Synaptic and cellular profile of neurons in the lateral habenula.

Abstract:

:The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neurons drives negative states and avoidance. Furthermore, the hyperexcitability of neurons in the LHb, especially those projecting to the midbrain, may represent an important cellular correlate for neuropsychiatric disorders like depression and drug addiction. Despite the recent insights regarding the implications of the LHb in the context of reward and aversion, the exact nature of the synaptic and cellular players regulating LHb neuronal functions remains largely unknown. Here we focus on the synaptic and cellular physiology of LHb neurons. First, we discuss the properties of excitatory transmission and the implications of glutamate receptors for long-term synaptic plasticity; second, we review the features of GABAergic transmission onto LHb neurons; and finally, we describe the contribution that neuromodulators such as dopamine (DA) and serotonin may have for LHb neuronal physiology. We relate these findings to the role that the LHb can play in processing aversive and rewarding stimuli, both in health and disease states.

journal_name

Front Hum Neurosci

authors

Meye FJ,Lecca S,Valentinova K,Mameli M

doi

10.3389/fnhum.2013.00860

subject

Has Abstract

pub_date

2013-12-16 00:00:00

pages

860

issn

1662-5161

journal_volume

7

pub_type

杂志文章,评审
  • Cortical Neural Synchronization Underlies Primary Visual Consciousness of Qualia: Evidence from Event-Related Potentials.

    abstract::This article reviews three experiments on event-related potentials (ERPs) testing the hypothesis that primary visual consciousness (stimulus self-report) is related to enhanced cortical neural synchronization as a function of stimulus features. ERP peak latency and sources were compared between "seen" trials and "not ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2016.00310

    authors: Babiloni C,Marzano N,Soricelli A,Cordone S,Millán-Calenti JC,Del Percio C,Buján A

    更新日期:2016-06-30 00:00:00

  • Diagnosis of Autism Spectrum Disorders Using Multi-Level High-Order Functional Networks Derived From Resting-State Functional MRI.

    abstract::Functional brain networks derived from resting-state functional magnetic resonance imaging (rs-fMRI) have been widely used for Autism Spectrum Disorder (ASD) diagnosis. Typically, these networks are constructed by calculating functional connectivity (FC) between any pair of brain regions of interest (ROIs), i.e., usin...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00184

    authors: Zhao F,Zhang H,Rekik I,An Z,Shen D

    更新日期:2018-05-14 00:00:00

  • Region-Specific Slowing of Alpha Oscillations is Associated with Visual-Perceptual Abilities in Children Born Very Preterm.

    abstract::Children born very preterm (≤32 weeks gestational age) without major intellectual or neurological impairments often express selective deficits in visual-perceptual abilities. The alterations in neurophysiological development underlying these problems, however, remain poorly understood. Recent research has indicated th...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00791

    authors: Doesburg SM,Moiseev A,Herdman AT,Ribary U,Grunau RE

    更新日期:2013-11-15 00:00:00

  • Designing Guiding Systems for Brain-Computer Interfaces.

    abstract::Brain-Computer Interface (BCI) community has focused the majority of its research efforts on signal processing and machine learning, mostly neglecting the human in the loop. Guiding users on how to use a BCI is crucial in order to teach them to produce stable brain patterns. In this work, we explore the instructions a...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00396

    authors: Kosmyna N,Lécuyer A

    更新日期:2017-07-31 00:00:00

  • The impact of physical exercise on convergent and divergent thinking.

    abstract::Anecdotal literature suggests that creative people sometimes use bodily movement to help overcome mental blocks and lack of inspiration. Several studies have shown that physical exercise may sometimes enhance creative thinking, but the evidence is still inconclusive. In this study we investigated whether creativity in...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00824

    authors: S Colzato L,Szapora A,Pannekoek JN,Hommel B

    更新日期:2013-12-02 00:00:00

  • The Effect of Aging in Inhibitory Control of Major Depressive Disorder Revealed by Event-Related Potentials.

