Abstract:
:We investigated whether genetic differences in various forms of intraspecific aggression and anxiety in four different genetic lines of mice (i.e. wild, outbred Swiss-CD1, inbred DBA/2 and inbred C57/BL6N) may reflect modifications in behavioral strategy. Experiments 1 and 2 used ethologically based paradigms to analyze aggressive and anxiety responses both in social (i.e. aggression) and non-social (i.e. novel environment exploration) contexts. In Experiment 3, an anxiolytic drug (chlordiazepoxide (CDP)) was used to examine possible differences in proximal mechanisms underlying anxiety-related behaviors. The data show that intrasexual aggression, infanticide and maternal aggressions are related and covarying. Genetic lines with the highest levels of intermale attack (i.e. Wild and Swiss-CD1) also have highest levels of infanticide, interfemale attack and maternal aggression but, interestingly, the lowest levels of anxiety. In fact, exploratory behavior is lower and risk assessment behavior markedly higher in DBA/2 and C57/BL6N mice (i.e. the less aggressive strains) compared to Swiss and Wild genetic lines. Although reproductive status influences anxiety levels in female mice, our findings show that (contrary to previous studies) lactating mice are more anxious than virgin females in terms of risk assessment activities. These data demonstrate the importance of studying behavior in a more ecologically-relevant context which emphasizes the function of behavior in a specific situation. Moreover, differential strain sensitivity to the behavioral effects of CDP suggests that genetic lines of mice may differ in the underlying mechanisms mediating behavior. It is therefore possible that artificial selection of different genotypes has resulted in differences in proximate mechanisms modulating the levels of aggression and anxiety, thereby leading to modification of social behavior. Overall, the results presented here suggest that subtle genetic alterations in specific underlying neural mechanisms are likely to cause profound effects on behavioral responses and their adaptive significance. Implications for behavioral neuroscience research that seeks to understand both the proximal and ultimate mechanisms of behavior are discussed.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Parmigiani S,Palanza P,Rogers J,Ferrari PFdoi
10.1016/s0149-7634(99)00029-9subject
Has Abstractpub_date
1999-11-01 00:00:00pages
957-69issue
7eissn
0149-7634issn
1873-7528pii
S0149763499000299journal_volume
23pub_type
杂志文章,评审abstract::For decades, the nosology of mental illness has been based largely upon the descriptions in the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM). A recent challenge to the DSM approach to psychiatric nosology from the National Institute on Mental Health (USA) defines Research Domain Crit...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2016.10.029
更新日期:2017-05-01 00:00:00
abstract::Prevailing theories of hippocampal function argue that memories are rapidly encoded by non-overlapping memory traces. Concurrently, the hippocampus has been argued to integrate across related experiences, enabling generalization. The cognitive neuroscience of memory has been transformed by the recent proliferation of ...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2020.07.024
更新日期:2020-11-01 00:00:00
abstract::In ingestive taste reactivity analysis, the rhythmic oral motor responses observed during intraoral infusion of fluids normally ingested by rats are categorized and counted. These rhythmic movements can be likened to spout-licking in several respects. Both are emitted in the same frequency range (5-8 Hz), organized in...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章
doi:10.1016/0149-7634(94)00023-t
更新日期:1995-04-01 00:00:00
abstract::To improve the translational predictability of treatment strategies for Huntington's disease (HD), sensitive and analogous cognitive outcomes are needed across HD animal models and humans. Spatial memory measures are promising candidates because they are based on 'visual' or 'non-verbal' cognition, and are commonly te...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2019.01.015
更新日期:2019-03-01 00:00:00
abstract::A systematic review with meta-analyses was performed to: 1) quantify the association between ADHD and risk of unintentional physical injuries in children/adolescents ("risk analysis"); 2) assess the effect of ADHD medications on this risk ("medication analysis"). We searched 114 databases through June 2017. For the ri...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.neubiorev.2017.11.007
更新日期:2018-01-01 00:00:00
abstract::In the present study, we have investigated how various 5-HT agonists (m-chlorophenylpiperazine (mCPP) (0.1-1 mg/kg), 8-hydroxy 2-(di-N-propylamino) tetralin (8-OH DPAT) (0.125-2 mg/kg) and 5-HT (0.5-2 mg/kg)), the 5-HT uptake blocker sertraline (1-10 mg/kg), and the 5-HT uptake blocker and releaser dexfenfluramine (0....
