Disrupting the brain to validate hypotheses on the neurobiology of language.

Abstract:

:Comprehension of words is an important part of the language faculty, involving the joint activity of frontal and temporo-parietal brain regions. Transcranial Magnetic Stimulation (TMS) enables the controlled perturbation of brain activity, and thus offers a unique tool to test specific predictions about the causal relationship between brain regions and language understanding. This potential has been exploited to better define the role of regions that are classically accepted as part of the language-semantic network. For instance, TMS has contributed to establish the semantic relevance of the left anterior temporal lobe, or to solve the ambiguity between the semantic vs. phonological function assigned to the left inferior frontal gyrus (LIFG). We consider, more closely, the results from studies where the same technique, similar paradigms (lexical-semantic tasks) and materials (words) have been used to assess the relevance of regions outside the classically-defined language-semantic network-i.e., precentral motor regions-for the semantic analysis of words. This research shows that different aspects of the left precentral gyrus (primary motor and premotor sites) are sensitive to the action-non action distinction of words' meanings. However, the behavioral changes due to TMS over these sites are incongruent with what is expected after perturbation of a task-relevant brain region. Thus, the relationship between motor activity and language-semantic behavior remains far from clear. A better understanding of this issue could be guaranteed by investigating functional interactions between motor sites and semantically-relevant regions.

journal_name

Front Hum Neurosci

authors

Papeo L,Pascual-Leone A,Caramazza A

doi

10.3389/fnhum.2013.00148

subject

Has Abstract

pub_date

2013-04-24 00:00:00

pages

148

issn

1662-5161

journal_volume

7

pub_type

杂志文章
  • A FreeSurfer-compliant consistent manual segmentation of infant brains spanning the 0-2 year age range.

    abstract::We present a detailed description of a set of FreeSurfer compatible segmentation guidelines tailored to infant MRI scans, and a unique data set of manually segmented acquisitions, with subjects nearly evenly distributed between 0 and 2 years of age. We believe that these segmentation guidelines and this dataset will h...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00021

    authors: de Macedo Rodrigues K,Ben-Avi E,Sliva DD,Choe MS,Drottar M,Wang R,Fischl B,Grant PE,Zöllei L

    更新日期:2015-02-18 00:00:00

  • Declarative and Non-declarative Memory Consolidation in Children with Sleep Disorder.

    abstract::Healthy sleep is essential in children's cognitive, behavioral, and emotional development. However, remarkably little is known about the influence of sleep disorders on different memory processes in childhood. Such data could give us a deeper insight into the effect of sleep on the developing brain and memory function...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00709

    authors: Csábi E,Benedek P,Janacsek K,Zavecz Z,Katona G,Nemeth D

    更新日期:2016-01-11 00:00:00

  • "Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited".

    abstract::Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00365

    authors: Brix MK,Ersland L,Hugdahl K,Grüner R,Posserud MB,Hammar Å,Craven AR,Noeske R,Evans CJ,Walker HB,Midtvedt T,Beyer MK

    更新日期:2015-06-22 00:00:00

  • Spatial attention in written word perception.

    abstract::The role of attention in visual word recognition and reading aloud is a long debated issue. Studies of both developmental and acquired reading disorders provide growing evidence that spatial attention is critically involved in word reading, in particular for the phonological decoding of unfamiliar letter strings. Howe...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00042

    authors: Montani V,Facoetti A,Zorzi M

    更新日期:2014-02-10 00:00:00

  • The impact of physical exercise on convergent and divergent thinking.

    abstract::Anecdotal literature suggests that creative people sometimes use bodily movement to help overcome mental blocks and lack of inspiration. Several studies have shown that physical exercise may sometimes enhance creative thinking, but the evidence is still inconclusive. In this study we investigated whether creativity in...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00824

    authors: S Colzato L,Szapora A,Pannekoek JN,Hommel B

    更新日期:2013-12-02 00:00:00

  • Variation in Event-Related Potentials by State Transitions.

