Isoproterenol sensitivity and total body clearance of propranolol in hypertensive patients.

abstract：:Upadacitinib is a selective Janus kinase 1 inhibitor that was recently approved for treatment of rheumatoid arthritis and is currently being evaluated for treatment of several other autoimmune diseases, including atopic dermatitis (AD). The relationships between upadacitinib plasma exposure and efficacy (assessed as E...

journal_title：Journal of clinical pharmacology

authors： Mohamed MF,Gopalakrishnan S,Teixeira HD,Othman AA

更新日期：2020-11-06 00:00:00

abstract：:The antipyretic activity of ibuprofen (Brufen) and paracetamol (Crocin) was compared in 22 children with pyrexia who received either ibuprofen or paracetamol in syrup form. Both axillary and rectal temperatures were recorded prior to drug administration and 1/2, 1, 2, 3, 4, 5, 6, 8, and 12 hours after dosing. Analysis...

journal_title：Journal of clinical pharmacology

authors： Sheth UK,Gupta K,Paul T,Pispati PK

更新日期：1980-11-01 00:00:00

abstract：:CPX-351, a dual-drug liposomal encapsulation of cytarabine and daunorubicin at a synergistic ratio, is approved in the United States for adults with newly diagnosed therapy-related acute myeloid leukemia or acute myeloid leukemia with myelodysplasia-related changes. Population pharmacokinetics analyses were performed ...

journal_title：Journal of clinical pharmacology

authors： Wang Q,Banerjee K,Vasilinin G,Marier JF,Gibbons JA

更新日期：2019-05-01 00:00:00

abstract：:A total of 175 physicians were surveyed by questionnaire before a Clinical Pharmacology Consult Service was started. Of those that responded, 72% thought the service would be helpful, although 40% said they would use the service no more than once a month. Most physicians (75%) preferred self-initiated consultations to...

journal_title：Journal of clinical pharmacology

authors： Casner PR,Dillon KR

更新日期：1988-01-01 00:00:00

abstract：:Half-life is a standard result reported with analysis of pharmacokinetic data. Different definitions such as noncompartmental half-life, terminal half-life, effective half-life, and context-sensitive half-life can yield substantially different estimates of the quantity "half-life." Time to attainment of steady-state c...

journal_title：Journal of clinical pharmacology

authors： Krause A,Lott D,Dingemanse J

更新日期：2021-01-01 00:00:00

abstract：:Taranabant is a novel cannabinoid CB-1 receptor (CB1R) inverse agonist in clinical development for the treatment of obesity. This double-blind, randomized, placebo-controlled, single oral dose study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of taranabant (0.5-600 mg) in 24 healthy male...

journal_title：Journal of clinical pharmacology

authors： Addy C,Li S,Agrawal N,Stone J,Majumdar A,Zhong L,Li H,Yuan J,Maes A,Rothenberg P,Cote J,Rosko K,Cummings C,Warrington S,Boyce M,Gottesdiener K,Stoch A,Wagner J

更新日期：2008-04-01 00:00:00

abstract：:The present study was conducted to determine the absolute bioavailability of fimasartan (FMS; Kanarb(®) ) after the single oral administration of a 60-mg tablet or a single 30-mg intravenous (IV) infusion. This investigation was a randomized, single-dose, open-labeled, two-way crossover study of 16 healthy Korean male...

journal_title：Journal of clinical pharmacology

authors： Ghim JL,Paik SH,Hasanuzzaman M,Chi YH,Choi HK,Kim DH,Shin JG

更新日期：2016-05-01 00:00:00

abstract：:Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study were to develop a robust exposure-response model for the relationship ...

journal_title：Journal of clinical pharmacology

authors： Du L,Wenning LA,Carvalho B,Duley L,Brookfield KF,Witjes H,de Greef R,Lumbiganon P,Titapant V,Kongwattanakul K,Long Q,Sangkomkamhang US,Gülmezoglu AM,Oladapo OT

更新日期：2019-11-01 00:00:00

abstract：:Standard of care for ulcerative colitis involves long-term pharmacotherapy or colectomy. Approximately 20% to 30% of patients eventually require a colectomy because patients either do not respond or cannot tolerate the currently available pharmacotherapies. Advances in our knowledge of the pathophysiology of ulcerativ...

journal_title：Journal of clinical pharmacology

authors： Sands BE,Kaplan GG

更新日期：2007-08-01 00:00:00

abstract：:The selective T-cell costimulation modulator abatacept is approved for treatment of adult rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (pJIA; 6-17 years [intravenous] and 2-17 years [subcutaneous]). An extrapolation approach was taken to determine subcutaneous weight-tiered doses of abatac...

journal_title：Journal of clinical pharmacology

authors： Gandhi Y,Passarell JA,Roy A,Murthy B

更新日期：2020-12-07 00:00:00

abstract：:A bioequivalence study of two oral formulations of 300 mg ranitidine was carried out in 16 healthy volunteers (8 men and 8 women), and the pharmacokinetics in both sexes were compared. There was bioequivalence of both formulations. The terminal half-life of ranitidine was 7% shorter and the oral apparent clearance 10....

