当前位置： SCI文献检索 > PHYSICS IN MEDICINE AND BIOLOGY期刊下所有文献 > Comparison of large-area position-sensitive solid-state photomultipliers for small animal PET.

Comparison of large-area position-sensitive solid-state photomultipliers for small animal PET.

Abstract：

:This paper evaluates the performance of two large-area position-sensitive solid-state photomultipliers (PS-SSPM) for use in small animal PET detector designs. Both PS-SSPM device designs are 1 cm² in area, the first being a 2 × 2 tiled array of 5 mm × 5 mm PS-SSPMs and the second being a 10 mm × 10 mm continuous PS-SSPM. Signal-to-noise measurements were performed to investigate the optimal operating parameters for each device and to compare the performance of the two PS-SSPM designs. A maximum signal-to-noise ratio of 29.3 was measured for the 5 mm PS-SSPM array and 15.1 for the 10 mm PS-SSPM, both measurements were made at 0 °C and at the optimal bias voltage. The best energy resolution measured with an array of 1.3 mm polished LSO crystals was 16% for the 5 mm PS-SSPM array and 18% for the 10 mm PS-SSPM. The timing properties of both devices were similar, with a best timing resolution (in coincidence with an LSO/PMT detector) of 6.8 ns (range 6.8-8.9 ns) and 7.1 ns (range 7.1-9.6 ns) for the 5 mm PS-SSPM and 10 mm PS-SSPM respectively. The 2 × 2 array of 5 mm PS-SSPMs was able to visually resolve the elements in an 0.5 × 0.5 × 20 mm LYSO scintillator array (unpolished, diffuse reflector) with an average peak-to-valley ratio in the flood histograms of ∼11 indicating clear separation of the crystals. Advantages and drawbacks of PET detector designs using PS-SSPM photodetectors are addressed and comparisons to other small-animal PET detector designs using position-sensitive avalanche photodiodes are made.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Schmall JP,Du J,Yang Y,Dokhale PA,McClish M,Christian J,Shah KS,Cherry SR

doi

10.1088/0031-9155/57/24/8119

subject

Has Abstract

pub_date

2012-12-21 00:00:00

pages

8119-34

issue

24

eissn

0031-9155

issn

1361-6560

journal_volume

57

pub_type

杂志文章

相关文献

PHYSICS IN MEDICINE AND BIOLOGY文献大全
  • Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique.

    abstract：:Subharmonic contrast imaging promises to improve ultrasound-imaging quality by taking advantage of an increased contrast to tissue signal. However, acoustic pressures beyond the subharmonic generation threshold using common ultrasound pulses may induce significant contrast microbubble destruction. In this work, a chir...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/52/18/005

    authors： Zhang D,Gong Y,Gong X,Liu Z,Tan K,Zheng H

    更新日期：2007-09-21 00:00:00

  • Image domain multi-material decomposition using single energy CT.

    abstract：:Multi-material decomposition (MMD) technique decomposes the CT images into basis material images and has been promising in clinical practice for material composition quantification within the human body. MMD could be implemented using the image data acquired from spectral CT or its special case, dual-energy CT (DECT) ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab7503

    authors： Xue Y,Luo C,Jiang Y,Yang P,Hu X,Zhou Q,Wang J,Hu X,Sheng K,Niu T

    更新日期：2020-03-23 00:00:00

  • Microdosimetric investigations on collimated fast neutron beams for radiation therapy: II. The problem of radiation quality and RBE.

    abstract：:The correlation between radiation quality and cellular RBE of a mixed n-gamma field produced by a collimated fast-neutron beam produced by the bombardment of 14 MeV deuterons on Be in a water phantom is investigated. The microdosimetric parameters yF and YD are used for a physical description of the local distribution...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/26/1/006

    authors： Booz J,Fidorra J

    更新日期：1981-01-01 00:00:00

  • Assessment of induced radio-frequency electromagnetic fields in various anatomical human body models.

    abstract：:The reference levels for testing compliance of human exposure with radio-frequency (RF) safety limits have been derived from very simplified models of the human. In order to validate these findings for anatomical models, we investigated the absorption characteristics for various anatomies ranging from 6 year old child...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/54/4/004

    authors： Kühn S,Jennings W,Christ A,Kuster N

    更新日期：2009-02-21 00:00:00

  • Bayesian multiresolution method for local tomography in dental x-ray imaging.

