The role of niacin in lipid-lowering treatment: are we aiming too high?

abstract：:Mechanical loading provides an anabolic stimulus for bone. More importantly, the mechanosensing apparatus in bone directs osteogenesis to where it is most needed for improving bone strength. The biological processes involved in bone mechanotransduction are poorly understood and further investigation of the molecular m...

journal_title：Current pharmaceutical design

authors： Turner CH,Robling AG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. There...

journal_title：Current pharmaceutical design

authors： Jiang X,Zhang QL,Liu TG,Zhao WP,Yang M,Wang LN,Sun WL,Pan L,Luo AP,Huang JC,Gu XH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...

journal_title：Current pharmaceutical design

authors： Zhao Q,Zhang W,Wang R,Wang Y,Ouyang D

更新日期：2017-01-01 00:00:00

abstract：:LIM (Lin-11, Isl-1, Mec-3), RING (Really interesting new gene), PHD (Plant homology domain) and MYND (myeloid, Nervy, DEAF-1) domains are all zinc-binding domains that ligate two zinc ions. Unlike the better known classical zinc fingers, these domains do not bind DNA, but instead mediate interactions with other protei...

journal_title：Current pharmaceutical design

authors： Matthews JM,Bhati M,Lehtomaki E,Mansfield RE,Cubeddu L,Mackay JP

更新日期：2009-01-01 00:00:00

abstract：:The vasoconstrictive and antidiuretic physiologic properties of vasopressin (antidiuretic hormone) have long been known. Until recently however, vasopressin was mostly used for diabetes insipidus and noctournal enuresis. This review summarizes the growing body of evidence regarding the perioperative use of vasopressin...

journal_title：Current pharmaceutical design

authors： Udeh CI,Diaz-Gómez JL,Anthony D,Satyapriya A,Perez-Protto S,Hata JS

更新日期：2012-01-01 00:00:00

abstract：:The understanding of cytokine networks and the exploitation of these networks for the treatment of immune and inflammatory diseases as well as cancer depend on in vivo delivery of cytokines. Due to instability of recombinant cytokine proteins, investigators have employed cytokine-encoding gene therapy vectors to induc...

journal_title：Current pharmaceutical design

authors： Hitt MM,Gauldie J

更新日期：2000-04-01 00:00:00

abstract：:Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma. The mechanism of action of these drugs consists in inhibition ...

journal_title：Current pharmaceutical design

authors： Mincione F,Scozzafava A,Supuran CT

更新日期：2008-01-01 00:00:00

abstract：:Vascular disorders, resulting from endothelial cell dysfunction, may be caused by various stimuli, including infectious pathogens, cytotoxic reagents, and pathophysiological mechanisms mediated by immune responses. Endothelial cell dysfunction characterized by apoptosis and abnormal immune activation is, at least in p...

journal_title：Current pharmaceutical design

authors： Lin YS,Lin CF,Lei HY,Liu HS,Yeh TM,Chen SH,Liu CC

更新日期：2004-01-01 00:00:00

abstract：:Protection of the brain is strengthened by active transport and ABC transporters. P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a substrate from the brain, which is important for maintaining loco-regional homeostasis in the brain and protection against toxic com...

journal_title：Current pharmaceutical design

authors： Bartels AL

更新日期：2011-01-01 00:00:00

abstract：:Monoclonal antibodies have undergone a radical evolutionary journey over the last 25 years, with advances in molecular biology, process development and drug formulation underpinning their rise to becoming one of the most efficacious and economically important class of drug today. The success of antibodies for the trea...

journal_title：Current pharmaceutical design

authors： Lowe DC,Vaughan TJ

更新日期：2015-01-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, functions to keep alveoli from collapsing at expiration. Surfactant proteins A (SP-A) and D (SP-D) belong to the collectin family and play pivotal roles in the innate immunity of the lung. Pulmonary collectins directly bind with broad specificities to a variety o...

journal_title：Current pharmaceutical design

authors： Takahashi H,Sano H,Chiba H,Kuroki Y

更新日期：2006-01-01 00:00:00

abstract：:First generation drug-eluting stents (DES) have significantly improved the treatment options for patients with symptomatic coronary artery disease by decreasing rates of acute vessel closure and restenosis after percutaneous coronary revascularization procedures. However, early enthusiasm was temperd by reports of lat...

journal_title：Current pharmaceutical design

authors： Vorpahl M,Yazdani SK,Nakano M,Ladich E,Kolodgie FD,Finn AV,Virmani R

更新日期：2010-01-01 00:00:00

abstract：:Stroke remains a major cause of death in the US and around the world. Despite major scientific advances in our understanding of stroke pathology, the only FDA-approved drug for ischemic stroke is tissue plasminogen activator (tPA). Moreover, the therapeutic window for tPA is confined to the acute phase of stroke, ther...

journal_title：Current pharmaceutical design

authors： Tajiri N,Lau T,Glover LE,Shinozuka K,Kaneko Y,van Loveren H,Borlongan CV

更新日期：2012-01-01 00:00:00

abstract：:Drug design based on the structure of specific enzymes playing a role in carcinogenesis, e.g. tyrosine kinases, has been successful at identifying novel effective anticancer drugs. In contrast, no success has been achieved in drug design attempts, in which transcription factors or DNA-transcription factor complexes in...

journal_title：Current pharmaceutical design

authors： D'Incalci M,Brunelli D,Marangon E,Simone M,Tavecchio M,Gescher A,Mantovani R

