Decision rule approach applied to estimate occupational lead exposure in a case-control study of kidney cancer.

Abstract:

BACKGROUND:We developed a systematic, data-driven approach to estimate metrics of occupational exposure to lead to aid in epidemiologic analyses in a case-control study of kidney cancer. METHODS:Probability of exposure to ten lead sources was assigned using decision rules developed from an extensive literature review and expert judgement. For jobs with >50% probability of exposure, we assigned source-specific frequency based on subjects' self-reported task frequencies or means of subjects' job-groups and source-specific intensity estimates of blood lead (μg/dL). RESULTS:In our study, 18.7% of employed person-years were associated with high (≥80%) probability of exposure to any lead source. The most common medium (>50%) or high probability source of lead exposure was leaded gasoline (2.5% and 11.5% of employed person-years, respectively). The median blood lead attributed to occupational exposure was 3.1 μg/dL. CONCLUSIONS:These rules can aid in future studies after population-specific adaption for geographic differences and different exposure scenarios.

journal_name

Am J Ind Med

authors

Callahan CL,Locke SJ,Dopart PJ,Stewart PA,Schwartz K,Ruterbusch JJ,Graubard BI,Rothman N,Hofmann JN,Purdue MP,Friesen MC

doi

10.1002/ajim.22912

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

901-910

issue

11

eissn

0271-3586

issn

1097-0274

journal_volume

61

pub_type

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