Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation.


:Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal-directed behaviors become corrupted, which may lead to cognitive deficits that coexist with other addiction symptoms and predict a worse treatment outcome. New learning experiences that are not motivated by drugs may improve both cognitive deficits and drug-induced symptoms by promoting adaptive neuroplastic changes that could alleviate or reverse those involved in addiction. The present review will focus on whether potentiating healthy cognitive function, either by formal cognitive training or non-drug related environmental experiences, could exert beneficial effects in the therapeutics of addiction. Although additional studies are needed, the available clinical and preclinical evidence suggests that cognitive stimulation may provide a valuable adjuvant intervention in drug addiction.


Neurosci Biobehav Rev


Sampedro-Piquero P,Ladrón de Guevara-Miranda D,Pavón FJ,Serrano A,Suárez J,Rodríguez de Fonseca F,Santín LJ,Castilla-Ortega E




Has Abstract


2019-11-01 00:00:00












  • Importance of astrocytes for potassium ion (K+) homeostasis in brain and glial effects of K+ and its transporters on learning.

    abstract::Initial clearance of extracellular K+ ([K+]o) following neuronal excitation occurs by astrocytic uptake, because elevated [K+]o activates astrocytic but not neuronal Na+,K+-ATPases. Subsequently, astrocytic K+ is re-released via Kir4.1 channels after distribution in the astrocytic functional syncytium via gap junction...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Hertz L,Chen Y

    更新日期:2016-12-01 00:00:00

  • The puzzling question of inhibitory control in Tourette syndrome: A meta-analysis.

    abstract::Tourette syndrome (TS) is a neuropsychiatric disorder involving motor and phonic tics. Inhibitory control is a key issue in TS, and many disruptive or impulsive behaviors might arise from inhibitory deficits. However, conflicting findings regarding TS patients' inhibitory performance in neuropsychological tasks have b...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Morand-Beaulieu S,Grot S,Lavoie J,Leclerc JB,Luck D,Lavoie ME

    更新日期:2017-09-01 00:00:00

  • Role of the serotonergic system in the forced swimming test.

    abstract::The effect of manipulations aimed at modifying the function of the 5-HT system has been reviewed. 5-HT uptake inhibitors are devoid of any activity in rats and induce an anti-immobility effect in mice. The so-called 5-HT1A agonists reduce the immobility time with some differences in mice and rats, mice being less sens...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Borsini F

    更新日期:1995-10-01 00:00:00

  • Electrophysiological studies of d-lysergic acid diethylamide in the visual system.

    abstract::Experiments involving the use of LSD and observing its effects on neurons involved in the processing of visual information are reviewed. These studies typically involved either intravenous or iontophoretic application of the compound. Both modes of application appeared to block the optic afferent synapse at the level ...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章


    authors: Foote WE

    更新日期:1982-01-01 00:00:00

  • What do animals learn in artificial grammar studies?

    abstract::Artificial grammar learning is a popular paradigm to study syntactic ability in nonhuman animals. Subjects are first trained to recognize strings of tokens that are sequenced according to grammatical rules. Next, to test if recognition depends on grammaticality, subjects are presented with grammar-consistent and gramm...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Beckers GJL,Berwick RC,Okanoya K,Bolhuis JJ

    更新日期:2017-10-01 00:00:00

  • Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.

    abstract::Dopamine hypotheses of several psychiatric disorders are based upon the clinical benefits of drugs affecting dopamine transporter or receptors, and have prompted intensive candidate gene research within the dopaminergic system during the last two decades. The aim of this review is to survey the most important findings...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Nemoda Z,Szekely A,Sasvari-Szekely M

    更新日期:2011-08-01 00:00:00

  • Tactile, acoustic and vestibular systems sum to elicit the startle reflex.

    abstract::The startle reflex is elicited by intense tactile, acoustic or vestibular stimuli. Fast mechanoreceptors in each modality can respond to skin or head displacement. In each modality, stimulation of cranial nerves or primary sensory nuclei evokes startle-like responses. The most sensitive sites in rats are found in the ...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Yeomans JS,Li L,Scott BW,Frankland PW

    更新日期:2002-01-01 00:00:00

  • Airway structure variability in the Long-Evans rat lung.

    abstract::Mathematical models used to study deposition of inhaled toxicants require morphometric data to represent the tracheobronchial airways of laboratory animals. Because of the difficulty and cost of obtaining detailed measurements, morphometric models are generally based on measurements from a small number of specimens. T...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章


    authors: Ménache MG,Patra AL,Miller FJ

    更新日期:1991-04-01 00:00:00

  • Reward, memory and substance abuse: functional neuronal circuits in the nucleus accumbens.