journal_title：Journal of clinical pharmacology

authors： Abad-Santos F,Carcas AJ,Guerra P,Govantes C,Montuenga C,Gómez E,Fernández A,Frias J

更新日期：1996-08-01 00:00:00

abstract：:A double-blind controlled trial was carried out to compare the effects of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (UDCA), and placebo on cholesterol and triglyceride levels in patients with endogenous hypertriglyceridemias. The dose of both bile acids was four 150-mg capsules day. Total serum cholesterol le...

journal_title：Journal of clinical pharmacology

authors： Carulli N,Ponz de Leon M,Podda M,Zuin M,Strata A,Frigerio G,Digrisolo A

更新日期：1981-10-01 00:00:00

abstract：:A clinical study of bumetanide, a new diuretic, was conducted in outpatients of a cardiology clinic to determine its long-term effectiveness and safety in the treatment of peripheral edema due to congestive heart failure. The drug was administered for at least 24 weeks on a selected group of 34 patients. The patients ...

journal_title：Journal of clinical pharmacology

authors： Handler B,Dhingra RC,Rosen KM

更新日期：1981-11-01 00:00:00

abstract：:The aim of the study was to investigate the pharmacokinetics and removal of midazolam and unconjugated and glucuronidated 1-hydroxy-midazolam in 4 intensive care patients on continuous venovenous hemodialysis. Plasma midazolam and its metabolites were assessed by HPLC from blood samples collected during continuous inf...

journal_title：Journal of clinical pharmacology

authors： Bolon M,Bastien O,Flamens C,Paulus S,Boulieu R

更新日期：2001-09-01 00:00:00

abstract：:In most Wuchereria bancrofti and Brugia malayi infections, the microfilaria are found in the blood in greatest number between 10 p.m. and 2 a.m., indicating that chronotherapy may be beneficial in treating such infections. This study reports the influence of time of administration on the pharmacokinetics of diethylcar...

journal_title：Journal of clinical pharmacology

authors： Bolla S,Boinpally RR,Poondru S,Devaraj R,Jasti BR

更新日期：2002-03-01 00:00:00

abstract：:After intravenous injection, sotalol follows a two-compartment distribution pattern. The processes of distribution and elimination are of first order; the intravenous biological half-life is 6 to 8 hours. The drug is mainly excreted by glomerular filtration via the kidney, and metabolites are not found. Of the pharmac...

journal_title：Journal of clinical pharmacology

authors： Schnelle K,Klein G,Schinz A

更新日期：1979-08-01 00:00:00

abstract：:The 30-minute ratio of 1'-hydroxymidazolam:midazolam plasma concentrations has been used as a measure of midazolam clearance in liver transplant patients. This study determined if a single concentration of 1'-hydroxymidazolam or the ratio of 1'-hydroxymidazolam:midazolam could be used to predict midazolam clearance in...

journal_title：Journal of clinical pharmacology

authors： Rogers JF,Nafziger AN,Kashuba AD,Streetman DS,Rocci ML Jr,Choo EF,Wilkinson GR,Bertino JS Jr

更新日期：2002-10-01 00:00:00

abstract：:Categorizations of best response observed at week 8 (between week 3 and 14) of first-line treatment in two studies of bevacizumab plus chemotherapy in Western (878 patients) and Chinese (198 patients) patients with non-small cell lung cancer were assessed together with baseline prognostic factors in multivariate param...

journal_title：Journal of clinical pharmacology

authors： Claret L,Gupta M,Han K,Joshi A,Sarapa N,He J,Powell B,Bruno R

更新日期：2014-03-01 00:00:00

abstract：:The angiotensin-converting enzyme (ACE) gene is a candidate genetic locus for coronary artery disease (CAD). Studies investigating the relationship between the ACE-insertion/deletion (I/D) gene polymorphism and myocardial infarction (MI) have been inconsistent. The authors hypothesized that age may be an important mod...

journal_title：Journal of clinical pharmacology

authors： Hamelin BA,Zakrzewski-Jakubiak M,Robitaille NM,Bogaty P,Labbé L,Turgeon J

更新日期：2011-09-01 00:00:00

abstract：:The pharmacokinetic actions, bioequivalence, and cardiovascular effects of two verapamil products were studied in a randomized, double-blind, crossover study in eight elderly hypertensive patients (median age, 69.5 years; range, 60-79 years) given brand-name or generic immediate-release verapamil in 120-mg twice-daily...

