Abstract:
OBJECTIVE: To determine the influence of type 1 diabetes mellitus (T1DM) on the first trimester serum markers of fetal aneuploidy; pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free β-hCG) and to evaluate the influence of glycemic control on these parameters in the pregnant diabetic women. DESIGN: Retrospective study. SETTING: Data were extracted from electronic obstetric and laboratory databases at two Danish University Hospitals. POPULATION: Based on 36 415 pregnancies without T1DM (non-T1DM) and 331 pregnancies with T1DM; β-hCG and PAPP-A were obtained at 8+0 to 14+2 gestational weeks. METHODS: Medians for PAPP-A and free β-hCG were generated and multiple of the normal gestation-specific median (MoM) values were calculated for each separate pregnancy. After adjustment for maternal weight, ethnicity and smoking status, MoM values were compared across the T1DM and non-T1DM groups, respectively. Additionally, the relationship between PAPP-A MoM and HgbA1C was examined in 348 T1DM pregnancies by Spearman's rank correlation. MAIN OUTCOME MEASURES. Difference in biochemical marker levels between T1DM and non-T1DM. RESULTS: PAPP-A was 0.86 MoM in T1DM pregnancies and 1.01 MoM in non-T1DM pregnancies, p < 0.0001. Conversely, free β-hCG was not altered in T1DM pregnancies (T1DM 0.99 MoM, non-T1DM 0.98 MoM; p=0.14). There was a significant inverse correlation between HgbA1C and PAPP-A (rho=-0.12, p=0.02). CONCLUSIONS: In T1DM pregnancies, PAPP-A MoM values were lower than in non-T1DM pregnancies. This suggests that correction should be considered in first trimester biochemical screening for fetal aneuploidy in T1DM women.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Madsen HN,Ekelund CK,Tørring N,Ovesen PG,Friis-Hansen L,Ringholm L,Petersen OBdoi
10.1111/j.1600-0412.2011.01212.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
57-61issue
1eissn
0001-6349issn
1600-0412journal_volume
91pub_type
杂志文章abstract::Complications and satisfaction with anterior and/or posterior prolapse repair using a transobturator polypropylene mesh (Prolift) in a single center prospective cohort was assessed. Among 30 women six mesh erosions were noted, five (17%) after anterior and one (3%) with combined anterior and posterior procedures. The ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802348294
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:A systematic review of prospective controlled clinical trials was performed to assess the effectiveness of physical therapy interventions for the prevention and treatment of pregnancy-related back and pelvic pain. Pregnancy-related low back and pelvic pain has an impact on daily life for many women. Preventi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0412.2003.00125.x
更新日期:2003-11-01 00:00:00
abstract::A prospective study of the clinical value of the symphysis-fundus (SF) distance was performed on 528 women, all at risk for developing intrauterine growth retardation (IUGR). Four different types of SF curves were observed and denoted as normal, static, catch-up and low. A normal or static SF curve predicted a normal ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409155527
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To compare two treatment strategies in women undergoing surgery for endometrial carcinoma. DESIGN:Retrospective cohort study. SETTING:Tertiary care center. POPULATION:1166 patients. Uterine biopsy/curettage was obtained in 1140 women, of whom 229 also had pelvic magnetic resonance imaging (MRI). METHODS:W...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12523
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:In assisted reproductive technology, aneuploidy is considered a primary cause of failed embryo implantation. This has led to the implementation of preimplantation genetic testing for aneuploidy in some clinics. The prevalence of aneuploidy and the use of aneuploidy screening during preimplantation genetic ...
journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
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abstract:OBJECTIVES:Hysterectomy represents the current routine therapy for high-risk endometrial precancers. More sophisticated methods are needed for treatment decision among women who want to preserve fertility and seriously ill patients. Among women diagnosed with high-risk hyperplasia, approximately 40% show signs of endom...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903281014
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the contribution of non-medical factors to actual mode of delivery in a setting with high cesarean rates. DESIGN:Follow-up survey. SETTING:University department of obstetrics and gynecology. SAMPLE:Women with singleton pregnancies (n = 453) where there was no awareness of medical contradictions t...
journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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abstract:OBJECTIVE:To analyze compensation claims with neurological sequela or death following alleged birth asphyxia. DESIGN:A cohort study. SETTING:A nationwide study in Norway. SAMPLE:All claims made to The Norwegian System of Compensation to Patients (NPE) concerning sequela related to alleged birth asphyxia, between 199...
journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:2014-02-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:10.3109/00016349709047780
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309155791
更新日期:1983-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109007873
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abstract::As immune globulin anti-D given in the immediate post partum period fails to prevent the development of anti-D antibodies in about 1.5-2% of women at risk, probably as a result of feto-maternal bleeding during pregnancy, 300 micrograms of immune globulin anti-D was administered to 609 Rh-negative women in the 28th ges...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:2019-10-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348809004163
更新日期:1988-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347809155903
更新日期:1978-01-01 00:00:00
abstract::We report a case of galactorrhea in a normoprolactinemic fertile woman (30 years old) wearing a copper intra-uterine device (Gravigard). The Gravigard was first inserted in July 1977. In February 1979 our patient noted spontaneous galactorrhea, mainly on the left, but it was also present on the right, after breast pre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409156269
更新日期:1984-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349609033335
更新日期:1996-04-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409154654
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::This retrospective analysis compares laparoscopy versus culdoscopy results in the investigation of infertility. 52 women underwent culdoscopy; 49 women underwent laparoscopy. Then a change in method was made due to the acquisition of a cold-light laparoscopy. A third group of 73 women were examined with the new ins...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347409156901
更新日期:1974-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12439
更新日期:2014-09-01 00:00:00