    abstract::The firing patterns of neurons in the nucleus accumbens (NA) are examined and discussed with respect to different types of rewards and reward conditions. Comparisons and contrasts between individually identified NA neuron responses to cocaine self-administration and water reinforcement are presented with an emphasis o...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Deadwyler SA,Hayashizaki S,Cheer J,Hampson RE

    更新日期:2004-01-01 00:00:00

  • Unisensory and multisensory temporal processing in autism and dyslexia: A systematic review and meta-analysis.

    abstract::This study presents a comprehensive systematic review and meta-analysis of temporal processing in autism spectrum disorder (ASD) and developmental dyslexia (DD), two neurodevelopmental disorders in which temporal processing deficits have been highly researched. The results provide strong evidence for impairments in te...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Meilleur A,Foster NEV,Coll SM,Brambati SM,Hyde KL

    更新日期:2020-09-01 00:00:00

  • Centenary of Christfried Jakob's discovery of the visceral brain: an unheeded precedence in affective neuroscience.

    abstract::The benchmark discovery of the cingulate gyrus as a brain structure receiving stimuli from muscles and viscera (proprioception and interoception) is traced to a 1907/1908 article by neuropathologist Christfried Jakob. Further, the involvement of the mamillary bodies, anterior thalamic nucleus, cingulate cortex and hip...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 传,历史文章,杂志文章,评审


    authors: Triarhou LC

    更新日期:2008-07-01 00:00:00

  • The Cartesian clock metaphor for pineal gland operation pervades the origin of modern chronobiology.

    abstract::In theoretical descriptions formulated during the 1600s, R. Descartes attributed a clock-like role to the pineal gland. He established the belief that pineal function underlies the laws of the universe that determine the cyclic sleep-awake states in man. Recent reports about pineal circadian pacemakers now validate th...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Barrera-Mera B,Barrera-Calva E

    更新日期:1998-01-01 00:00:00

  • Reconsolidation of drug memories.

    abstract::Persistent, unwanted memories are believed to be key contributors to drug addiction and the chronic relapse problem over the lifetime of the addict. Contrary to the long-held idea that memories are static and fixed, new studies in the last decade have shown that memories are dynamic and changeable. However, they are c...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Sorg BA

    更新日期:2012-05-01 00:00:00

  • Towards a neuroscience of empathy: ontogeny, phylogeny, brain mechanisms, context and psychopathology.

    abstract::Empathy allows individuals to share the affective states of others, predict others' actions, and stimulate prosocial behavior. Whilst the proximate mechanisms of empathy, modulated in part by neuropeptides such as oxytocin, control the ways we interact with our social environment, the ultimate causes seem to have aris...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Gonzalez-Liencres C,Shamay-Tsoory SG,Brüne M

    更新日期:2013-09-01 00:00:00

  • Cerebral plasticity as the basis for upper limb recovery following brain damage.

    abstract::Neural plasticity is the basis for an adaptation process of functional and structural characteristics of the nervous system in response to a changing environment. However, changes during training in healthy volunteers are only partially comparable to that observed in patients with circumscribed lesions. Pathologies ca...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Lotze M,Ladda AM,Stephan KM

    更新日期:2019-04-01 00:00:00

  • The translocator protein (18kDa) and its role in neuropsychiatric disorders.

    abstract::Translocator protein (TSPO) is an 18kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. TSPO is involved in cellular functions, including the regulation of cell proliferation, transport of cholesterol to the inner ...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Barichello T,Simões LR,Collodel A,Giridharan VV,Dal-Pizzol F,Macedo D,Quevedo J

    更新日期:2017-12-01 00:00:00

  • Beyond good and evil: A putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment.

    abstract::Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplas...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Diniz CRAF,Casarotto PC,Resstel L,Joca SRL

    更新日期:2018-07-01 00:00:00

  • Natriuretic peptides in the central nervous system: Novel targets for cognitive impairment.

    abstract::Natriuretic peptides (NPs) are traditionally known as cardiac hormones with diuretic, natriuretic and blood pressure lowering properties. Evidence indicates that NPs and their receptors are abundant in the central nervous system, suggesting their involvement in regulation of various brain functions. It has been shown ...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Mahinrad S,de Craen AJM,Yasar S,van Heemst D,Sabayan B

    更新日期:2016-09-01 00:00:00

  • Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS.

    abstract::There are roughly 30-40 million HIV-infected individuals in the world as of December 2007, and drug abuse directly contributes to one-third of all HIV infections in the United States. Antiretroviral therapy has increased the lifespan of HIV-seropositives, but CNS function often remains diminished, effectively decreasi...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Ferris MJ,Mactutus CF,Booze RM

