Abstract：
:The possible implication of 5-HT2 receptors in CNS disorders such as schizophrenia, anxiety and depression suggests that 5-HT2 antagonists may be useful in the treatment of these disorders. The present review examines behavioral procedures used to characterize 5-HT2 antagonist properties of compounds and behavioral models of clinical activity in which 5-HT2 antagonists have been reported to be active. The pharmacological profile of 5-HT2 receptors in part resembles that of 5-HT1C receptors. Responses that have been proposed to involve the activation of 5-HT1C receptors are examined for their usefulness to detect 5-HT1C antagonist properties of compounds; these responses would help to differentiate 5-HT2 from 5-HT1C antagonist activity.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Koek W,Jackson A,Colpaert FCdoi
10.1016/s0149-7634(05)80056-9subject
Has Abstractpub_date
1992-04-01 00:00:00pages
95-105issue
1eissn
0149-7634issn
1873-7528pii
S0149-7634(05)80056-9journal_volume
16pub_type
杂志文章,评审abstract：:Cognitive dysfunction in schizophrenia is an important target for novel therapies. Effectively measuring the cognitive effects of compounds in clinical trials of schizophrenia could be a major barrier to drug development. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) programme ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2010.01.012
更新日期：2010-07-01 00:00:00
abstract：:The human brain consists of millions of neural nerve cells being interconnected and firing in parallel in order to process information. A fundamental question is how this parallel neuron-firing can result in a unified experience. This is the so-called binding problem--a problem that is one of today's key questions abo...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,收录出版,评审
doi：10.1016/j.neubiorev.2009.11.014
更新日期：2010-06-01 00:00:00
abstract：:Space flight factors (SFF) significantly affect the operating activity of astronauts during deep space missions. Gravitational overloads, hypo-magnetic field and ionizing radiation are the main SFF that perturb the normal activity of the central nervous system (CNS). Acute and chronic CNS risks include alterations in ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.10.006
更新日期：2016-12-01 00:00:00
abstract：:The componential view of human emotion recognises that affective states comprise conscious, behavioural, physiological, neural and cognitive elements. Although many animals display bodily and behavioural changes consistent with the occurrence of affective states similar to those seen in humans, the question of whether...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2019.11.014
更新日期：2020-01-01 00:00:00
abstract：:The last few years have seen a growing interest in the assessment of audiotactile interactions in information processing in peripersonal space. In particular, these studies have focused on investigating peri-hand space [corrected] and, more recently, on the functional differences that have been demonstrated between th...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.07.004
更新日期：2011-01-01 00:00:00
abstract：:Prenatal maternal stress has been found to have long-lasting effects on the behavioral and physiological development of the offspring. These programming effects on the fetus would be physiologically mediated through heightened and/or abnormal activity of the maternal sympathetic-adrenal-medullary system (SAM) and espe...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2004.10.005
更新日期：2005-04-01 00:00:00
abstract：:A review of selected works on spatial memory in animals and humans is presented, and some ideas about the encoding of geometry and its role in evolution are presented, based on recently accumulated evidence from psychology, ethology and the neurosciences. It is argued that comparative analyses at the level of both spa...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2011.12.007
更新日期：2012-02-01 00:00:00
abstract：:Williams syndrome (WS) is a rare genetically based neurodevelopmental disorder which is associated with mental retardation and a distinctive cognitive and behavioural profile, including weaknesses in visuospatial processing but preserved language abilities and face recognition. Relative to the cognitive characteristic...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2007.09.003
更新日期：2008-01-01 00:00:00
abstract：:Though the most recognizable symptoms of Parkinson's disease (PD) are motor-related, many patients also suffer from debilitating affective symptoms that deleteriously influence quality of life. Dopamine (DA) loss is likely involved in the onset of depression and anxiety in PD. However, these symptoms are not reliably ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.06.007
更新日期：2011-01-01 00:00:00
abstract：:Adolescence as highlighted in this special issue is a period of tremendous growth, synaptic exuberance, and plasticity, but also a period for the emergence of mental illness and addiction. This commentary aims to stimulate research on prevention science to reduce the impact of early life events that often manifest dur...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2016.07.012
更新日期：2016-11-01 00:00:00
abstract：:In the present study, we have investigated how various 5-HT agonists (m-chlorophenylpiperazine (mCPP) (0.1-1 mg/kg), 8-hydroxy 2-(di-N-propylamino) tetralin (8-OH DPAT) (0.125-2 mg/kg) and 5-HT (0.5-2 mg/kg)), the 5-HT uptake blocker sertraline (1-10 mg/kg), and the 5-HT uptake blocker and releaser dexfenfluramine (0....
