Abstract：
:Insulin is a potent mitogen for many cell types in vitro. During tissue culture, supraphysiological concentrations of insulin are necessary to promote cell replication in connective or musculoskeletal tissues. Insulin promotes the growth of these cells by binding, with low affinity, to the type I insulin-like growth factor (IGF) receptor, not through the high affinity insulin receptor. In other cell types, such as hepatocytes, embryonal carcinoma cells, or mammary tumor cells, the type I IGF receptor is virtually absent, and insulin stimulates the growth of these cells at physiological concentrations by binding to the high affinity insulin receptor. Both receptor systems activate phosphorylation reactions within the cell which extend to ribosomal proteins. Insulin acts synergistically with other factors, such as platelet-derived growth factor and epidermal growth factor, to stimulate the progression of cells through the cycle of proliferation. Abnormal insulin secretion or action, before or after birth, often is associated with disordered growth suggesting that insulin may function as a growth factor in vivo. Poor growth follows impaired insulin secretion in diabetes mellitus. This is associated with reduced circulating levels of IGF's which may be partly responsible for the growth failure. Insulin has a direct action on release of IGF's from the liver in vitro, but during experimental diabetes there is a reduced number of hepatic somatotropic receptors which could limit the ability of growth hormone to regulate IGF release. Diabetic children, treated conventionally, have normal circulating IGF levels, but both growth rate and serum IGF concentration may increase dramatically when diabetic control is optimized.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Hill DJ,Milner RDdoi
10.1203/00006450-198509000-00001subject
Has Abstractpub_date
1985-09-01 00:00:00pages
879-86issue
9eissn
0031-3998issn
1530-0447journal_volume
19pub_type
杂志文章,评审abstract：:The present study employed an animal model in an attempt to document effects on brain growth of long-term exposure to theophylline in the presence or absence of malnutrition. One group of dams was randomly divided into half. One-half was fed a 20% protein diet and the other half a 6% protein diet. Similarly, a second ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198406000-00014
更新日期：1984-06-01 00:00:00
abstract：BACKGROUND:To investigate whether the YAP/TAZ (Yes-associated protein/transcriptional coactivator with PDZ binding motif) pathway contributes to the pathogenesis of lymphatic malformations (LMs). METHODS:YAP, TAZ, CTGF (connective tissue growth factor), and Ki-67 were detected in LMs by immunohistochemistry. The coloc...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-0863-0
更新日期：2020-04-12 00:00:00
abstract：:Chenodeoxycholic acid labeled with 2H in the 11 and positions was prepared by catalytic reduction of delta 11-12 unsaturated derivatives of cholic acid. To validate the use of this stable isotope for the determination of bile acid kinetics by isotope dilution, it was administered to seven normal male volunteers simult...
journal_title：Pediatric research
pub_type： 杂志文章
doi：
更新日期：1975-10-01 00:00:00
abstract：:Argininosuccinate synthetase and argininosuccinate lyase catalyze the conversion of citrulline to arginine in kidney. Immunohistochemical staining of mouse kidney sections with antibodies to these two enzymes, compared with the staining patterns of known markers for proximal tubules, demonstrated that these enzymes ar...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199102000-00010
更新日期：1991-02-01 00:00:00
abstract：:The ontogeny of glutamine uptake by jejunal brush border membrane vesicles was studied in suckling and weanling rats and compared with the data obtained from previous studies done on adult rats in our laboratory. Glutamine uptake represented transport into the intravesicular space rather than mere binding into the mem...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199005000-00021
更新日期：1990-05-01 00:00:00
abstract：:The two pathways of de novo lecithin synthesis, choline incorporation (I) and phosphatidylethanolamine methylation (II), were examined in lung slices from rhesus monkey fetuses throughout the last half of gestation. Incorporation rates of pathway-specific radioactive precursors were used as a measure of lecithin produ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197508000-00009
更新日期：1975-08-01 00:00:00
abstract：:Indomethacin, because of its prostaglandin inhibition, may cause constriction of the ductus arteriosus and affect the pulmonary circulation. To study this possibility, we gave indomethacin daily by gavage to two groups of pregnant rats from the 17th day of pregnancy through delivery (group 1, 2 mg/kg/day; group 2, 4 m...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198102000-00013