journal_title：Journal of clinical pharmacology

authors： Saseen JJ,Porter JA,Barnette DJ,Bauman JL,Zajac EJ Jr,Carter BL

更新日期：1997-06-01 00:00:00

abstract：:Dual inhibition of neutral endopeptidase 24.11 (NEP) and angiotensin-converting enzyme (ACE) has gained increasing interest in the treatment of hypertension, heart failure, and renoprotection. Specifically, M100240, the thioester of the dual ACE/NEP inhibitor MDL100,173, has been evaluated in the management of hyperte...

journal_title：Journal of clinical pharmacology

authors： Pfister M,Martin NE,Haskell LP,Barrett JS

更新日期：2004-06-01 00:00:00

abstract：:In June 1999, the Food and Drug Administration issued draft guidance for bioequivalence studies for nasal aerosols and nasal sprays for local action. The purpose of this opinion paper is to highlight the need for a balanced scientific debate before this guidance is used by underscoring the areas in the document that a...

journal_title：Journal of clinical pharmacology

authors： Harrison LI

更新日期：2000-07-01 00:00:00

abstract：:Inhaled glucocorticoids induce therapeutic and adverse systemic effects via the same types of receptors. Analysis of the pharmacokinetic/pharmacodynamic parameters of inhaled glucocorticoids generates a risk-benefit value (RBV). Targeted efficacy with minimal adverse effects helps to quantify an appropriate RBV. High ...

journal_title：Journal of clinical pharmacology

authors： Rohatagi S,Appajosyula S,Derendorf H,Szefler S,Nave R,Zech K,Banerji D

更新日期：2004-01-01 00:00:00

abstract：:Triamcinolone acetonide (TCA) is a corticosteroid that is frequently used in the treatment of asthma. After inhalation, TCA can become systemically available when the inhaled formulation is swallowed, causing undesirable systemic effects. A clinical study was conducted to determine the systemic side effects of TCA aft...

journal_title：Journal of clinical pharmacology

authors： Rohatagi S,Hochhaus G,Mollmann H,Barth J,Galia E,Erdmann M,Sourgens H,Derendorf H

更新日期：1995-12-01 00:00:00

abstract：:In many industrialized nations, the elderly comprise the fastest growing subpopulation and constitute an increasing proportion of the total population compared to other age groups. The elderly use a disproportionately larger amount of health care resources since they experience a higher incidence of disease-related mo...

journal_title：Journal of clinical pharmacology

authors： Schmucker DL,Vesell ES

更新日期：1999-11-01 00:00:00

abstract：:Trecovirsen, a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene, was administered to HIV-positive volunteers as an i.v. infusion. Single doses ranged from 0.1 to 2.5 mg/kg in an ascending escalation in cohorts of 6 to 12 subjects. Plasma trecovirsen concentrations and pharmaco...

journal_title：Journal of clinical pharmacology

authors： Séréni D,Tubiana R,Lascoux C,Katlama C,Taulera O,Bourque A,Cohen A,Dvorchik B,Martin RR,Tournerie C,Gouyette A,Schechter PJ

更新日期：1999-01-01 00:00:00

abstract：:A physiologically based pharmacokinetic model (PBPK) was built for citalopram using Simcyp-based absorption, distribution, metabolism, and excretion simulator. Various physicochemical properties of citalopram were obtained from the published literature. The in vitro-in vivo extrapolation method was used to predict cle...

journal_title：Journal of clinical pharmacology

authors： Wu X,Zhang H,Miah MK,Caritis SN,Venkataramanan R

更新日期：2020-04-01 00:00:00

abstract：:An open-label study evaluated the effect of steady-state venlafaxine on the single-dose pharmacokinetic profile of risperidone, a CYP2D6 substrate; its active metabolite, 9-hydroxyrisperidone; and the total active moiety (risperidone plus 9-hydroxyrisperidone). Thirty healthy subjects received a 1 mg oral dose of risp...

journal_title：Journal of clinical pharmacology

authors： Amchin J,Zarycranski W,Taylor KP,Albano D,Klockowski PM

更新日期：1999-03-01 00:00:00

abstract：:Microgravity is produced for 20 to 30 seconds in NASA's KC-135 aircraft at the end of a 2 G pullup for each of 40 parabolas per flight. Continuous transcranial Doppler ultrasound, arterial blood pressure, and acceleration levels were recorded for 12 male and 8 female healthy subjects without known cardiovascular or ce...

journal_title：Journal of clinical pharmacology

authors： Bondar RL,Stein F,Kassam MS,Dunphy PT,Bennett BS,Johnston KW

更新日期：1991-10-01 00:00:00

abstract：:Intravenous amiodarone is an effective agent for the treatment of recurrent ventricular fibrillation and hemodynamically unstable ventricular tachycardia. PM101 Premixed Injection is a new formulation of intravenous amiodarone that uses a cyclodextrin to maintain amiodarone in the aqueous phase. Eighty-eight subjects ...

journal_title：Journal of clinical pharmacology

authors： Cushing DJ,Adams MP,Cooper WD,Agha B,Souney PF

更新日期：2012-02-01 00:00:00