Abstract：
BACKGROUND:Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. OBJECTIVES:To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty. RESULTS:Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited. CONCLUSIONS:Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Carucci S,Balia C,Gagliano A,Lampis A,Buitelaar JK,Danckaerts M,Dittmann RW,Garas P,Hollis C,Inglis S,Konrad K,Kovshoff H,Liddle EB,McCarthy S,Nagy P,Panei P,Romaniello R,Usala T,Wong ICK,Banaschewski T,Sonuga-Bardoi
10.1016/j.neubiorev.2020.09.031subject
Has Abstractpub_date
2020-10-17 00:00:00eissn
0149-7634issn
1873-7528pii
S0149-7634(20)30592-3pub_type
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