Abstract：
:The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learning. More importantly, the "molecular actors" of the memory dialogue are well-conserved both across phylogenetic groups and learning paradigms, involving single- or multi-trials, aversion or reward, operant or classical conditioning. At the same time, this model could help to study how, where and when the memory dialog is impaired in stressful conditions and during aging and neurodegeneration in humans and thus offers new insights and targets in order to develop innovative therapies and technology for the treatment of a range of neurological and neurodegenerative disorders.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Rivi V,Benatti C,Colliva C,Radighieri G,Brunello N,Tascedda F,Blom JMCdoi
10.1016/j.neubiorev.2019.11.020subject
Has Abstractpub_date
2020-01-01 00:00:00pages
602-616eissn
0149-7634issn
1873-7528pii
S0149-7634(19)30654-2journal_volume
108pub_type
杂志文章,评审abstract：:The firing patterns of neurons in the nucleus accumbens (NA) are examined and discussed with respect to different types of rewards and reward conditions. Comparisons and contrasts between individually identified NA neuron responses to cocaine self-administration and water reinforcement are presented with an emphasis o...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2003.11.011
更新日期：2004-01-01 00:00:00
abstract：:Cognitive impairment is highly prevalent in the progression of both diabetes mellitus and bipolar disorder. The relationship between insulin resistance in diabetes and the risk of developing major neurocognitive disorders such as Alzheimer's disease has been well described. Insulin resistance and the associated metabo...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2020.01.022
更新日期：2020-04-01 00:00:00
abstract：:The rapid rise in obesity prevalence in the modern world parallels a significant reduction in restorative sleep (Agras et al., 2004; Dixon et al., 2007, 2001; Gangwisch and Heymsfield, 2004; Gupta et al., 2002; Sekine et al., 2002; Vioque et al., 2000; Wolk et al., 2003). Reduced sleep time and quality increases the r...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2012.01.001
更新日期：2012-03-01 00:00:00
abstract：:The risk of improbable, uncertain, but grave potential dangers poses unique adaptive challenges. We argue that to manage such risks, a special motivational system evolved, which we term the security motivation system. Review of work across a range of species indicates that this system is designed to detect subtle indi...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.08.003
更新日期：2011-03-01 00:00:00
abstract：:Lick sensors are versatile instruments that are routinely used in behavioral and neuroscience research involving fluid ingestion in the rat. There are three different types of sensors: electrical, optical and force sensors. They differ in the exact moment of activation during the tongue protrusion/retraction cycle. Pr...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(98)00003-7
更新日期：1998-10-01 00:00:00
abstract：:To understand the onset and the molecular mechanisms triggering dopaminergic (DA) dysregulation in Attention-Deficit Hyperactivity Disorder (ADHD), we have used the Spontaneously Hypertensive Rats (SHR), the most widely studied animal model for this disease. We have studied the pattern of expression of specific genes ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2003.08.009
更新日期：2003-11-01 00:00:00
abstract：:Exposure to enriched environment has been shown to induce robust neuronal plasticity in both intact and injured adult central nervous system, including up-regulation of multiple neurotrophic factors, enhanced neurogenesis in the dentate gyrus of the hippocampus, and improved spatial learning and memory function. Neuro...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2007.10.004
更新日期：2008-01-01 00:00:00
abstract：:Vago-vagal reflex control circuits in the dorsal vagal complex of the brainstem provide overall coordination over digestive functions of the stomach, small intestine and pancreas. The neural components forming these reflex circuits are under significant descending neural control. By adjusting the excitability of the d...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(95)00040-l
更新日期：1996-01-01 00:00:00
abstract：:In vitro and in vivo electrophysiological studies have been used to assess the effects of glutamate, as well as specific agonists and antagonists for ionotropic, N-methyl-D-aspartate (NMDA), (R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and kainate, and metabotropic subtypes of the glutamate re...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(96)00030-9
更新日期：1997-07-01 00:00:00
abstract：:The present paper reviews a series of experiments aimed at elucidating the interaction between specific dopamine (DA) and 5-hydroxytryptamine (5-HT) receptors in the mediation of extrapyramidal motor functions in the rat. There is strong evidence to suggest that (1) the catalepsy produced by dopamine D1 or D2 receptor...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(95)00057-7
更新日期：1996-07-01 00:00:00
abstract：:The intent of this paper is to evaluate decreases of food intake and body weight that occur when a peptide is administered to an animal. Using the pancreatic hormone insulin as an example, the case is made that endogenous insulin is normally secreted in response to circulating nutrients as well as in proportion to the...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(95)00044-f
更新日期：1996-01-01 00:00:00
abstract：:Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in the European Union alone. Although a wealth of research has been directed toward understanding and treating MDD, still no therapy has ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2015.07.011
更新日期：2015-11-01 00:00:00
abstract：:Creative cognition is key to human functioning yet the underlying neurobiological mechanisms are sparsely addressed and poorly understood. Here we address the possibility that creative cognition is a function of dopaminergic modulation in fronto-striatal brain circuitries. It is proposed that (i) creative cognition be...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2017.04.007
更新日期：2017-07-01 00:00:00
abstract：:There is an increasing body of research investigating whether abnormal glucose tolerance is associated with cognitive impairments, the evidence from which is equivocal. A systematic search of the literature identified twenty-three studies which assessed either clinically defined impaired glucose tolerance (IGT) or var...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2008.10.008
更新日期：2009-03-01 00:00:00