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章
doi:10.1016/s0149-7634(05)80195-2
更新日期:1992-01-01 00:00:00
abstract::Although many people are exposed to extreme stress, only some of them develop psychobiological disturbances that can lead to posttraumatic stress disorder (PTSD) or other posttrauma psychopathology. This paper examines the effects of different types of appraisal and coping to find clues to how individuals differ in th...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2004.12.006
更新日期:2005-05-01 00:00:00
abstract::Two major consequences of placentophagia, the ingestion of afterbirth materials that occurs usually during mammalian parturition, have been uncovered in the past several years. The first is that increased contact, associated with ingesting placenta and amniotic fluid from the surface of the young, causes an accelerate...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/s0149-7634(05)80035-1
更新日期:1991-10-01 00:00:00
abstract::The incentive sensitization theory is a promising model for understanding the mechanisms underlying drug addiction, and has received support in animal and human studies. So far the theory has not been applied to the case of behavioral addictions like Gambling Disorder, despite sharing clinical symptoms and underlying ...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2014.07.009
更新日期:2014-09-01 00:00:00
abstract::Defense patterns of rats and mice have been characterized in terms of the relationships between the type of defensive behavior (e.g. flight, freezing, hiding, defensive threat/attack, and risk assessment) and particular features of the eliciting (threat) stimulus and the situation in which it is encountered. Because t...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章
doi:10.1016/s0149-7634(01)00056-2
更新日期:2001-12-01 00:00:00
abstract::Deep brain stimulation (DBS), a neuromodulation therapy that has been used successfully in the treatment of symptoms associated with movement disorders, has recently undergone clinical trials for individuals suffering from treatment-resistant depression (TRD). Although the small patient numbers and open label study de...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2012.06.001
更新日期:2012-09-01 00:00:00
abstract::The recent proposal of a new type of agnosia termed 'affective agnosia' extends Freud's legacy and captures the concept of not knowing one's own emotions. This concept links well with the theory of levels of emotional awareness and maps onto a hierarchical model of neural substrates of emotional experience, but does n...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 评论,杂志文章
doi:10.1016/j.neubiorev.2016.05.025
更新日期:2016-09-01 00:00:00
abstract::Depression is a serious neurological disorder characterized by strong loss of interest, possibly leading to suicide. According to the World Health Organization, more than 300 million people worldwide suffer from this disorder, being the leading cause of disability. The advancements in electroencephalography (EEG) make...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2019.07.021
更新日期:2019-10-01 00:00:00
abstract::Many psychiatric illnesses are associated with early mortality and with an increased risk of developing physical diseases that are more typically seen in the elderly. Moreover, certain psychiatric illnesses may be associated with accelerated cellular aging, evidenced by shortened leukocyte telomere length (LTL), which...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2015.05.007
更新日期:2015-08-01 00:00:00
abstract::Pentylenetetrazol (PTZ), a GABA(A) receptor antagonist and prototypical anxiogenic drug, has been extensively utilized in animal models of anxiety. PTZ produces a reliable discriminative stimulus which is largely mediated by the GABA(A) receptor. Several classes of compounds can modulate the PTZ discriminative stimulu...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/s0149-7634(02)00010-6
更新日期:2002-06-01 00:00:00
abstract::Previous reviews have specifically looked at computer-based or Internet-based approaches. However, there has been no systematic review focused upon electronic communication based interventions for hazardous young drinkers. Out of 3298 relevant citations, 13 papers consisting of 11 studies met the inclusion criteria. E...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2016.07.021
更新日期:2016-09-01 00:00:00
abstract::Anatomical and functional studies show that the hypothalamus is at the junction of mechanisms involved in the exploratory appraisal phase of behaviour and mechanisms involved in the execution of specific consummatory acts. However, the hypothalamus is also a crucial link in endocrine regulation. In natural settings it...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/s0149-7634(98)00018-9
更新日期:1998-01-01 00:00:00
