Abstract:
OBJECTIVE:The primary aim of this study was to examine the association between inherited thrombophilias and adverse pregnancy outcomes in an Australian population. DESIGN:Case-control study. SETTING:Two Australian tertiary level maternity hospitals. POPULATION:One hundred and fifteen cases with adverse pregnancy outcomes, comprising severe pre-eclampsia (n=45), fetal growth restriction (n=44), placental abruption (n=16) or stillbirth (n=10), and 115 controls matched for ethnicity, parity and maternal age. METHODS:Genotyping for factor V Leiden, prothrombin gene mutation, methylenetetrahydrofolate reductase 677 and 1298 and thrombomodulin polymorphism was performed using Taqman assays in an ABI prism 7700 Sequencer. Pregnancy outcome data were extracted from the medical record at the time of recruitment. MAIN OUTCOME MEASURES:Prevalence of inherited thrombophilias in women with adverse pregnancy outcomes and matched control women. RESULTS:There were no differences in baseline characteristics between cases and control women, apart from duration of gestation and neonatal birthweight. Overall, there was no significant difference in the prevalence of these inherited thrombophilia polymorphisms between cases and control women. Heterozygosity for the factor V Leiden mutation, however, was significantly associated with an increased risk of both stillbirth (odds ratio 9.33, 95% confidence interval 1.36-64.15, p=0.02) and placental abruption (odds ratio 8.62, 95% confidence interval 1.57-47.17, p=0.01). CONCLUSIONS:Overall, this study does not support a significant association between inherited thrombophilia polymorphisms and adverse pregnancy outcomes. Our two statistically significant findings should be interpreted with caution given the small number of patients in these subgroups (10 stillbirths and 16 placental abruption cases) and the wide confidence intervals.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Said JM,Higgins JR,Moses EK,Walker SP,Monagle PT,Brennecke SPdoi
10.1111/j.1600-0412.2011.01293.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
250-5issue
2eissn
0001-6349issn
1600-0412journal_volume
91pub_type
杂志文章abstract:BACKGROUND:During the war in former Yugoslavia people endured great suffering. Although many had sought refuge in other countries, the majority remained within Bosnia-Herzegovina. Special service for women within the war zone was urgently needed. A Women's Therapy Center was established in Zenica, Bosnia-Herzegovina of...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.1997.tb07991.x
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Open multidisciplinary centers were operated in the mid 1990s for victims of sexual assaults in Oslo and Reykjavik. However, in Copenhagen and Helsinki forensic medical examination was only available to victims who reported directly to the police. One of the main aims of this study was to compare the effect ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00641.x
更新日期:2005-02-01 00:00:00
abstract::Minor degrees of endometriosis have often been regarded as being of no import and hence remain untreated, but a study of the natural history of endometriosis has demonstrated that 47% (95% confidence limits, 23-71%) of patients (n=35) given placebo in a double-blind, randomized controlled trial showed progression of t...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.1989.68.s150.27
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a seri...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13203
更新日期:2017-11-01 00:00:00
abstract::In double-blind, crossover studies, piroxicam was compared with naproxen sodium and with placebo. The different parameters studied were pain intensity, patient's opinion of the drugs tested, complementary pharmacological treatment, ability to work, overall effect, treatment preference, and side effects. It was conclud...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016348509155138
更新日期:1985-01-01 00:00:00
abstract::In a series of 43 healthy women menstrual blood loss was determined before and after insertion of copper IUD (Gravigard). The menstrual blood loss before insertion was compared with the blood loss 1, 2, 3, 4, 5, 6, 7 and 12 months after insertion. An increase amounting to approximately 20 ml per period without signifi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347509156760
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:To study the association between maternal weight gain in pregnancy and fetal abdominal circumference in the second trimester. DESIGN:Prospective cross-sectional study. SETTING:Low-risk antenatal clinic. POPULATION:Six hundred and fifty women with low-risk pregnancy. METHODS:Women with a regular menstrual ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2011.01129.x
更新日期:2011-06-01 00:00:00
abstract::Conventional marsupialization was compared with incision plus curettage and primary suture of the abscess cavity under antibiotic (Clindamycin) cover in a prospective, randomized study of 32 patients with Bartholin's abscess. The median time to healing was 5 days less after suture than after marsupialization alone. Th...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016349209007949
更新日期:1992-01-01 00:00:00
abstract:UNLABELLED:MAIN QUESTION: To test previously established hypotheses on associations of birth defects with paternal occupation on the basis of a Norwegian registry material. METHODS:The study comprised all births in Norway 1970 -1993 for which linkage with population censuses 1970, -80 and -90 on parents' job title cou...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the differences in shear-wave sonoelastography (SWS) scores between the different parts of cervix, explore the association between the cervical SWS scores with cervical length and evaluate repeatability of the measurement of cervical SWS scores. MATERIAL AND METHOD...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/aogs.13874
更新日期:2020-11-01 00:00:00
abstract::We compared urodynamic findings and results of lateral urethrocystography in 84 case. The aim of the study was to establish a possible correlation between anatomic findings and functional results. Clinically, a significantly greater increase in the normal axis of urethral inclination was noted in patients with a urody...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109006214
更新日期:1991-01-01 00:00:00
abstract::The oviductal and plasma levels of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in 9 women after oral and i.v. administration of a drug combination (Eusaprim R, Wellcome Foundation Ltd). The concentration of TMP in a healthy endosalpinx was found to be twice as high (4.7 microgram/g, range 2.8-8.3) as in...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348209156546
更新日期:1982-01-01 00:00:00
abstract::With the object of examining the diagnostic accuracy of and pain reaction to endocervical curettage (ECC) either by using a new instrument, Vabra mc cervix, or with a conventional 3 mm metal curette, 298 patients with histologically verified cervical intraepithelial neoplasia (CIN) or cytological suspicion have been i...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348809004171