更新日期：1981-02-01 00:00:00
abstract：:Whether severe hypoglycemia alone or in combination with hyperketonemia might cause deterioration of cardiac function has been controversial. Therefore, the influence of acute hypoglycemia (mean 33 mg/dL) with and without hyperketonemia (mean 1.3 and 3.3 mM) on cardiac function, substrate utilization, and myocardial h...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198912000-00002
更新日期：1989-12-01 00:00:00
abstract：:We studied the effects of anemia and ouabain administration on cardiac function, oxygen physiology, and blood catecholamine levels in nine newborn lambs. We measured oxygen consumption continuously, along with traditional hemodynamic variables. Oxygen transport was calculated. Following baseline measurements, lambs we...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198705000-00005
更新日期：1987-05-01 00:00:00
abstract：:The effect of alpha-adrenergic blockade by phentolamine on the pulmonary vascular response to dopamine was studied in chronically prepared newborn lambs. Dopamine was administered at doses of 2.7 micrograms . kg-1 . min-1, 27 micrograms . kg-1 . min-1 and 270 micrograms . kg-1 . min-1 with and without alpha-adrenergic...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198306000-00007
更新日期：1983-06-01 00:00:00
abstract：INTRODUCTION:Very early preterm infants (VPIs) are exposed to unpredictable noise in neonatal intensive care units. Their ability to perceive moderate acoustic environmental changes has not been fully investigated. RESULTS:Physiological values of the 598 isolated sound peaks (SPs) that were 5-10 and 10-15 dB slow-resp...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2011.76
更新日期：2012-04-01 00:00:00
abstract：:Little information is available regarding the time, rhythm, number, and appropriate dosage of human chorionic gonadotropin (HCG) for adequate testing of testicular function in human. The time course of the effect of two, three, or seven HCG injections at intervals of one, five, and two days, respectively, on the plasm...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198006000-00009
更新日期：1980-06-01 00:00:00
abstract：:An infant with the acute neonatal form of pyruvate carboxylase deficiency (cross-reacting material negative) presented with severe intractable lactic acidosis within 4 h after birth. He also had hyperammonemia, hypercitrullinemia, and hyperlysinemia. Plasma glutamine was not elevated. He had a rapidly deteriorating cl...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198603000-00016
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND:Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persistence of PDA, and with failure of pharmacological treatment for PDA, in extremely preterm infants. MET...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-018-0182-x
更新日期：2019-09-01 00:00:00
abstract：:The relationship between cerebral blood flow (CBF) and the evolution of brain edema was investigated in an experimental model of perinatal hypoxic-ischemic brain damage. Seven-d postnatal rats were subjected to unilateral common carotid artery ligation followed by 3 h of hypoxia with 8% oxygen at 37 degrees C. This in...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199005000-00007
更新日期：1990-05-01 00:00:00
abstract：:Myocardial oxygen demand may be increased in chronically hypoxemic lambs because of their increased heart rate. Therefore, we determined whether left ventricular (LV) oxygen supply, oxygen uptake and oxygen demand were proportionally increased in 6-wk-old lambs, after 4 wk of hypoxemia (n = 15), as compared with contr...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199310000-00017
更新日期：1993-10-01 00:00:00
abstract：:Pregnane steroids have sedative and neuroprotective effects on the brain, due to interactions with the steroid-binding site of the GABAA receptor. In the adult brain, synthesis of the pregnane steroids is increased in response to stress. Therefore, we have used umbilicoplacental embolization to mimic chronic placental...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000088066.47755.36
更新日期：2003-12-01 00:00:00
abstract：:Ca2+ transients were examined in embryonic chick hearts with an experimentally induced cardiac neural crest-related outflow tract defect known as persistent truncus arteriosus (PTA). In all of the animal models of neural crest-related heart defects, prenatal mortality is too high to be attributed to structural defects...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199712000-00002
更新日期：1997-12-01 00:00:00
