Abstract:
:Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Brix MK,Ersland L,Hugdahl K,Grüner R,Posserud MB,Hammar Å,Craven AR,Noeske R,Evans CJ,Walker HB,Midtvedt T,Beyer MKdoi
10.3389/fnhum.2015.00365subject
Has Abstractpub_date
2015-06-22 00:00:00pages
365issn
1662-5161journal_volume
9pub_type
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