Impact of type 1 diabetes and glycemic control on fetal aneuploidy biochemical markers.

Abstract:

OBJECTIVE: To determine the influence of type 1 diabetes mellitus (T1DM) on the first trimester serum markers of fetal aneuploidy; pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free β-hCG) and to evaluate the influence of glycemic control on these parameters in the pregnant diabetic women.  DESIGN: Retrospective study.  SETTING: Data were extracted from electronic obstetric and laboratory databases at two Danish University Hospitals.  POPULATION: Based on 36 415 pregnancies without T1DM (non-T1DM) and 331 pregnancies with T1DM; β-hCG and PAPP-A were obtained at 8+0 to 14+2 gestational weeks.  METHODS: Medians for PAPP-A and free β-hCG were generated and multiple of the normal gestation-specific median (MoM) values were calculated for each separate pregnancy. After adjustment for maternal weight, ethnicity and smoking status, MoM values were compared across the T1DM and non-T1DM groups, respectively. Additionally, the relationship between PAPP-A MoM and HgbA1C was examined in 348 T1DM pregnancies by Spearman's rank correlation. MAIN OUTCOME MEASURES. Difference in biochemical marker levels between T1DM and non-T1DM.  RESULTS: PAPP-A was 0.86 MoM in T1DM pregnancies and 1.01 MoM in non-T1DM pregnancies, p < 0.0001. Conversely, free β-hCG was not altered in T1DM pregnancies (T1DM 0.99 MoM, non-T1DM 0.98 MoM; p=0.14). There was a significant inverse correlation between HgbA1C and PAPP-A (rho=-0.12, p=0.02).  CONCLUSIONS: In T1DM pregnancies, PAPP-A MoM values were lower than in non-T1DM pregnancies. This suggests that correction should be considered in first trimester biochemical screening for fetal aneuploidy in T1DM women.

authors

Madsen HN,Ekelund CK,Tørring N,Ovesen PG,Friis-Hansen L,Ringholm L,Petersen OB

doi

10.1111/j.1600-0412.2011.01212.x

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

57-61

issue

1

eissn

0001-6349

issn

1600-0412

journal_volume

91

pub_type

杂志文章
  • Complications and patient satisfaction after transobturator anterior and/or posterior tension-free vaginal polypropylene mesh for pelvic organ prolapse.

    abstract::Complications and satisfaction with anterior and/or posterior prolapse repair using a transobturator polypropylene mesh (Prolift) in a single center prospective cohort was assessed. Among 30 women six mesh erosions were noted, five (17%) after anterior and one (3%) with combined anterior and posterior procedures. The ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340802348294

    authors: Pacquée S,Palit G,Jacquemyn Y

    更新日期:2008-01-01 00:00:00

  • Physical therapy for pregnancy-related low back and pelvic pain: a systematic review.

    abstract:BACKGROUND:A systematic review of prospective controlled clinical trials was performed to assess the effectiveness of physical therapy interventions for the prevention and treatment of pregnancy-related back and pelvic pain. Pregnancy-related low back and pelvic pain has an impact on daily life for many women. Preventi...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0412.2003.00125.x

    authors: Stuge B,Hilde G,Vøllestad N

    更新日期:2003-11-01 00:00:00

  • Symphysis-fundus measurements and intrauterine growth retardation.

    abstract::A prospective study of the clinical value of the symphysis-fundus (SF) distance was performed on 528 women, all at risk for developing intrauterine growth retardation (IUGR). Four different types of SF curves were observed and denoted as normal, static, catch-up and low. A normal or static SF curve predicted a normal ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348409155527

    authors: Cnattingius S,Axelsson O,Lindmark G

    更新日期:1984-01-01 00:00:00

  • Combined use of endometrial sample and magnetic resonance imaging in the preoperative risk-stratification of endometrial carcinomas.

    abstract:OBJECTIVE:To compare two treatment strategies in women undergoing surgery for endometrial carcinoma. DESIGN:Retrospective cohort study. SETTING:Tertiary care center. POPULATION:1166 patients. Uterine biopsy/curettage was obtained in 1140 women, of whom 229 also had pelvic magnetic resonance imaging (MRI). METHODS:W...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12523

    authors: Luomaranta A,Bützow R,Pauna AR,Leminen A,Loukovaara M

    更新日期:2015-01-01 00:00:00

  • A systematic review on concurrent aneuploidy screening and preimplantation genetic testing for hereditary disorders: What is the prevalence of aneuploidy and is there a clinical effect from aneuploidy screening?

