A Combination of Ulinastatin and Xuebijing Amplifies Neuroprotection after Transient Cerebral Ischemia via Attenuating Apoptosis Signal Pathways in Hippocampus.

abstract：:Unhealthy diet and alcohol are serious health problems, especially in adolescents and young adults. "Binge" is defined as the excessive and uncontrolled consumption of food (binge eating) and alcohol (binge drinking). Both behaviors are frequent among young people and have a highly negative impact on health and qualit...

journal_title：Current pharmaceutical design

authors： Escrivá-Martínez T,Herrero R,Molinari G,Rodríguez-Arias M,Verdejo-García A,Baños RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:According to the World Health Organization (WHO), diabetes mellitus is considered the 7th leading cause of death as of 2016, while almost half of all deaths related to high blood glucose occur before the age of 70. According to the 2019 American Diabetes Association's (ADA) guidelines, metformin is the first...

journal_title：Current pharmaceutical design

authors： Gillani SW,Moosvi AF

更新日期：2020-01-01 00:00:00

abstract：:The present mini review offers a brief overview on the preparation and modification of gold nanomaterials (AuNMs) designed for biomedical applications, including biosensors, bioimaging, phototherapy and importantly gene/drug delivery. As biocompatibility is a prerequisite for safe pharmaceutical application, the poten...

journal_title：Current pharmaceutical design

authors： Rossi M,Pina CD,Falletta E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:There is a strong rationale for usage of anti-angiogenic agents in epithelial ovarian cancer. Bevacizumab is the most widely investigated anti-VEGF agent and has shown promising results in recent clinical trials. OBJECTIVE:To review the rationale and usage of bevacizumab in advanced epithelial ovarian cance...

journal_title：Current pharmaceutical design

authors： Kroep JR,Nortier JW

更新日期：2012-01-01 00:00:00

abstract：:The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate substrates, such as fatty acids, is the predominant metabolic pathway in the normal heart, because this provides the highest energy yield per molecule of substrate metab...

journal_title：Current pharmaceutical design

authors： Nagoshi T,Yoshimura M,Rosano GM,Lopaschuk GD,Mochizuki S

更新日期：2011-12-01 00:00:00

abstract：:Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibr...

journal_title：Current pharmaceutical design

authors： Wallace DJ

更新日期：2006-01-01 00:00:00

abstract：:The serotonergic system is involved in pathomechanisms of both epilepsy and neuropathic pain. So far, participation in the epileptogenesis and maintenance of epilepsy was proved for 5-HT1A, 5-HT2C, 5-HT3, 5-HT4 and 5-HT7 receptors as well as 5-HTT serotonin transporter. Depending on the receptor type or its localizati...

journal_title：Current pharmaceutical design

authors： Panczyk K,Golda S,Waszkielewicz A,Zelaszczyk D,Gunia-Krzyzak A,Marona H

更新日期：2015-01-01 00:00:00

abstract：:There is initial evidence, at least in cardiac surgery, that total intra-venous anesthesia (usually a propofol-based total intravenous anesthesia) is associated with an increased mortality when compared to an anesthetic plan including a halogenated anesthetics. The cardiac protective properties of halogenated agents (...

journal_title：Current pharmaceutical design

authors： Landoni G,Pasin L,Borghi G,Zangrillo A

更新日期：2014-01-01 00:00:00

abstract：:Since identifying a transmissible agent responsible for tumorigenesis in chickens, the v-Src oncogene, significant progress has been made in determining the functions of its cellular homologue. c-Src is the product of the SRC gene and has been found both over-expressed and highly activated in a number of human cancers...

journal_title：Current pharmaceutical design

authors： Alper O,Bowden ET

更新日期：2005-01-01 00:00:00

abstract：:We carried out a systematic review of HPV vaccine pre- and post-licensure trials to assess the evidence of their effectiveness and safety. We find that HPV vaccine clinical trials design, and data interpretation of both efficacy and safety outcomes, were largely inadequate. Additionally, we note evidence of selective ...

journal_title：Current pharmaceutical design

authors： Tomljenovic L,Spinosa JP,Shaw CA

更新日期：2013-01-01 00:00:00

abstract：:Heat shock proteins (HSPs) are involved in a number of cellular processes, including cell cycle, growth, and survival, apoptosis, stress responses, angiogenesis, and oncogenesis. Among the characterized HSPs, the molecular chaperone HSP90 has emerged as an exciting molecular target for cancer therapy since its discove...

journal_title：Current pharmaceutical design

authors： Kondoh Y,Osada H

更新日期：2013-01-01 00:00:00

abstract：:In this review we discuss the role of protonation states in receptor-ligand interactions, providing experimental evidences and computational predictions that complex formation may involve titratable groups with unusual pKa's and that protonation states frequently change from unbound to bound states. These protonation ...

journal_title：Current pharmaceutical design

authors： Petukh M,Stefl S,Alexov E

更新日期：2013-01-01 00:00:00

abstract：:The ever-growing resistance of pathogens to antibiotics and crop disease due to pest has triggered severe health concerns in recent years. Consequently, there is a need of powerful and protective materials for the eradication of diseases. Metal/metal oxide nanoparticles (M/MO NPs) are powerful agents due to their ther...

journal_title：Current pharmaceutical design

authors： Chaudhary RG,Bhusari GS,Tiple AD,Rai AR,Somkuvar SR,Potbhare AK,Lambat TL,Ingle PP,Abdala AA

更新日期：2019-01-01 00:00:00

abstract：:Urological cancer refers to cancer in organs of the urinary system and the male reproductive system. It mainly includes prostate cancer, bladder cancer, renal cancer, etc., seriously threatening patients' survival. Although there are many advances in the treatment of urological cancer, approved targeted therapies ofte...