更新日期：2007-01-01 00:00:00

abstract：:Cardiovascular disease remains the number one killer in the United States and many other countries. Each year, there are enormous research efforts on its pathogenesis, prevention and treatment led by scientists worldwide. One of the most significant research areas is the impact and mechanisms of existing or new cardio...

journal_title：Current pharmaceutical design

authors： Jamaluddin MS,Liang Z,Lu JM,Yao Q,Chen C

更新日期：2014-01-01 00:00:00

abstract：:Ischaemic stroke of the brain accounts for about one third of all deaths in industrialized countries. Many of the patients who survive are severily impaired. Thus, there is an enormous need for pharmacotherapy for the treatment of ischaemic stroke. Why is such a treatment not available yet? Are the pathophysiological ...

journal_title：Current pharmaceutical design

authors： Weiser T

更新日期：2002-01-01 00:00:00

abstract：:Patients with diabetes mellitus (DM) type 2 have a high prevalence of coronary artery disease (CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Hyperglycemia, elevated free fatty acid, increased amount of circulating end-glucosylated serum products and insulin resistance are the main mechani...

journal_title：Current pharmaceutical design

authors： Tousoulis D,Kampoli AM,Papageorgiou N,Papaoikonomou S,Antoniades C,Stefanadis C

更新日期：2009-01-01 00:00:00

abstract：:The three opioid receptors, mu, delta and kappa all mediate analgesia, and knockout mice with opioid receptor deletion have proven unique tools to investigate in vivo opioid pharmacology. Since a few years, a number of new mouse lines have been engineered, with several distinct mutations of the mu receptor, to assess ...

journal_title：Current pharmaceutical design

authors： Gavériaux-Ruff C

更新日期：2013-01-01 00:00:00

abstract：:Mass spectrometry information has long offered the potential of discovering biomarkers that would enable clinicians to diagnose disease, and treat it with targeted therapies. PeptideAtlas currently provides access to large-scale spectra data and identification information. This data, and the generation of targeted pep...

journal_title：Current pharmaceutical design

authors： Killcoyne S,Deutsch EW,Boyle J

更新日期：2012-01-01 00:00:00

abstract：:Dengue is one of the most important arboviral infections worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. He...

journal_title：Current pharmaceutical design

authors： Reginald K,Chan Y,Plebanski M,Poh CL

更新日期：2018-01-01 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles (SPIONs) comprise a fundamental technology class within the emerging field of nanomedicine, and have been extensively researched for cancer imaging and therapy. This review article will discuss the chemistry and design considerations associated with the synthesis of SPIONs an...

journal_title：Current pharmaceutical design

authors： Yoffe S,Leshuk T,Everett P,Gu F

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a global epidemic involving 20-40% of the general population. NAFLD is rapidly becoming the leading cause of hepatocellular carcinoma (HCC) worldwide. Knowledge about NAFLD-HCC peculiar features is needed to understand this emerging disease better. OBJECTIVE:To r...

journal_title：Current pharmaceutical design

authors： Tovoli F,Ferri S,Piscaglia F

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we...

journal_title：Current pharmaceutical design

authors： Kitazawa M,Medeiros R,Laferla FM

更新日期：2012-01-01 00:00:00

abstract：:HIV infection remains incurable although several anti-HIV drugs have been identified and developed. Among these the nucleoside analogues were and remain in the forefront of anti-HIV chemotherapeutic regimens. Most of these nucleoside analogues are modified mainly in the sugar moiety. In general, they lack a free hydro...

journal_title：Current pharmaceutical design

authors： el Kouni MH

更新日期：2002-01-01 00:00:00

abstract：:Transpeptidation reactions result in the formation of new peptide bonds and this can occur between two separate peptides or within the one peptide. These reactions are catalyzed by enzymes and when the N- and C-terminus of the one peptide are joined it results in the formation of cyclic proteins. Cyclization via head-...

journal_title：Current pharmaceutical design

authors： Conlan BF,Anderson MA

更新日期：2011-12-01 00:00:00

abstract：:Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activatio...

journal_title：Current pharmaceutical design

authors： Dimakopoulou A,Foran D,Jayasena CN,Minhas S

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND & AIMS:Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal li...

journal_title：Current pharmaceutical design

authors： Su H,Liu D,Shao J,Li Y,Wang X,Gao Q

更新日期：2020-01-01 00:00:00

abstract：:Arrhythmias in left ventricular hypertrabeculation/noncompaction (LVHT) comprise sustained or non-sustained ventricular tachycardia (VT) (n=135), atrial fibrillation (AF) (n=96) AV block (n=55) and QT prolongation (n=47). The prevalence differs between children and adults. In children most frequent are WPW-syndrome (n...

journal_title：Current pharmaceutical design

authors： Stöllberger C,Finsterer J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Cancer and its treatment therapies, such as chemotherapy and radiotherapy, have negative effects on taste and smell functions. It is easy to explain smell and taste dysfunctions when a cancer involves the peripheric end organs or neurologic pathways of smell and taste. However, it is difficult to understand ...

journal_title：Current pharmaceutical design

authors： Altundag A,Cayonu M

更新日期：2016-01-01 00:00:00

abstract：:Synaptic transmission through descending motor pathways to lumbar motoneurons and then to leg muscles is essential for walking in humans and rats. Spinal cord injury (SCI), even when incomplete, results in diminished transmission to motoneurons and very limited recovery of motor function. Neurotrophins have emerged as...

journal_title：Current pharmaceutical design

authors： Arvanian V

更新日期：2013-01-01 00:00:00