Predictors of Long-term Clinical and Endoscopic Remission in Children With Crohn Disease Treated With Infliximab.

Abstract:

OBJECTIVES:We aimed to identify early noninvasive predictors of clinical and endoscopic remission in children with Crohn disease (CD) under infliximab (IFX). METHODS:Prospective observational study conducted in children with moderate-to-severe CD starting IFX. All patients underwent weighted pediatric CD activity index (wPCDAI) assessment, C-reactive protein and fecal calprotectin (FC) at week 0, 14, and 48. Endoscopy was performed at 0 and 48 weeks. The primary outcome was to determine the ability of 14-week wPCDAI, C-reactive protein, and FC to predict 1-year steroid-free clinical remission and mucosal healing. As a secondary outcome we evaluated their concordance with Simple Endoscopic Score for CD (SES-CD) at week 48. RESULTS:Forty-one children were enrolled. At 1 year, 21 (51%) and 16 (39%) were in clinical and endoscopic remission. Only combined postinduction FC and wPCDAI were able to predict 1-year clinical and endoscopic remission (hazard ratio 4.81 [95% confidence interval 1.76-20.45], P = 0.05 and hazard ratio 5.51 [95% confidence interval 1.83-26.9], P = 0.03). One-year SES-CD moderately correlated with FC (r = 0.52; P = 0.001). The FC cut-off value for mucosal healing was 120.5 μg/g (area under the curve 0.863, 83% sensitivity, 75.5% specificity; P = 0.005). The concordance between wPCDAI and SES-CD was excellent and good for severe disease and remission (k 0.87 and 0.76). CONCLUSIONS:Post induction FC combined with wPCDAI can predict 1-year clinical and endoscopic response to IFX in pediatric CD. FC shows a moderate correlation with SES-CD, whereas wPCDAI has a good concordance with endoscopic remission or severe disease, but not with mild and moderate disease.

authors

D'Arcangelo G,Oliva S,Dilillo A,Viola F,Civitelli F,Isoldi S,Cucchiara S,Aloi M

doi

10.1097/MPG.0000000000002262

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

841-846

issue

6

eissn

0277-2116

issn

1536-4801

journal_volume

68

pub_type

杂志文章
  • Breath hydrogen analysis: a review of the methodologies and clinical applications.

    abstract::Hydrogen gas (H2) is a product of the fermentation of dietary carbohydrate (CHO) by bacteria in the lumen of the gastrointestinal tract in man. Thus, H2 is actually an exogenously produced gas, which either is passed as flatus, or diffuses into the body and is exhaled. In the adult, a fairly constant fraction is expir...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Ostrander CR,Cohen RS,Hopper AO,Shahin SM,Kerner JA Jr,Johnson JD,Stevenson DK

    更新日期:1983-01-01 00:00:00

  • Environmental Enteropathy, Micronutrient Adequacy, and Length Velocity in Nepalese Children: the MAL-ED Birth Cohort Study.

    abstract:OBJECTIVES:Environmental enteropathy (EE) is likely associated with growth retardation in children, but the association between EE and length velocity z score (LVZ) has not been investigated. The objective of the study was to assess associations between fecal markers for intestinal inflammation and LVZ and whether thes...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001990

    authors: Morseth MS,Henjum S,Schwinger C,Strand TA,Shrestha SK,Shrestha B,Chandyo RK,Ulak M,Torheim LE

    更新日期:2018-08-01 00:00:00

  • Endoscopic assessment of the colonic response to corticosteroids in children with ulcerative colitis.

    abstract::Twenty children with active ulcerative colitis were assessed before and after 8 weeks of medical therapy with 5-aminosalicylic acid (5-ASA) derivatives and corticosteroids. Local therapy was given for distal disease (seven cases); other disease was treated with oral prednisolone (1-2 mg/kg/day, maximum 40 mg). Eightee...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199605000-00006

    authors: Beattie RM,Nicholls SW,Domizio P,Williams CB,Walker-Smith JA

    更新日期:1996-05-01 00:00:00

  • Severity and extent of upper small bowel mucosal damage in cow's milk protein-sensitive enteropathy.