    abstract::The probability of an event's occurrence affects event-related potentials (ERPs) on electroencephalograms. The relation between probability and potentials has been discussed by using a quantity called surprise that represents the self-information that humans receive from the event. Previous studies have estimated surp...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00075

    authors: Higashi H,Minami T,Nakauchi S

    更新日期:2017-02-27 00:00:00

  • Rating the Intensity of a Laser Stimulus, but Not Attending to Changes in Its Location or Intensity Modulates the Laser-Evoked Cortical Activity.

    abstract::Top-down attention towards nociceptive stimuli can be modulated by asking participants to pay attention to specific features of a stimulus, or to provide a rating about its intensity/unpleasantness. Whether and how these different top-down processes may lead to different modulations of the cortical response to nocicep...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00120

    authors: Torta DME,Ninghetto M,Ricci R,Legrain V

    更新日期:2020-03-31 00:00:00

  • Electrical Stimulation Mapping of Brain Function: A Comparison of Subdural Electrodes and Stereo-EEG.

    abstract::Despite technological and interpretative advances, the non-invasive modalities used for pre-surgical evaluation of patients with drug-resistant epilepsy (DRE), fail to generate a concordant anatomo-electroclinical hypothesis for the location of the seizure onset zone in many patients. This requires chronic monitoring ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.611291

    authors: Grande KM,Ihnen SKZ,Arya R

    更新日期:2020-12-07 00:00:00

  • Pseudo-Bootstrap Network Analysis-an Application in Functional Connectivity Fingerprinting.

    abstract::Brain parcellation divides the brain's spatial domain into small regions, which are represented by nodes within the network analysis framework. While template-based parcellations are widely used, the parcels on the template do not necessarily match individual's functional nodes. A new method is developed to overcome t...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00351

    authors: Cheng H,Li A,Koenigsberger AA,Huang C,Wang Y,Sheng J,Newman SD

    更新日期:2017-07-13 00:00:00

  • Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness.

    abstract::Mindfulness-as a state, trait, process, type of meditation, and intervention has proven to be beneficial across a diverse group of psychological disorders as well as for general stress reduction. Yet, there remains a lack of clarity in the operationalization of this construct, and underlying mechanisms. Here, we provi...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00296

    authors: Vago DR,Silbersweig DA

    更新日期:2012-10-25 00:00:00

  • The trait anger affects conflict inhibition: a Go/Nogo ERP study.

    abstract::To explore the time course of inhibitory control in high trait anger individuals, we recorded and analyzed ERP data relevant to visual Go/Nogo task in high and low trait anger participants. Compared with low trait anger participants, high trait anger participants revealed faster RTs in the Go/Nogo task. The nogo effec...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.01076

    authors: Liu Y,Zhan X,Li W,Han H,Wang H,Hou J,Yan G,Wang Y

    更新日期:2015-01-21 00:00:00

  • Habits: bridging the gap between personhood and personal identity.

    abstract::In philosophy, the criteria for personhood (PH) at a specific point in time (synchronic), and the necessary and sufficient conditions of personal identity (PI) over time (diachronic) are traditionally separated. Hence, the transition between both timescales of a person's life remains largely unclear. Personal habits r...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00330

    authors: Wagner NF,Northoff G

    更新日期:2014-05-21 00:00:00

  • Evidence for [Coronal] Underspecification in Typical and Atypical Phonological Development.

    abstract::The Featurally Underspecified Lexicon (FUL) theory predicts that [coronal] is the language universal default place of articulation for phonemes. This assumption has been consistently supported with adult behavioral and event-related potential (ERP) data; however, this underspecification claim has not been tested in de...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.580697

    authors: Cummings AE,Ogiela DA,Wu YC

    更新日期:2020-12-22 00:00:00

  • Spatial and temporal features of superordinate semantic processing studied with fMRI and EEG.

