Abstract：
:Functional magnetic resonance imaging (fMRI) offers great promise for elucidating the neuropathology associated with a single or repetitive mild traumatic brain injury (mTBI). The current review discusses the physiological underpinnings of the blood-oxygen level dependent response and how trauma affects the signal. Methodological challenges associated with fMRI data analyses are considered next, followed by a review of current mTBI findings. The majority of evoked studies have examined working memory and attentional functioning, with results suggesting a complex relationship between cognitive load/attentional demand and neuronal activation. Researchers have more recently investigated how brain trauma affects functional connectivity, and the benefits/drawbacks of evoked and functional connectivity studies are also discussed. The review concludes by discussing the major clinical challenges associated with fMRI studies of brain-injured patients, including patient heterogeneity and variations in scan-time post-injury. We conclude that the fMRI signal represents a complex filter through which researchers can measure the physiological correlates of concussive symptoms, an important goal for the burgeoning field of mTBI research.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Mayer AR,Bellgowan PS,Hanlon FMdoi
10.1016/j.neubiorev.2014.11.016subject
Has Abstractpub_date
2015-02-01 00:00:00pages
8-18eissn
0149-7634issn
1873-7528pii
S0149-7634(14)00318-2journal_volume
49pub_type
杂志文章,评审abstract：:The neural systems underlying reward-related behaviors across development have recently generated a great amount of interest. Yet, the neurodevelopmental literature on reward processing is marked by inconsistencies due to the heterogeneity of the reward paradigms used, the complexity of the behaviors being studied, an...
journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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journal_title：Neuroscience and biobehavioral reviews
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abstract：:The human brain consists of millions of neural nerve cells being interconnected and firing in parallel in order to process information. A fundamental question is how this parallel neuron-firing can result in a unified experience. This is the so-called binding problem--a problem that is one of today's key questions abo...
journal_title：Neuroscience and biobehavioral reviews
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更新日期：2010-06-01 00:00:00
