Abstract：
:Few proteins have had such a strong impact on a field as the lac repressor has had in Molecular Biology. Over 40 years ago, Jacob and Monod [Genetic regulatory mechanisms in the synthesis of proteins, J. Mol. Biol. 3 (1961) 318] proposed a model for gene regulation, which survives essentially unchanged in contemporary textbooks. It is a cogent depiction of how a set of 'structural' genes may be coordinately transcribed in response to environmental conditions and regulates metabolic events in the cell. In bacteria, the genes required for lactose utilization are negatively regulated when a repressor molecule binds to an upstream cis activated operator. The repressor and its operator together form a genetic switch, the lac operon. The switch functions when inducer molecules alter the conformation of the repressor in a specific manner. In the presence of a particular metabolite, the repressor undergoes a conformational change that reduces its affinity for the operator. The structures of the lac repressor and its complexes with operator DNA and effector molecules have provided a physical platform for visualizing at the molecular level the different conformations the repressor and the molecular basis for the switch. The structures of lac repressor, bound to its operator and inducer, have also been invaluable for interpreting a plethora of biochemical and genetic data.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Lewis Mdoi
10.1016/j.crvi.2005.04.004subject
Has Abstractpub_date
2005-06-01 00:00:00pages
521-48issue
6eissn
1631-0691issn
1768-3238pii
S1631-0691(05)00068-5journal_volume
328pub_type
历史文章,杂志文章,评审abstract：:Aphids are among the few organisms capable of reproducing either sexually or asexually. This plasticity in reproductive mode is viewed as an adaptive response to cope with seasonal changes. Clonal reproduction occurs during the growing season allowing rapid population increase, while sexual reproduction occurs during ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2010.03.003
更新日期：2010-06-01 00:00:00
abstract：:Hardwood trees are able to reorient their axes owing to tension wood differentiation. Tension wood is characterised by important ultrastructural modifications, such as the occurrence in a number of species, of an extra secondary wall layer, named gelatinous layer or G-layer, mainly constituted of cellulose microfibril...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.07.006
更新日期：2004-09-01 00:00:00
abstract：:Choosing a suitable habitat is a main step in the settlement process, particularly for species having weak movement abilities. Reliable cues are thus needed for habitat selection. In silk-spinning arthropods, silk can be used as a social cue to select an appropriate location. Silk can also provide information on the p...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.07.001
更新日期：2012-08-01 00:00:00
abstract：:A model of plant succession has been built for simulating the growth of six species, based on physiological processes such as photosynthesis, growth and maintenance respiration, carbon allocation, nitrogen absorption, fixation and remobilisation, organ mortality, seed dispersal and germination. The simulated global pl...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2005.07.008
更新日期：2006-01-01 00:00:00
abstract：:Using protein loci and DNA markers, we show by a multilocus genetic analysis that certain populations of the two sympatric mouse species Mus musculus domesticus and Mus spretus show clear signs of partial introgression. Given the sterility of F1 males and the known partial genetic incompatibilities between the genomes...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01413-0
更新日期：2002-02-01 00:00:00
abstract：:Meiosis is a specialized cell division at the origin of the haploid cells that eventually develop into the gametes. It therefore lies at the heart of Mendelian heredity. Recombination and redistribution of the homologous chromosomes arising during meiosis constitute an important source of genetic diversity, conferring...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2016.04.003
更新日期：2016-07-01 00:00:00
abstract：:The objective of this study is to investigate the genetic diversity, the relationships among six Tunisian wild cardoon populations (Cynara cardunculus var. sylvestris) and a Tunisian's population of cultivated cardoon (Cynara cardunculus var. altilis DC) in seven different geographical locations (Tiurif, Bahra, Zriba,...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.04.005
更新日期：2012-06-01 00:00:00
abstract：:Cnidarians (corals and sea anemones) harbouring photosynthetic microalgae derive several benefits from their association. To allow this association, numerous symbiotic-dependent adaptations in both partners, resulting from evolutionary pressures, have been selected. The dinoflagellate symbionts (zooxanthellae) are loc...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2018.03.007
更新日期：2018-01-01 00:00:00
abstract：:The history of selection of Daphnia magna populations living in North African temporary ponds may differ from populations inhabiting permanent ponds. Laboratory experiments were conducted to examine the effect of fish Gambusia holbrooki and invertebrate Notonecta glauca kairomones on the life history traits of the fre...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.09.004
更新日期：2010-11-01 00:00:00
abstract：:This article is the result of a symposium organized at the French Academy of Sciences on May 31, 2016, entitled: Do we need to know the causes to understand and intervene? Questions on causality in the biological and medical sciences, and published in French in a book entitled: Causality in the biological and medical ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2019.03.001
更新日期：2019-01-01 00:00:00
abstract：:Citrus trees are subject to several abiotic constraints such as salinity. Providing new rootstocks more tolerant is thus a requirement. In this article, we investigated salt stress tolerance of three tetraploid rootstock genotypes when compared to their respective diploid rootstocks (Poncirus trifoliata, Carrizo citra...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.06.007
更新日期：2008-09-01 00:00:00
abstract：:Cleome is the largest genus in the family Cleomaceae and it is known for its various medicinal properties. Recently, some species from the Cleome genus (Cleome viscosa, Cleome chelidonii, Cleome felina and Cleome speciosa) are split into genera Corynandra (Corynandra viscosa, Corynandra chelidonii, Corynandra felina),...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2016.02.005
更新日期：2016-03-01 00:00:00
abstract：:Daily numbers of deaths at a regional level were collected in 16 European countries. Summer mortality was analyzed for the reference period 1998-2002 and for 2003. More than 70,000 additional deaths occurred in Europe during the summer 2003. Major distortions occurred in the age distribution of the deaths, but no harv...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.12.001
