Abstract:
:Over the past half a century, many investigations in experimental animal have explored the functional roles of specific regions in the brainstem. Despite the accumulation of a considerable body of knowledge in, primarily, anesthetized preparations, relatively few studies have explored brainstem function in awake humans. It is important that human brainstem function is explored given that many neurological conditions, from obstructive sleep apnea, chronic pain, and hypertension, likely involve significant changes in the processing of information within the brainstem. Recent advances in the collection and processing of magnetic resonance images have resulted in the possibility of exploring brainstem activity changes in awake healthy individuals and in those with various clinical conditions. We and others have begun to explore changes in brainstem activity in humans during a number of challenges, including cutaneous and muscle pain, as well as during maneuvers that evoke increases in sympathetic nerve activity. More recently we have successfully recorded sympathetic nerve activity concurrently with functional magnetic resonance imaging of the brainstem, which will allow us, for the first time to explore brainstem sites directly responsible for conditions such as hypertension. Since many pathophysiological conditions no doubt involve changes in brainstem function and structure, defining these changes will likely result in a greater ability to develop more effective treatment regimens.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Henderson LA,Macefield VGdoi
10.3389/fnhum.2013.00569subject
Has Abstractpub_date
2013-09-17 00:00:00pages
569issn
1662-5161journal_volume
7pub_type
杂志文章,评审abstract::Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic perf...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00334
更新日期:2016-07-05 00:00:00
abstract::The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neurons drives negative states and avoidance. Furthermore, the hyperexcitability of neurons in the LHb, especially those projecti...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2013.00860
更新日期:2013-12-16 00:00:00
abstract::The main objectives of this study were to investigate the development of face perception in Japanese children, focusing on the changes in face processing strategies (holistic and/or configural vs. feature-based) that occur during childhood. To achieve this, we analyzed the face-related N170 component, evoked by uprigh...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00263
更新日期:2015-06-02 00:00:00
abstract::Breakfast consumption is associated with positive outcomes for diet quality, micronutrient intake, weight status and lifestyle factors. Breakfast has been suggested to positively affect learning in children in terms of behavior, cognitive, and school performance. However, these assertions are largely based on evidence...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00425
更新日期:2013-08-08 00:00:00
abstract::To investigate the neural systems that contribute to the formation of complex, self-relevant emotional memories, dedicated fans of rival college basketball teams watched a competitive game while undergoing functional magnetic resonance imaging (fMRI). During a subsequent recognition memory task, participants were show...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2010.00034
更新日期:2010-05-18 00:00:00
abstract::The current study investigated the time course of the other-race classification advantage (ORCA) in the subordinate classification of normally configured faces and distorted faces by race. Slightly distorting the face configuration delayed the categorization of own-race faces and had no conspicuous effects on other-ra...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00679
更新日期:2015-12-21 00:00:00
abstract::An important but poorly understood aspect of sensory processing is the role of active sensing, the use of self-motion such as eye or head movements to focus sensing resources on the most rewarding or informative aspects of the sensory environment. Here, we present behavioral data from a visual search experiment, as we...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00955
更新日期:2014-12-03 00:00:00
abstract::The aim of this study is to investigate the influence of passive movement repetition frequency at 1.5-Hz and 1-Hz on changes in cerebral oxygenation and assess the temporal properties of these changes using functional near-infrared spectroscopy (fNIRS). No significant differences in systemic hemodynamics were observed...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00641
更新日期:2015-11-25 00:00:00
abstract::The serotonin transporter gene (5-HTTLPR) influences emotional reactivity and attentional bias toward or away from emotional stimuli, and has been implicated in psychopathological states, such as depression and anxiety disorder. The short allele is associated with increased reactivity and attention toward negatively-v...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00327
更新日期:2013-07-04 00:00:00
abstract::Attention facilitates the processing of task-relevant visual information and suppresses interference from task-irrelevant information. Modulations of neural activity in visual cortex depend on attention, and likely result from signals originating in fronto-parietal and cingulo-opercular regions of cortex. Here, we tes...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00338
更新日期:2015-06-08 00:00:00
abstract::Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional con...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00513
更新日期:2015-09-22 00:00:00
abstract::Perceptual bistability arises when two conflicting interpretations of an ambiguous stimulus or images in binocular rivalry (BR) compete for perceptual dominance. From a computational point of view, competition models based on cross-inhibition and adaptation have shown that noise is a crucial force for rivalry, and ope...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2011.00145
更新日期:2011-11-28 00:00:00
abstract:AIMS:Questions regarding perception of pain in non-communicating patients and the management of pain continue to raise controversy both at a clinical and ethical level. The aim of this study was to examine the cortical response to salient visual, acoustic, somatosensory electric non-nociceptive and nociceptive laser st...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00017
更新日期:2015-01-29 00:00:00
