Abstract：
:In this report, we review the recent advances in evaluation and treatment of transfusional iron overload (IO). Results of the French thalassaemia registry are described. According to the disease, thalassaemia major or sickle cell anaemia, mechanisms and toxicity of iron overload, knowledge about IO long-term outcome and chelation treatment results, respective value of IO markers, differ. The recent tools evaluating organ specific IO and the diversification of iron chelator agents make possible to individualize chelation therapy in clinical practice. The severity of IO and the level of transfusional iron intake, the preferential localization of IO (heart/liver) as well as the tolerance and adherence profiles of the patient can now be taken into account. Introduction of cardiac magnetic resonance imaging for the quantification of myocardial iron and use of oral chelators have already been reported as decreasing the cardiac mortality rate related to IO in thalassaemia major patients. Long-term observation of patients under oral chelators will show if morbidity is also improving via a more continuous control of toxic iron and/or a better accessibility to cellular iron pools.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Thuret Idoi
10.1016/j.crvi.2012.09.010subject
Has Abstractpub_date
2013-03-01 00:00:00pages
164-72issue
3eissn
1631-0691issn
1768-3238pii
S1631-0691(12)00239-9journal_volume
336pub_type
杂志文章,评审abstract：:Spermiogenesis in Robphildollfusium fractum begins with the formation of a differentiation zone containing: two centrioles, each bearing striated rootlets, nucleus, several mitochondria and an intercentriolar body constituted by seven electron-dense layers. The two centrioles originate two free flagella growing orthog...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.06.003
更新日期：2012-07-01 00:00:00
abstract：:A numerical simulation for the dynamics of a model that describes the sexual phase of Monogonont Rotifera reproduction is presented. The simulation is carried out by means of a numerical method based on the integration along the characteristic curves. The numerical experiments cover two basic situations: the existence...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2003.08.006
更新日期：2004-03-01 00:00:00
abstract：:The development of molecular biology placed in the foreground a mechanistic and deterministic conception of the functioning of macromolecules. In this article, I show that this conception was neither obvious, nor necessary. Taking Jacques Monod as a case study, I detail the way he gradually came loose from a statistic...
journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章
doi：10.1016/j.crvi.2015.03.008
更新日期：2015-06-01 00:00:00
abstract：:In the present study, we have screened 71, 713, 525, 119 and 241 mature miRNA variants from Hordeum vulgare, Oryza sativa, Brachypodium distachyon, Triticum aestivum, and Sorghum bicolor, respectively, and classified them with respect to their conservation status and expression levels. These Poaceae non-redundant miRN...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2016.05.011
更新日期：2016-09-01 00:00:00
abstract：:A field experiment was conducted with paddy (Oryza sativa L.) irrigated with different concentrations (Control, 2.5, 5, 10, 25, 50, 75, 100 and 200 mg/l) of chromium. The changes in growth, yield, nutrient content and chromium accumulation in the paddy are reported. The growth of shoot, root, total leaf area, fresh we...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.03.002
更新日期：2010-08-01 00:00:00
abstract：:This article is the result of a symposium organized at the French Academy of Sciences on May 31, 2016, entitled: Do we need to know the causes to understand and intervene? Questions on causality in the biological and medical sciences, and published in French in a book entitled: Causality in the biological and medical ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2019.03.001
更新日期：2019-01-01 00:00:00
abstract：:Over the decades, basic research in life sciences has profited greatly from the study of the small unicellular fungal species Saccharomyces cerevisiae. This yeast turned out to be key for the identification and understanding of molecular mechanisms that underlay the basic functions of all eukaryotic cells. These inclu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2011.05.007
更新日期：2011-08-01 00:00:00
abstract：:Austronesians colonized the islands of Rapa Nui, Hawaii, the Marquesas and Madagascar. All of these islands have been found to harbor Austronesian artifacts and also, all of them are known nesting sites for marine turtles. Turtles are well known for their transoceanic migrations, sometimes totalling thousands of miles...
journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章
doi：10.1016/j.crvi.2015.12.001
更新日期：2016-02-01 00:00:00
abstract：:The Mediterranean stone pine Pinus pinea L. (gymnosperm, Pinaceae) is much appreciated for its seed production, widely used in food preparation in the Mediterranean Basin. Seeds contain 25% proteins on a dry-weight basis. Pinus pinea accumulate globulins as major storage proteins in seeds (75% of total storage protein...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.03.011
更新日期：2007-05-01 00:00:00
abstract：:Surgical resection of hepatic tumours is not always possible, since it depends on different factors, among which their location inside the liver functional segments. Alternative techniques consist in local use of chemical or physical agents to destroy the tumour. Radio frequency and cryosurgical ablations are examples...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01439-7
更新日期：2002-04-01 00:00:00
abstract：:Epilithic diatom communities are particularly suitable for the evaluation of freshwater quality. In Ecuador, however, no water quality index includes this biotic parameter. This work is the first attempt in the country to determine the composition of epilithic diatom communities associated with different degrees of eu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2018.03.008
更新日期：2018-04-01 00:00:00
abstract：:Females must evaluate male quality to perform mate choice. Since females generally base their selection on different male features, individual females may differ in their choice. In this study, we show that concordance between females in mate choice decisions may arise without any experimental maximization of a partic...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.01.004
更新日期：2012-03-01 00:00:00
abstract：:For a very long time, arguments supporting the neuro-humoral theory, produced by the pharmacologist Henri Dale, did not convince one of the main supporters of the electrical theory, the neurophysiologist John C. Eccles. This article gives a reminder of certain technical elements of this debate between two giants, whic...