abstract::Theoretical and experimental investigations of the color vision system in honeybees are reviewed. Grassmann's model and receptor models of color vision are discussed with respect to the problem of color difference. A recent analysis of the bee's color opponent coding system is presented in brief. Predictions for the s...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/s0149-7634(05)80045-4
更新日期:1992-04-01 00:00:00
abstract::Primary-process experiences, both raw affects and perceptions, are self-creating processes, and the associated motoric-action tendencies serve survival values, providing the raw materials for learning. Actions seem to play a key role in providing 'meaning' for the primary sensations and associated feelings. We suggest...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2011.02.014
更新日期:2011-10-01 00:00:00
abstract::Physical activity is an integral component of stroke prevention. Although approximately 80% of strokes are due to cerebral ischemia, the mechanisms linking physical activity to the incidence of and recovery from ischemic stroke are not completely understood. This review summarizes evidence from human and animal studie...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2012.11.011
更新日期:2013-02-01 00:00:00
abstract::Adolescence is characterized by pronounced changes in motivated behavior, during which emphasis on potential rewards may result in an increased tendency to approach things that are novel and bring potential for positive reinforcement. While this may result in risky and health-endangering behavior, it may also lead to ...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2016.06.037
更新日期:2016-11-01 00:00:00
abstract::This review describes the various subtypes of eating disorders and examines factors associated with the risk of illness. It considers evidence that the development and maintenance of eating disorders is due to gene-environment interactions (GxE) that alter genetic expression via epigenetic processes. It describes how ...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2010.09.012
更新日期:2011-01-01 00:00:00
abstract::Current literature on the effects of chronic stress in general health converges to the concept of allostatic load (AL). AL is the bodily 'wear and tear' that emerges with sustained allostatic states. In the field of bipolar disorder (BD), AL offers an important clue as to why patients who undergo recurrent mood episod...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2007.10.005
更新日期:2008-01-01 00:00:00
abstract::The technology toolbox by which neural elements can be selectively manipulated in vertebrate and invertebrate brains has expanded greatly in recent years, to now include sophisticated optogenetics and novel designer receptors. Application of such tools allow for ascertaining whether a particular behavioural phenotype ...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2014.07.026
更新日期:2014-11-01 00:00:00
abstract::It has long been known that the estrogen, 17β-estradiol (17β-E), plays a central role for female reproductive physiology and behavior. Numerous studies have established the neurochemical and molecular basis of estrogenic induction of female sexual behavior, i.e., lordosis, in animal models. In addition, 17β-E also reg...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2018.10.012
更新日期:2020-03-01 00:00:00
abstract::The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting pla...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2019.11.020
更新日期:2020-01-01 00:00:00
abstract::One of the core diagnostic criteria for Dementia with Lewy Bodies (DLB) is the presence of visual hallucinations. The presence of hallucinations, along with fluctuations in the level of arousal and sleep disturbance, point to potential pathological mechanisms at the level of the thalamus. However, the potential role o...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2019.06.006
更新日期:2019-08-01 00:00:00
abstract::Imaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the literature on IG has exponentially grown over the past years, the majority of studies have mainly anal...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章
doi:10.1016/j.neubiorev.2018.06.013
更新日期:2018-10-01 00:00:00
abstract::Most models of conduct disorders are based on a biopsychosocial perspective. In such models, genetic and/or neuropsychological determinants are assumed to have a core hierarchical role by conferring vulnerabilities during a child's development. Based on a review of recent literature, I will show that other views are a...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2009.07.011
更新日期:2010-01-01 00:00:00
abstract::Although largely unrecognized by sleep scholars, sleeping is a pleasure. This report aims first, to fill the gap: sleep, like food, water and sex, is a primary reinforcer. The levels of extracellular mesolimbic dopamine show circadian oscillations and mark the "wanting" for pro-homeostatic stimuli. Further, the dopami...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2018.03.012
更新日期:2018-05-01 00:00:00