    更新日期:2008-07-01 00:00:00

  • Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?

    abstract::Numerous studies have documented a link between psychological disorders and cardiac disease. Yet, no systematic attempts have been made to develop pharmacological approaches for mood and anxiety disorders that could also be beneficial for cardiac health. The endocannabinoid system has been implicated in the regulation...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Carnevali L,Rivara S,Nalivaiko E,Thayer JF,Vacondio F,Mor M,Sgoifo A

    更新日期:2017-03-01 00:00:00

  • Reproduction and the renin-angiotensin system.

    abstract::A unique aspect of the circulating renin-angiotensin system and the many independent tissue renin-angiotensin systems is their interactions at multiple levels with reproduction. These interactions, which have received relatively little attention, include effects of estrogens and possibly androgens on hepatic and renal...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Ganong WF

    更新日期:1995-07-01 00:00:00

  • Physiological control of elaborate male courtship: female choice for neuromuscular systems.

    abstract::Males of many animal species perform specialized courtship behaviours to gain copulations with females. Identifying physiological and anatomical specializations underlying performance of these behaviours helps clarify mechanisms through which sexual selection promotes the evolution of elaborate courtship. Our knowledg...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Fusani L,Barske J,Day LD,Fuxjager MJ,Schlinger BA

    更新日期:2014-10-01 00:00:00

  • Color vision in honeybees.

    abstract::Theoretical and experimental investigations of the color vision system in honeybees are reviewed. Grassmann's model and receptor models of color vision are discussed with respect to the problem of color difference. A recent analysis of the bee's color opponent coding system is presented in brief. Predictions for the s...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Backhaus W

    更新日期:1992-04-01 00:00:00

  • Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies.

    abstract::Stressful events have been implicated in the precipitation of depression and anxiety. These disorders may evolve owing to one or more of an array of neuronal changes that occur in several brain regions. It seems likely that these stressor-provoked neurochemical alterations are moderated by genetic determinants, as wel...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Anisman H,Merali Z,Stead JD

    更新日期:2008-08-01 00:00:00

  • Neuroimaging and fetal alcohol spectrum disorders.

    abstract::Heavy prenatal alcohol exposure causes permanent structural alterations to the brain and can lead to numerous cognitive and behavioral outcomes. Consistent with many of the neuropsychological and behavioral deficits that have been reported, neuroimaging studies reveal a pattern of structural abnormalities associated w...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Spadoni AD,McGee CL,Fryer SL,Riley EP

    更新日期:2007-01-01 00:00:00

  • Reviewing the functional basis of the syntactic Merge mechanism for language: A coordinate-based activation likelihood estimation meta-analysis.

    abstract::The ability to create structures out of single words is a key aspect of human language. This combinatorial capacity relies on a low-level syntactic mechanism-Merge-assembling words into hierarchies. Neuroscience has explored Merge by comparing syntax to word-lists. Here, we first review potential issues with the word-...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Zaccarella E,Schell M,Friederici AD

    更新日期:2017-09-01 00:00:00

  • Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal.

    abstract::This paper offers a reexamination of some long-held beliefs relating to the physiology of erectile function and dysfunction, including the idea that there is a singular physiology of erection. Rather, there appear to be plural neural, neurochemical, and endocrine mechanisms whose participation in erectile function dep...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Sachs BD

    更新日期:2000-07-01 00:00:00

  • The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder.

    abstract::The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-f...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Miskowiak KW,Kjærstad HL,Meluken I,Petersen JZ,Maciel BR,Köhler CA,Vinberg M,Kessing LV,Carvalho AF

    更新日期:2017-02-01 00:00:00

  • Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?

    abstract::A long-standing concern has been whether epilepsy contributes to cognitive decline or so-called 'epileptic dementia'. Although global cognitive decline is generally reported in the context of chronic refractory epilepsy, it is largely unknown what percentage of patients is at risk for decline. This review is focused o...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Breuer LE,Boon P,Bergmans JW,Mess WH,Besseling RM,de Louw A,Tijhuis AG,Zinger S,Bernas A,Klooster DC,Aldenkamp AP

    更新日期:2016-05-01 00:00:00

  • Testing the NMDA, long-term potentiation, and cholinergic hypotheses of spatial learning.

    abstract::The problems and issues associated with the use of pharmacological antagonists in studies on learning and memory are considered in a review of the role of N-methyl-D-aspartate (NMDA) receptors, NMDA receptor-mediated long-term potentiation (LTP), and muscarinic receptors in spatial learning in the water maze. The evid...

    journal_title:Neuroscience and biobehavioral reviews

    pub_type: 杂志文章,评审


    authors: Cain DP

    更新日期:1998-03-01 00:00:00