Levels of trimethoprim and sulfamethoxazole in human oviduct mucosa and plasma.

Abstract:

:The oviductal and plasma levels of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in 9 women after oral and i.v. administration of a drug combination (Eusaprim R, Wellcome Foundation Ltd). The concentration of TMP in a healthy endosalpinx was found to be twice as high (4.7 microgram/g, range 2.8-8.3) as in plasma (2.6 microgram/ml, range 2.1-3.6). Conversely, the endosalpingeal level of SMZ (38 microgram/g, range 12-65) was about half that in plasma (77 microgram/ml, range 58-95). The agar well diffusion method was used for the concentration determinations. The specimens were collected during surgery for non-infectious genital diseases. The implication of treatment by the given drugs is discussed.

authors

Brihmer C,Brundin J,Dornbusch K

doi

10.3109/00016348209156546

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

149-52

issue

2

eissn

0001-6349

issn

1600-0412

journal_volume

61

pub_type

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