A comparison of the anti-hypertensive effectiveness of two triameterene/hydrochlorothiazide combinations: Maxzide versus Dyazide.

abstract：:Apomorphine-induced vomiting is often used for preclinical efficacy testing of putative antiemetics in normal volunteers. The usual technique of individual intravenous titration for finding the threshold emitic dose of apomorphine in each subject is slow and tedious. We used a uniform dose of 0.05 mg/kg apomorphine gi...

journal_title：Journal of clinical pharmacology

authors： Proctor JD,Chremos AN,Evans EF,Wasserman AJ

更新日期：1978-02-01 00:00:00

abstract：:A randomized, single-blind, placebo-controlled, parallel-group study was conducted to assess the effect of age and gender on the pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct Factor Xa inhibitor. Subjects (n = 34) were enrolled into four groups: young males or females (aged 18-45 years) and el...

journal_title：Journal of clinical pharmacology

authors： Kubitza D,Becka M,Roth A,Mueck W

更新日期：2013-03-01 00:00:00

abstract：:The analgesic activity of buprenorphine was monitored versus that of morphine in a double-blind, randomized, multiple-dose, parallel-design study involving 97 postsurgical patients. Patients could receive intramuscular injections of either buprenorphine (0.3, o.45, or 0.6 mg) or morphine (10, 15, or 20 mg) every 3 or ...

journal_title：Journal of clinical pharmacology

authors： Ouellette RD

更新日期：1982-04-01 00:00:00

abstract：:Cannabinoids, including smoked marijuana and delta9-tetrahydrocannabinol (THC) (dronabinol, Marinol), have been used to treat human immunodeficiency virus-1 (HIV)-associated anorexia and weight loss. Concerns have been raised, however, that these compounds might have adverse effects on the immune system of subjects wi...

journal_title：Journal of clinical pharmacology

authors： Bredt BM,Higuera-Alhino D,Shade SB,Hebert SJ,McCune JM,Abrams DI

更新日期：2002-11-01 00:00:00

abstract：:This study aimed to evaluate the safety and tolerability of intravenous (IV) levetiracetam (LEV) as a monotherapy in children aged 1 month-16 years and to explore the pharmacokinetics (PK) of IV LEV and the time to seizure after IV then oral administration of LEV in pediatric children with epilepsy. Children diagnosed...

journal_title：Journal of clinical pharmacology

authors： Kim MJ,Yum MS,Yeh HR,Ko TS,Lim HS

更新日期：2018-12-01 00:00:00

abstract：:To investigate whether methyldopa alters digoxin disposition, eight healthy subjects received methyldopa titrated to 250 mg t.i.d. or placebo in a double-blind, cross-over manner for 16 consecutive days, with 0.25 mg intravenous digoxin coadministered on day 5 and 0.25 mg oral digoxin on days 9 to 16. Digoxin concentr...

journal_title：Journal of clinical pharmacology

authors： May CA,Vlasses PH,Rocci ML Jr,Rotmensch HH,Swanson BN,Tannenbaum RP,Ferguson RK,Abrams WB

更新日期：1984-08-01 00:00:00

abstract：:CS-0777 is a selective sphingosine 1-phosphate receptor-1 (S1P(1)) modulator under development for treatment of autoimmune conditions. A randomized, double-blind, placebo-controlled study was conducted to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CS-0777 in escalat...

journal_title：Journal of clinical pharmacology

authors： Moberly JB,Rohatagi S,Zahir H,Hsu C,Noveck RJ,Truitt KE

更新日期：2012-07-01 00:00:00

abstract：:Sixteen healthy volunteers were given either oral or intravenous doses of aminophylline (125 mg) at 9:00 A.M. and 9:00 P.M. under controlled food conditions. Measured at regular time intervals by homogeneous enzyme immunoassay, the plasma theophylline concentrations 1.5 and 2 hours after oral aminophylline were signif...

journal_title：Journal of clinical pharmacology

authors： Watanabe H,Nakano S,Nagai K,Ogawa N

更新日期：1984-11-01 00:00:00

abstract：:Four protease inhibitor antiviral agents (ritonavir, indinavir, nelfinavir, saquinavir) were evaluated as in vitro inhibitors of the activity of six human cytochromes using an in vitro model based on human liver microsomes. Ritonavir was a highly potent inhibitor of P450-3A activity (triazolam hydroxylation), having i...

journal_title：Journal of clinical pharmacology

authors： von Moltke LL,Greenblatt DJ,Grassi JM,Granda BW,Duan SX,Fogelman SM,Daily JP,Harmatz JS,Shader RI

