当前位置： SCI文献检索 > NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS期刊下所有文献 > Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-protein in children with neurodevelopmental disorders.

Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-protein in children with neurodevelopmental disorders.

Abstract：

:The tubulin-associated unit (Tau) protein is an intrinsically disordered protein that plays a well-established role in promoting microtubule assembly and regulation of microtubule dynamics in neuronal axons at all stages of development. Identification of new interacting partners and different sub-cellular localizations of Tau in recent years led to the discovery of novel physiological functions in regulation of neuronal activity, neurogenesis, long-term depression, iron export and genomic integrity. In addition, Tau gene mutations, aberrant mRNA splicing and abnormal post-translational modifications, such as hyperphosphorylation, lead to formation of pathological, insoluble Tau aggregates that are a hallmark of neurodegenerative diseases, collectively known as tauopathies. Characterized by synaptic dysfunction, neuroinflammation/neuronal cell death and dementia, tauopathies are designated as a group of adult-onset neurodegenerative diseases. Recent studies summarized in this review document several neurological conditions and diseases in an early life stage with upregulated levels or even pathological aggregation of abnormally phosphorylated Tau protein. These findings suggest that Tau might play a previously underestimated role in neurodevelopmental disorders and regression in children.

journal_name

Neurosci Biobehav Rev

journal_title

Neuroscience and biobehavioral reviews

authors

Rankovic M,Zweckstetter M

doi

10.1016/j.neubiorev.2018.12.014

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

1-9

eissn

0149-7634

issn

1873-7528

pii

S0149-7634(18)30730-9

journal_volume

98

pub_type

杂志文章,评审

相关文献

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS文献大全
  • Evidence for the role of corticotropin-releasing factor in major depressive disorder.

    abstract：:Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in the European Union alone. Although a wealth of research has been directed toward understanding and treating MDD, still no therapy has ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2015.07.011

    authors： Waters RP,Rivalan M,Bangasser DA,Deussing JM,Ising M,Wood SK,Holsboer F,Summers CH

    更新日期：2015-11-01 00:00:00

  • Lateralization of brain mechanisms underlying automatic and controlled forms of spatial orienting of attention.

    abstract：:Unilateral Spatial Neglect (USN) can be considered as a defect in spatial orienting of attention toward the half space contralateral to the damaged hemisphere. Since the classical work of Brain, W.R. Brain 64:224-272 (1941), several authors have emphasized that this defect is definitely more frequent and severe in pat...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/0149-7634(95)00074-7

    authors： Gainotti G

    更新日期：1996-01-01 00:00:00

  • Prenatal malnutrition and development of the brain.

    abstract：:In this review, we have summarized various aspects as to how prenatal protein malnutrition affects development of the brain and have attempted to integrate several broad principles, concepts, and trends in this field in relation to our findings and other studies of malnutrition insults. Nutrition is probably the singl...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(05)80234-9

    authors： Morgane PJ,Austin-LaFrance R,Bronzino J,Tonkiss J,Díaz-Cintra S,Cintra L,Kemper T,Galler JR

    更新日期：1993-04-01 00:00:00

  • The role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for autism spectrum disorder and schizophrenia.

    abstract：:Exposure to maternal infection in utero increases the risk that offspring will develop neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Research in animal models has confirmed this link and demonstrated that maternal immune activation (MIA) is sufficient to induce alterations in o...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章

    doi：10.1016/j.neubiorev.2019.06.020

    authors： Guma E,Plitman E,Chakravarty MM

    更新日期：2019-09-01 00:00:00

  • Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy.

    abstract：:Seizures induced by pilocarpine (PILO) have proven to be a useful procedure for investigating the basic mechanisms essential for generation, spread and motor expression of seizures in rodents. Here we report the long-term effects of PILO in rats. Following PILO (380 mg/kg, IP), 3 distinct phases were observed: 1) an a...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章

    doi：10.1016/s0149-7634(05)80076-4

    authors： Leite JP,Bortolotto ZA,Cavalheiro EA

    更新日期：1990-01-01 00:00:00

  • Interacting brain systems modulate memory consolidation.

    abstract：:Emotional arousal influences the consolidation of long-term memory. This review discusses experimental approaches and relevant findings that provide the foundation for current understanding of coordinated interactions between arousal activated peripheral hormones and the brain processes that modulate memory formation....

