Abstract：
PURPOSE:Microbial keratitis (MK) is a major cause of corneal blindness worldwide. Variations in season and temperature can affect MK incidence due to specific causative organisms; however, few studies have examined these factors in the UK. METHODS:Retrospective review of all corneal scrapes from patients with MK presenting to Manchester Royal Eye Hospital, UK, between January 2004 and December 2015. Manchester's monthly temperature data were obtained from Met Office UK. Analysis was performed using logistic regression. RESULTS:From 4229 corneal scrapes, 1539 organisms grew (90.6% bacteria, 7.1% fungi, and 2.3% Acanthamoebae sp.). Gram-positive bacteria grew with increasing temperature [odds ratio (OR) 1.62, 95% CI: 1.11-2.39, P = 0.014], and fungi grew with decreasing temperature (OR 0.29, 95% CI: 0.16-0.51, P < 0.001). Moraxella sp. grew with decreasing temperature (OR 0.91, 95% CI: 0.86-0.96, P = 0.001). Compared with winter, overall culture positivity was significantly less likely in summer (OR 0.57, 95% CI: 0.38-0.87, P = 0.008) and spring (OR 0.65, 95% CI: 0.43-0.99, P = 0.045). Gram-negative bacteria were more likely in summer (OR 1.48, 95% CI: 1.06-2.09, P = 0.022) and autumn (OR 1.75, 95% CI: 1.24-2.47, P = 0.001). Candida sp. were less likely in summer (OR 0.25, 95% CI: 0.07-0.82, P = 0.027) and autumn (OR 0.18, 95% CI: 0.05-0.62, P = 0.009), and Acanthamoeba sp. were less likely in summer (OR 0.39, 95% CI: 0.15-0.92, P = 0.037) and spring (OR 0.26, 95% CI: 0.08-0.69, P = 0.011). CONCLUSIONS:Herein we report variation in the incidence of MK-causing organisms by season and temperature; this finding may aid clinicians in predicting possible causative organisms for MK at differing times of the year.
journal_name
Corneajournal_title
Corneaauthors
Walkden A,Fullwood C,Tan SZ,Au L,Armstrong M,Brahma AK,Chidambaram JD,Carley Fdoi
10.1097/ICO.0000000000001748subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1555-1560issue
12eissn
0277-3740issn
1536-4798journal_volume
37pub_type
杂志文章,多中心研究相关文献
CORNEA文献大全abstract：:The objective of this study was to compare four methods of counting corneal endothelial cell density using the Topcon SP 1000 microscope and Image-NET digital graphic software. Two independent observers quantified cell density from 63 endothelial photomicrographs using the various standardized techniques. The first me...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/00003226-199605000-00008
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:To describe a case of bilateral peripheral ulcerative keratitis after Salmonella gastroenteritis. METHODS:Case report with description of treatment and outcome. RESULTS:The peripheral ulcerative keratitis gradually resolved in both eyes after appropriate systemic antibiotic therapy and local ocular care. CON...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/00003226-199811000-00017
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:This study explored a new method for removing thermosensitive acrylic punctal plugs from lacrimal puncta. METHODS:A total of 14 dry eye patients (14 eyes), who required the removal of thermosensitive acrylic punctal plugs from the lacrimal puncta because of serious complications, were recruited. Among the 14 p...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000000633
更新日期：2015-12-01 00:00:00
abstract：:An evaluation of the final "sutures out" postoperative astigmatism in two groups of keratoconus patients undergoing penetrating keratoplasty is presented. Group I consists of a retrospective evaluation of keratoconus patients who underwent penetrating keratoplasty without using the Troutman Keratometer prior to suturi...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/00003226-199309000-00005
更新日期：1993-09-01 00:00:00
abstract：PURPOSE:To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS:Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence...