更新日期：1998-02-01 00:00:00

abstract：:A clinical study was performed on 41 asthmatic patients. After complete physical and spirometric examinations, they received capsules containing 200 mg anhydrous theophylline per capsule t.i.d. for three weeks. All other antiasthmatic medications were omitted during this study. The results showed that these capsules (...

journal_title：Journal of clinical pharmacology

authors： Miller J,Salem H

更新日期：1976-07-01 00:00:00

abstract：:The isoproterenol sensitivity (dose-response curve) and the total body clearance of propranolol were measured in 80 men including 15 normal subjects and 65 essential hypertensive patients (20 borderline and 45 permanent hypertensives). The critical dose of isoproterenol was found to be directly correlated to weight (P...

journal_title：Journal of clinical pharmacology

authors： London GM,Safar ME,Weiss YA,Milliez PL

更新日期：1976-04-01 00:00:00

abstract：:Fifteen healthy women participated in a study to determine the effect of multiple doses of troglitazone on the pharmacokinetics of Ortho-Novum 1/35 (35 micrograms ethinyl estradiol [EE] and 1 mg norethindrone [NE]). Participants received three cycles (21 days each of active drug followed by 7 days without medication) ...

journal_title：Journal of clinical pharmacology

authors： Loi CM,Stern R,Koup JR,Vassos AB,Knowlton P,Sedman AJ

更新日期：1999-04-01 00:00:00

abstract：:The effects of large doses of anabolic steroids on 24-hour blood pressure, cardiac structure and function, and lipid profiles were studied in 10 body builders using anabolic steroids and 14 body builders who did not use steroids (control subjects). All subjects underwent noninvasive 24-hour blood pressure monitoring, ...

journal_title：Journal of clinical pharmacology

authors： Palatini P,Giada F,Garavelli G,Sinisi F,Mario L,Michieletto M,Baldo-Enzi G

更新日期：1996-12-01 00:00:00

abstract：:Precision medicine in oncology is the result of an increasing awareness of patient-specific clinical features coupled with the development of genomic-based diagnostics and targeted therapeutics. Companion diagnostics designed for specific drug-target pairs were the first to widely utilize clinically applicable tumor b...

journal_title：Journal of clinical pharmacology

authors： Schmidt KT,Chau CH,Price DK,Figg WD

更新日期：2016-12-01 00:00:00

abstract：:To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Patients were taking isosorbide dinitrate, 2% nitroglycer...

journal_title：Journal of clinical pharmacology

authors： Arsura E,Lichstein E,Guadagnino V,Nicchi V,Sanders M,Hollander G,Greengart A

更新日期：1984-04-01 00:00:00

abstract：:Hypertensive emergency is a condition in which there is elevation of both systolic and diastolic blood pressure with the presence of acute target organ disease. Hypertensive urgency is a condition where the blood pressure is elevated (diastolic > 120 mmHg) with the absence of acute target organ disease. Hypertensive e...

journal_title：Journal of clinical pharmacology

authors： Abdelwahab W,Frishman W,Landau A

更新日期：1995-08-01 00:00:00

abstract：:This study examined warfarin usage for elderly Medicare beneficiaries with atrial fibrillation (AF) who suffered traumatic brain injury (TBI), hip fracture, or torso injuries. Using the 5% Chronic Condition Data Warehouse administrative claims data, this study included fee-for-service Medicare beneficiaries who had a ...

journal_title：Journal of clinical pharmacology

authors： Liu X,Baumgarten M,Smith G,Gambert S,Gottlieb S,Rattinger G,Albrecht J,Langenberg P,Zuckerman I

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the potential pharmacokinetic interaction between the direct renin inhibitor aliskiren and modulators of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Aliskiren stimulated in vitro P-glycoprotein ATPase activity in recombinant baculovirus-infected Sf9 cells with high affinity (K(m) 2.1 micro...

journal_title：Journal of clinical pharmacology

authors： Vaidyanathan S,Camenisch G,Schuetz H,Reynolds C,Yeh CM,Bizot MN,Dieterich HA,Howard D,Dole WP

更新日期：2008-11-01 00:00:00

abstract：:To explore the clinical relevance of inhibition of multidrug resistance transporter 1 and organic anion transporting polypeptide transporter, a drug-drug interaction study was conducted using aliskiren and cyclosporine. This was an open-label, single-sequence, parallel-group, single-dose study in healthy subjects. Sub...

journal_title：Journal of clinical pharmacology

authors： Rebello S,Compain S,Feng A,Hariry S,Dieterich HA,Jarugula V

更新日期：2011-11-01 00:00:00

abstract：:The integrated minimal model allows assessment of clinical diagnosis indices, for example, insulin sensitivity (SI ) and glucose effectiveness (SG ), from data of the insulin-modified intravenous glucose tolerance test (IVGTT), which is laborious with an intense sampling schedule, up to 32 samples. The aim of this stu...