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:The awareness of the incidence and timing of postpartum venous thromboembolic events guides the use of thromboprophylaxis. Our aims were to assess the incidence and mortality of venous thromboembolic events and identify its associated risk factors during different postpartum periods. MATERIAL AND METHODS:...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13137
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Patients after treatment for cervical cancer have increased risk of developing second squamous cell malignancy of the lower genital tract. MATERIAL AND METHODS:A retrospective study of 46 patients with second lower genital tract epidermoid cancers following previous treatment for invasive cervical carcinoma...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Iatrogenic ureteral injury during pelvic surgical procedures is a well-known complication and important cause of morbidity. The authors investigated the circumstances surrounding registered ureteral injuries in order to identify potential opportunities to prevent such injuries. DESIGN:Evaluation of claims co...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903433974
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:To describe the prevalence of women using systemic hormone replacement therapy in various age groups. To identify their reasons for choosing or not choosing the therapy, reasons for discontinuing the treatment, the prevalence of side effects among current users, and to estimate the duration of treatment. ME...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To compare maternal and neonatal outcomes of term large for gestational age (LGA) pregnancies and adequate for gestational age (AGA) pregnancies. DESIGN:Retrospective analysis. SETTING:Large university research medical center. POPULATION:All term singleton LGA (birthweight ≥ 90th percentile) and AGA pregna...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2012.01412.x
更新日期:2012-07-01 00:00:00
abstract::From January 1984 to October 1986, a total of 185 prenatal diagnostic procedures were performed, viz. 120 chorionic villus samplings, 42 fetal blood samplings, 12 skin biopsies and 11 tumor biopsies. All procedures were performed under continuous ultrasound guidance. The methods are described, and indications for each...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348709015728
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:The proof-of-concept of uterus transplantation, as a treatment for absolute uterine factor infertility, came with the first live birth after uterus transplantation, which took place in Sweden in 2014. This was after a live donor procedure, with laparotomy in both donor and recipient. In our second, ongoing...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13853
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Women with allergy may be at increased risk of developing preeclampsia. We assessed serum levels of immunoglobulin E (IgE) in the first and second trimester, and changes in concentration between trimesters, in relation to risk of preeclampsia. MATERIALS AND METHODS:Population based case-control study within ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340701832687
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To study the predictive value of biphasic ST-events for interventions for suspected fetal distress and adverse neonatal outcome, when using ST-analysis of the fetal electrocardiogram (FECG) for intrapartum fetal monitoring. DESIGN:Prospective cohort study. SETTING:Three academic hospitals in Sweden. POPULA...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.12548
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:More than 30 000 legal abortions are performed every year in Sweden despite sexual education in schools, widespread youth-clinics and family planning services that are free of charge. The aim of this study was to investigate reasons for induced abortion, contraceptive habits and reasons for contraceptive fai...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1046/j.0001-6349.2001.00169.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To describe quality of life in men and women who had terminated in vitro fertilization (IVF) within the public health system 4-5.5 years previously, and for whom treatment did not result in childbirth. DESIGN:Cross-sectional study. SETTING:Reproductive Unit, Sahlgrenska University Hospital, Gothenburg, Swed...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802705956
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Reproductive scientists have postulated various risk factors for lower birthweight following conventional gonadotropin-stimulated in vitro fertilization compared with spontaneously conceived children: parental factors (age, health, duration of subfertility and smoking habits); ovarian stimulation; laborato...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13691
更新日期:2019-12-01 00:00:00
abstract::The malignancy risk of endometrial polyps in postmenopausal women was correlated with the presence or absence of abnormal uterine bleeding. Of 481 postmenopausal women who presented with endometrial polyps at diagnostic hysteroscopy between 2004 and 2007, 48.9% were asymptomatic and 51.1% had postmenopausal uterine bl...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902818188
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To examine whether strenuous working conditions in pregnancy are associated with reduced birthweight. METHOD:Cross-sectional, population based study. Retrospective data collection by questionnaire to parturients in all maternity wards in Norway 16.10-26.11.89, completed before discharge from hospital, with r...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:To evaluate if calcium supplementation during pregnancy could have any influence on primary dentition measured as the reduction of dental caries of the child. DESIGN:Individual randomized controlled trial. SETTING:One hospital in Rosario, Argentina. POPULATION:Random sample of 195 12-year-old children fro...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.3109/00016349.2010.518228
更新日期:2010-11-01 00:00:00
abstract::Prolactin (PRL) levels in maternal serum, amniotic fluid and mixed cord blood from 11 women with post-term pregnancies and 64 women with normal term pregnancies were measured by immunoenzymetric assay in order to investigate their possible role in the onset of labor. No differences were found between term and post-ter...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349309013376
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:To study local treatment of ectopic pregnancy by injection of hyperosmolar (50%) glucose, guided either by transvaginal ultrasound or by laparoscopy. METHODS:Eighty women were randomized, 39 into the sonography and 41 into the laparoscopy group. Criteria for inclusion were 1) ectopic pregnancy < or = 4 cm se...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016349509013476
更新日期:1995-09-01 00:00:00