Abstract：
:Cannabinoids, including smoked marijuana and delta9-tetrahydrocannabinol (THC) (dronabinol, Marinol), have been used to treat human immunodeficiency virus-1 (HIV)-associated anorexia and weight loss. Concerns have been raised, however, that these compounds might have adverse effects on the immune system of subjects with HIV infection. To determine whether such effects occur, the authors designed a randomized, prospective, controlled trial comparing the use of marijuana cigarettes (3.95% THC), dronabinol (2.5 mg), and oral placebo in HIV-infected adults taking protease inhibitor-containing highly active antiretroviral therapy (HAART). Assays of immune phenotype (including flow cytometric quantitation of T cell subpopulations, B cells, and natural killer [NK] cells) and immunefunction (including assays for induced cytokine production, NK cell function, and lymphoproliferation) were performed at baseline and weekly thereafter. On the basis of these measurements and during this short 21-day study period, few statistically significant effects were noted on immune system phenotypes orfunctions in this patient population.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Bredt BM,Higuera-Alhino D,Shade SB,Hebert SJ,McCune JM,Abrams DIdoi
10.1002/j.1552-4604.2002.tb06007.xsubject
Has Abstractpub_date
2002-11-01 00:00:00pages
82S-89Sissue
S1eissn
0091-2700issn
1552-4604journal_volume
42pub_type
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