    abstract::The relationships between the anatomical representation of semantic knowledge in the human brain and the timing of neurophysiological mechanisms involved in manipulating such information remain unclear. This is the case for superordinate semantic categorization-the extraction of general features shared by broad classe...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00293

    authors: Costanzo ME,McArdle JJ,Swett B,Nechaev V,Kemeny S,Xu J,Braun AR

    更新日期:2013-07-01 00:00:00

  • Relationship between Self-Administered Cues and Rehabilitation Outcomes in Individuals with Aphasia: Understanding Individual Responsiveness to a Technology-Based Rehabilitation Program.

    abstract::An advantage of rehabilitation administered on computers or tablets is that the tasks can be self-administered and the cueing required to complete the tasks can be monitored. Though there are many types of cueing, few studies have examined how participants' response to rehabilitation is influenced by self-administered...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00007

    authors: Des Roches CA,Mitko A,Kiran S

    更新日期:2017-02-01 00:00:00

  • Comparing different stimulus configurations for population receptive field mapping in human fMRI.

    abstract::Population receptive field (pRF) mapping is a widely used approach to measuring aggregate human visual receptive field properties by recording non-invasive signals using functional MRI. Despite growing interest, no study to date has systematically investigated the effects of different stimulus configurations on pRF es...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00096

    authors: Alvarez I,de Haas B,Clark CA,Rees G,Schwarzkopf DS

    更新日期:2015-02-20 00:00:00

  • Calibrating Doppler imaging of preterm intracerebral circulation using a microvessel flow phantom.

    abstract:INTRODUCTION:Preterm infants are born during critical stages of brain development, in which the adaptive capacity of the fetus to extra-uterine environment is limited. Inadequate brain perfusion has been directly linked to preterm brain damage. Advanced high-frequency ultrasound probes and processing algorithms allow v...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.01068

    authors: Camfferman FA,Ecury-Goossen GM,La Roche JE,de Jong N,van 't Leven W,Vos HJ,Verweij MD,Nasserinejad K,Cools F,Govaert P,Dudink J

    更新日期:2015-01-13 00:00:00

  • The thinker: opposing directionality of lighting bias within sculptural artwork.

    abstract::Individuals tend to perceive the direction of light to come from above and slightly from the left; it has been speculated that this phenomenon is also producing similar lighting preferences within 2-dimensional artworks (e.g., paintings, advertisements). The purpose of the present study was to address if lighting bias...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00251

    authors: Sedgewick JR,Weiers B,Stewart A,Elias LJ

    更新日期:2015-05-06 00:00:00

  • Executive functions in developmental dyslexia.

    abstract::The present study was aimed at investigating different aspects of Executive Functions (EF) in children with Developmental Dyslexia (DD). A neuropsychological battery tapping verbal fluency, spoonerism, attention, verbal shifting, short-term and working memory was used to assess 60 children with DD and 65 with typical ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00120

    authors: Varvara P,Varuzza C,Sorrentino AC,Vicari S,Menghini D

    更新日期:2014-03-07 00:00:00

  • Effects of optimism on creativity under approach and avoidance motivation.

    abstract::Focusing on avoiding failure or negative outcomes (avoidance motivation) can undermine creativity, due to cognitive (e.g., threat appraisals), affective (e.g., anxiety), and volitional processes (e.g., low intrinsic motivation). This can be problematic for people who are avoidance motivated by nature and in situations...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2014.00105

    authors: Icekson T,Roskes M,Moran S

    更新日期:2014-02-28 00:00:00

  • Resting Heart Rate Variability, Facets of Rumination and Trait Anxiety: Implications for the Perseverative Cognition Hypothesis.

    abstract::The perseverative cognition hypothesis (PCH) posits that perseveration, defined as the repetitive or sustained activation of cognitive representations of a real or imagined stressor, is a primary mechanism linking psychological (or stress) vulnerability with poor health and disease. Resting vagally mediated heart rate...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00520

    authors: Williams DP,Feeling NR,Hill LK,Spangler DP,Koenig J,Thayer JF

    更新日期:2017-10-31 00:00:00

  • Navigating the complex path between the oxytocin receptor gene (OXTR) and cooperation: an endophenotype approach.

