Prolactin responsiveness to TRH in amenorrheic women with and without galactorrhea.

Abstract:

:Sixty women were given intravenous injection of 200 microgram TRH to assess its diagnostic potential as a stimulus to PRL release. Following the administration of TRH, there was a prompt increase in serum PRL to 614.6%, to 296%, to 282.1%, and 34% in normal women, amenorrheic patients, non tumoral galactorrheic cases, and patients with pituitary tumors respectively. The TRH response above baseline of PRL levels was statistically significant in all groups, but the women with pituitary tumors which showed a blunted response. The per cent of increment of PRL levels after TRH was similar in amenorrheic women regardless the presence or not of galactorrhea; this increase was significantly greater than in patients with pituitary tumors (p less than 0.01). The per cent of increment above baseline of PRL was significantly greater in menstruating women than in amenorrheic patients (p less than 0.001). In basis of present data: 1) there is a diminished PRL secretion after TRH in amenorrheic women regardless the presence of galactorrhea or hyperprolactinemia; 2) a blunted response to TRH in hyperprolactinemic women may be indicative of a pituitary tumor. :60 women were given 200 mcg thyrotropin releasing hormone (TRH) iv to assess its stimulus to prolactin (PRL) release as a diagnostic tool. It has been suggested that a blunted response to TRH in hyperprolactinemic women may be indicative of a pituitary tumor. The group included 6 normal women, 18 with hypothalamic amenorrhea, 31 with idiopathic amenorrhea galactorrhea, and 11 with pituitary tumor. Following TRH administration, serum PRL increased 614.6% in normal women, 296% in the amenorrheic, 282.1% in the nontumoral galactorrheic, and 34% in the patients with pituitary tumors. TRH response above baseline PRL levels was significant (p .001) in all but the tumor patients. Increase above baseline PRL was also greater in menstruating women than in amenorrheic (p .001). It is suggested that there is diminished PRL secretion after TRH in amenorrheic women regardless of the presence of galactorrhea or hyperprolactinemia and that a blunted response may be helpful in separating patients with pituitary tumor from those with galactorrhea of other causes.

authors

MacGregor C,Maldonado D,Canales ES,Soria J,Zárate A

doi

10.3109/00016347709154988

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

333-6

issue

4

eissn

0001-6349

issn

1600-0412

journal_volume

56

pub_type

杂志文章
  • Treatment of ilioinguinal nerve entrapment - a randomized controlled trial.

    abstract:OBJECTIVE:Neuralgic pain caused by entrapment of peripheral nerves can be a difficult clinical problem. The objective of the present study was to assess pain and quality of life in women with pain secondary to ilioinguinal nerve entrapment. DESIGN:In a controlled prospective crossover study, women with ilioinguinal ne...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0412.2011.01194.x

    authors: Hahn L

    更新日期:2011-09-01 00:00:00

  • Cause of and factors associated with stillbirth: a systematic review of classification systems.

    abstract:INTRODUCTION:An estimated 2.6 million stillbirths occur worldwide each year. A standardized classification system setting out possible cause of death and contributing factors is useful to help obtain comparative data across different settings. We undertook a systematic review of stillbirth classification systems to hig...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aogs.13126

    authors: Aminu M,Bar-Zeev S,van den Broek N

    更新日期:2017-05-01 00:00:00

  • The suppression of puerperal lactation with bromocryptine.

    abstract::The therapeutic value of 2-Br-alpha-ergocryptine for the suppression of puerperal lactation was studied in 30 normal women; 16 received the drug, 14 were controls. In six women plasma levels of FSH, oestradiol and alpha-lactalbulmin were measured in labour and in the early puerperium. Brom-ergocryptine was found effec...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016347709158357

    authors: Willmott MP,Colhoun EM,Bolton AE

    更新日期:1977-01-01 00:00:00

  • Diazepam as a sedative in induced abortion.

    abstract::In 136 patients, who underwent induced abortion by the vacuum curettage method under local anaesthesia (paracervical block), the effect of 10 mg diazepam intravenously as preoperative sedative was investigated for its ability to abolish the subjective experience of pain. The trial was carried out as a paired sample, r...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00016347509157768

    authors: Nielsen JB,Madsen OG,Campbell UD

    更新日期:1975-01-01 00:00:00

  • Spontaneous abortion: a prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants.

