COMT Val(158)Met Polymorphism Is Associated with Verbal Working Memory in Neurofibromatosis Type 1.

Abstract:

:Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic performance in 50 NF1 individuals. A significant association of the COMT polymorphism was observed only with verbal working memory, as measured by the backward digit-span task with an advantageous performance for Met/Met carriers. To study how genetic modifiers influence NF1 cognitive performance might be of importance to decrease the unpredictability of the cognitive profile among NF1 patients.

journal_name

Front Hum Neurosci

authors

Costa Dde S,de Paula JJ,Alvim-Soares AM Jr,Pereira PA,Malloy-Diniz LF,Rodrigues LO,Romano-Silva MA,de Miranda DM

doi

10.3389/fnhum.2016.00334

subject

Has Abstract

pub_date

2016-07-05 00:00:00

pages

334

issn

1662-5161

journal_volume

10

pub_type

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