    abstract:INTRODUCTION:In assisted reproductive technology, aneuploidy is considered a primary cause of failed embryo implantation. This has led to the implementation of preimplantation genetic testing for aneuploidy in some clinics. The prevalence of aneuploidy and the use of aneuploidy screening during preimplantation genetic ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13823

    authors: Toft CLF,Ingerslev HJ,Kesmodel US,Diemer T,Degn B,Ernst A,Okkels H,Kjartansdóttir KR,Pedersen IS

    更新日期:2020-06-01 00:00:00

  • Saline infusion sonohysterography in endometrial cancer: assessment of malignant cells dissemination risk.

    abstract:BACKGROUND:To assess the risk of malignant cells dissemination in patients with endometrial cancer undergoing saline infusion sonohysterography (SIS). METHODS:Fourteen consecutive patients (mean age: 58.1 years, range: 41-74 years) diagnosed as having a clinical stage I endometrial carcinoma and scheduled for surgical...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Alcázar JL,Errasti T,Zornoza A

    更新日期:2000-04-01 00:00:00

  • Prognostic markers for coexistent carcinoma in high-risk endometrial hyperplasia with negative D-score: significance of morphometry, hormone receptors and apoptosis for outcome prediction.

    abstract:OBJECTIVES:Hysterectomy represents the current routine therapy for high-risk endometrial precancers. More sophisticated methods are needed for treatment decision among women who want to preserve fertility and seriously ill patients. Among women diagnosed with high-risk hyperplasia, approximately 40% show signs of endom...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016340903281014

    authors: Ørbo A,Kaino T,Arnes M,Larsen K,Pettersen I,Moe B

    更新日期:2009-01-01 00:00:00

  • Non-medical determinants of cesarean section in a medically dominated maternity system.

    abstract:OBJECTIVE:To assess the contribution of non-medical factors to actual mode of delivery in a setting with high cesarean rates. DESIGN:Follow-up survey. SETTING:University department of obstetrics and gynecology. SAMPLE:Women with singleton pregnancies (n = 453) where there was no awareness of medical contradictions t...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12466

    authors: Dweik D,Girasek E,Mészáros G,Töreki A,Keresztúri A,Pál A

    更新日期:2014-10-01 00:00:00

  • Economics of childbirth.

    abstract:BACKGROUND:Increasing birth rates have raised questions for policy makers and hospital management about the economic costs of childbirth. OBJECTIVE:The purpose of this article is to identify and review all existing scientific studies in relation to the economic costs of alternative modes of childbirth delivery and to ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/aogs.12117

    authors: Fahy M,Doyle O,Denny K,McAuliffe FM,Robson M

    更新日期:2013-05-01 00:00:00

  • Dietary and lifestyle interventions to limit weight gain during pregnancy for obese or overweight women: a systematic review.

    abstract:BACKGROUND:To assess the benefits and harm of dietary and lifestyle interventions during pregnancy to improve maternal and infant outcomes for pregnant women who are overweight or obese. METHODS:Randomized controlled trials comparing any form of dietary or lifestyle intervention during pregnancy for women who are over...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1080/00016340802061111

    authors: Dodd JM,Crowther CA,Robinson JS

    更新日期:2008-01-01 00:00:00

  • Claims for compensation after alleged birth asphyxia: a nationwide study covering 15 years.

    abstract:OBJECTIVE:To analyze compensation claims with neurological sequela or death following alleged birth asphyxia. DESIGN:A cohort study. SETTING:A nationwide study in Norway. SAMPLE:All claims made to The Norwegian System of Compensation to Patients (NPE) concerning sequela related to alleged birth asphyxia, between 199...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12276

    authors: Andreasen S,Backe B,Øian P

    更新日期:2014-02-01 00:00:00

  • Ability of intrauterine bacterial lipopolysaccharide to cause in situ uterine contractions in pregnant rabbits.

    abstract:BACKGROUND:To investigate the ability of bacterial lipopolysaccharide delivered by the intra-uterine route to cause uterine contractions in rabbits, and to assess the suppressive effect of urinary trypsin inhibitor on them. METHODS:Both pregnant and non-pregnant rabbits were chronically implanted with a force-transduc...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349709047780

    authors: Katsuki Y,Kaga N,Kakinuma C,Takagaki K,Kajikawa S,Shibutani Y

    更新日期:1997-01-01 00:00:00

  • Different Nordic facilities for victims of sexual assault: a comparative study.