    abstract:OBJECTIVE:To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion. METHODS:We used interview data from a population-based prospective cohort ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340500494887

    authors: Buss L,Tolstrup J,Munk C,Bergholt T,Ottesen B,Grønbaek M,Kjaer SK

    更新日期:2006-01-01 00:00:00

  • Effects of thyroxine therapy on bone metabolism in postmenopausal women with hypothyroidism.

    abstract:OBJECTIVE:To evaluate whether thyroid stimulating hormone-suppressive thyroxine replacement therapy increases bone loss in postmenopausal women. MATERIALS AND METHOD:The study had a cross-sectional design. Fifty-four postmenopausal women on long-term treatment with thyroxine for primary hypothyroidism, who showed supp...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349609054714

    authors: Affinito P,Sorrentino C,Farace MJ,di Carlo C,Moccia G,Canciello P,Palomba S,Nappi C

    更新日期:1996-10-01 00:00:00

  • Ovarian and intra-uterine pregnancy combined.

    abstract::Combined ectopic and intra-uterine gestations are uncommon, especially if the ectopic pregnancy is located in the ovary. A case of combined ovarian and intrauterine pregnancy that resulted in a full-term delivery is reported. ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348809029873

    authors: Nilsson BG,Gerdes U

    更新日期:1988-01-01 00:00:00

  • Preterm breech delivery. Early and late complications.

    abstract::One hundred and ten singleton breech infants with a birth-weight less than 2 500 g have been delivered at Huddinge University Hospital during the years 1972-78. The cesarean section rate was 30.1 per cent. Vaginal and abdominal deliveries were compared with regard to perinatal mortality and asphyxial morbidity at birt...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348109154124

    authors: Nisell H,Bistoletti P,Palme C

    更新日期:1981-01-01 00:00:00

  • Maternal smoking predicts the risk of spontaneous abortion.

    abstract:BACKGROUND:Few studies have examined smoking prior to pregnancy and the occurrence of spontaneous abortion, as most studies have addressed the risk of spontaneous abortion in relation to smoking during pregnancy. However, results are not entirely consistent. The aim of the present study was to assess the risk of sponta...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340600589560

    authors: Nielsen A,Hannibal CG,Lindekilde BE,Tolstrup J,Frederiksen K,Munk C,Bergholt T,Buss L,Ottesen B,Grønbaek M,Kjaer SK

    更新日期:2006-01-01 00:00:00

  • Independent risk factors for ovarian metastases in stage IA-IIB cervical carcinoma.

    abstract:INTRODUCTION:Cervical cancer is a common malignant tumor in women; most cervical cancer patients are premenopausal. Ovarian resection or preservation remains controversial. The purpose of this study was to discover the risk factors for ovarian metastasis in women with stage I-II cervical cancer. MATERIAL AND METHODS:A...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/aogs.13442

    authors: Zhou L,Sun CT,Lin L,Xie Y,Huang Y,Li Q,Liu X

    更新日期:2019-01-01 00:00:00

  • Bone turnover from early pregnancy to postweaning.

    abstract:BACKGROUND:To elucidate the sequences of changes in bone metabolism and bone density during pregnancy, lactation and postweaning. METHODS:Women were recruited (n = 254) in early pregnancy and followed for 2 years. Markers of bone formation (osteocalcin) and resorption (NTx) were measured at five occasions. Bone minera...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.0001-6349.2004.00428.x

    authors: Akesson A,Vahter M,Berglund M,Eklöf T,Bremme K,Bjellerup P

    更新日期:2004-11-01 00:00:00

  • Management of postmenopausal women with vaginal bleeding when the endometrium can not be visualized.

    abstract:OBJECTIVE:To determine the risk of endometrial cancer when endometrial thickness is not visualized using ultrasonography. DESIGN:Cross-sectional study. SETTING:Gynecological oncology center in the United Kingdom. POPULATION:All postmenopausal women referred with vaginal bleeding. METHODS:All women were investigated...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2012.01407.x

    authors: Burbos N,Musonda P,Crocker SG,Morris EP,Nieto JJ,Duncan TJ

    更新日期:2012-06-01 00:00:00

  • A prospective randomized trial to compare immediate and 24-hour delayed catheter removal following total abdominal hysterectomy.

    abstract:OBJECTIVE:To assess whether early or immediate removal of a 12F in-dwelling Foley catheter after total abdominal hysterectomy affects the level of subjective pain assessment postoperatively. DESIGN:Randomized controlled trial. SETTING:University Hospital. POPULATION:Seventy women underwent total abdominal hysterecto...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0412.2011.01104.x

    authors: Chai J,Pun TC

    更新日期:2011-05-01 00:00:00

  • A quality of life perspective on who benefits from estradiol replacement therapy.