journal_title：Cornea
pub_type： 杂志文章,多中心研究
doi：10.1097/ICO.0000000000001654
更新日期：2018-09-01 00:00:00
abstract：:Infectious keratitis after penetrating keratoplasty can be devastating to the survival of the graft and its visual outcome. From November 1989 to October 1994, we treated 41 episodes of late microbial keratitis among 354 consecutive penetrating keratoplasty patients and reviewed their medical records retrospectively. ...
journal_title：Cornea
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：PURPOSE:To investigate the effects of pterygium excision with conjunctival autograft plus corneal polishing on ocular higher-order aberrations (HOAs) and to monitor the changes throughout the first postoperative year. METHODS:A total of 18 eyes of 16 patients with primary pterygium who had an indication for surgical e...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3182431465
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:Patients undergoing primary pterygium excision with autologous conjunctival autograft and human tissue adhesive in New Zealand, currently receive subconjunctival anesthesia with oral postoperative analgesia for pain. Our aim was to investigate the potential added benefit of intraoperative subtenon bupivacaine t...
journal_title：Cornea
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/ICO.0000000000001973
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:To examine the validity of the observations made by specialist corneal surgeons that there seems to be an absence or loss of older patients with keratoconus (KC). METHODS:Using a PubMed search and key words such as KC, epidemiology, mortality, mitral valve prolapse, atopy, and asthma, the literature related to...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/ICO.0b013e31825aba0e
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To review ocular injuries secondary to airbag deployment that were seen in our institution and were reported in the literature. METHODS:Patients examined at our institution between 1997 and 2000 were evaluated for ocular injuries caused by airbags. A review of the medical literature using Medline was performed...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/00003226-200103000-00009
更新日期：2001-03-01 00:00:00
abstract：:Endothelial keratoplasty has revolutionized the treatment of corneal endothelial dysfunction and lowered the threshold for treatment by providing rapid visual rehabilitation and setting a high standard for safety and efficacy. Over time, endothelial keratoplasty techniques have evolved toward the use of thinner tissue...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000002565
更新日期：2020-11-30 00:00:00
abstract：:Two cases of intracorneal hemorrhage developing as a complication of aphakic contact lens use are reported. Patient 1 had a penetrating keratoplasty to restore vision and therefore the histologic examination could be performed on the corneal button. In patient 2 the contact lens use was discontinued with partial resol...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/00003226-199201000-00011
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To identify whether histopathologic presence of neovascularization is predictive for allograft failure following penetrating keratoplasty for herpes simplex virus (HSV) keratitis. METHODS:Retrospective, interventional case series of 62 consecutive patients with HSV keratitis who underwent penetrating keratopla...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31819c4e55
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare topographic and biomechanical properties of corneas in patients with acromegaly with those of healthy individuals. METHODS:Thirty-five patients with acromegaly (study group) and 35 healthy individuals (control group) were enrolled in this prospective study. Topographic meas...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000000297
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To describe the Oxford Scheme for grading ocular surface staining in dry eye and to discuss optimization of stain detection using various dyes and filters. Also, to propose a sequence of testing for dry eye diagnosis. METHODS:The grading of corneal and conjunctival staining is described, using the Oxford Schem...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/00003226-200310000-00008
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:To examine the tissue samples of 2 corneal recipients from a rabies-infected donor for the presence of rabies to explain their survival. METHODS:Interventional case series with a review of the literature. The explanted corneal donor buttons were examined via nested reverse transcriptase polymerase chain reacti...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/ICO.0b013e3181e4572a
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy of Dermabond with conventional nylon sutures for sealing linear corneal incisions. METHODS:A keratome knife was used to create a 4-mm full-thickness linear corneal incision anterior to the limbal arcade in 20 fresh pig eyes. The incision was sealed with Dermabond tissue adhesive or cl...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/01.ico.0000159734.75672.c4
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:Evaluation of contact lens-induced cytologic changes on the conjunctival surface. METHODS:Fifty eyes of 25 patients wearing soft or rigid gas-permeable contact lenses, and 50 healthy eyes of 25 control subjects were examined with conjunctival impression cytology. Of the patients wearing contact lenses, 40% did...
