Abstract：
:The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: 'cold' and 'hot' cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Miskowiak KW,Kjærstad HL,Meluken I,Petersen JZ,Maciel BR,Köhler CA,Vinberg M,Kessing LV,Carvalho AFdoi
10.1016/j.neubiorev.2016.12.011subject
Has Abstractpub_date
2017-02-01 00:00:00pages
1-22eissn
0149-7634issn
1873-7528pii
S0149-7634(16)30319-0journal_volume
73pub_type
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