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2011.11.001

    authors： McIntyre CK,McGaugh JL,Williams CL

    更新日期：2012-08-01 00:00:00

  • Life stages and risk-avoidance: status- and context-sensitivity in precaution systems.

    abstract：:Human typical life history involves specific tradeoffs, resulting in the selection of specific cognitive adaptations, among which a suite of age- and gender-specific precaution systems sensitive to variations in the physical and social environment. Precaution systems take into account the individual's status and life-...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2010.09.007

    authors： Lienard P

    更新日期：2011-03-01 00:00:00

  • The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes.

    abstract：:Depression is a common and disabling psychiatric disorder with a complex etiology, which includes predisposing risk genes and environmental stressors. Variation in the Catechol-O-Methyltransferase (COMT) gene, the Val158Met polymorphism in particular, has been extensively investigated in relation to clinical phenotype...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2013.06.006

    authors： Antypa N,Drago A,Serretti A

    更新日期：2013-09-01 00:00:00

  • Neurosteroids, stress and depression: potential therapeutic opportunities.

    abstract：:Neurosteroids are potent and effective neuromodulators that are synthesized from cholesterol in the brain. These agents and their synthetic derivatives influence the function of multiple signaling pathways including receptors for γ-aminobutyric acid (GABA) and glutamate, the major inhibitory and excitatory neurotransm...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2012.10.005

    authors： Zorumski CF,Paul SM,Izumi Y,Covey DF,Mennerick S

    更新日期：2013-01-01 00:00:00

  • Applying incentive sensitization models to behavioral addiction.

    abstract：:The incentive sensitization theory is a promising model for understanding the mechanisms underlying drug addiction, and has received support in animal and human studies. So far the theory has not been applied to the case of behavioral addictions like Gambling Disorder, despite sharing clinical symptoms and underlying ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2014.07.009

    authors： Rømer Thomsen K,Fjorback LO,Møller A,Lou HC

    更新日期：2014-09-01 00:00:00

  • Recovering from cocaine: insights from clinical and preclinical investigations.

    abstract：:Cocaine remains one of the most addictive substances of abuse and one of the most difficult to treat. Although increasingly sophisticated experimental and technologic advancements in the last several decades have yielded a large body of clinical and preclinical knowledge on the direct effects of cocaine on the brain, ...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2013.04.007

    authors： Hanlon CA,Beveridge TJ,Porrino LJ

    更新日期：2013-11-01 00:00:00

  • Hormonal regulation of sociosexual behavior in female mammals.

    abstract：:The role of estrogen (E) and progesterone (P) in regulating the expression of agonistic, scent marking and proceptive displays is reviewed. In the intact sexually mature female, data indicate that agonistic, scent marking and proceptive patterns of behavior fluctuate significantly prior to and during the period of mat...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(05)80062-4

    authors： Takahashi LK

    更新日期：1990-01-01 00:00:00

  • Depression after myocardial infarction: TNF-α-induced alterations of the blood-brain barrier and its putative therapeutic implications.

    abstract：:Patients experiencing an acute myocardial infarction (AMI) have a three times higher chance to develop depression. Vice versa, depressive symptoms increase the risk of cardiovascular events. The co-existence of both conditions is associated with substantially worse prognosis. Although the underlying mechanism of the i...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2013.02.004

    authors： Liu H,Luiten PG,Eisel UL,Dejongste MJ,Schoemaker RG

    更新日期：2013-05-01 00:00:00

  • Changing handedness: What can we learn from preference shift studies?

    abstract：:Handedness is a dynamic and complex aspect of human behavior. Changing it through practice, either willingly or obliged by some reason, requires a considerable amount of effort. Analyzing studies that presented handedness shifts may expand our comprehension of this phenomenon, since knowing how to change it might prov...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2019.09.019

    authors： Marcori AJ,Monteiro PHM,Okazaki VHA

    更新日期：2019-12-01 00:00:00

  • Neural correlates of emotion-attention interactions: From perception, learning, and memory to social cognition, individual differences, and training interventions.