    abstract：:Dental tomographic cone-beam x-ray imaging devices record truncated projections and reconstruct a region of interest (ROI) inside the head. Image reconstruction from the resulting local tomography data is an ill-posed inverse problem. A new Bayesian multiresolution method is proposed for local tomography reconstructio...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/52/22/008

    authors： Niinimäki K,Siltanen S,Kolehmainen V

    更新日期：2007-11-21 00:00:00

  • Optimization and performance study of a proton CT system for pre-clinical small animal imaging.

    abstract：:Proton computed tomography (pCT) promises to reduce or even eliminate range uncertainties inherent in the conversion of Hounsfield units into relative stopping power (RSP) for proton therapy treatment planning. This is of particular interest for proton irradiation studies in animal models due to the high precision req...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab8afc

    authors： Meyer S,Bortfeldt J,Lämmer P,Englbrecht FS,Pinto M,Schnürle K,Würl M,Parodi K

    更新日期：2020-08-13 00:00:00

  • Ion concentration and haematocrit as determinants of impedance in an erythrocyte suspension model of renal medullary tissue.

    abstract：:In order to analyse the respective roles of ion concentration and fractional volume of the interstitial compartment as determinants of the impedance, Z, of renal medullary tissue, a model was needed in which both these factors could be varied independently. An array of blood cell suspensions ions in saline (different ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/35/11/011

    authors： Niewiadomski W,Sadowski J,Badzyńska B,Rasmussen SN

    更新日期：1990-11-01 00:00:00

  • Development of 4D mathematical observer models for the task-based evaluation of gated myocardial perfusion SPECT.

    abstract：:This paper presents two 4D mathematical observer models for the detection of motion defects in 4D gated medical images. Their performance was compared with results from human observers in detecting a regional motion abnormality in simulated 4D gated myocardial perfusion (MP) SPECT images. The first 4D mathematical obs...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/60/7/2751

    authors： Lee TS,Frey EC,Tsui BM

    更新日期：2015-04-07 00:00:00

  • Improving source detection and separation in a spatiotemporal Bayesian inference dipole analysis.

    abstract：:Most existing spatiotemporal multi-dipole approaches for MEG/EEG source localization assume that the dipoles are active for the full time range being analysed. If the actual time range of activity of sources is significantly shorter than the time range being analysed, the detectability, localization and time-course de...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/51/10/004

    authors： Jun SC,George JS,Plis SM,Ranken DM,Schmidt DM,Wood CC

    更新日期：2006-05-21 00:00:00

  • Analytical calculation of the portal scatter to primary dose ratio: an EGS4 Monte Carlo and experimental validation at large air gaps.

    abstract：:An analytical approximation for the scatter to primary dose ratio (SPR) on the central axis was validated against Monte Carlo results and experimental measurements for homogeneous and inhomogeneous phantoms. The analytical approximation only included first-order Compton scatter. The contribution to the total SPR from ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/46/6/310

    authors： Ozard SR,Grein EE

    更新日期：2001-06-01 00:00:00

  • An automated, fast and accurate registration method to link stranded seeds in permanent prostate implants.

    abstract：:The geometry of a permanent prostate implant varies over time. Seeds can migrate and edema of the prostate affects the position of seeds. Seed movements directly influence dosimetry which relates to treatment quality. We present a method that tracks all individual seeds over time allowing quantification of seed moveme...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/60/20/N391

    authors： Westendorp H,Nuver TT,Moerland MA,Minken AW

    更新日期：2015-10-21 00:00:00

  • Computational dosimetry for grounded and ungrounded human models due to contact current.

    abstract：:This study presents the computational dosimetry of contact currents for grounded and ungrounded human models. The uncertainty of the quasi-static (QS) approximation of the in situ electric field induced in a grounded/ungrounded human body due to the contact current is first estimated. Different scenarios of cylindrica...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/58/15/5153

    authors： Chan KH,Hattori J,Laakso I,Hirata A,Taki M

    更新日期：2013-08-07 00:00:00

  • Dielectric studies on the reaction of the intracellular matter of fish red blood cells to detergent toxicity.

    abstract：:Results from dielectric studies on the freshwater fish Cyprinus carpio exposed to a sublethal concentration of sodium alkyl benzene sulphonate were compared with those from untreated control fish; recovery from the test solution was also checked. The influence of the anionic detergent on the intracellular matter of fi...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/29/5/005

    authors： Bielinska I,Terlecki J

    更新日期：1984-05-01 00:00:00

  • Investigation of ultrasonic properties of PAG and MAGIC polymer gel dosimeters.

