Abstract：
:The voltage-gated sodium channel (VGSC) is a complex, which is composed of one pore-forming α subunit and at least one β subunit. Up to now, five β subunits are known: β1/β1A, β1B, β2, β3, and β4, encoded by four genes (SCN1B∼SCN4B). It is critical to have a deep understanding of the interaction between β1 and β3 subunits, two subunits which frequently appear in many diseases concurrently. In this study, we had screened out the new template of β1 subunit for homology modelling, which shares higher similarity to β3. Docking studies of the β1 and β3 homology model were conducted, and likely β1 and β3 binding loci were investigated. The results revealed that β1-β3 is more likely to form a di-polymer than β1-β1 based on molecular interaction analysis, including potential energy analysis, Van der Waals (VDW) energy analysis and electrostatic energy analysis, and in addition, consideration of the hydrogen bonds and hydrophobic contacts that are involved. Based on these analyses, the residues His122 and Lys140 of β1 and Glu 66, Asn 131, Asp 118, Glu 120, Glu133, Asn135, Ser 137 of β3 were predicted to play a functional role.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Liu Q,Jin Y,Wang K,Meng XX,Yang Y,Yang Z,Zhao YS,Zhao MY,Zhang JHdoi
10.1016/j.crvi.2013.11.009subject
Has Abstractpub_date
2014-02-01 00:00:00pages
73-7issue
2eissn
1631-0691issn
1768-3238pii
S1631-0691(13)00277-1journal_volume
337pub_type
杂志文章abstract：:The green birdmouth wrasse Gomphosus caeruleus is present all year round on the coral reefs of Reunion Island (Indian Ocean). A group of individuals was followed on one of these reefs with the objective of studying the reproduction mode of the species, the influence of environmental factors, and social behaviors on th...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2017.11.004
更新日期：2018-01-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.12.006
更新日期：2008-03-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2009.02.008
更新日期：2009-07-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2009.06.003
更新日期：2009-10-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2004.05.009
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2016.07.002
更新日期：2016-09-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2007.07.001
更新日期：2007-09-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.5802/crbiol.15
更新日期：2020-10-09 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2003.12.002
更新日期：2004-01-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.08.012
更新日期：2007-12-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2005.06.002
更新日期：2005-08-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.03.002
更新日期：2010-08-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.04.006
更新日期：2015-07-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2007.03.009
更新日期：2007-06-01 00:00:00
abstract：:The overall rate of functioning of a set of free sequential enzymes of the Michaelis-Menten type involved in a metabolic pathway has been computed as a function of the concentration of the initial substrate under steady-state conditions. Curves monotonically increasing up to a saturation plateau have been obtained in ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.02.008
更新日期：2006-12-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2010.01.013
更新日期：2010-04-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.10.008
更新日期：2005-01-01 00:00:00
abstract：:Spermiogenesis in Robphildollfusium fractum begins with the formation of a differentiation zone containing: two centrioles, each bearing striated rootlets, nucleus, several mitochondria and an intercentriolar body constituted by seven electron-dense layers. The two centrioles originate two free flagella growing orthog...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.06.003
更新日期：2012-07-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.09.001
更新日期：2007-01-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2003.09.006
更新日期：2003-10-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.11.001
更新日期：2016-01-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2014.12.001
更新日期：2015-02-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.09.006
更新日期：2004-11-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.11.005
更新日期：2007-02-01 00:00:00
abstract：:Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) are potent inhibitors of HIV infection. Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein. In Vif's absence, inhibitory APOBEC proteins are encapsidated by budding v...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.01.012
更新日期：2006-11-01 00:00:00
abstract：:In the present study, we have screened 71, 713, 525, 119 and 241 mature miRNA variants from Hordeum vulgare, Oryza sativa, Brachypodium distachyon, Triticum aestivum, and Sorghum bicolor, respectively, and classified them with respect to their conservation status and expression levels. These Poaceae non-redundant miRN...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2016.05.011
更新日期：2016-09-01 00:00:00
abstract：:Austronesians colonized the islands of Rapa Nui, Hawaii, the Marquesas and Madagascar. All of these islands have been found to harbor Austronesian artifacts and also, all of them are known nesting sites for marine turtles. Turtles are well known for their transoceanic migrations, sometimes totalling thousands of miles...
journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章
doi：10.1016/j.crvi.2015.12.001
更新日期：2016-02-01 00:00:00
abstract：:The larvicidal activity of ethanolic leaf extracts from two Artemisia species, Artemisia campestris var. glutinosa and A. molinieri, on mosquito Culex pipiens Linnaeus (Diptera, Culicidae) larvae was investigated. Since A. molinieri is a rare and protected species confined to temporary ponds of Southern France, its to...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2011.10.003
更新日期：2012-01-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章
doi：10.1016/j.crvi.2006.03.004
更新日期：2006-05-01 00:00:00
abstract：:This article presents the floristic, structural, and syntaxonomical features of plant assemblages in temporary wetlands and the pattern of the corresponding habitat types; according to the Habitats Directive. Nine pristine temporary wetlands covering a wide range of shapes, elevations and substrates were monitored. Th...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.06.006
更新日期：2010-09-01 00:00:00
