Abstract：
:Current literature on the effects of chronic stress in general health converges to the concept of allostatic load (AL). AL is the bodily 'wear and tear' that emerges with sustained allostatic states. In the field of bipolar disorder (BD), AL offers an important clue as to why patients who undergo recurrent mood episodes are clinically perceived as less resilient. In addition, AL helps explaining the cumulative disruptive health effects of intermittent episodes and stressors. Stress- and episode-induced changes in brain regions involved in the emotional circuitry may lead to dysfunctional processing of information, which would render BD patients more vulnerable to subsequent environmental stressors, episodes, and drugs of abuse. Mood stabilizing agents exert opposite effects than chronic stress in neurons, increasing neuroprotective factors what may help to quench the cycle of affective episode recurrence and neural and bodily deterioration. Therefore, AL provides an explanatory link to apparently unrelated findings such as cognitive impairment and higher rates of physical comorbidity and mortality that are observed in the course of BD and further highlight the importance of effective long-term prophylaxis.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Kapczinski F,Vieta E,Andreazza AC,Frey BN,Gomes FA,Tramontina J,Kauer-Sant'anna M,Grassi-Oliveira R,Post RMdoi
10.1016/j.neubiorev.2007.10.005subject
Has Abstractpub_date
2008-01-01 00:00:00pages
675-92issue
4eissn
0149-7634issn
1873-7528pii
S0149-7634(07)00140-6journal_volume
32pub_type
杂志文章,评审abstract：:We review neuroimaging research investigating self-referential processing (SRP), that is, how we respond to stimuli that reference ourselves, prefaced by a lexical-thematic analysis of words indicative of "self-feelings". We consider SRP as occurring verbally (V-SRP) and non-verbally (NV-SRP), both in the controlled, ...
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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