abstract：:Noting important recent discoveries, we review primate social learning, traditions and culture, together with associated findings about primate brains. We survey our current knowledge of primate cultures in the wild, and complementary experimental diffusion studies testing species' capacity to sustain traditions. We r...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.12.018
更新日期：2017-11-01 00:00:00
abstract：:Stressful events have been implicated in the precipitation of depression and anxiety. These disorders may evolve owing to one or more of an array of neuronal changes that occur in several brain regions. It seems likely that these stressor-provoked neurochemical alterations are moderated by genetic determinants, as wel...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2008.03.001
更新日期：2008-08-01 00:00:00
abstract：:Human adolescence is a time of enormous developmental change, second only to infancy and early childhood in terms of brain shaping and growth. It is also a period in life when the young adult is faced with distinct environmental challenges and stressors. Interestingly, we now know that these external sources of stress...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2016.06.005
更新日期：2016-11-01 00:00:00
abstract：:The role of early-life stressors in the calibration of individual responses to future challenges has long been investigated in laboratory rodents. Specifically, countless studies show that exposure to early-life stressors - in the form of various periods of maternal separation, administration of exogenous corticostero...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/j.neubiorev.2010.12.014
更新日期：2011-06-01 00:00:00
abstract：:The role of estrogen (E) and progesterone (P) in regulating the expression of agonistic, scent marking and proceptive displays is reviewed. In the intact sexually mature female, data indicate that agonistic, scent marking and proceptive patterns of behavior fluctuate significantly prior to and during the period of mat...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/s0149-7634(05)80062-4
更新日期：1990-01-01 00:00:00
abstract：:This paper aims to systematically review the influence of apolipoprotein E (ApoE) on the effects of potentially modifiable mid and late life risk factors for dementia. Scopus, Medline, PubMed, PsycINFO, and HuGE databases were searched up to November 2008. Two independent reviewers selected 94 articles from 13,122 res...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2009.08.007
更新日期：2010-03-01 00:00:00
abstract：:Taste aversion learning (TAL) consists of the avoidance of a taste previously associated with a noxious visceral stimulus. Clinical and experimental studies suggest that this adaptive process can be established by different procedures that imply distinct forms of learning and memory, although the final result is analo...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2005.06.002
更新日期：2005-01-01 00:00:00
abstract：:Drug addiction affects approximately 10% of the population and these numbers are rising. Treatment and prevention of addiction are impeded by current diagnostic systems, such as DSM-5, which are based on outcomes rather than processes. Here, we review the importance of adopting a dimensional framework, specifically th...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2018.06.005
更新日期：2019-11-01 00:00:00
abstract：:Several newer magnetic resonance imaging (MRI) techniques are increasingly being applied to the study of white matter development and pathology across the lifespan. These techniques go beyond traditional macrostructural volumetric methods and provide valuable information about underlying tissue integrity and organizat...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2006.06.003
更新日期：2006-01-01 00:00:00
abstract：:Structural and functional magnetic resonance imaging modalities have been critical in advancing our understanding of the neuroanatomical and pathophysiological changes that emerge during the premanifest and symptomatic stages of Huntington's disease (HD). However, the relationship between underlying neuropathology and...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2013.05.009
更新日期：2013-09-01 00:00:00
abstract：:Paradoxical sleep in rats, cats and mice is usually preceded and sometimes followed by a short-lasting (a few seconds) electroencephalogram (EEG) stage characterized by high-amplitude spindles in the anterior cortex and low-frequency theta rhythm in the dorsal hippocampus. The former is an index of advanced slow-wave ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(95)00055-0
更新日期：1996-10-01 00:00:00
abstract：:Horseradish peroxidase, 13% Sigma Type VI, was administered iontophoretically to the lateral preoptic area (LPA) of male hooded rats. Animals were perfused intracardially on the following day and brains were removed and sliced in the coronal plane into 50 microns sections. Alternate sections were processed with DAB an...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章
doi：10.1016/0149-7634(83)90042-8
更新日期：1983-10-01 00:00:00
abstract：:Though the most recognizable symptoms of Parkinson's disease (PD) are motor-related, many patients also suffer from debilitating affective symptoms that deleteriously influence quality of life. Dopamine (DA) loss is likely involved in the onset of depression and anxiety in PD. However, these symptoms are not reliably ...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.06.007
更新日期：2011-01-01 00:00:00
abstract：:The effect of manipulations aimed at modifying the function of the 5-HT system has been reviewed. 5-HT uptake inhibitors are devoid of any activity in rats and induce an anti-immobility effect in mice. The so-called 5-HT1A agonists reduce the immobility time with some differences in mice and rats, mice being less sens...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/0149-7634(94)00050-b
更新日期：1995-10-01 00:00:00
abstract：:A review of selected works on spatial memory in animals and humans is presented, and some ideas about the encoding of geometry and its role in evolution are presented, based on recently accumulated evidence from psychology, ethology and the neurosciences. It is argued that comparative analyses at the level of both spa...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2011.12.007
更新日期：2012-02-01 00:00:00
abstract：:Although it is known that primary auditory cortex (A1) contributes to the processing and perception of sound, its precise functions and the underlying mechanisms are not well understood. Recent studies point to a remarkably broad spectral range of largely subthreshold inputs to individual neurons in A1--seemingly enco...
journal_title：Neuroscience and biobehavioral reviews
pub_type： 杂志文章,评审
doi：10.1016/j.neubiorev.2010.11.010
更新日期：2011-11-01 00:00:00