abstract::Empathy is inherently interpersonal, but the majority of research has only examined observers. Targets of need have been largely held constant through hypothetical and fictionalized depictions of sympathetic distress and need. In the real world, people's response to life stressors varies widely-from stoicism to resili...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00488
更新日期:2013-08-22 00:00:00
abstract::Numerous cognitive studies have demonstrated experience-induced plasticity in the primary sensory cortex, indicating that repeated decisions could modulate sensory processing. In this context, we investigated whether an auditory version of the monetary incentive delay (MID) task could change the neural processing of t...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00382
更新日期:2019-11-01 00:00:00
abstract::[This corrects the article on p. 673 in vol. 8, PMID: 25221500.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 已发布勘误
doi:10.3389/fnhum.2014.00923
更新日期:2014-11-14 00:00:00
abstract::In daily life the brain is exposed to a large amount of external signals that compete for processing resources. The attentional system can select relevant information based on many possible combinations of goal-directed and stimulus-driven control signals. Here, we investigate the behavioral and physiological effects ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00320
更新日期:2016-06-28 00:00:00
abstract::Curvature is a highly informative visual cue for shape perception and object recognition. We introduce a novel illusion-the Lemon Illusion-in which subtle illusory curvature is perceived along contour regions that are devoid of physical curvature. We offer several perceptual demonstrations and observations that lead u...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00095
更新日期:2015-02-23 00:00:00
abstract::The frequency-following response (FFR) is an auditory evoked potential (AEP) that follows the periodic characteristics of a sound. Despite being a widely studied biosignal in auditory neuroscience, the neural underpinnings of the FFR are still unclear. Traditionally, FFR was associated with subcortical activity, but r...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.00250
更新日期:2020-07-08 00:00:00
abstract::Social interactions fill our everyday life and put strong demands on our brain function. However, the possibilities for studying the brain basis of social interaction are still technically limited, and even modern brain imaging studies of social cognition typically monitor just one participant at a time. We present he...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00083
更新日期:2012-04-10 00:00:00
abstract::Current studies have got a series of satisfying accuracies in EEG-based emotion classification, but most of the classifiers used in previous studies are totally time-limited. To produce generalizable results, the emotion classifier should be stable over days, in which the day-to-day variations of EEG should be appropr...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2018.00267
更新日期:2018-06-29 00:00:00
abstract::While recent studies have explored the maintenance of the effect of meditation on stress resilience, the underlying neural mechanisms have not yet been investigated. The present study conducted a highly controlled residential study of a 4-day meditation intervention to investigate the brain functional changes and long...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00101
更新日期:2019-03-26 00:00:00
abstract:AIM:Whether the unaffected function of the hand of patients presenting with nerve injury is affected remains inconclusive. We aimed to evaluate whether there are differences in finger tapping following central or peripheral nerve injury compared with the unaffected hand and the ipsilateral hand of a healthy subject. M...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00260
更新日期:2015-05-13 00:00:00
abstract::This study investigates the relation between individual language ability and neural semantic processing abilities. Our aim was to explore whether high-level language ability would correlate to decreased activation in language-specific regions or rather increased activation in supporting language regions during process...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00110
更新日期:2016-03-11 00:00:00
abstract::A Brain-computer Interface (BCI) can be used as a neurofeedback training tool to improve cognitive performance. BCIs aim to improve the effectiveness and efficiency of the conventional neurofeedback methods by focusing on the self-regulation of individualized neuromarkers rather than generic ones in a graphically appe...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2018.00524
更新日期:2019-01-04 00:00:00
abstract::Familial risk plays a significant role in the etiology of schizophrenia (SZ). Many studies using neuroimaging have demonstrated structural and functional alterations in relatives of SZ patients, with significant results found in diverse brain regions involving the anterior cingulate cortex (ACC), caudate, dorsolateral...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00383
更新日期:2016-07-27 00:00:00
abstract::Background: Cultural neuroscience is an emerging research field concerned with studying the influences of different cultures on brain anatomy and function. In this study, we examined whether different cultural or genetic influences might influence the resting state electroencephalogram (EEG) in young children (mean ag...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00559
更新日期:2016-11-02 00:00:00
abstract::Training on a visual task leads to increased perceptual and neural responses to visual features that were attended during training as well as decreased responses to neglected distractor features. However, the time course of these attention-based modulations of neural sensitivity for visual features has not been invest...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.09.069.2009
更新日期:2010-01-06 00:00:00
abstract::The right inferior fronto-parietal network monitors the current status of the musculoskeletal system and builds-up and updates our postural model. The kinesthetic illusion induced by tendon vibration has been utilized in experiments on the modulation of body awareness. The right inferior fronto-parietal cortices activ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00330
更新日期:2019-09-24 00:00:00
abstract::According to theoretical accounts, both, N-back and complex span tasks mainly require working memory (WM) processing. In contrast, simple span tasks conceptually mainly require WM storage. Thus, conceptually, an N-back task and a complex span task share more commonalities as compared to a simple span task. In the curr...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00006
更新日期:2017-01-25 00:00:00