    abstract::A series of 31 infants, 28 with cow's milk protein sensitive enteropathy (CMPSE) and 3 controls, was studied for severity and extent of mucosal damage of the upper small bowel in relation to the development of clinical symptoms. Following challenge with the offending cow's milk, 18 infants (Group 1) developed severe m...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198809000-00008

    authors: Iyngkaran N,Yadav M,Boey CG,Lam KL

    更新日期:1988-09-01 00:00:00

  • Nephritis associated with an infected peritoneovenous LeVeen shunt.

    abstract::A patient with chronic active hepatitis and medically unmanageable ascites developed staphylococcal bacteremia after insertion of a peritoneovenous LeVeen shunt. The patient developed glomerulonephritis, manifested by moderate proteinuria, microscopic hematuria with red cell casts, azotemia, and evidence of complement...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198510000-00029

    authors: Salcedo JR,Sorkin L

    更新日期:1985-10-01 00:00:00

  • Bone quantitative ultrasound and bone mineral density in children with celiac disease.

    abstract:OBJECTIVES:Osteoporosis is the most common manifestation of untreated celiac disease (CD). Bone quantitative ultrasound (QUS) has recently emerged as a new modality for bone status assessment. We evaluated bone status in children with CD using dual-energy x-ray absorptiometry and quantitative ultrasound. METHODS:This ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200411000-00011

    authors: Hartman C,Hino B,Lerner A,Eshach-Adiv O,Berkowitz D,Shaoul R,Pacht A,Rozenthal E,Tamir A,Shamaly H,Shamir R

    更新日期:2004-11-01 00:00:00

  • Rotavirus A Infections in Community Childhood Diarrhea in the Brazilian Semiarid Region During Postvaccination Era.

    abstract:BACKGROUND:Rotavirus A (RVA) is one of the leading causes of acute gastroenteritis worldwide; however, few studies assessed RVA genetics with community surveillance. OBJECTIVES:This study aimed to investigate clinical data, genetic diversity, and coinfection patterns of RVA infections in children from 2 to 36 months o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002416

    authors: Pankov RC,Gondim RNDG,Prata MMG,Medeiros PHQS,Veras HN,Santos AKS,Havt A,da Silva MFM,Fumian TM,Miagostovich MP,Leite JPG,Lima AAM

    更新日期:2019-10-01 00:00:00

  • Functional fecal retention with encopresis in childhood.

    abstract:OBJECTIVES:The most common cause of encopresis in children is functional fecal retention (FFR). An international working team suggested that FFR be defined by the following criteria: a history of >12 weeks of passage of <2 large-diameter bowel movements (BMs) per week, retentive posturing, and accompanying symptoms, su...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200401000-00018

    authors: Loening-Baucke V

    更新日期:2004-01-01 00:00:00

  • Fecal secretory immunoglobulin A in breast milk versus formula feeding in early infancy.

    abstract::We studied the effects of breast milk feeding versus formula feeding during the first 8 weeks of life on the development of local gastrointestinal humoral immune response by measuring fecal secretory immunoglobulin A (SIgA). Forty-four infants were studied and classified into two groups: breast milk (n = 21) and stand...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Koutras AK,Vigorita VJ

    更新日期:1989-07-01 00:00:00

  • Serum transaminases in children with Wilson's disease.

    abstract:OBJECTIVES:The response of serum transaminase levels to penicillamine and zinc treatment in Wilson's disease is poorly understood. The aim of this multicenter retrospective study was to evaluate transaminase levels after penicillamine and zinc treatment in children with Wilson's disease. PATIENTS AND METHODS:One hundr...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200410000-00006

    authors: Iorio R,D'Ambrosi M,Marcellini M,Barbera C,Maggiore G,Zancan L,Giacchino R,Vajro P,Marazzi MG,Francavilla R,Michielutti F,Resti M,Frediani T,Pastore M,Mazzarella G,Fusco G,Cirillo F,Vegnente A,Hepatology Committee of