journal_title：Cornea
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：PURPOSE:To document the relationship of iris cavernous hemangiomas with multiorgan hemangiomas in a child. METHODS:A 7-year-old girl with kidney hemangiomas, brain hemangiomas, and skin hemangiomas developed blurred vision and darkening of the right iris. She had undergone 6 previous brain surgeries and multiple revis...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3180303b46
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the reliability of tear film osmolarity as a diagnostic tool for detecting dry eye disease (DED) in patients with rheumatoid arthritis (RA). The second aim was to determine whether there is a relationship between tear film osmolarity, a commonly used RA score, and diagnosti...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000000257
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:To examine the cornea of patients with Marfan syndrome in comparison with a control group by using the in vivo confocal microscope. METHODS:Twenty-four eyes of 12 patients with Marfan syndrome had their corneas examined using the in vivo confocal microscope Heidelberg Retina Tomograph (HRT) II/Rostock Cornea M...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31806c7729
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:To compare the relative diagnostic value of confocal microscopy and superficial corneal cultures in the diagnosis of Acanthamoeba keratitis by using clinical and microbiologic definitions of disease. METHODS:Results of confocal microscopy, superficial corneal smear, and superficial corneal culture were analyze...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31816f27bf
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To examine the carbohydrate sulfotransferase 6 (CHST6) gene in Chinese patients with macular corneal dystrophy (MCD). METHODS:Nineteen unrelated Chinese families with MCD, including 24 patients and 3 unaffected relatives, were examined. Genomic DNA was extracted from peripheral blood leukocytes. The coding reg...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3181ca2e74
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:Light reflex from the cornea and tear film as contributors to beautiful eyes ("eye sparkling") are reviewed. METHODS:A systematic literature review was conducted using "Purkinje-Sanson image," "corneal light reflex," "corneal topography," "corneal wavefront aberration," and "tear interference image" as search ...
journal_title：Cornea
pub_type： 杂志文章,评审
doi：10.1097/01.ico.0000247219.18295.5e
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:To present a novel apparatus for simulating the anterior and posterior segment pressure dynamics involved in executing Descemet membrane endothelial keratoplasty (DMEK) surgery when using a chamber-shallowing technique. METHODS:An artificial anterior chamber (AAC), 18-mm trephine, latex glove, two 3-mL syringe...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000001435
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:To evaluate endothelial cell damage after eye bank preparation and passage through 1 of 2 different injectors for Descemet membrane endothelial keratoplasty grafts. METHODS:Eighteen Descemet membrane endothelial keratoplasty grafts were prepared by Lions VisionGift with the standard partial prepeel technique a...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0000000000000690
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To assess the use of serial computed tomography (CT) in the detection of osteo-odonto-lamina resorption in osteo-odonto-keratoprosthesis (OOKP) and to investigate the use of new volumetric software, Advanced Lung Analysis software (3D-ALA; GE Healthcare), for detecting changes in OOKP laminar volume. METHODS:A...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e31825425d0
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Clinical research addressing the issue of donor globe decontamination is yet to establish convincing data for the optimal choice of an antimicrobial agent. METHODS:In a donor-globe decontamination study, the antimicrobial effectiveness of a fluoroquinolone antibiotic (ciprofloxacin, 0.3%) was evaluated for the...
journal_title：Cornea
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00003226-199801000-00008
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To study the corneal biocompatibility of bevacizumab on various cultured human corneal cells. METHODS:Cell cultures of corneal keratinocytes (CKs), corneal fibroblasts (CFs), and corneal endothelial cells (CECs) were harvested from human donor eyes and exposed to various concentrations of bevacizumab (0.25-5.0...
journal_title：Cornea
pub_type： 杂志文章
doi：10.1097/ICO.0b013e3180de1d0a
更新日期：2007-09-01 00:00:00
abstract：:Spontaneous ruptures in Descemet's membrane in Terrien's degeneration can result in a corneal intralamellar pocket of fluid. We present a case and discuss its management. ...
journal_title：Cornea
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