journal_title：Comptes rendus biologies
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.crvi.2006.03.013
更新日期：2006-05-01 00:00:00
abstract：:The biological effect of seasonality on cadmium, lead and metallothionein contents was assessed in mussels Mytilus galloprovincialis from natural banks located along the coastline of the Gulf of Naples (Campania, Italy). Heavy metals and metallothionein concentrations were measured in digestive and reproductive glands...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2014.05.003
更新日期：2014-07-01 00:00:00
abstract：:This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish Lagocephalus lagocephalus collected along the Tunisian coast. Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of L. lagocephalus. Control rats received...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.05.005
更新日期：2008-08-01 00:00:00
abstract：:We evaluated two biodiversity criteria, higher taxonomic diversity and phylogenetic diversity in French Guiana. For this, we used a recent assessment of the knowledge accumulated since 30 years of study on the amphibian species currently known in French Guiana. We focused on two well-represented genera, Hyla and Scina...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2005.07.005
更新日期：2005-10-01 00:00:00
abstract：:The cardiac gland region in the stomachs of eleven babirusa (Babyrousa babyrussa) from zoological collections was studied by scanning and transmission electron microscopy. An array of tightly-packed, thin-walled tubes, closely resembling a 'honeycomb' covered this region. The tubes were between twelve and sixteen cell...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.10.007
更新日期：2008-01-01 00:00:00
abstract：:Stochastic modeling of dairy cattle populations using multiple ovulation and embryo transfer (MOET) was used to compare 15-year genetic responses with an artificial insemination (AI) program. MOET and AI techniques were simulated in four populations, two with 100 breeding females each and two with 400 breeding females...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.07.001
更新日期：2010-10-01 00:00:00
abstract：:The voltage-gated sodium channel (VGSC) is a complex, which is composed of one pore-forming α subunit and at least one β subunit. Up to now, five β subunits are known: β1/β1A, β1B, β2, β3, and β4, encoded by four genes (SCN1B∼SCN4B). It is critical to have a deep understanding of the interaction between β1 and β3 subu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.11.009
更新日期：2014-02-01 00:00:00
abstract：:Few proteins have had such a strong impact on a field as the lac repressor has had in Molecular Biology. Over 40 years ago, Jacob and Monod [Genetic regulatory mechanisms in the synthesis of proteins, J. Mol. Biol. 3 (1961) 318] proposed a model for gene regulation, which survives essentially unchanged in contemporary...
journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.crvi.2005.04.004
更新日期：2005-06-01 00:00:00
abstract：:Described here are the findings of an electron and ion microscopic study of renal biopsies of young children, with a particular attention to the intracytoplasmic and intranuclear changes observed in the podocytes of the proteinuric patients. In the cytoplasm, there is a considerable development of the ergastoplasm, as...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2011.06.006
更新日期：2011-10-01 00:00:00
abstract：:Several studies have demonstrated that, in a context of oxidative stress, resveratrol, a polyphenol found in wine, could act as a protective agent on endothelial cells by various mechanisms but without showing that it could penetrate inside the cell. The aim of this study was to detect for the first time resveratrol i...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.03.013
更新日期：2012-04-01 00:00:00
abstract：:The green birdmouth wrasse Gomphosus caeruleus is present all year round on the coral reefs of Reunion Island (Indian Ocean). A group of individuals was followed on one of these reefs with the objective of studying the reproduction mode of the species, the influence of environmental factors, and social behaviors on th...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2017.11.004
更新日期：2018-01-01 00:00:00
abstract：:Plectroctena minor workers have long mandibles that can snap and deliver a sharp blow to intruders or prey, stunning or killing them. Encounters between homocolonial P. minor workers separated for 24 h or 15 days never resulted in snapping, while this behaviour was always noted during encounters between heterocolonial...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01484-1
更新日期：2002-07-01 00:00:00
abstract：:In this study, we investigate skull size and shape differentiation between sibling species of Mastomys with the aim to characterize and discriminate three sympatric species found in West Africa: M. huberti, M. erythroleucus and M. natalensis. A total of 133 genetically determined specimens were used for the morphometr...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.11.004
更新日期：2009-05-01 00:00:00
abstract：:This note presents a mechanistic explanation of the transition between the morphology of cephalochordates to that of amniotes. By a careful study of the morphogenetic movements which occur during the early stages of development of a typical amniote (a chicken embryo), we are able to show that the formation of a verteb...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.11.009
更新日期：2011-02-01 00:00:00
abstract：:Why was sexual selection so important to Darwin? And why was it de-emphasized by almost all of Darwin's followers until the second half of the 20th century? These two questions shed light on the complexity of the scientific tradition named "Darwinism". Darwin's interest in sexual selection was almost as old as his dis...
journal_title：Comptes rendus biologies
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.crvi.2009.12.001
更新日期：2010-02-01 00:00:00
abstract：:Discriminative canonical analysis of 87 biometric parameters in the marine and lagoon atherinids of 'Atherina boyeri' complex from the Mediterranean Sea helps defining three distinct atherinid groups: marine punctuated, marine unpunctuated and lagoon atherinids. Each atherinid group constitutes a clearly independent o...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01506-8
更新日期：2002-09-01 00:00:00
abstract：:Choosing a suitable habitat is a main step in the settlement process, particularly for species having weak movement abilities. Reliable cues are thus needed for habitat selection. In silk-spinning arthropods, silk can be used as a social cue to select an appropriate location. Silk can also provide information on the p...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.07.001
更新日期：2012-08-01 00:00:00
abstract：:The overall rate of functioning of a set of free sequential enzymes of the Michaelis-Menten type involved in a metabolic pathway has been computed as a function of the concentration of the initial substrate under steady-state conditions. Curves monotonically increasing up to a saturation plateau have been obtained in ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.02.008
更新日期：2006-12-01 00:00:00