    abstract:STUDY OBJECTIVE:To examine who may benefit from estrogen replacement therapy from a quality of life (QoL) perspective, taking both disease-specific and general aspects at baseline into account. DESIGN:A double-blind multi-center randomized placebo-controlled prospective study. The subjects were randomized to receive e...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00016349509024430

    authors: Karlberg J,Mattsson LA,Wiklund I

    更新日期:1995-05-01 00:00:00

  • Consumption of anti-D in the erythroblastotic fetus.

    abstract:BACKGROUND:Maternal serum anti-D is actively transported across the placenta into the fetal blood where it adheres to D-positive erythrocytes. The anti-D coated red cells attach to Fc-receptors on fetal reticuloendothelial cells and are subsequently phagocytosed and hemolysed. It is not known if anti-D is consumed or r...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Gottvall T,Selbing A

    更新日期:1998-05-01 00:00:00

  • Estradiol, estriol and human placental lactogen in serum in threatened abortion.

    abstract::In 64 pregnant women admitted to hospital because of threatened abortion the prognostic value of estradiol-17-beta, estriol and human placental lactogen (HPL) in serum was examined. The hormones were determined by radioimmunoassay. Blood samples were taken at regular intervals during admission to hospital and subseque...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016347909154597

    authors: Hertz JB,Larsen JF,Svenstrup B,Johnsen SG

    更新日期:1979-01-01 00:00:00

  • Gonadal steroids, gonadotropins and endometrial histology in postmenopausal women with malignant ovarian tumors.

    abstract::The concentrations of FSH, LH, 17-beta-estradiol (E2), estrone (E1) and progesterone (P) were measured in peripheral and ovarian vein sera obtained at preoperative pelvic angiography from 5 postmenopausal women with malignant ovarian tumors. In 5 others the concentrations of E2, P and testosterone (T) were also measur...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348609155172

    authors: Jeppsson S,Karlsson S,Kullander S

    更新日期:1986-01-01 00:00:00

  • Are repeated assisted reproductive technology treatments and an unsuccessful outcome risk factors for unipolar depression in infertile women?

    abstract:INTRODUCTION:Previous studies have shown conflicting results as to whether unsuccessful medically assisted reproduction is a risk factor for depression among women. This study therefore investigated if women with no live birth after assisted reproductive technology (ART) treatment had a higher risk of unipolar depressi...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12705

    authors: Sejbaek CS,Pinborg A,Hageman I,Forman JL,Hougaard CØ,Schmidt L

    更新日期:2015-10-01 00:00:00

  • Verrucous carcinoma of the vulval region.

    abstract::Verrucous carcinoma is a variant of epidermoid carcinoma with distinctive clinical and pathological features. The diagnosis is often difficult. To date, 20 verrucous carcinomas involving the vulva have been reported in the literature. Metastases to the inguino-femoral lymph nodes have not been described. The treatment...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348309155788

    authors: Andreasson B,Bock JE,Strøm KV,Visfeldt J

    更新日期:1983-01-01 00:00:00

  • Relation of estriol in saliva to serum estriol during normal pregnancy.

    abstract::As saliva is an easily accessible biological material, compared with 24-hour urine and blood, the salivary concentration of estriol was studied from the 30th to the 41st week of gestation in 268 samples from 124 normal pregnancies. At the same time, venous blood samples were drawn and analyzed for total and unconjugat...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348109154137

    authors: Fischer-Rasmussen W,Gabrielsen MV,Wisborg T

    更新日期:1981-01-01 00:00:00

  • Studies in normal pregnancy. I. Serum lipids and fatty acid composition of serum phosphoglycerides.

    abstract::Elevated serum lipids in normal pregnancy have been confirmed by the present study. In normal pregnancy the relative fatty acid composition of serum lecithin was characteristically high in palmitic acid (15:0). From the present knowledge of lipid metabolism in pregnancy there is no obvious explanation for this finding...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016347509157774

    authors: Samsioe G,Johnson P,Gustafson A

    更新日期:1975-01-01 00:00:00

  • Stillbirths and rate of neonatal deaths in 76,761 postterm pregnancies in Sweden, 1982-1991: a register study.

    abstract:OBJECTIVE:To study stillbirths and neonatal mortality in the postterm period. DESIGN:Register study of information obtained from the Swedish Medical Birth Registry (MBR), National Board of Health and Welfare, Stockholm. METHODS:Singleton pregnancies with deliveries occurring between 1982 and 1991 were selected involv...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.3109/00016349709024606

    authors: Ingemarsson I,Källén K

    更新日期:1997-08-01 00:00:00

  • Focusing on the pregnancy test.

