Abstract：
:Gray's approach to understanding hippocampal functioning [The Neuropsychology of Anxiety: An Enquiry into the Function of the Septo-hippocampal System, 1982; The Neuropsychology of Anxiety, 2000] departs from the prevailing view of that structure as a substrate for memory. Instead, Gray and McNaughton have proposed that hippocampus is involved with a function that is more fundamental than memory, namely the resolution of conflict between competing approach and avoidance tendencies. The present paper attempts to advance this perspective by describing how the effects of selective lesions of the hippocampus on performance in both relatively simple Pavlovian conditioning tasks and in more complex radial maze problems could be a consequence of an impairment in a simple form of inhibitory learning. Specifically, we consider the idea that the hippocampus is needed to form simple inhibitory associations between events that are concurrently embedded in simple excitatory associations [Behav Brain Res 119 (2001) 111]. This idea is compared with the conflict resolution hypothesis offered by Gray and McNaughton and avenues of integration are noted. In addition, the potential role for inhibitory learning in hippocampal-dependent spatial and contextual information processing is also discussed.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Davidson TL,Jarrard LEdoi
10.1016/j.neubiorev.2004.02.001subject
Has Abstractpub_date
2004-05-01 00:00:00pages
261-71issue
3eissn
0149-7634issn
1873-7528pii
S0149763404000302journal_volume
28pub_type
杂志文章,评审abstract：:The apolipoprotein (APOE) ε4 allele has been proposed as an example of an antagonistic pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental impact on cognition during later years. However, findings on the cognitive associations of the ε4 allele in younger persons are mixed. This...
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abstract：:The consumption of alcohol during gestation is detrimental to the developing central nervous system (CNS). The severity of structural and functional brain alterations associated with alcohol intake depends on many factors including the timing and duration of alcohol consumption. The hippocampal formation, a brain regi...
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