abstract：:Catecholamines (CA) are released from and resynthesized in the adrenal medulla in response to stress. In the mature animal, stimulus-secretion-synthesis coupling occurs through transsynaptic (neuronal) activity. In contrast, in the immature animal, before functional adrenal innervation, certain stressors (hypoglycemia...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199412000-00006
更新日期：1994-12-01 00:00:00
abstract：:To study the normal development of blood coagulation factor activities in a growing fetus while avoiding the effects of labor and delivery, a chronic fetal lamb model was developed in which serial blood samples from 10 fetuses were studied during the third trimester of pregnancy and 24 hr after birth. Under operating ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198107000-00014
更新日期：1981-07-01 00:00:00
abstract：:Phototherapy results in the conversion of bilirubin to more water-soluble isomers. Six clinically used phototherapy lamps which differ in their emission spectra have been compared in their ability to produce configurational and structural isomers of bilirubin in vitro. For all of the lamps, the initial rate of configu...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198407000-00021
更新日期：1984-07-01 00:00:00
abstract：:Mutations in multidrug resistance 3 gene (MDR3 or ABCB4) underlie progressive familial intrahepatic cholestasis type 3 (PFIC3), a severe pediatric liver disease progressing to cirrhosis. Abcb4-/- mice exhibit slowly developing hepatic lesions that can be accelerated by feeding a cholic acid (CA)-supplemented diet. We ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/pdr.0b013e31802d7780
更新日期：2007-02-01 00:00:00
abstract：:Fetal dermal wounds heal scarlessly and with a minimal inflammatory response. When a robust inflammatory response is induced at the site of fetal dermal wounds by the application of cytokines, healing results in fibrosis. To test the hypothesis that the reduced inflammatory response in fetal wounds is due to impaired ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.pdr.0000184326.01884.bc
更新日期：2005-12-01 00:00:00
abstract：:This study was made to determine the life span of adult red cells transfused to early preterm infants. Nineteen very preterm infants (birth weight, 878.7 +/- 221 g; gestational age, 26.8 +/- 1.5 wk at birth) were sampled weekly after their last blood transfusion to determine the level (%) of fetal Hb in their circulat...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199707000-00002
更新日期：1997-07-01 00:00:00
abstract：INTRODUCTION:The Coulter LH780 hematology analyzer can evaluate mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS), and distribution width (DW). We sought to investigate the value of volume, conductivity, and scatter (VCS) parameters in diagnosis and treatment efficacy of neonatal sepsis. RESULTS:We obser...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2011.16
更新日期：2012-01-01 00:00:00
abstract：:We studied the mechanisms by which C16:0 lysophosphatidylcholine (LPC) and albumin inhibit the surface activity of calf lung surfactant extract (CLSE) by using a pulsating bubble apparatus with a specialized hypophase exchange system, plus adsorption and Wilhelmy balance measurements. In the absence of inhibitors, CLS...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199907000-00015
更新日期：1999-07-01 00:00:00
abstract：:Studies in adult animal and human subjects have suggested that the methylxanthine drugs can delay the onset or attenuate the severity of diaphragmatic fatigue. We have investigated the effect of aminophylline and caffeine on the pressure-generating capacity of the fatigued diaphragm in 1-mo-old piglets. Measurements o...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199211000-00019
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:A lack of consensus exists as to the timing of kidney biopsy in children with steroid-dependent nephrotic syndrome (SDNS) where minimal change disease (MCD) predominates. This study aimed at examining the applicability of a biomarker-assisted risk score model to select SDNS patients at high risk of focal seg...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0277-z
更新日期：2019-03-01 00:00:00
abstract：:The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of ...
journal_title：Pediatric research
pub_type： 杂志文章,评审
doi：10.1203/01.PDR.0000181381.82856.23
更新日期：2005-11-01 00:00:00
abstract：:To localize fetal rabbit lung beta-adrenoreceptors before and after glucocorticoid treatment, light microscopic autoradiography was performed with the reversible radiolabeled beta-adrenergic antagonist, [3H]dihydroalprenolol, on day 26 of gestation. Autoradiograms of adult lung and fetal myocardium were also prepared....
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198411000-00028
更新日期：1984-11-01 00:00:00
