Abstract:
:There is now sufficient evidence to support the feasibility and efficacy of ovarian tissue (OT) cryopreservation and transplantation for both fertility preservation and restoration purposes. However, there are still issues to address regarding the grafting procedure itself, since transplanted tissue suffers massive follicle loss in the early post-grafting period. To improve follicle survival after transplantation, our group recently developed a two-step transplantation technique for OT transplantation in a xenografting model using adipose tissue-derived stem cells (ASCs). The aim of this narrative review is to describe and discuss the previously reported findings. ASCs were initially characterized by flow cytometry as positive for CD29, CD44, CD73, CD90, CD105 and CD166 (>95%) and negative for CD34, CD14, CD31, CD45 and Lin1. ASCs were used in a model of xenotransplantation, were they were embedded in a fibrin scaffold and transplanted to the peritoneum of immunodeficient mice. The goal of the first step was to increase levels of partial pressure of oxygen (pO2 ) and revascularization in the peritoneal transplantation site for further OT transplantation. As ASCs showed the ability to differentiate into endothelial-like cells and vessels in our model, OT transplantation was then performed with ASC grafts in a controlled experiment. At 7 days post-transplantation, the ASC group showed: (1) significantly higher pO2 levels; (2) significantly greater human and murine CD34-positive endothelial areas; (3) significantly higher primordial follicle survival rates; (4) and significantly lower numbers of apoptotic follicles compared with the control group. Our research model demonstrates that by adding ASCs to a fibrin scaffold before OT transplantation, faster and better graft reoxygenation and revascularization may be obtained, resulting in increased follicle survival and reduced follicle apoptosis.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Dolmans MM,Cacciottola L,Amorim CA,Manavella Ddoi
10.1111/aogs.13610subject
Has Abstractpub_date
2019-05-01 00:00:00pages
665-671issue
5eissn
0001-6349issn
1600-0412journal_volume
98pub_type
杂志文章,评审abstract:BACKGROUND:Maternal symptoms such as severe headache, nausea and vomiting, visual disturbances and epigastric pain have been associated with complications in women with preeclampsia. OBJECTIVE:To determine the accuracy of maternal symptoms in predicting complications in women with preeclampsia by systematic review. D...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0412.2011.01111.x
更新日期:2011-06-01 00:00:00
abstract::Sixty women were given intravenous injection of 200 microgram TRH to assess its diagnostic potential as a stimulus to PRL release. Following the administration of TRH, there was a prompt increase in serum PRL to 614.6%, to 296%, to 282.1%, and 34% in normal women, amenorrheic patients, non tumoral galactorrheic cases,...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347709154988
更新日期:1977-01-01 00:00:00
abstract:INTRODUCTION:Postpartum hemorrhage (PPH) is recognized as a leading cause of obstetric morbidity and mortality. Population-wide studies have used International Classification of Diseases (ICD) diagnostic codes to track and report the prevalence of PPH. Although the 10th revision (ICD-10) was introduced in Sweden in 199...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13994
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:Early mother-infant relationships in preterm populations were evaluated in the context of a systematic review of the literature. DESIGN AND SETTING:A systematic search of three electronic databases (PsychINFO, PubMed and Cochrane Library) was undertaken. Three studies of maternal attachment, 18 studies of mo...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0412.2011.01304.x
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Chorioamnionitis (CAM) may accelerate lung maturation in fetuses. It is possible that CAM prevents infant death after live birth. METHODS:A retrospective study of live-born singletons at < 32 weeks of gestation between 1993 and 1997. Perinatal risk factors for adverse outcomes were analyzed using a logistic...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract::The malignancy risk of endometrial polyps in postmenopausal women was correlated with the presence or absence of abnormal uterine bleeding. Of 481 postmenopausal women who presented with endometrial polyps at diagnostic hysteroscopy between 2004 and 2007, 48.9% were asymptomatic and 51.1% had postmenopausal uterine bl...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902818188
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:This study aims to compare pelvic floor muscle (PFM) function in postmenopausal women with and without pelvic floor dysfunction (PFD) and the relation between PFM function and quality of life. MATERIAL AND METHODS:A case-control study with 216 postmenopausal women with (n = 126) and without (n = 90) PFD. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13305
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Current health policies advocate patient participation in treatment decision-making. Objective. To explore whether role preferences among women with urinary incontinence (UI) change depending on the treatment decision-making context. We also explore what factors are associated with role preferences and chang...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340701622310
更新日期:2007-01-01 00:00:00
abstract::Heavy menstrual bleedings frequently lead to iron deficiency. Iron supplementation is usually given to cover the increased losses. In the present study one tablet containing 100 mg of iron (Duroferon R, Durules R) was given daily for 10 days in connection with the menstrual period in 15 women with menorrhagia. The tab...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Eighty-two gynecological patients with clinical signs of a lower urinary tract infection (UTI) were randomized to 10 days' treatment with either a fixed combination of pivampicillin-pivmecillinam (PAPM) or trimethoprim-sulphamethoxazole (TMPS). The effect of treatment could be evaluated in 25 patients on PAPM and in 1...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348309154228
更新日期:1983-01-01 00:00:00
abstract::The aim of the present study was to investigate whether low-dose oral contraceptives affect oxytocin concentrations in plasma. Twenty women participated in an open cross-over study. Six consecutive blood samples were drawn twice, with a 4-week interval, in the luteal phase of the menstrual cycle when the women were/we...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016348909087694
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:We wanted to study to what extent induced abortion rates influence the age-dependent estimates of miscarriage risk. DESIGN:Register-based study. SETTING:Linkage between hospital records and the Norwegian Population Registry. POPULATION:Included were all women 15-49 years of age in Oslo, Norway, who were pr...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902814567