更新日期：2008-02-01 00:00:00
abstract：:The present study focuses on the potential of glucose oxidase (GOD) as a promising biocontrol agent for fungal plant pathogens. In fact, a new GOD producing fungus was isolated and identified as an Aspergillus tubingensis. GOD (125 AU) has been found to inhibit Fusarium solani growth and spore production. Indeed, GOD ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.05.007
更新日期：2015-10-01 00:00:00
abstract：:The authors' purpose will be here to underline the continuity of the adaptative processes that make Homo sapiens, sometimes a brilliant inventor, sometimes a mere imitator, forging tools already conceived by Nature itself. ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.06.006
更新日期：2007-10-01 00:00:00
abstract：:Any clinician dreams to obtain the regeneration of the destroyed organ for his patient. In the human being, the regeneration of complex structures is not possible, except the liver and the bone marrow, which can be regenerated because of the presence of adult stem cells in these tissues. The stem cells have two princi...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2007.07.001
更新日期：2007-09-01 00:00:00
abstract：:Submerged fermentation in a stirred bioreactor of the white rot fungus Cerrena unicolor C-139 was done at a 120-L scale in the presence of wheat bran as a cheap lignocellulosic substrate for fungus growth and laccase production. Enzyme monitoring showed that laccase production started after 2 days of cultivation, atta...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2014.12.001
更新日期：2015-02-01 00:00:00
abstract：:The genus Pseudouroplectes Lourenço, 1995 (Buthidae) remains among the less speciose Malagasy genera and all the known species are extremely rare. A new species is described from the dry forests in the Tsingy formations of the National Park Bemaraha, extending the distribution of the genus further north. Once again, t...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.11.001
更新日期：2016-01-01 00:00:00
abstract：:With an expectation of life at birth of 27 years in the middle of the 18th century, 21% of males reached their 60th birthday with a remaining expectation of life of 12 years. Under the conditions of mortality of 1950, in France, 70 percent could celebrate their 60th birthday, and they had still 15 years (only) to live...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01469-5
更新日期：2002-06-01 00:00:00
abstract：:The overall rate of functioning of a set of free sequential enzymes of the Michaelis-Menten type involved in a metabolic pathway has been computed as a function of the concentration of the initial substrate under steady-state conditions. Curves monotonically increasing up to a saturation plateau have been obtained in ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.02.008
更新日期：2006-12-01 00:00:00
abstract：:In the present investigation, a total of 51 marine fungi were obtained from wood samples collected from four locations of Tamil Nadu (Tuthukudi, Chennai, Kanyakumari and Pichavaram), India. Out of these 51, 28 were ascomycetes, one was basidiomycete and 22 were mitosporic fungi. Maximum fungal diversity was encountere...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.03.008
更新日期：2008-06-01 00:00:00
abstract：:Since the early 2000s, the genus Buthus Leach, 1815 (family Buthidae) has been the subject of an important number of studies. These concerned particularly the species belonging to the 'Buthus occitanus' complex. A number of populations previously considered as subspecies or varieties of B. occitanus Leach were raised ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.10.002
更新日期：2016-01-01 00:00:00
abstract：:The shoot apical meristem is a population of stem cells which controls the initiation of leaves, flowers and branches during the entire life of the plant. Although we have gained significant new insight in the nature of the genetic networks and cellular processes that control meristem function, major questions have re...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2009.09.008
更新日期：2009-11-01 00:00:00
abstract：:Epilithic diatom communities are particularly suitable for the evaluation of freshwater quality. In Ecuador, however, no water quality index includes this biotic parameter. This work is the first attempt in the country to determine the composition of epilithic diatom communities associated with different degrees of eu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2018.03.008
更新日期：2018-04-01 00:00:00
abstract：:Sleep is a ubiquitous component of animal life, and prolonged sleep deprivation is fatal in both vertebrates and invertebrates. The physiologic function of sleep, however, is not known. We propose here that sleep provides a period of time necessary to reapportion resources within neurons and neural systems that become...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2004.05.009
更新日期：2004-08-01 00:00:00
abstract：:A new high-elevation scorpion species of the genus Scorpiops is described from the Indian state of Himachal Pradesh. Scorpiops spitiensis sp. nov. is the second highest-elevation scorpion species in Asia and the first one from India occurring at elevations above 4200 m. The new species closely resembles Scorpiops pete...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2014.04.004
更新日期：2014-06-01 00:00:00
abstract：:In this paper we consider cell cycle models for which the transition operator for the evolution of birth mass density is a simple, linear dynamical system with a stochastic perturbation. The convolution model for a birth mass distribution is presented. Density functions of birth mass and tail probabilities in n-th gen...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2003.05.002
更新日期：2004-03-01 00:00:00
abstract：:In this study, we investigate skull size and shape differentiation between sibling species of Mastomys with the aim to characterize and discriminate three sympatric species found in West Africa: M. huberti, M. erythroleucus and M. natalensis. A total of 133 genetically determined specimens were used for the morphometr...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.11.004
更新日期：2009-05-01 00:00:00
abstract：:A key point in the study of acoustic perception is whether brain responsiveness to sounds depends on sound acoustic structure or sound perceptive salience. Songbirds provide some evidence that higher auditory regions are sensitive to the subjective importance of the stimulus for the subject. In the present paper, we c...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.02.004
更新日期：2008-05-01 00:00:00
abstract：:This article demonstrates how that the effectiveness of nervous system in doing the computations essential to an organism can be based on using algorithms that are readily implemented by nervous system 'device biophysics'. Collective effects and collective algorithms that exploit their dynamics provide powerful potent...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/s1631-0691(03)00017-9
更新日期：2003-02-01 00:00:00
