Abstract:
BACKGROUND:Caffeine is a nonspecific adenosine receptor antagonist used in premature neonates to treat apnea of prematurity. While its use may reduce the incidence of bronchopulmonary dysplasia (BPD), the precise mechanisms remain unknown. Evidence of increased adenosine levels are noted in chronic lung diseases including tracheal aspirates of infants with BPD. Utilizing a well-characterized newborn mouse model of alveolar hypoplasia, we hypothesized that hyperoxia-induced alveolar inflammation and hypoplasia is associated with alterations in the adenosine signaling pathway. METHODS:Newborn murine pups were exposed to a 14-d period of hyperoxia and daily caffeine administration followed by a 14-d recovery period in room air. Lungs were collected at both time points for bronchoalveolar lavage (BAL) analysis as well as histopathology and mRNA and protein expression. RESULTS:Caffeine treatment increased inflammation and worsened alveolar hypoplasia in hyperoxia-exposed newborn mice. These changes were associated with decreased alveolar type II (ATII) cell numbers, increased cell apoptosis, and decreased expression of A2A receptors. Following discontinuation of caffeine and hyperoxia, lung histology returned to baseline levels comparable to hyperoxia exposure alone. CONCLUSION:Results of this study suggest a potentially adverse role of caffeine on alveolar development in a murine model of hyperoxia-induced alveolar hypoplasia.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Dayanim S,Lopez B,Maisonet TM,Grewal S,Londhe VAdoi
10.1038/pr.2013.233subject
Has Abstractpub_date
2014-03-01 00:00:00pages
395-402issue
3eissn
0031-3998issn
1530-0447pii
pr2013233journal_volume
75pub_type
杂志文章abstract::The response to the capsular polysaccharide of Haemophilus influenzae type b (Hib PS) has been used to determine the molecular basis of antibody gene diversity in humans. In contrast to the relatively restricted nature of anti-Hib PS heavy-chain variable region gene expression, a variety of light-chain variable region...
journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
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abstract::Supine sleeping, recommended to prevent sudden infant death, should be started in the delivery hospital, but meets concern that neonates may exhibit more intermittent hypoxia in this position. We aimed to demonstrate that intermittent hypoxia is equally rare in supine and side position. We enrolled 609 term neonates i...
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journal_title:Pediatric research
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journal_title:Pediatric research
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journal_title:Pediatric research
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pub_type: 杂志文章,多中心研究
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Pediatric research
pub_type: 杂志文章,多中心研究
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journal_title:Pediatric research
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更新日期:2006-08-01 00:00:00
abstract::Thyroid hemiagenesis is a rare form of thyroid dysgenesis of which some familial cases have been reported, including one associated with a heterozygous mutation in the Pax8 gene. However, the physiopathology remains not well known. The objectives of this study were 1) to describe the clinical features, 2) to look for ...
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