endovascular explorations because, unlike saccular aneurysms, they lack all layers of t...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-014-2212-8
更新日期：2014-11-01 00:00:00
abstract：:A case of a patient with acute paraparesis after compression fracture of the twelfth vertebra with progressive neurological deterioration is reported. The occurrence of clinical asymptomatic thoracic meningioma and coincidence with posttraumatic compression fracture of the vertebra at the same level resulting in acute...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-004-0438-6
更新日期：2005-06-01 00:00:00
abstract：:Myelocystoceles are rare lesions. Rarer still are thoracic myelocystoceles. Two patients with thoracic myelocystoceles are being reported. The first patient presented with swelling in the thoracic region with paraplegia and incontinence. MR with MR myelography revealed the malformation to be a thoracic myelocystocele....
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-006-0734-4
更新日期：2006-07-01 00:00:00
abstract：:A case of primary intraspinal melanoma is presented. This is a very rarely observed lesion, as only 37 cases have been described up to now. Patient presenting with signs and symptoms of spinal cord compression after MRI and spinal angiography was operated upon. Total removal of an intraspinal cervical tumour was perfo...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010070066
更新日期：2000-01-01 00:00:00
abstract：:Vascular endothelium synthesizes mediators which either cause vasorelaxation or vasoconstriction. The purpose of this study is to investigate the role of these mediators in the pathogenesis of cerebral vasospasm. An inhibitor of endothelium-derived relaxing factor is haemoglobin; endothelium removal by triton X-100 an...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401136
更新日期：1993-01-01 00:00:00
abstract：:The authors describe a case of a post-traumatic subdural haematoma with an unusual evolution in two phases, one slow, the other very rapid. The rapidity of the evolution was caused by the rupture of a cortical dural artery, shown angiographically. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401797
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:Autogenous cranioplasty infection requiring bone flap removal is under-recognised as a major complication causing significant morbidity. Microbial contamination of stored bone flaps may be a significant contributing factor. Current infection control practices and storage procedures vary. It is not known whet...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-012-1517-8
更新日期：2013-02-01 00:00:00
abstract：:Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. T...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01420048
更新日期：1997-01-01 00:00:00
abstract：:The unusual presentation of Gorham's disease of skull base and cervical spine in a two-year-old female child with radiological signs mimicking those of raised intracranial pressure is discussed. The differential diagnosis consists of skull base tumours, meningitis, osteomyelitis of the base of skull, congenital hydroc...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0806-x
更新日期：2006-08-01 00:00:00
abstract：:A method based on growth of cells from glioma biopsies in a triple layer agarose system has been used to test the sensitivity of the tumour cells to different chemotherapeutic and immunotherapeutic agents. A special agarose that could be melted at 65 degrees C, enabled registration of proliferation by an easy and prec...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400530
更新日期：1988-01-01 00:00:00
abstract：INTRODUCTION:Gamma knife radiosurgery (GKRS) has for the last decades been an established treatment option for patients with small- or medium-sized vestibular schwannomas (VS), although little data is reported on long-term outcome regarding quality of life (QOL) and tumour control in this patient category. The objectiv...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-013-1924-5
更新日期：2014-02-01 00:00:00