    abstract:BACKGROUND:Open multidisciplinary centers were operated in the mid 1990s for victims of sexual assaults in Oslo and Reykjavik. However, in Copenhagen and Helsinki forensic medical examination was only available to victims who reported directly to the police. One of the main aims of this study was to compare the effect ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.0001-6349.2005.00641.x

    authors: Nesvold H,Worm AM,Vala U,Agnarsdóttir G

    更新日期:2005-02-01 00:00:00

  • Alterations of calcium and phosphate metabolism in primary hyperparathyroidism during pregnancy.

    abstract::Primary hyperparathyroidism (PHP) is rare during pregnancy and has been claimed to be associated with significant increase of neonatal morbidity and mortality. Whether the well recognized changes in calcium (Ca) and phosphate (Pi) homeostasis occurring in pregnancy might influence the biochemical expression of PHP is ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349309021140

    authors: Ammann P,Irion O,Gast J,Bonjour JP,Beguin F,Rizzoli R

    更新日期:1993-08-01 00:00:00

  • Labor induction by vaginal misoprostol in grand multiparous women.

    abstract:BACKGROUND:Grand multiparous women in poor and under-privileged settings run a high risk of uterine rupture at labor induction. The purpose was to elucidate whether vaginal misoprostol medication is a safe and cost-effective alternative induction method in grand multiparous women, in whom, under prevailing circumstance...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Bique C,Bugalho A,Bergström S

    更新日期:1999-03-01 00:00:00

  • Endometrial foam cells. Non-estrogenic and estrogenic.

    abstract::Four patients with endometrial foam cells are described. In one the endometrium was obtained after parturition. It showed decidua and endometritis, whereas in the second patient, who had received birth control medication in the past, the endometrium was proliferative. In both cases there was a considerable amount of e...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348309155791

    authors: Ashkenazy M,Lancet M,Borenstein R,Czernobilsky B

    更新日期:1983-01-01 00:00:00

  • Oxytocin, somatostatin, insulin and gastrin concentrations vis-à-vis late pregnancy, breastfeeding and oral contraceptives.

    abstract::Oxytocin concentrations increased during pregnancy and during medication with low-dose oral contraceptives (o.c.). Postprandial somatostatin concentrations were lower during medication with o.c. Insulin concentrations were elevated during pregnancy with the same tendency during medication with o.c. Gastrin levels were...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349109007873

    authors: Silber M,Larsson B,Uvnäs-Moberg K

    更新日期:1991-01-01 00:00:00

  • Prenatal Rh-immune prophylaxis with 300 micrograms immune globulin anti-D in the 28th week of pregnancy.

    abstract::As immune globulin anti-D given in the immediate post partum period fails to prevent the development of anti-D antibodies in about 1.5-2% of women at risk, probably as a result of feto-maternal bleeding during pregnancy, 300 micrograms of immune globulin anti-D was administered to 609 Rh-negative women in the 28th ges...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.3109/00016348909087688

    authors: Trolle B

    更新日期:1989-01-01 00:00:00

  • Subgroups of preterm delivery in the Norwegian Mother and Child Cohort Study.

    abstract::The preterm deliveries in the Norwegian Mother and Child Cohort (MoBa) study were divided into subgroups: spontaneous preterm delivery, iatrogenic preterm delivery, multiple pregnancies, congenital malformations and intrauterine fetal deaths (IUFD). Records were linked with the Medical Birth Registry of Norway in orde...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340802491508

    authors: Morken NH,Magnus P,Jacobsson B

    更新日期:2008-01-01 00:00:00

  • Good accuracy of ultrasound estimations of fetal weight performed by midwives.

    abstract:BACKGROUND:This study was undertaken to evaluate the quality of ultrasound estimation of fetal weight when performed by midwives experienced in ultrasound examinations. We also examined whether the accuracy was affected by fetal presentation, twin pregnancy or birth weight category. The results of 5 different formulas ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1080/00016340701322119

    authors: Mattsson N,Rosendahl H,Luukkaala T

    更新日期:2007-01-01 00:00:00

  • The changing pattern of contraceptive use and pregnancies in four generations of young women.

    abstract:INTRODUCTION:The aim of this study was to describe contraceptive use and pregnancies and their relationship to socio-economic status (SES) in four generations of young Swedish women. MATERIAL AND METHODS:Questionnaires regarding contraceptive use and pregnancies were sent to random samples of 19-year-old women in 1981...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13003

    authors: Lindh I,Hognert H,Milsom I

    更新日期:2016-11-01 00:00:00

  • Is it worth reducing twins to singletons after IVF-ET? A retrospective cohort study using propensity score matching.