    abstract::Elderly depressed patients manifest pronounced executive dysfunction compared with younger subjects with depressive disorder. Aging-related brain changes may result in executive dysfunction in geriatric depression. We investigated the neural correlates of inhibitory control processing in depressed subjects at differen...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00116

    authors: Zhang BW,Xu J,Chang Y

    更新日期:2016-03-30 00:00:00

  • Evaluating the relationship between change in performance on training tasks and on untrained outcomes.

    abstract::Training interventions for older adults are designed to remediate performance on trained tasks and to generalize, or transfer, to untrained tasks. Evidence for transfer is typically based on the trained group showing greater improvement than controls on untrained tasks, or on a correlation between gains in training an...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00617

    authors: Zelinski EM,Peters KD,Hindin S,Petway KT 2nd,Kennison RF

    更新日期:2014-08-13 00:00:00

  • Individual differences in emotion-cognition interactions: emotional valence interacts with serotonin transporter genotype to influence brain systems involved in emotional reactivity and cognitive control.

    abstract::The serotonin transporter gene (5-HTTLPR) influences emotional reactivity and attentional bias toward or away from emotional stimuli, and has been implicated in psychopathological states, such as depression and anxiety disorder. The short allele is associated with increased reactivity and attention toward negatively-v...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00327

    authors: Stollstorff M,Munakata Y,Jensen AP,Guild RM,Smolker HR,Devaney JM,Banich MT

    更新日期:2013-07-04 00:00:00

  • An Increase in Postural Load Facilitates an Anterior Shift of Processing Resources to Frontal Executive Function in a Postural-Suprapostural Task.

    abstract::Increase in postural-demand resources does not necessarily degrade a concurrent motor task, according to the adaptive resource-sharing hypothesis of postural-suprapostural dual-tasking. This study investigated how brain networks are organized to optimize a suprapostural motor task when the postural load increases and ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00420

    authors: Huang CY,Chang GC,Tsai YY,Hwang IS

    更新日期:2016-08-19 00:00:00

  • Global versus local processing: seeing the left side of the forest and the right side of the trees.

    abstract::Previous studies using hierarchical figures (where a large global shape is composed of a series of smaller local shapes) suggest that performance is better for local features presented in the right relative to left visual field, whereas the opposite pattern is observed for global features. However, these previous stud...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00028

    authors: Christie J,Ginsberg JP,Steedman J,Fridriksson J,Bonilha L,Rorden C

    更新日期:2012-02-22 00:00:00

  • Effective Connectivity within the Default Mode Network: Dynamic Causal Modeling of Resting-State fMRI Data.

    abstract::The Default Mode Network (DMN) is a brain system that mediates internal modes of cognitive activity, showing higher neural activation when one is at rest. Nowadays, there is a lot of interest in assessing functional interactions between its key regions, but in the majority of studies only association of Blood-oxygen-l...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00014

    authors: Sharaev MG,Zavyalova VV,Ushakov VL,Kartashov SI,Velichkovsky BM

    更新日期:2016-02-01 00:00:00

  • Current State and Future Prospects of EEG and fNIRS in Robot-Assisted Gait Rehabilitation: A Brief Review.

    abstract::Gait and balance impairments are frequently considered as the most significant concerns among individuals suffering from neurological diseases. Robot-assisted gait training (RAGT) has shown to be a promising neurorehabilitation intervention to improve gait recovery in patients following stroke or brain injury by poten...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2019.00172

    authors: Berger A,Horst F,Müller S,Steinberg F,Doppelmayr M

    更新日期:2019-06-05 00:00:00

  • FMRI in translation: the challenges facing real-world applications.

    abstract::Functional neuroimaging has increased our understanding of human brain function tremendously and has become a standard tool in clinical and cognitive neuroscience research. We briefly review its methodological foundations and describe remaining challenges for translational research. The application of neuroimaging res...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.063.2009

    authors: Schleim S,Roiser JP

    更新日期:2009-12-23 00:00:00

  • On Response Bias in the Face Congruency Effect for Internal and External Features.

