Hydrogels in calcium phosphate moldable and injectable bone substitutes: Sticky excipients or advanced 3-D carriers?

abstract：:Hyposalivation is associated with radiation therapy, Sjögren's syndrome and/or aging, and is a significant clinical problem that decreases oral health and overall health in many patients and currently lacks effective treatment. Hence, methods to regenerate salivary glands and restore saliva secretion are urgently need...

journal_title：Acta biomaterialia

authors： Nam K,Dean SM,Brown CT,Smith RJ Jr,Lei P,Andreadis ST,Baker OJ

更新日期：2019-06-01 00:00:00

abstract：:Current developments in computer-aided design (CAD) and solid free-form fabrication (SFF) techniques enable fabrication of scaffolds with precisely designed architectures and mechanical properties. The present study demonstrates the effect of precisely designed three-dimensional scaffold architectures on in vivo degra...

journal_title：Acta biomaterialia

authors： Saito E,Liu Y,Migneco F,Hollister SJ

更新日期：2012-07-01 00:00:00

abstract：:Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based ...

journal_title：Acta biomaterialia

authors： Tao Y,Tong X,Zhang Y,Lai J,Huang Y,Jiang YR,Guo BH

更新日期：2013-02-01 00:00:00

abstract：:Biomineralization is a dehydration process in which water from the intrafibrillar compartments of collagen fibrils are progressively replaced by apatites. As water is an important element that induces a lack of durability of resin-dentin bonds, this study has examined the use of a biomimetic remineralization strategy ...

journal_title：Acta biomaterialia

authors： Kim YK,Mai S,Mazzoni A,Liu Y,Tezvergil-Mutluay A,Takahashi K,Zhang K,Pashley DH,Tay FR

更新日期：2010-09-01 00:00:00

abstract：:Articular cartilage has limited capacity for regeneration and when damaged cannot be repaired with currently available metallic or synthetic implants. We aim to bioengineer a microfibre-reinforced hydrogel that can capture the zonal depth-dependent mechanical properties of native cartilage, and simultaneously support ...

journal_title：Acta biomaterialia

authors： Castilho M,Mouser V,Chen M,Malda J,Ito K

更新日期：2019-09-01 00:00:00

abstract：:Poly(ethylene glycol) PEG-based hydrogels are promising for cell encapsulation and tissue engineering, but are known to elicit a foreign body response (FBR) in vivo. The goal of this study was to investigate the impact of the FBR, and specifically the presence of inflammatory macrophages, on encapsulated cells and the...

journal_title：Acta biomaterialia

authors： Saleh LS,Carles-Carner M,Bryant SJ

更新日期：2018-04-15 00:00:00

abstract：:Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context, in this work, liposomes of differen...

journal_title：Acta biomaterialia

authors： Yang K,Mesquita B,Horvatovich P,Salvati A

更新日期：2020-04-01 00:00:00

abstract：:The active and passive mechanical behavior of a cosmetic tightening product for skin anti-aging is investigated based on a wide range of in vivo and in vitro measurements. The experimental data are used to inform a numerical model of the attained cosmetic effect, which is then implemented in a commercial finite-elemen...

journal_title：Acta biomaterialia

authors： Pensalfini M,Rotach M,Hopf R,Bielicki A,Santoprete R,Mazza E

更新日期：2020-10-01 00:00:00

abstract：:We have performed a comparative analysis of glutaraldehyde-preserved ostrich pericardium, as a novel biomaterial, with bovine pericardium. The biochemical characteristics (histology, water content, amino acid composition, and collagen and elastin contents), mechanical properties, and in vivo calcification in a subcuta...

journal_title：Acta biomaterialia

authors： Maestro MM,Turnay J,Olmo N,Fernández P,Suárez D,García Páez JM,Urillo S,Lizarbe MA,Jorge-Herrero E

更新日期：2006-03-01 00:00:00

abstract：:Functional and perfusable vascular network formation is critical to ensure the long-term survival and functionality of engineered tissues after their transplantation. Although several vascularization strategies have been reviewed in past, the significance of microvessel organization in three-dimensional (3D) scaffolds...

journal_title：Acta biomaterialia

authors： Sharma D,Ross D,Wang G,Jia W,Kirkpatrick SJ,Zhao F

更新日期：2019-09-01 00:00:00

abstract：:Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based nanomaterial loaded with iron phthalocyanine for X-ray and NIR l...

