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Intranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis.

Abstract：

:Intranasal oxytocin has been shown to promote social functioning and has recently been applied as a treatment for autism spectrum disorders (ASD). The current meta-analysis aims to assess the crucial question of oxytocin's efficacy in the treatment of ASD. We performed a systematic literature search, including randomized, single- or double-blind/open-label and placebo-controlled clinical trials as well as single-arm, non-randomized and uncontrolled studies investigating exogenous oxytocin effect on ASD. A total of 28 studies (N = 726 ASD patients) met our predefined inclusion criteria. We used a multilevel meta-analytic model and found that oxytocin had beneficial effects on social functioning, but did not find strong evidence for symptoms improvement in the non-social domain. Our findings suggest that oxytocin administration can be regarded as an effective treatment for some core aspects of ASD, especially in the domain of social functioning, highlighting the promise of using oxytocin as a new-generation therapeutic to address core social impairments in ASD.

journal_name

Neurosci Biobehav Rev

journal_title

Neuroscience and biobehavioral reviews

authors

Huang Y,Huang X,Ebstein RP,Yu R

doi

10.1016/j.neubiorev.2020.12.028

subject

Has Abstract

pub_date

2021-01-02 00:00:00

pages

18-27

eissn

0149-7634

issn

1873-7528

pii

S0149-7634(20)30703-X

journal_volume

122

pub_type

杂志文章,评审

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