    更新日期:2004-10-01 00:00:00

  • Quality Improvement in Pediatric Endoscopy: A Clinical Report From the NASPGHAN Endoscopy Committee.

    abstract::The current era of healthcare reform emphasizes the provision of effective, safe, equitable, high-quality, and cost-effective care. Within the realm of gastrointestinal endoscopy in adults, renewed efforts are in place to accurately define and measure quality indicators across the spectrum of endoscopic care. In pedia...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1097/MPG.0000000000001592

    authors: Kramer RE,Walsh CM,Lerner DG,Fishman DS

    更新日期:2017-07-01 00:00:00

  • Antiendomysial antibody detection in biopsy culture allows avoidance of gluten challenge in celiac children.

    abstract:OBJECTIVE:Antiendomysial antibody (EMA) production has been induced in vitro by the small bowel mucosa of celiac disease (CD) patients in clinical remission cultured in the presence of gliadin peptides. The aim of the present study was to use this in vitro system to determine whether it could be used to predict the cli...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200502000-00015

    authors: Bonamico M,Sabbatella L,Di Tola M,Vetrano S,Ferri M,Nenna R,Mariani P,Picarelli A

    更新日期:2005-02-01 00:00:00

  • Primary sclerosing cholangitis in Arab children: report of four cases and literature review.

    abstract:BACKGROUND:The prevalence of primary sclerosing cholangitis, a rare progressive liver disorder, is increasing with the advent of endoscopic retrograde cholangiography in the investigation of children with obscure liver disease. The etiology of primary sclerosing cholangitis is not known, clinical presentation is variab...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199702000-00007

    authors: Kagalwalla AF,Altraif I,Shamsan L,Omojola M,Khan H,Kagalwalla YA

    更新日期:1997-02-01 00:00:00

  • Milk feeding and changes in intestinal permeability and morphology in the newborn.

    abstract::The contrasting effects of natural versus cow's milk formula (CMF) on upper gastrointestinal development in the newborn were studied. The passive intestinal permeability of neonatal human infants and guinea pigs was measured using the nonmetabolisable markers lactulose and mannitol. Mucosal morphology was examined in ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198705000-00008

    authors: Weaver LT,Laker MF,Nelson R,Lucas A

    更新日期:1987-05-01 00:00:00

  • Effects of biliary diversion to the ileum on the in situ disaccharidase activities of duodenal and ileal mucosa in the rat: a study on enzyme kinetics in tissue sections.

    abstract::In order to study the influence of biliary secretions on the in situ kinetic data of brush border disaccharidases in relation to small intestinal villus-crypt architecture, an anastomosis was constructed between the common bile duct, which had been divided before its entrance into the pancreatic head, and the ileum in...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198311000-00019

    authors: Gutschmidt S,Gartemann H

    更新日期:1983-11-01 00:00:00

  • Early Obesity: Risk Factor for Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for live...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002523

    authors: Cuzmar V,Alberti G,Uauy R,Pereira A,García C,De Barbieri F,Corvalán C,Santos JL,Mericq V,Villarroel L,Gana JC

    更新日期:2020-01-01 00:00:00

  • Burden of illness in screen-detected children with celiac disease and their families.

    abstract:OBJECTIVES:Because of a variable clinical picture, most children with celiac disease remain unrecognized without active serologic screening. Because, however, many patients are asymptomatic, the justification for screening remains unclear. We assessed health and well-being and the effect of a 1-year gluten-free diet in...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31825f18ff

    authors: Kinos S,Kurppa K,Ukkola A,Collin P,Lähdeaho ML,Huhtala H,Kekkonen L,Mäki M,Kaukinen K