    abstract:INTRODUCTION:Many studies have shown that multifetal reduction of high-order multiple pregnancies results in improved pregnancy outcomes. However, whether conducting elective fetal reduction from dichorionic twins after in vitro fertilization (IVF) is worthwhile remains controversial. This study aimed to determine whet...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.13640

    authors: Luo L,Fan XZ,Jie HY,Gao Y,Chen M,Zhou C,Wang Q

    更新日期:2019-10-01 00:00:00

  • The oral contraceptive user.

    abstract::The use of oral contraceptives (OC) has been correlated to several diseases, primarily thromboembolic conditions. Whether these correlations represent a causal relationship or a mere statistical correlation based on other variables, depends on whether users of OC differ in other respects from women in fertile age not ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348809004163

    authors: Lidegaard O,Overgaard K,Hauch O

    更新日期:1988-01-01 00:00:00

  • Rupture of the spleen during delivery.

    abstract::A case of traumatic rupture of a normal spleen in a complicated delivery is presented. The etiology of splenic rupture and therapeutic aspects of this unusual occurrence are discussed. It is pointed out that a violent expression of the fetus might be dangerous for the mother. ...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016347809155903

    authors: Christau S,Klebe JG

    更新日期:1978-01-01 00:00:00

  • Normoprolactinemic galactorrhea in a fertile woman with a copper intra-uterine device (copper IUD).

    abstract::We report a case of galactorrhea in a normoprolactinemic fertile woman (30 years old) wearing a copper intra-uterine device (Gravigard). The Gravigard was first inserted in July 1977. In February 1979 our patient noted spontaneous galactorrhea, mainly on the left, but it was also present on the right, after breast pre...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348409156269

    authors: Giampietro O,Ramacciotti C,Moggi G

    更新日期:1984-01-01 00:00:00

  • Prospective study of incidence and predisposing factors for clavicular fracture in the newborn.

    abstract:OBJECTIVE:To determine the incidence of clavicular fracture, associated fetal and maternal risk factors and its connection with quality care control. SUBJECTS AND METHODS:A total of 3030 newborns delivered vaginally were evaluated for clavicular fractures by three separate physicians. The study group included all newb...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016349609033335

    authors: Many A,Brenner SH,Yaron Y,Lusky A,Peyser MR,Lessing JB

    更新日期:1996-04-01 00:00:00

  • The plasma concentration of medroxyprogesterone acetate and ovarian function during treatment with medroxyprogesterone acetate in 5 and 10 mg doses.

    abstract::Peripheral plasma levels of medroxyprogesterone acetate (MPA) were determined by radioimmunoassay in 5 women after oral administration of 5 and 10 mg medroxyprogesterone acetate daily. Peak levels of MPA in plasma were recorded within 1 - 3 hours of taking the tablet, which indicates a rapid absorption from the gastro...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016348409154654

    authors: Wikström A,Green B,Johansson ED

    更新日期:1984-01-01 00:00:00

  • Neurochemical and cellular markers in human cervix of late pregnant, postpartal and non-pregnant women.

    abstract:BACKGROUND:The aim was to evaluate the peptidergic innervation and the dendritic cell content in the cervix uteri. METHODS:Cervical biopsies were obtained from late pregnant (n=5), postpartal (n=5) and non-pregnant (n=5) women. The samples were prepared for immunohistochemistry using antibodies to protein S-100 (S-100...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Stjernholm Y,Sennström M,Granström L,Ekman G,Liang Y,Johansson O

    更新日期:2000-07-01 00:00:00

  • Laparoscopy versus culdoscopy in the investigation of infertility.

    abstract::This retrospective analysis compares laparoscopy versus culdoscopy results in the investigation of infertility. 52 women underwent culdoscopy; 49 women underwent laparoscopy. Then a change in method was made due to the acquisition of a cold-light laparoscopy. A third group of 73 women were examined with the new ins...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.3109/00016347409156901

    authors: Fredricsson B

    更新日期:1974-01-01 00:00:00

  • Potential avoidability of planned cesarean sections in a French national database.

    abstract:OBJECTIVE:To study the frequency and determinants of potentially avoidable planned cesarean sections, with a classification based on their indications, maternal obstetric history, and information about the current pregnancy. DESIGN:Cross-sectional population-based study. SETTING:All maternity units in France (n = 535...

    journal_title:Acta obstetricia et gynecologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aogs.12439

    authors: Coulm B,Blondel B,Alexander S,Boulvain M,Le Ray C

    更新日期:2014-09-01 00:00:00