Abstract:
:Chronic pain and anxiety can be debilitating disorders and are often comorbid. There is significant overlap in the neural circuitry of pain and anxiety. Current treatments for these disorders are often ineffective and have negative side-effects, making further research into pain and anxiety circuitry crucial. The technique of optogenetics is propelling the possibilities for functional neuroanatomical research. With the use of light-activated proteins called opsins, optogenetics enables the switching on or off of a selective population of neurons, with precise temporal control. This manuscript reviews recent research that has employed optogenetic methodology to advance understanding of the neural circuitry of pain and anxiety and identify novel approaches for their improved treatment.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Jarrin S,Finn DPdoi
10.1016/j.neubiorev.2019.08.007subject
Has Abstractpub_date
2019-10-01 00:00:00pages
200-211eissn
0149-7634issn
1873-7528pii
S0149-7634(19)30128-9journal_volume
105pub_type
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