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(05)80195-2
更新日期：1992-01-01 00:00:00
abstract：:The thalamus, with its cortical, subcortical, and cerebellar connections, is a critical node in networks supporting cognitive functions known to decline in normal aging, including component processes of memory and executive functions of attention and information processing. The macrostructure, microstructure, and neur...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2015.03.008
更新日期：2015-07-01 00:00:00
abstract：:Among the most useful models for depressive disorders are those, which involve a stress induced change in behaviour. Learned helplessness is one such model and is induced through exposure to uncontrollable and unpredictable aversive events. Learned helplessness as induced in rats using foot shock is well characterized...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2005.03.019
更新日期：2005-01-01 00:00:00
abstract：:Defense patterns of rats and mice have been characterized in terms of the relationships between the type of defensive behavior (e.g. flight, freezing, hiding, defensive threat/attack, and risk assessment) and particular features of the eliciting (threat) stimulus and the situation in which it is encountered. Because t...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(01)00056-2
更新日期：2001-12-01 00:00:00
abstract：:How do ensembles of neurons distributed across the hippocampal and entorhinal cortices effectively interact? In the awake-behaving rat, specific subpopulations of hippocampal and entorhinal neurons become entrained into two prominent fast-frequency rhythms (gamma [40-100 Hz], and 200 Hz). These fast rhythms are couple...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(97)00016-x
更新日期：1998-03-01 00:00:00
abstract：:The neural regulation of circulatory function is mainly effected through the interplay of the sympathetic and vagal outflows. This interaction can be explored by assessing cardiovascular rhythmicity with appropriate spectral methodologies. Spectral analysis of cardiovascular signal variability, and in particular of RR...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2008.07.006
更新日期：2009-02-01 00:00:00
abstract：:In ingestive taste reactivity analysis, the rhythmic oral motor responses observed during intraoral infusion of fluids normally ingested by rats are categorized and counted. These rhythmic movements can be likened to spout-licking in several respects. Both are emitted in the same frequency range (5-8 Hz), organized in...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/0149-7634(94)00023-t
更新日期：1995-04-01 00:00:00
abstract：:The Roman high- (RHA) and low-avoidance (RLA) rat lines were selected for, respectively, rapid vs poor acquisition of two-way active avoidance in the shuttle-box. Here, we review experimental evidence indicating that, compared with their RLA counterparts, RHA rats display a robust sensation/novelty seeking profile, a ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2006.07.008
更新日期：2007-01-01 00:00:00
abstract：:Chronic pain and anxiety can be debilitating disorders and are often comorbid. There is significant overlap in the neural circuitry of pain and anxiety. Current treatments for these disorders are often ineffective and have negative side-effects, making further research into pain and anxiety circuitry crucial. The tech...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2019.08.007
更新日期：2019-10-01 00:00:00
abstract：:This paper critically reviews the unidimensional construct of General Arousal as utilised by models of temperament in differential psychology for example, to underlie 'Extraversion'. Evidence suggests that specialization within monoamine neurotransmitter systems contrasts with the attribution of a "general arousal" of...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.03.008
更新日期：2016-05-01 00:00:00
abstract：:The role of early-life stressors in the calibration of individual responses to future challenges has long been investigated in laboratory rodents. Specifically, countless studies show that exposure to early-life stressors - in the form of various periods of maternal separation, administration of exogenous corticostero...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2010.12.014
更新日期：2011-06-01 00:00:00
abstract：:Translocator protein (TSPO) is an 18kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. TSPO is involved in cellular functions, including the regulation of cell proliferation, transport of cholesterol to the inner ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2017.10.010
更新日期：2017-12-01 00:00:00
abstract：:The present review deals with findings related to the contribution of pro- and anticonvulsant effects of "neuroactive" steroids and the role of the gamma-aminobutyric acid (GABA) receptor as a physiological target for naturally occurring steroids. Ways are discussed via which GABAergic neurotransmission can be enhance...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(05)80148-4
更新日期：1993-07-01 00:00:00
abstract：:Water intake may or may not be associated with sodium appetite. There are excitatory and inhibitory mechanisms that control these behaviors whose mediators and interactions are unclear. We investigated the effects of specific antisera against angiotensin II (AB-AII) and atrial natriuretic peptide (AB-ANP) on the induc...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/s0149-7634(96)00052-8
更新日期：1997-09-01 00:00:00
abstract：:Response inhibition has been shown to be associated with monoamine-related gene polymorphisms, although evidence is inconclusive. To comprehensively examine these genotype effects on behavioural correlates of response inhibition in non-clinical adult populations, we performed a two-step approach. A systematic review o...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2017.11.009
更新日期：2018-01-01 00:00:00
abstract：:One obstacle to understanding the exact processes unfolding inside the hippocampus is that it is still difficult to clearly define what the hippocampus actually does, at the system level. Associated for a long time with the formation of episodic and semantic memories, and with their temporary storage, the hippocampus ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2011.12.002
更新日期：2012-08-01 00:00:00
abstract：:Human adolescence is a time of enormous developmental change, second only to infancy and early childhood in terms of brain shaping and growth. It is also a period in life when the young adult is faced with distinct environmental challenges and stressors. Interestingly, we now know that these external sources of stress...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.06.005
更新日期：2016-11-01 00:00:00
abstract：:An extensive body of research suggests the spontaneous eye blink rate (EBR) is a non-invasive indirect marker of central dopamine (DA) function, with higher EBR predicting higher DA function. In the present review we provide a comprehensive overview of this literature. We broadly divide the available research in studi...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.08.020
更新日期：2016-12-01 00:00:00
abstract：:The gene coding for the dopamine transporter (DAT), SLC6A3, contains a 40-base pair variable number of tandem repeats (VNTR) polymorphism (rs28363170) in its 3' untranslated region. This VNTR has been associated with attention deficit hyperactivity disorder (ADHD) and has been investigated in relation to cognition and...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.neubiorev.2015.09.021
更新日期：2016-01-01 00:00:00
abstract：:This review describes the various subtypes of eating disorders and examines factors associated with the risk of illness. It considers evidence that the development and maintenance of eating disorders is due to gene-environment interactions (GxE) that alter genetic expression via epigenetic processes. It describes how ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.09.012
更新日期：2011-01-01 00:00:00
