Abstract：
:In utero exposure to environmental stress in both animals and humans could result in long-term epigenome alterations which further lead to consequences for adaptation and development in the offspring. Epigenetics, especially DNA methylation, is considered one of the most widely studied and well-characterized mechanisms involved in the long-lasting effects of in utero stress exposure. In this review, we outlined evidence from animal and human prenatal research supporting the view that prenatal stress could lead to lasting, broad and functionally organized signatures in DNA methylation which, in turn, could mediate exposure-phenotype associations. We also emphasized the advantage of using stressor from quasi-randomly assigned experiments. Furthermore, we discuss challenges that still need to be addressed in this field in the future.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Cao-Lei L,de Rooij SR,King S,Matthews SG,Metz GAS,Roseboom TJ,Szyf Mdoi
10.1016/j.neubiorev.2017.05.016subject
Has Abstractpub_date
2020-10-01 00:00:00pages
198-210eissn
0149-7634issn
1873-7528pii
S0149-7634(16)30726-6journal_volume
117pub_type
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