    更新日期:2012-10-01 00:00:00

  • Hepatitis B virus infections transmitted from retarded children to their families during brief home exposure.

    abstract::Hepatitis B virus (HBV) infection is endemic among institutionalized retarded patients, who usually have mild, anicteric hepatitis following nonparenteral exposure. We evaluated the risk of HBV infection (as evidenced by serologic studies) among their contacts, including noninstitutional caretakers, during brief home ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198401000-00015

    authors: McPhillips JC,Collins JC,Spigland I

    更新日期:1984-01-01 00:00:00

  • Safety of a 1-Day Polyethylene Glycol 3350 Bowel Preparation for Colonoscopy in Children.

    abstract:OBJECTIVES:Electrolyte-free polyethylene glycol powder (PEG-3350) has been widely used for colonoscopy preparation (prep); however, limited safety data on electrolyte changes exists with 1-day prep regimens. The primary aim of this study was to determine the proportion of patients with significant serum chemistry abnor...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001072

    authors: Sahn B,Chen-Lim ML,Ciavardone D,Farace L,Jannelli F,Nieberle M,Ely E,Zhang X,Kelsen J,Puma A,Mamula P

    更新日期:2016-07-01 00:00:00

  • Eculizumab Is Safe and Effective as a Long-term Treatment for Protein-losing Enteropathy Due to CD55 Deficiency.

    abstract:OBJECTIVES:Loss of the complement inhibitor CD55 leads to a syndrome of early-onset protein-losing enteropathy (PLE), associated with intestinal lymphangiectasia and susceptibility to large-vein thrombosis. The in vitro and short-term treatment benefits of eculizumab (C5-inhibitor) therapy for CD55-deficiency have been...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002198

    authors: Kurolap A,Eshach Adiv O,Hershkovitz T,Tabib A,Karbian N,Paperna T,Mory A,Vachyan A,Slijper N,Steinberg R,Zohar Y,Mevorach D,Baris Feldman H

    更新日期:2019-03-01 00:00:00

  • Homeostatic mechanisms in the utilization of exogenous iron in children recovering from severe malnutrition.

    abstract::We evaluated the role of initial iron stores on iron accumulation during recovery from severe edematous protein-energy malnutrition in children. Twenty-six preschool children were divided in two groups according to their initial iron reserves, as estimated from serum ferritin concentration, using a cutoff criterion of...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198502000-00018

    authors: Caballero B,Solomons NW,Batres R,Torún B

    更新日期:1985-02-01 00:00:00

  • Infliximab therapy in 30 patients with refractory pediatric crohn disease with and without fistulas in The Netherlands.

    abstract:OBJECTIVE:The purpose of this study was to describe the clinical experience with the anti-tumor necrosis factor chimeric monoclonal antibody, infliximab, in pediatric patients with Crohn disease in The Netherlands. DESIGN:Descriptive. METHODS:Clinical response and adverse effects of infliximab were recorded for pedia...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200407000-00010

    authors: de Ridder L,Escher JC,Bouquet J,Schweizer JJ,Rings EH,Tolboom JJ,Houwen RH,Norbruis OF,Derkx BH,Taminiau JA

    更新日期:2004-07-01 00:00:00

  • Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic pigs.

    abstract:OBJECTIVE:The aim of this study was to study the effect of continued Lactobacillus rhamnosus GG strain (LGG) feeding on rotavirus gastroenteritis in the gnotobiotic (Gn) pig model of virulent human rotavirus (HRV) infection. METHODS:Gn pigs were assigned to treatment groups: mock control, LGG only, HRV only, or LGG pl...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182a356e1

    authors: Liu F,Li G,Wen K,Wu S,Zhang Y,Bui T,Yang X,Kocher J,Sun J,Jortner B,Yuan L