    abstract::Some years ago Cheung et al. (2008) proposed the complete design (CD) for measuring the failure of selective attention in composite objects. Since the CD is a fully balanced design, analysis of response bias may reveal potential effects of the experimental manipulation, the stimulus material, and/or attributes of the ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00494

    authors: Meinhardt G,Meinhardt-Injac B,Persike M

    更新日期:2017-10-17 00:00:00

  • Characterization of Face-Selective Patches in Orbitofrontal Cortex.

    abstract::Face processing involves a complex, multimodal brain network. While visual-perceptual face patches in posterior parts of the brain have been studied for over a decade, the existence and properties of face-selective regions in orbitofrontal cortex (OFC) is a relatively new area of research. While regions of OFC are imp...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00279

    authors: Troiani V,Dougherty CC,Michael AM,Olson IR

    更新日期:2016-06-14 00:00:00

  • Disrupting the brain to validate hypotheses on the neurobiology of language.

    abstract::Comprehension of words is an important part of the language faculty, involving the joint activity of frontal and temporo-parietal brain regions. Transcranial Magnetic Stimulation (TMS) enables the controlled perturbation of brain activity, and thus offers a unique tool to test specific predictions about the causal rel...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00148

    authors: Papeo L,Pascual-Leone A,Caramazza A

    更新日期:2013-04-24 00:00:00

  • Dynamic Office Environments Improve Brain Activity and Attentional Performance Mediated by Increased Motor Activity.

    abstract::Current research demonstrates beneficial effects of physical activity on brain functions and cognitive performance. To date, less is known on the effects of gross motor movements that do not fall into the category of sports-related aerobic or anaerobic exercise. In previous studies, we found beneficial effects of dyna...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00121

    authors: Henz D,Schöllhorn WI

    更新日期:2019-04-12 00:00:00

  • Origins Matter: Culture Impacts Cognitive Testing in Parkinson's Disease.

    abstract::Cognitive decline is common in Parkinson's disease (PD), and precise cognitive assessment is important for diagnosis, prognosis, and treatment. To date, there are no studies in PD investigating cultural bias on neuropsychological tests. Clinical practice in multicultural societies such as, Toronto Canada where nearly ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00269

    authors: Statucka M,Cohn M

    更新日期:2019-08-08 00:00:00

  • Music Games: Potential Application and Considerations for Rhythmic Training.

    abstract::Rhythmic skills are natural and widespread in the general population. The majority can track the beat of music and move along with it. These abilities are meaningful from a cognitive standpoint given their tight links with prominent motor and cognitive functions such as language and memory. When rhythmic skills are ch...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2017.00273

    authors: Bégel V,Di Loreto I,Seilles A,Dalla Bella S

    更新日期:2017-05-29 00:00:00

  • Dissociation between Semantic Representations for Motion and Action Verbs: Evidence from Patients with Left Hemisphere Lesions.

    abstract::This multiple single case study contrasted left hemisphere stroke patients (N = 6) to healthy age-matched control participants (N = 15) on their understanding of action (e.g., holding, clenching) and motion verbs (e.g., crumbling, flowing). The tasks required participants to correctly identify the matching verb or ass...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00035

    authors: Taylor LJ,Evans C,Greer J,Senior C,Coventry KR,Ietswaart M

    更新日期:2017-02-14 00:00:00

  • The Differential Effect of Arm Movements during Gait on the Forward Acceleration of the Centre of Mass in Children with Cerebral Palsy and Typically Developing Children.

    abstract::Background: We aimed to study the contribution of upper limb movements to propulsion during walking in typically developing (TD) children (n = 5) and children with hemiplegic and diplegic cerebral palsy (CP; n = 5 and n = 4, respectively). Methods: Using integrated three-dimensional motion capture data and a scaled ge...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00096

    authors: Meyns P,Molenaers G,Duysens J,Jonkers I

    更新日期:2017-03-01 00:00:00

  • Neurophysiological correlates of anhedonia in feedback processing.