journal_title：Current pharmaceutical design

authors： Liu Q,Gu J,Zhang E,He L,Yuan ZX

更新日期：2020-01-01 00:00:00

abstract：:Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cel...

journal_title：Current pharmaceutical design

authors： Ferrín G,Linares CI,Muntané J

更新日期：2011-01-01 00:00:00

abstract：:The production of autoreactive antibodies from self-reactive B cells results in the formation of immune complexes that deposit in tissue and fix complement, contributing to the pathogenesis of rheumatoid arthritis (RA). Earlier mouse models emphasize the importance of autoreactive antibodies formed against "self" prot...

journal_title：Current pharmaceutical design

authors： Low JM,Moore TL

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI). METHODS:A c...

journal_title：Current pharmaceutical design

authors： Li F,Li H,Xiao Z,Lu R,Zhang Z,Zhu H,Ren L

更新日期：2017-01-01 00:00:00

abstract：:Diabetes is one of the most common endocrine non-communicable metabolic disorders which is mainly caused either due to insufficient insulin or inefficient insulin or both together and is characterized by hyperglycemia. Diabetes emerged as a serious health issue in the industrialized and developing country especially i...

journal_title：Current pharmaceutical design

authors： Prabhakar PK,Sivakumar PM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) despite the advances in medical management keeps on as the primary cause of morbidity and mortality for both genders in Western societies. Sex differences though modify the clinical picture as well as the effectiveness of treatment. METHODS AND RESULTS:In this literature review ...

journal_title：Current pharmaceutical design

authors： Oikonomou E,Tsigkou V,Lazaros G,Papamikroulis GA,Papaioannou S,Siasos G,Tousoulis D

更新日期：2016-01-01 00:00:00

abstract：:Reduced levels of high-density lipoprotein cholesterol (HDL) are associated with a substantially increased risk of coronary disease and cardiovascular events. Furthermore, numerous studies have suggested that HDL may exert several potentially important antiatherosclerotic and endothelial-protective effects. In particu...

journal_title：Current pharmaceutical design

authors： Besler C,Heinrich K,Riwanto M,Lüscher TF,Landmesser U

更新日期：2010-05-01 00:00:00

abstract：:Development of effective drug delivery systems is important for medicine and healthcare. Polymer particulates (micro- and nanoparticles) have opened new opportunities in the field of drug delivery by overcoming various limitations of conventional delivery methods. The properties of polymeric particles can be readily t...

journal_title：Current pharmaceutical design

authors： Kaur H,Kumar V,Kumar K,Rathor S,Kumari P,Singh J

更新日期：2016-01-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a major cause of morbidity and mortality in transfused hosts and like other causes of acute lung injury, there is no effective pharmacologic treatment. The pathophysiology of TRALI is still being defined, but neutrophils have a major role in the pathogenesis of both hum...

journal_title：Current pharmaceutical design

authors： Caudrillier A,Looney MR

更新日期：2012-01-01 00:00:00

abstract：:Natural products have served humankind as drug leads for thousands of years. In the last century natural products have not only served as drugs but have inspired the generation of countless synthetic drugs and drug-leads around natural product pharmacophores. There are no disease targets for which natural products hav...

journal_title：Current pharmaceutical design

authors： Hamann MT

更新日期：2007-01-01 00:00:00

abstract：:The clinically most relevant medications for lipid management are the statins, which constitute in the majority of the cases the basis of any lipid-modulating therapy. However, other agents are often needed to either reduce low-density cholesterol to target levels and/or to treat residual serum lipoprotein abnormaliti...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Berthold HK

更新日期：2013-01-01 00:00:00

abstract：:Hyperglycemia is a common feature of the critically ill in general and of patients with sepsis in particular. Even a moderate degree of hyperglycemia appears detrimental for the outcome of critically ill patients, since maintenance of normoglycemia (blood glucose levels

journal_title：Current pharmaceutical design

authors： Van Cromphaut SJ,Vanhorebeek I,Van den Berghe G

更新日期：2008-01-01 00:00:00

abstract：:Mesenchymal Stem Cells (MSCs) are a population of adherent cells that can differentiate into mesenchymal lineage populations (cartilage, bone and fat tissue). In addition, they seem to be able to differentiate also into a broader type of lineages other than the original mesodermal germ layer. Bone marrow MSCs are a st...

journal_title：Current pharmaceutical design

authors： Mariani E,Facchini A

更新日期：2012-01-01 00:00:00

abstract：:Opioid peptides showing selectivity for delta receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulose-bisphosphate-carboxylase/oxygenase (Rubisco), a...

journal_title：Current pharmaceutical design

authors： Yoshikawa M,Takahashi M,Yang S

更新日期：2003-01-01 00:00:00

abstract：:Packaging small-molecule drugs into nanoparticles improves their bio-availability, bio-compatibility and safety profiles. Multifunctional particles carrying large drug payloads for targeted transport, immune evasion and favourable drug release kinetics at the target site, require a certain minimum size usually 30-300 ...

journal_title：Current pharmaceutical design

authors： Debbage P

更新日期：2009-01-01 00:00:00

abstract：:Human serum albumin (HSA) is one of the major carrier proteins in the body and constitutes approximately half of the protein found in blood plasma. It plays an important role in lipid metabolism, and its ability to reversibly bind a large variety of pharmaceutical compounds makes it a crucial determinant of drug pharm...

journal_title：Current pharmaceutical design

authors： Abou-Zied OK

更新日期：2015-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high mortality rate. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in normal intestinal tissue function, but has also been implicated in the development of CRC. MicroRNAs (miRNAs) have al...

journal_title：Current pharmaceutical design

authors： Moradi-Marjaneh R,Khazaei M,Ferns GA,Aghaee-Bakhtiari SH

更新日期：2018-01-01 00:00:00