    abstract:BACKGROUND:Due to high abortion rates in a low status area in Göteborg, Sweden, a study was performed focused on the pregnancy test. METHOD AND MATERIAL:The aim of the study was to facilitate the accessibility of contraceptive counseling offering immediate and extended family planning advice to women with negative pre...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/j.1600-0412.1998.770313.x

    authors: Westerståhl A,Björkelund C,Marklund B,Bengtsson C,Hagen D,Höglund D,Lindström M

    更新日期:1998-03-01 00:00:00

  • Influence of maternal, obstetric and fetal risk factors on the prevalence of birth asphyxia at term in a Swedish urban population.

    abstract:BACKGROUND:The influence of maternal, obstetric and fetal risk factors on the prevalence of birth asphyxia at term in a Swedish urban population. OBJECTIVE:To investigate risk factors for Apgar score-defined birth asphyxia, birth asphyxia with hypoxic-ischemic encephalopathy and birth asphyxia-related death/disability...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0412.2002.811003.x

    authors: Milsom I,Ladfors L,Thiringer K,Niklasson A,Odeback A,Thornberg E

    更新日期:2002-10-01 00:00:00

  • Interest in alternative birth settings in Finland.

    abstract:BACKGROUND:The aim of this study was to examine the extent of wishes for and realised choices of alternative and conventional birth care in Finland based on survey and registry data. METHODS:A population-based national survey to 3000 women of reproductive age and 400 men aged 18-24 and 40-44 in Finland and a cross-sec...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Viisainen K,Gissler M,Räikkönen O,Perälä ML,Hemminki E

    更新日期:1998-08-01 00:00:00

  • Inherited thrombophilias and adverse pregnancy outcomes: a case-control study in an Australian population.

    abstract:OBJECTIVE:The primary aim of this study was to examine the association between inherited thrombophilias and adverse pregnancy outcomes in an Australian population. DESIGN:Case-control study. SETTING:Two Australian tertiary level maternity hospitals. POPULATION:One hundred and fifteen cases with adverse pregnancy out...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0412.2011.01293.x

    authors: Said JM,Higgins JR,Moses EK,Walker SP,Monagle PT,Brennecke SP

    更新日期:2012-02-01 00:00:00

  • Laparoscopy versus culdoscopy in the investigation of infertility.

    abstract::This retrospective analysis compares laparoscopy versus culdoscopy results in the investigation of infertility. 52 women underwent culdoscopy; 49 women underwent laparoscopy. Then a change in method was made due to the acquisition of a cold-light laparoscopy. A third group of 73 women were examined with the new ins...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016347409156901

    authors: Fredricsson B

    更新日期:1974-01-01 00:00:00

  • Preoperative and intraoperative assessment of myometrial invasion in endometrial cancer: comparison of magnetic resonance imaging and frozen sections.

    abstract:OBJECTIVE:To compare the diagnostic characteristics of the evaluation of myometrial invasion (MI) retrospectively between preoperative magnetic resonance imaging (MRI) and intraoperative frozen sections. DESIGN:A retrospective study. SETTING:University hospital. SAMPLE:201 women diagnosed with endometrial carcinoma....

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12048

    authors: Kisu I,Banno K,Lin LY,Ueno A,Abe T,Kouyama K,Okuda S,Masugi Y,Umene K,Nogami Y,Tsuji K,Masuda K,Ueki A,Kobayashi Y,Yamagami W,Susumu N,Aoki D

    更新日期:2013-05-01 00:00:00

  • Long-acting recombinant follicle-stimulating hormone in random-start ovarian stimulation protocols for fertility preservation in women with cancer.

    abstract:INTRODUCTION:The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer. MATERIAL AND METHODS:This is a retrospective before-and-after study perfor...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13146

    authors: Sarais V,Paffoni A,Pagliardini L,Filippi F,Martinelli F,Mangili G,Candiani M,Papaleo E

    更新日期:2017-08-01 00:00:00

  • Laparoscopic sterilization with the Falope-ring technique.

    abstract::One hundred and sixteen women were admitted to hospital for laparoscopic sterilization by the Falope-ring technique. Up to the present, and with an average observation period of 20.8 months, no pregnancies have occurred. Bleeding from the distal site of puncture and tubal transection were the most common peroperative ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348209156943

    authors: Hertz JB

    更新日期:1982-01-01 00:00:00