journal_title：Acta biomaterialia

authors： Liu J,Zhang J,Huang F,Deng Y,Li B,Ouyang R,Miao Y,Sun Y,Li Y

更新日期：2020-09-01 00:00:00

abstract：:Analytical protocol greatly influences the measurement of human serum albumin (HSA) adsorption to commercial expanded polytetrafluororethylene (ePTFE) exhibiting superhydrophobic wetting properties. Degassing of buffer solutions and evacuation of ePTFE adsorbent to remove trapped air immediately prior to contact with ...

journal_title：Acta biomaterialia

authors： Leibner ES,Barnthip N,Chen W,Baumrucker CR,Badding JV,Pishko M,Vogler EA

更新日期：2009-06-01 00:00:00

abstract：:Recently, a significant amount of effort has been dedicated to understanding factors that influence the functionality of bio-electronic sensors and to development of novel coating technologies for modifying biosensor surfaces. Due to its well-known biocompatibility, alginate hydrogel (HG) has been used as a coating ma...

journal_title：Acta biomaterialia

authors： Kim DH,Wiler JA,Anderson DJ,Kipke DR,Martin DC

更新日期：2010-01-01 00:00:00

abstract：:A major challenge to the successful clinical application of bioengineered cartilage remains its integration to surrounding tissues upon implantation. One way to address this consists of generating biphasic constructs composed of articular cartilage formed in vitro on the top surface and integrated with the porous sub-...

journal_title：Acta biomaterialia

authors： St-Pierre JP,Pilliar RM,Grynpas MD,Kandel RA

更新日期：2010-08-01 00:00:00

abstract：:Human enamel has been found to be a coating with excellent mechanical performance, and has undergone extensive investigation and discussion. However, most of the reported studies consider the enamel as a homogeneous anisotropic biocomposite. The current study illustrated the graded properties of the biocomposite from ...

journal_title：Acta biomaterialia

authors： He LH,Yin ZH,van Vuuren LJ,Carter EA,Liang XW

更新日期：2013-05-01 00:00:00

abstract：:Three-dimensional (3D) printing is a promising technology for tissue engineering. However, 3D-printing methods are limited in their ability to produce desired microscale features or electrochemical properties in support of robust cell adhesion, proliferation, and differentiation. This study addresses this deficiency b...

journal_title：Acta biomaterialia

authors： Liu X,George MN,Park S,Miller Ii AL,Gaihre B,Li L,Waletzki BE,Terzic A,Yaszemski MJ,Lu L

更新日期：2020-07-15 00:00:00

abstract：:Molecular imprinting is a technique used to create specific recognition sites on the surface of materials. Although widely developed for chromatographic separation of small molecules, this approach has not been adequately investigated for biomaterial applications. Thus, the objective of these experiments was to explor...

journal_title：Acta biomaterialia

authors： Lee K,Itharaju RR,Puleo DA

更新日期：2007-07-01 00:00:00

abstract：:Higher order tasks in development for brain-computer interfacing applications require the invasiveness of intracortical microelectrodes. Unfortunately, the resulting inflammatory response contributes to the decline of detectable neural signal. The major components of the neuroinflammatory response to microelectrodes h...

journal_title：Acta biomaterialia

authors： Bedell HW,Schaub NJ,Capadona JR,Ereifej ES

更新日期：2020-01-15 00:00:00

abstract：:Cationic polymer-based vectors have been considered a promising strategy in gene therapy area due to their inherent ability to condense genetic material and successfully transfect cells. However, they usually exhibit high cytotoxicity. In this work, it is proposed the use of a tailor-made gene carrier based on a tri-b...

journal_title：Acta biomaterialia

authors： Cordeiro RA,Santo D,Farinha D,Serra A,Faneca H,Coelho JFJ

更新日期：2017-01-01 00:00:00

abstract：:In this paper, the 3D-morphology of the porosity in dentin is investigated within the first 350μm from the dentin-enamel junction (DEJ) by fluorescence confocal laser scanning microscopy (CLSM). We found that the porous microstructure exhibits a much more complex geometry than classically described, which may impact o...

journal_title：Acta biomaterialia

authors： Vennat E,Wang W,Genthial R,David B,Dursun E,Gourrier A

更新日期：2017-03-15 00:00:00

abstract：:The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loaded-antibiotic within this matrix would ...