    abstract：:Ultrasonic speed of propagation and attenuation were investigated as a function of absorbed radiation dose in PAG and MAGIC polymer gel dosimeters. Both PAG and MAGIC gel dosimeters displayed a dependence of ultrasonic parameters on absorbed dose with attenuation displaying significant changes in the dose range invest...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/47/24/307

    authors： Mather ML,De Deene Y,Whittaker AK,Simon GP,Rutgers R,Baldock C

    更新日期：2002-12-21 00:00:00

  • Broadband ultrasound attenuation imaging: algorithm development and clinical assessment of a region growing technique.

    abstract：:This paper presents a computerized method for the selection of an irregular region of interest (ROI) in broadband ultrasound attenuation (BUA) images. A region growing algorithm searches an initial region in the posterior part of the calcaneus until the pixel with the lowest attenuation value is found; this is the sta...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/47/2/310

    authors： Damilakis J,Stratakis J,Perisinakis K,Gourtsoyiannis N

    更新日期：2002-01-21 00:00:00

  • Non-uniform depth scanning for proton therapy systems employing active energy variation.

    abstract：:In proton scanning systems that employ active energy variation for depth modulation, a switch of the particle energy might typically require 1-2 s. For plans comprising many energy slices, these seconds could sum up to a non-negligible fraction of the total treatment duration. We have applied the Nyquist-Shannon sampl...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/53/9/N01

    authors： Kang JH,Wilkens JJ,Oelfke U

    更新日期：2008-05-07 00:00:00

  • An experimental evaluation of the Agility MLC for motion-compensated VMAT delivery.

    abstract：:An algorithm for dynamic multileaf-collimator (dMLC) tracking of a target performing a known a priori, rigid-body motion during volumetric modulated arc therapy (VMAT), has been experimentally validated and applied to investigate the potential of the Agility (Elekta AB, Stockholm, Sweden) multileaf-collimator (MLC) fo...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/58/13/4643

    authors： Davies GA,Clowes P,Bedford JL,Evans PM,Webb S,Poludniowski G

    更新日期：2013-07-07 00:00:00

  • A rigid motion correction method for helical computed tomography (CT).

    abstract：:We propose a method to compensate for six degree-of-freedom rigid motion in helical CT of the head. The method is demonstrated in simulations and in helical scans performed on a 16-slice CT scanner. Scans of a Hoffman brain phantom were acquired while an optical motion tracking system recorded the motion of the bed an...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/60/5/2047

    authors： Kim JH,Nuyts J,Kyme A,Kuncic Z,Fulton R

    更新日期：2015-03-07 00:00:00

  • Estimation of tissue resistivities from multiple-electrode impedance measurements.

    abstract：:In order to measure in vivo resistivity of tissues in the thorax, the possibility of combining anatomical data extracted from high-resolution images with multiple-electrode impedance measurements, a priori knowledge of the range of tissue resistivities, and a priori data on the instrumentation noise is assessed in thi...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/39/1/001

    authors： Eyüboğlu BM,Pilkington TC,Wolf PD

    更新日期：1994-01-01 00:00:00

  • Integral equations and boundary-element solution for static potential in a general piece-wise homogeneous volume conductor.

    abstract：:Boundary element methods (BEM) are used for forward computation of bioelectromagnetic fields in multi-compartment volume conductor models. Most BEM approaches assume that each compartment is in contact with at most one external compartment. In this work, I present a general surface integral equation and BEM discretiza...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/61/22/N606

    authors： Stenroos M

    更新日期：2016-11-21 00:00:00

  • Optical artefact characterization and correction in volumetric scintillation dosimetry.

    abstract：:The goals of this study were (1) to characterize the optical artefacts affecting measurement accuracy in a volumetric liquid scintillator detector, and (2) to develop methods to correct for these artefacts. The optical artefacts addressed were photon scattering, refraction, camera perspective, vignetting, lens distort...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/59/1/23

    authors： Robertson D,Hui C,Archambault L,Mohan R,Beddar S

    更新日期：2014-01-06 00:00:00

  • Posture-specific phantoms representing female and male adults in Monte Carlo-based simulations for radiological protection.

    abstract：:Does the posture of a patient have an effect on the organ and tissue absorbed doses caused by x-ray examinations? This study aims to find the answer to this question, based on Monte Carlo (MC) simulations of commonly performed x-ray examinations using adult phantoms modelled to represent humans in standing as well as ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/55/15/014

    authors： Cassola VF,Kramer R,Brayner C,Khoury HJ

    更新日期：2010-08-07 00:00:00

  • A new treatment planning approach accounting for prompt gamma range verification and interfractional anatomical changes.