    abstract：:Due to their ability to capture attention, emotional stimuli tend to benefit from enhanced perceptual processing, which can be helpful when such stimuli are task-relevant but hindering when they are task-irrelevant. Altered emotion-attention interactions have been associated with symptoms of affective disturbances, an...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2019.08.017

    authors： Dolcos F,Katsumi Y,Moore M,Berggren N,de Gelder B,Derakshan N,Hamm AO,Koster EHW,Ladouceur CD,Okon-Singer H,Pegna AJ,Richter T,Schweizer S,Van den Stock J,Ventura-Bort C,Weymar M,Dolcos S

    更新日期：2020-01-01 00:00:00

  • Rett syndrome before regression: A time window of overlooked opportunities for diagnosis and intervention.

    abstract：:Rett syndrome (RTT) is a rare neurological disorder primarily affecting females, causing severe cognitive, social, motor and physiological impairments for which no cure currently exists. RTT clinical diagnosis is based on the peculiar progression of the disease, since patients show an apparently normal initial develop...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2019.05.013

    authors： Cosentino L,Vigli D,Franchi F,Laviola G,De Filippis B

    更新日期：2019-12-01 00:00:00

  • Corticospinal activity during dual tasking: a systematic review and meta-analysis of TMS literature from 1995 to 2013.

    abstract：:This systematic review and meta-analysis was conducted across studies using transcranial magnetic stimulation to investigate corticospinal excitability and inhibition in response to a dual task (DT). Quantitative analysis was performed on eleven controlled studies that had included healthy participants over the age of...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.neubiorev.2014.03.017

    authors： Corp DT,Lum JA,Tooley GA,Pearce AJ

    更新日期：2014-06-01 00:00:00

  • Discontinuities along lines: psychophysics and neurophysiology.

    abstract：:If a segment of a line differs in luminance or color from the rest of the line, three illusory phenomena may be perceived: a reduction in contrast of the line segment relative to the background, subjective contours running perpendicularly to the ends of the line segment, and spread of color or brightness surrounding t...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(89)80047-8

    authors： Redies C

    更新日期：1989-04-01 00:00:00

  • Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: A meta-analysis.

    abstract：:Smaller hippocampal volume is associated with increased risk for PTSD following trauma, but the hippocampal functions involved remain unknown. We propose a conceptual model that identifies broad impairment in hippocampus-dependent associative learning as a vulnerability factor for PTSD. Associative learning of foregro...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.neubiorev.2019.09.024

    authors： Lambert HK,McLaughlin KA

    更新日期：2019-12-01 00:00:00

  • Audiotactile interactions in front and rear space.

    abstract：:The last few years have seen a growing interest in the assessment of audiotactile interactions in information processing in peripersonal space. In particular, these studies have focused on investigating peri-hand space [corrected] and, more recently, on the functional differences that have been demonstrated between th...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2010.07.004

    authors： Occelli V,Spence C,Zampini M

    更新日期：2011-01-01 00:00:00

  • Creative cognition and dopaminergic modulation of fronto-striatal networks: Integrative review and research agenda.

    abstract：:Creative cognition is key to human functioning yet the underlying neurobiological mechanisms are sparsely addressed and poorly understood. Here we address the possibility that creative cognition is a function of dopaminergic modulation in fronto-striatal brain circuitries. It is proposed that (i) creative cognition be...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2017.04.007

    authors： Boot N,Baas M,van Gaal S,Cools R,De Dreu CKW

    更新日期：2017-07-01 00:00:00

  • Unisensory and multisensory temporal processing in autism and dyslexia: A systematic review and meta-analysis.

    abstract：:This study presents a comprehensive systematic review and meta-analysis of temporal processing in autism spectrum disorder (ASD) and developmental dyslexia (DD), two neurodevelopmental disorders in which temporal processing deficits have been highly researched. The results provide strong evidence for impairments in te...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2020.06.013

    authors： Meilleur A,Foster NEV,Coll SM,Brambati SM,Hyde KL

    更新日期：2020-09-01 00:00:00

  • Memory formation, consolidation and transformation.

