"Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited".

Abstract:

:Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.

journal_name

Front Hum Neurosci

authors

Brix MK,Ersland L,Hugdahl K,Grüner R,Posserud MB,Hammar Å,Craven AR,Noeske R,Evans CJ,Walker HB,Midtvedt T,Beyer MK

doi

10.3389/fnhum.2015.00365

subject

Has Abstract

pub_date

2015-06-22 00:00:00

pages

365

issn

1662-5161

journal_volume

9

pub_type

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