    更新日期:2013-12-01 00:00:00

  • Monitoring Eosinophilic Esophagitis Disease Activity With Blood Eosinophil Progenitor Levels.

    abstract:OBJECTIVES:A minimally invasive biomarker to monitor disease activity is one of the greatest unmet clinical needs of the pediatric eosinophilic esophagitis (EoE) population. We aimed to determine whether circulating eosinophil progenitors (EoPs) could be used as a biomarker to identify pediatric patients with active Eo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002583

    authors: Henderson A,Magier A,Schwartz JT,Martin LJ,Collins MH,Putnam PE,Mukkada VA,Abonia JP,Rothenberg ME,Fulkerson PC

    更新日期:2020-04-01 00:00:00

  • Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis.

    abstract:OBJECTIVES:Differentiating ulcerative colitis (UC) and Crohn disease (CD) can be clinically challenging, especially in children. Granulomatous inflammation has traditionally been attributed to CD. Crypt-associated giant cells and granulomas, however, have been observed in colonic biopsies of patients with UC. This phen...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001771

    authors: Queliza K,Ihekweazu FD,Schady D,Jensen C,Kellermayer R

    更新日期:2018-04-01 00:00:00

  • Factors Determining Optimal Fatty Acid Absorption in Preterm Infants.

    abstract:OBJECTIVES:The aim of the present study was to quantify absorption coefficients of specific fatty acids in preterm infants as a function of diet, formula or breast milk (BM), and postnatal age; to identify the fatty acid structural characteristics that determine optimal fatty acid absorption. METHODS:Fatty acids from ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000934

    authors: Martin CR,Cheesman A,Brown J,Makda M,Kutner AJ,DaSilva D,Zaman M,Freedman SD

    更新日期:2016-01-01 00:00:00

  • The prevalence of encopresis in a multicultural population.

    abstract:BACKGROUND:Population-based studies on the prevalence of encopresis in children are scarce and generally outdated. Prevalence estimates based on clinical studies are unreliable because parents tend to be reticent to seek medical help for this problem. Professional help is necessary, however, because encopresis can lead...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000149964.77418.27

    authors: van der Wal MF,Benninga MA,Hirasing RA

    更新日期:2005-03-01 00:00:00

  • Seasonality of birth month of children with celiac disease differs from that in the general population and between sexes and is linked to family history and environmental factors.

    abstract:BACKGROUND:Patients with autoimmune diseases, such as type 1 diabetes mellitus, atopic dermatitis, autoimmune thyroid diseases, and multiple sclerosis have a different seasonality of month of birth (MOB) from the general population. This study was undertaken to determine the seasonality of MOB in children with celiac d...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181709530

    authors: Lewy H,Meirson H,Laron Z

    更新日期:2009-02-01 00:00:00

  • Alanine-based oral rehydration solution: assessment of efficacy in acute noncholera diarrhea among children.

    abstract::This randomized, double-blind trial determined whether adding 90 mmol/L of alanine with a reduction in glucose to 90 mmol/L (alanine ORS) improves the efficacy of the standard oral rehydration solution (WHO-ORS). One hundred twenty-nine males aged 3-48 months with weight for length greater than or equal to 70% of NCHS...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sazawal S,Bhatnagar S,Bhan MK,Saxena SK,Arora NK,Aggarwal SK,Kashyap DK

    更新日期:1991-05-01 00:00:00

  • Effect of gum arabic in an oral rehydration solution on recovery from diarrhea in rats.

    abstract:BACKGROUND:It has been shown that gum arabic, a soluble fiber, enhances water, electrolyte, and glucose absorption from oral rehydration solutions in jejunal perfusion of healthy rats and in animals with theophylline-induced secretion or chronic osmotic-secretory diarrhea. This report concerns a study of the effectiven...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199910000-00008

    authors: Teichberg S,Wingertzahn MA,Moyse J,Wapnir RA

    更新日期:1999-10-01 00:00:00