    abstract：:Memory formation is a highly dynamic process. In this review we discuss traditional views of memory and offer some ideas about the nature of memory formation and transformation. We argue that memory traces are transformed over time in a number of ways, but that understanding these transformations requires careful anal...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2012.03.001

    authors： Nadel L,Hupbach A,Gomez R,Newman-Smith K

    更新日期：2012-08-01 00:00:00

  • Duchenne muscular dystrophy: a cerebellar disorder?

    abstract：:Cyrulnik, S.C., and V.J. Hinton. Duchenne muscular dystrophy: A cerebellar disorder? NEUROSCI. BIOBEHAV. REV. Duchenne muscular dystrophy (DMD) is a genetic disorder that is often associated with cognitive deficits. These cognitive deficits have been linked to the absence of dystrophin, a protein product which is norm...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2007.09.001

    authors： Cyrulnik SE,Hinton VJ

    更新日期：2008-01-01 00:00:00

  • Hippocampal GABAergic interneurons and their co-localized neuropeptides in stress vulnerability and resilience.

    abstract：:Studies in humans and rodents suggest a critical role for the hippocampal formation in cognition and emotion, but also in the adaptation to stressful events. Successful stress adaptation promotes resilience, while its failure may lead to stress-induced psychopathologies such as depression and anxiety disorders. Hippoc...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2020.11.002

    authors： Albrecht A,Redavide E,Regev-Tsur S,Stork O,Richter-Levin G

    更新日期：2020-11-12 00:00:00

  • Microgravity effects on the human brain and behavior: Dysfunction and adaptive plasticity.

    abstract：:Emerging plans for travel to Mars and other deep space destinations make it critical for us to understand how spaceflight affects the human brain and behavior. Research over the past decade has demonstrated two co-occurring patterns of spaceflight effects on the brain and behavior: dysfunction and adaptive plasticity....

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2020.11.017

    authors： Hupfeld KE,McGregor HR,Reuter-Lorenz PA,Seidler RD

    更新日期：2021-01-14 00:00:00

  • Modulation of dopamine neuronal activity by glutamate receptor subtypes.

    abstract：:In vitro and in vivo electrophysiological studies have been used to assess the effects of glutamate, as well as specific agonists and antagonists for ionotropic, N-methyl-D-aspartate (NMDA), (R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and kainate, and metabotropic subtypes of the glutamate re...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(96)00030-9

    authors： Meltzer LT,Christoffersen CL,Serpa KA

    更新日期：1997-07-01 00:00:00

  • Combining aerobic exercise and repetitive transcranial magnetic stimulation to improve brain function in health and disease.

    abstract：:The aetiology of various psychiatric and neurological disorders may be partially attributable to impairments in neuroplasticity. Developing novel methods of stimulating neuroplasticity is a promising treatment approach to counterbalance these maladaptive influences and alleviate symptomologies. Two non-pharmacological...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/j.neubiorev.2017.09.023

    authors： Hendrikse J,Kandola A,Coxon J,Rogasch N,Yücel M

    更新日期：2017-12-01 00:00:00

  • Variations of meal-to-meal liver glycogen in rats.

    abstract：:Liver glycogen content was determined in free feeding rats sacrificed at the beginning of nocturnal meals or 60 min later. It was found that the glycogen content at the beginning of meals and 60 min later was highly correlated with the cumulative food intake since the beginning of the dark cycle, and therefore, increa...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章

    doi：10.1016/0149-7634(80)90044-5

    authors： Le Magnen J,Devos M

    更新日期：1980-01-01 00:00:00

  • Enhancement of opioid-mediated analgesia: a solution to the enigma of placentophagia.

    abstract：:Two major consequences of placentophagia, the ingestion of afterbirth materials that occurs usually during mammalian parturition, have been uncovered in the past several years. The first is that increased contact, associated with ingesting placenta and amniotic fluid from the surface of the young, causes an accelerate...

    journal_title：Neuroscience and biobehavioral reviews

    pub_type： 杂志文章,评审

    doi：10.1016/s0149-7634(05)80035-1

    authors： Kristal MB

    更新日期：1991-10-01 00:00:00