    abstract::Although cooperation represents a core facet of human social behavior there exists considerable variability across people in terms of the tendency to cooperate. One factor that may contribute to individual differences in cooperation is a key gene within the oxytocin (OT) system, the OT reception gene (OXTR). In this a...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00801

    authors: Haas BW,Anderson IW,Smith JM

    更新日期:2013-11-28 00:00:00

  • Children With Reading Difficulty Rely on Unimodal Neural Processing for Phonemic Awareness.

    abstract::Phonological awareness skills in children with reading difficulty (RD) may reflect impaired automatic integration of orthographic and phonological representations. However, little is known about the underlying neural mechanisms involved in phonological awareness for children with RD. Eighteen children with RD, ages 9-...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00390

    authors: Randazzo M,Greenspon EB,Booth JR,McNorgan C

    更新日期:2019-11-14 00:00:00

  • Effects of Diazepam on Reaction Times to Stop and Go.

    abstract::Introduction: The ability to stop the execution of a movement in response to an external cue requires intact executive function. The effect of psychotropic drugs on movement inhibition is largely unknown. Movement stopping can be estimated by the Stop Signal Reaction Time (SSRT). In a recent publication, we validated ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.567177

    authors: Sarkar S,Choudhury S,Islam N,Chowdhury MSJH,Chowdhury MTI,Baker MR,Baker SN,Kumar H

    更新日期:2020-10-06 00:00:00

  • Subliminal Emotional Words Impact Syntactic Processing: Evidence from Performance and Event-Related Brain Potentials.

    abstract::Recent studies demonstrate that syntactic processing can be affected by emotional information and that subliminal emotional information can also affect cognitive processes. In this study, we explore whether unconscious emotional information may also impact syntactic processing. In an Event-Related brain Potential (ERP...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00192

    authors: Jiménez-Ortega L,Espuny J,de Tejada PH,Vargas-Rivero C,Martín-Loeches M

    更新日期:2017-04-25 00:00:00

  • Synaptic and cellular profile of neurons in the lateral habenula.

    abstract::The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neurons drives negative states and avoidance. Furthermore, the hyperexcitability of neurons in the LHb, especially those projecti...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00860

    authors: Meye FJ,Lecca S,Valentinova K,Mameli M

    更新日期:2013-12-16 00:00:00

  • Paradoxical dopaminergic drug effects in extraversion: dose- and time-dependent effects of sulpiride on EEG theta activity.

    abstract::Dopaminergic drugs frequently produce paradoxical effects depending on baseline performance levels, genotype, or personality traits. The present study for the first time aimed to specify the mechanisms underlying such opposite effects using the following recently reported scenario as an example: depending on the perso...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00117

    authors: Chavanon ML,Wacker J,Stemmler G

    更新日期:2013-04-08 00:00:00

  • fNIRS-based brain-computer interfaces: a review.

    abstract::A brain-computer interface (BCI) is a communication system that allows the use of brain activity to control computers or other external devices. It can, by bypassing the peripheral nervous system, provide a means of communication for people suffering from severe motor disabilities or in a persistent vegetative state. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2015.00003

    authors: Naseer N,Hong KS

    更新日期:2015-01-28 00:00:00

  • Precise timing when hitting falling balls.

    abstract::People are extremely good at hitting falling balls with a baseball bat. Despite the ball's constant acceleration, they have been reported to time hits with a standard deviation of only about 7 ms. To examine how people achieve such precision, we compared performance when there were no added restrictions, with performa...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00342

    authors: Brenner E,Driesen B,Smeets JB

    更新日期:2014-05-22 00:00:00

  • Enhancing emotional experiences to dance through music: the role of valence and arousal in the cross-modal bias.

    abstract::It is well established that emotional responses to stimuli presented to one perceptive modality (e.g., visual) are modulated by the concurrent presentation of affective information to another modality (e.g., auditory)-an effect known as the cross-modal bias. However, the affective mechanisms mediating this effect are ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00757

    authors: Christensen JF,Gaigg SB,Gomila A,Oke P,Calvo-Merino B

    更新日期:2014-10-06 00:00:00