Abstract：
:It has long been known that the estrogen, 17β-estradiol (17β-E), plays a central role for female reproductive physiology and behavior. Numerous studies have established the neurochemical and molecular basis of estrogenic induction of female sexual behavior, i.e., lordosis, in animal models. In addition, 17β-E also regulates male-type sexual and aggressive behavior. In males, testosterone secreted from the testes is irreversibly aromatized to 17β-E in the brain. We discuss the contribution of two nuclear receptor isoforms, estrogen receptor (ER)α and ERβ to the estrogenic regulation of sexually dimorphic brain formation and sex-typical expression of these social behaviors. Furthermore, 17β-E is a key player for social behaviors such as social investigation, preference, recognition and memory as well as anxiety-related behaviors in social contexts. Recent studies also demonstrated that not only nuclear receptor-mediated genomic signaling but also membrane receptor-mediated non-genomic actions of 17β-E may underlie the regulation of these behaviors. Finally, we will discuss how rapidly developing research tools and ideas allow us to investigate estrogenic action by emphasizing behavioral neural networks.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Ogawa S,Tsukahara S,Choleris E,Vasudevan Ndoi
10.1016/j.neubiorev.2018.10.012subject
Has Abstractpub_date
2020-03-01 00:00:00pages
46-59eissn
0149-7634issn
1873-7528pii
S0149-7634(18)30277-Xjournal_volume
110pub_type
杂志文章,评审abstract：:Neurobiological models of adolescent decision-making emphasize developmental changes in brain regions involved in affect (e.g., ventral striatum) and cognitive control (e.g., lateral prefrontal cortex). Although social context plays an important role in adolescent decision-making, current models do not discuss brain r...
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
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journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
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abstract：:Adolescence as highlighted in this special issue is a period of tremendous growth, synaptic exuberance, and plasticity, but also a period for the emergence of mental illness and addiction. This commentary aims to stimulate research on prevention science to reduce the impact of early life events that often manifest dur...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2016.07.012
更新日期：2016-11-01 00:00:00