    abstract：:Prompt gamma (PG) imaging is widely investigated for spot-by-spot in vivo range verification for proton therapy. Previous studies pointed out that the accuracy of prompt gamma imaging is affected by the statistics (number of protons delivered per pencil beam) of the proton beams and the conformity between prompt gamma...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab7d15

    authors： Tian L,Landry G,Dedes G,Pinto M,Kamp F,Belka C,Parodi K

    更新日期：2020-04-29 00:00:00

  • Numerical calculation of energy deposition by broad high-energy electron beams.

    abstract：:The feasibility is demonstrated of a numerical method to calculate dose deposition by broad high-energy electron beams in homogeneous matter or in heterogeneous matter in which the heterogeneities are arranged in slabs perpendicular to the beam axis. The method is based only on the basic physical interaction processes...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/34/10/003

    authors： Huizenga H,Storchi PR

    更新日期：1989-10-01 00:00:00

  • Volumetric CT with sparse detector arrays (and application to Si-strip photon counters).

    abstract：:Novel x-ray medical imaging sensors, such as photon counting detectors (PCDs) and large area CCD and CMOS cameras can involve irregular and/or sparse sampling of the detector plane. Application of such detectors to CT involves undersampling that is markedly different from the commonly considered case of sparse angular...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/61/1/90

    authors： Sisniega A,Zbijewski W,Stayman JW,Xu J,Taguchi K,Fredenberg E,Lundqvist M,Siewerdsen JH

    更新日期：2016-01-07 00:00:00

  • Diaphragm correction factors for free-air chamber standards for air kerma in x-rays.

    abstract：:At present, only a correction factor for photon transmission, k(l), is systematically applied for the entrance diaphragm of free-air chamber standards for air kerma. In the present work, the Monte Carlo code PENELOPE is used to re-evaluate k(l) for the BIPM standards and new correction factors are calculated for photo...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/54/9/009

    authors： Burns DT,Kessler C

    更新日期：2009-05-07 00:00:00

  • Analysis of a large number of clinical studies for breast cancer radiotherapy: estimation of radiobiological parameters for treatment planning.

    abstract：:Numerous studies of early-stage breast cancer treated with breast conserving surgery (BCS) and radiotherapy (RT) have been published in recent years. Both external beam radiotherapy (EBRT) and/or brachytherapy (BT) with different fractionation schemes are currently used. The present RT practice is largely based on emp...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章,meta分析

    doi：10.1088/0031-9155/48/20/004

    authors： Guerrero M,Li XA

    更新日期：2003-10-21 00:00:00

  • Automated detection of clustered microcalcifications on mammograms: CAD system application to MIAS database.

    abstract：:To investigate the detection performance of our automated detection scheme for clustered microcalcifications on mammograms, we applied our computer-aided diagnosis (CAD) system to the database of the Mammographic Image Analysis Society (MIAS) in the UK. Forty-three mammograms from this database were used in this study...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/42/12/021

    authors： Ibrahim N,Fujita H,Hara T,Endo T

    更新日期：1997-12-01 00:00:00

  • Leveraging multi-layer imager detector design to improve low-dose performance for megavoltage cone-beam computed tomography.

    abstract：:While megavoltage cone-beam computed tomography (CBCT) using an electronic portal imaging device (EPID) provides many advantages over kilovoltage (kV) CBCT, clinical adoption is limited by its high doses. Multi-layer imager (MLI) EPIDs increase DQE(0) while maintaining high resolution. However, even well-designed, hig...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aaa160

    authors： Hu YH,Rottmann J,Fueglistaller R,Myronakis M,Wang A,Huber P,Shedlock D,Morf D,Baturin P,Star-Lack J,Berbeco R

    更新日期：2018-01-30 00:00:00

  • A point kernel algorithm for microbeam radiation therapy.

    abstract：:Microbeam radiation therapy (MRT) is a treatment approach in radiation therapy where the treatment field is spatially fractionated into arrays of a few tens of micrometre wide planar beams of unusually high peak doses separated by low dose regions of several hundred micrometre width. In preclinical studies, this treat...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa8d63

    authors： Debus C,Oelfke U,Bartzsch S

    更新日期：2017-10-19 00:00:00