    abstract::Disturbances in feedback processing and a dysregulation of the neural circuit in which the cingulate cortex plays a key role have been frequently observed in depression. Since depression is a heterogeneous disease, instead of focusing on the depressive state in general, this study investigated the relations between th...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00096

    authors: Mies GW,Van den Berg I,Franken IH,Smits M,Van der Molen MW,Van der Veen FM

    更新日期:2013-03-26 00:00:00

  • Subclinical alexithymia modulates early audio-visual perceptive and attentional event-related potentials.

    abstract:INTRODUCTION:Previous studies have highlighted the advantage of using audio-visual oddball tasks (instead of unimodal ones) in order to electrophysiologically index subclinical behavioral differences. Since alexithymia is highly prevalent in the general population, we investigated whether the use of various bimodal tas...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00106

    authors: Delle-Vigne D,Kornreich C,Verbanck P,Campanella S

    更新日期:2014-03-03 00:00:00

  • Different Effects of 2 mA and 4 mA Transcranial Direct Current Stimulation on Muscle Activity and Torque in a Maximal Isokinetic Fatigue Task.

    abstract::Studies investigating the effects of transcranial direct current stimulation (tDCS) on fatigue and muscle activity have elicited measurable improvements using stimulation intensities ≤2 mA and submaximal effort tasks. The purpose of this study was to determine the effects of 2 mA and 4 mA anodal tDCS over the primary ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00240

    authors: Workman CD,Fietsam AC,Rudroff T

    更新日期:2020-06-25 00:00:00

  • Real World Problem-Solving.

    abstract::Real world problem-solving (RWPS) is what we do every day. It requires flexibility, resilience, resourcefulness, and a certain degree of creativity. A crucial feature of RWPS is that it involves continuous interaction with the environment during the problem-solving process. In this process, the environment can be seen...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00261

    authors: Sarathy V

    更新日期:2018-06-26 00:00:00

  • The neural circuitry of expertise: perceptual learning and social cognition.

    abstract::Amongst the most significant questions we are confronted with today include the integration of the brain's micro-circuitry, our ability to build the complex social networks that underpin society and how our society impacts on our ecological environment. In trying to unravel these issues one place to begin is at the le...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00852

    authors: Harré M

    更新日期:2013-12-17 00:00:00

  • Neuromagnetic vistas into typical and atypical development of frontal lobe functions.

    abstract::The frontal lobes are involved in many higher-order cognitive functions such as social cognition executive functions and language and speech. These functions are complex and follow a prolonged developmental course from childhood through to early adulthood. Magnetoencephalography (MEG) is ideal for the study of develop...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2014.00453

    authors: Taylor MJ,Doesburg SM,Pang EW

    更新日期:2014-06-18 00:00:00

  • Experimental and clinical usefulness of crossmodal paradigms in psychiatry: an illustration from emotional processing in alcohol-dependence.

    abstract::Crossmodal processing (i.e., the construction of a unified representation stemming from distinct sensorial modalities inputs) constitutes a crucial ability in humans' everyday life. It has been extensively explored at cognitive and cerebral levels during the last decade among healthy controls. Paradoxically however, a...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00394

    authors: Maurage P,Campanella S

    更新日期:2013-07-25 00:00:00

  • A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing.

    abstract::A review of the human developmental neuroimaging literature that investigates outcomes following exposure to psychosocial adversity is presented with a focus on two subcortical structures - the hippocampus and the amygdala. Throughout this review, we discuss how a consideration of developmental timing of adverse exper...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.068.2009

    authors: Tottenham N,Sheridan MA

    更新日期:2010-01-08 00:00:00

  • Corrigendum: Society, Organizations and the Brain: Building toward a Unified Cognitive Neuroscience Perspective.

    abstract::[This corrects the article on p. 289 in vol. 9, PMID: 26042022.]. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnhum.2015.00411

    authors: Senior C,Lee N,Braeutigam S

    更新日期:2015-07-20 00:00:00