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The primary aim of this study was to examine the association between inherited thrombophilias and adverse pregnancy outcomes in an Australian population. DESIGN:Case-control study. SETTING:Two Australian tertiary level maternity hospitals. POPULATION:One hundred and fifteen cases with adverse pregnancy out...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01293.x
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to describe contraceptive use and pregnancies and their relationship to socio-economic status (SES) in four generations of young Swedish women. MATERIAL AND METHODS:Questionnaires regarding contraceptive use and pregnancies were sent to random samples of 19-year-old women in 1981...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13003
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To assess whether gynecologists have impaired laparoscopic skills and/or reduced cognitive function after long on-call hours. DESIGN:Prospective cohort study. SETTING:Department of Gynecology and Obstetrics, Norway. POPULATION:28 gynecologists working long shifts in a single department. METHODS:Pre-traini...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12496
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a seri...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13203
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:We assessed the efficacy of maternal anthropometric measurements and clinical estimates of fetal weight in isolation and in combination as predictors of cephalopelvic disproportion (CPD). DESIGN:Prospective cohort study. SETTING:Tertiary care teaching hospital, two affiliated hospitals with facilities for c...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0412.2011.01267.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:This study aims to evaluate the feasibility and diagnostic validity of the sentinel lymph node technique in detecting inguinal lymph node metastases in patients with invasive squamous cancer of the vulva. DESIGN:Retrospective analysis of the in-house tumor registry. SETTING:Dr. Horst Schmidt Klinik, a terti...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903317982
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To explore procedures for providing information, assessment and documentation about ultrasound soft markers in Sweden. DESIGN:Descriptive, quantitative, cross-sectional survey. SAMPLE:Eighty-two percent of all obstetric ultrasound clinics in Sweden (covering >90% of routine fetal ultrasound examinations). ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12554
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Our aim was to estimate the prevalence of stress urinary incontinence 4 years after the first delivery and analyze its risk factors. METHODS:A retrospective cohort survey was conducted in a French university hospital. The 669 primiparous women who delivered in our department in 1996 a singleton in a vertex ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00457.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To compare two treatment strategies in women undergoing surgery for endometrial carcinoma. DESIGN:Retrospective cohort study. SETTING:Tertiary care center. POPULATION:1166 patients. Uterine biopsy/curettage was obtained in 1140 women, of whom 229 also had pelvic magnetic resonance imaging (MRI). METHODS:W...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12523
更新日期:2015-01-01 00:00:00
abstract::The excretion of phenoxymethylpenicillin in vaginal fluid was determined in 19 hysterectomized women, 8 totally and 11 subtotally operated. Phenoxymethylpenicillin was found in the vaginal fluid in high concentrations in both groups of women and it was concluded that the substance penetrates the vaginal wall. Concentr...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109006194
更新日期:1991-01-01 00:00:00
abstract::To differentiate between ovarian carcinoma and benign ovarian tumor, we compared alpha-hydroxybutyrate dehydrogenase (HBD), lactate dehydrogenase (LDH) and its isoenzyme activities in serum in 115 patients with ovarian carcinoma and benign ovarian tumor. Both serum HBD activity and total LDH activity in ovarian cancer...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348509156361
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To determine the risk of endometrial cancer when endometrial thickness is not visualized using ultrasonography. DESIGN:Cross-sectional study. SETTING:Gynecological oncology center in the United Kingdom. POPULATION:All postmenopausal women referred with vaginal bleeding. METHODS:All women were investigated...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2012.01407.x
更新日期:2012-06-01 00:00:00
abstract::Consanguinity is common in Arab countries. The Sultanate of Oman has a relatively small population with a high prevalence of consanguineous marriages. This is a retrospective study of women who had three or more consecutive miscarriages between January 2002 and December 2008, investigated in the non-pregnant state. Ag...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01200.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Our objective was to investigate the role of hydrogen peroxide in the vasocontraction induced in the human umbilical artery by serotonin. METHODS:Umbilical arteries collected from healthy women at term were cut helically and suspended in an organ bath to record isometric mechanical activity. In Study I, we ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349609054704
更新日期:1996-10-01 00:00:00
abstract:INTRODUCTION:This study compared healing of the scars after cesarean section during the first postpartum year using a single- or double-layer suturing technique. Scarring was assessed by a transvaginal ultrasound. We explored the appearance and localization of uterine scars with regard to the obstetric history. Our aim...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.13714
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To study pregnant women's knowledge, attitudes and behaviors towards tobacco use and secondhand smoke (SHS) exposure, and exposure to advertising for and against tobacco products in Zambia and the Democratic Republic of the Congo (DRC). DESIGN:Prospective cross-sectional survey between November 2004 and Sept...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016341003605693
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE: To determine the influence of type 1 diabetes mellitus (T1DM) on the first trimester serum markers of fetal aneuploidy; pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free β-hCG) and to evaluate the influence of glycemic control on these parameters in th...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01212.x
更新日期:2012-01-01 00:00:00
abstract::Acute pancreatitis verified at laparotomy occurred in the 37th week in 1 of 4 women who developed excessive hypertriglyceridemia (type V hyperlipoproteinemia) during pregnancy. The hypertriglyceridemia was associated with and possibly caused by deficiency of lipoprotein lipase, measured as the NaCl sensitive component...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348109154115
更新日期:1981-01-01 00:00:00