Comparison of MICs of fluconazole and flucytosine when dissolved in dimethyl sulfoxide or water.

Abstract:

:A total of 145 clinical strains of Candida species were tested by the Clinical and Laboratory Standards Institute M27-A3 methodology to determine if replacing water with dimethyl sulfoxide as the solvent for fluconazole and flucytosine impacted the in vitro potency. No significant differences in MIC values were observed with either antifungal between the two solvents against any Candida species, and the essential agreement for each agent between the two solvents was greater than 99%.

journal_name

J Clin Microbiol

authors

Fothergill AW,Sanders C,Wiederhold NP

doi

10.1128/JCM.00260-13

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

1955-7

issue

6

eissn

0095-1137

issn

1098-660X

pii

JCM.00260-13

journal_volume

51

pub_type

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