journal_title：Acta biomaterialia

authors： Martínez-Carmona M,Izquierdo-Barba I,Colilla M,Vallet-Regí M

更新日期：2019-09-15 00:00:00

abstract：:Nanofibre-based structures and their composites are increasingly being studied for many biomedical applications, including tissue engineering scaffolds. These materials enable architectures resembling the extracellular matrix to be obtained. The search for optimized supports and carriers of cells is still a major chal...

journal_title：Acta biomaterialia

authors： Pinho ED,Martins A,Araújo JV,Reis RL,Neves NM

更新日期：2009-05-01 00:00:00

abstract：:Implant-derived material from metal-on-metal (MOM) hip arthroplasties may be responsible for an unexplained tissue inflammatory response. The chemical form of the metal species in the tissues is predominantly chromium (Cr), but the currently used techniques have not been able to determine whether this is Cr(III) phosp...

journal_title：Acta biomaterialia

authors： Hart AJ,Quinn PD,Sampson B,Sandison A,Atkinson KD,Skinner JA,Powell JJ,Mosselmans JF

更新日期：2010-11-01 00:00:00

abstract：:The management of diabetic wounds remains a major therapeutic challenge in clinics. Herein, we report a personalized treatment using 3D scaffolds consisting of radially or vertically aligned nanofibers in combination with bone marrow mesenchymal stem cells (BMSCs). The 3D scaffolds have customizable sizes, depths, and...

journal_title：Acta biomaterialia

authors： Chen S,Wang H,Su Y,John JV,McCarthy A,Wong SL,Xie J

更新日期：2020-05-01 00:00:00

abstract：:Infection is a major cause of failure of inserted or implanted biomedical devices (biomaterials). During surgery, bacteria may adhere to the implant, initiating biofilm formation. Bacteria are also observed in and recultured from the tissue surrounding implants, and may even reside inside host cells. Whether these bac...

journal_title：Acta biomaterialia

authors： Riool M,de Boer L,Jaspers V,van der Loos CM,van Wamel WJB,Wu G,Kwakman PHS,Zaat SAJ

更新日期：2014-12-01 00:00:00

abstract：:Surgical removal remains the main clinical approach to treat breast cancer, although risks including high local recurrence of cancer and loss of breast tissues are the threats for the survival and quality of life of patients after surgery. In this study, bifunctional scaffold based on dopamine-modified alginate and po...

journal_title：Acta biomaterialia

authors： Luo Y,Wei X,Wan Y,Lin X,Wang Z,Huang P

更新日期：2019-07-01 00:00:00

abstract：UNLABELLED:The use of biomaterials to direct osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of osteogenic supplements is thought to be part of the next generation of orthopedic implants. We previously engineered surface-roughness gradients of average roughness (Ra) varying from the su...

journal_title：Acta biomaterialia

authors： Faia-Torres AB,Charnley M,Goren T,Guimond-Lischer S,Rottmar M,Maniura-Weber K,Spencer ND,Reis RL,Textor M,Neves NM

更新日期：2015-12-01 00:00:00

abstract：:The effect of calcium phosphate-based microchannels on the growth and orientation of human osteoblast cells is investigated in this study. As substrates, hydroxyapatite-based microchannels with high contouring accuracy were fabricated by a novel micro-moulding technique. Microchannels obtained by this method featured ...

journal_title：Acta biomaterialia

authors： Holthaus MG,Stolle J,Treccani L,Rezwan K

更新日期：2012-01-01 00:00:00

abstract：:Ultra-high molecular weight polyethylene (UHMWPE) is frequently employed in joint replacements because of its high biocompatibility; however, this material does not exhibit particularly strong wear performance, thus potentially reducing the longevity of such devices. Numerous techniques have been investigated to incre...

journal_title：Acta biomaterialia

authors： Perni S,Kong MG,Prokopovich P

更新日期：2012-03-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) are rupture-prone progressive dilations of the infrarenal aorta due to a loss of elastic matrix that lead to weakening of the aortic wall. Therapies to coax biomimetic regenerative repair of the elastic matrix by resident, diseased vascular cells may thus be useful to slow, arrest or ...

journal_title：Acta biomaterialia

authors： Sylvester A,Sivaraman B,Deb P,Ramamurthi A

更新日期：2013-12-01 00:00:00