Abstract:
:Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic performance in 50 NF1 individuals. A significant association of the COMT polymorphism was observed only with verbal working memory, as measured by the backward digit-span task with an advantageous performance for Met/Met carriers. To study how genetic modifiers influence NF1 cognitive performance might be of importance to decrease the unpredictability of the cognitive profile among NF1 patients.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Costa Dde S,de Paula JJ,Alvim-Soares AM Jr,Pereira PA,Malloy-Diniz LF,Rodrigues LO,Romano-Silva MA,de Miranda DMdoi
10.3389/fnhum.2016.00334subject
Has Abstractpub_date
2016-07-05 00:00:00pages
334issn
1662-5161journal_volume
10pub_type
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00064
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journal_title:Frontiers in human neuroscience
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abstract::[This corrects the article on p. 289 in vol. 9, PMID: 26042022.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 已发布勘误
doi:10.3389/fnhum.2015.00411
更新日期:2015-07-20 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00023
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journal_title:Frontiers in human neuroscience
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doi:10.3389/fnhum.2013.00027
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journal_title:Frontiers in human neuroscience
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doi:10.3389/fnhum.2017.00351
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journal_title:Frontiers in human neuroscience
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