journal_title：Journal of clinical pharmacology

authors： Ibrahim MMA,Redestad E,Kjellsson MC

更新日期：2021-01-01 00:00:00

abstract：:These studies were conducted to evaluate the pharmacokinetics of several retinoids after meal consumption or vitamin A supplementation to establish a reference for future assessment of teratogenic risks of retinoid therapeutic agents. In the first study, 36 healthy young female volunteers consumed single meals contain...

journal_title：Journal of clinical pharmacology

authors： Chen C,Mistry G,Jensen B,Heizmann P,Timm U,van Brummelen P,Rakhit AK

更新日期：1996-09-01 00:00:00

abstract：:In this investigation, the pharmacokinetic and pharmacodynamic properties were determined of multiple doses of sublingual tablets containing either buprenorphine alone or buprenorphine and naloxone. Subjects were experienced opiate users who received escalating doses (4-24 mg) of buprenorphine either alone or in combi...

journal_title：Journal of clinical pharmacology

authors： Ciraulo DA,Hitzemann RJ,Somoza E,Knapp CM,Rotrosen J,Sarid-Segal O,Ciraulo AM,Greenblatt DJ,Chiang CN

更新日期：2006-02-01 00:00:00

abstract：:The alpha 1-adrenoceptor antagonists doxazosin and terazosin and the 5 alpha-reductase inhibitor finasteride are used in the treatment of benign prostatic hyperplasia. The aim of this study was to assess the potential pharmacokinetic interaction of doxazosin or terazosin when coadministered with finasteride. This was ...

journal_title：Journal of clinical pharmacology

authors： Vashi V,Chung M,Hilbert J,Lawrence V,Phillips K

更新日期：1998-11-01 00:00:00

abstract：:Experimental interventions that activate specific components of clinical pain are necessary for characterization of underlying mechanisms and pharmacology. Cutaneous hyperalgesia has been described that uses nonpainful heat to induce secondary hyperalgesia. This study evaluated the effect of intravenous alfentanil on ...

journal_title：Journal of clinical pharmacology

authors： Schifftner C,Schulteis G,Wallace MS

更新日期：2017-09-01 00:00:00

abstract：:To assess the effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin, a third-party blind, placebo-controlled, randomized, two-way crossover study was performed in 12 healthy volunteers. Each participant received single 30-mg oral doses of racemic warfarin sodium (Coumadin; DuPont Pharma, Wilmingt...

journal_title：Journal of clinical pharmacology

authors： Zhi J,Melia AT,Guerciolini R,Koss-Twardy SG,Passe SM,Rakhit A,Sadowski JA

更新日期：1996-07-01 00:00:00

abstract：:Antibacterial drugs are among the most common medications used by pregnant women. While medical literature generally defines nitrofurantoin as an antibiotic that is safe for use during the first trimester of pregnancy, new concerns about a possible association between congenital malformations following exposure to nit...

journal_title：Journal of clinical pharmacology

authors： Goldberg O,Koren G,Landau D,Lunenfeld E,Matok I,Levy A

更新日期：2013-09-01 00:00:00

abstract：:Clinical pharmacologists are all dedicated to improving the use of medications and decreasing medication errors and adverse drug reactions. However, quality improvement requires that some significant parameters of quality be categorized, measured, and tracked to provide benchmarks to which future data (performance) ca...

journal_title：Journal of clinical pharmacology

authors： Benjamin DM,Pendrak RF

更新日期：2003-07-01 00:00:00

abstract：:The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The...

journal_title：Journal of clinical pharmacology

authors： Osterberg O,Savic RM,Karlsson MO,Simonsson US,Nørgaard JP,Walle JV,Agersø H

更新日期：2006-10-01 00:00:00

abstract：:Based on the discussion of NMS, certain conclusions may be reached in regard to this patient. In the psychiatric setting, agitation and confusion alone are not suggestive of NMS. However in this patient, the symptoms of agitation, the rapid development of EPS symptoms unresponsive to anticholinergic therapy, autonomic...

journal_title：Journal of clinical pharmacology

authors： Schneiderhan ME,Marken PA

更新日期：1994-04-01 00:00:00

abstract：:The in vitro plasma protein binding of warfarin was evaluated by ultrafiltration in plasma from seven normal subjects and seven patients with varying degrees of renal dysfunction. The unbound, or free, warfarin fraction was twice as high in the plasma samples withdrawn from patients with renal impairment than in the s...

journal_title：Journal of clinical pharmacology

authors： Bachmann K,Shapiro R,Mackiewicz J

更新日期：1976-10-01 00:00:00