Abstract:
OBJECTIVE:This study validates the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), a screening tool for low-risk toddlers, and demonstrates improved utility compared with the original M-CHAT. METHODS:Toddlers (N = 16,071) were screened during 18- and 24-month well-child care visits in metropolitan Atlanta and Connecticut. Parents of toddlers at risk on M-CHAT-R completed follow-up; those who continued to show risk were evaluated. RESULTS:The reliability and validity of the M-CHAT-R/F were demonstrated, and optimal scoring was determined by using receiver operating characteristic curves. Children whose total score was ≥ 3 initially and ≥ 2 after follow-up had a 47.5% risk of being diagnosed with autism spectrum disorder (ASD; confidence interval [95% CI]: 0.41-0.54) and a 94.6% risk of any developmental delay or concern (95% CI: 0.92-0.98). Total score was more effective than alternative scores. An algorithm based on 3 risk levels is recommended to maximize clinical utility and to reduce age of diagnosis and onset of early intervention. The M-CHAT-R detects ASD at a higher rate compared with the M-CHAT while also reducing the number of children needing the follow-up. Children in the current study were diagnosed 2 years younger than the national median age of diagnosis. CONCLUSIONS:The M-CHAT-R/F detects many cases of ASD in toddlers; physicians using the 2-stage screener can be confident that most screen-positive cases warrant evaluation and referral for early intervention. Widespread implementation of universal screening can lower the age of ASD diagnosis by 2 years compared with recent surveillance findings, increasing time available for early intervention.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Robins DL,Casagrande K,Barton M,Chen CM,Dumont-Mathieu T,Fein Ddoi
10.1542/peds.2013-1813subject
Has Abstractpub_date
2014-01-01 00:00:00pages
37-45issue
1eissn
0031-4005issn
1098-4275pii
peds.2013-1813journal_volume
133pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract::Safe transportation of preterm and low birth weight infants requires special considerations. Both physiologic immaturity and low birth weight must be taken into account to properly position such infants. This clinical report provides guidelines for pediatricians and other caregivers who counsel parents of preterm and ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0559
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Recognition and treatment of evolving critical illness is a fundamental element of hospital care. Hospital systems should triage patients to receive appropriate levels of care. We describe here the levels of care, the frequency of near or actual cardiopulmonary arrest (code-blue events), identification mecha...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0852
更新日期:2007-04-01 00:00:00
abstract::Pediatrics is a multifaceted specialty that encompasses children's physical, psychosocial, developmental, and mental health. Pediatric care may begin periconceptionally and continues through gestation, infancy, childhood, adolescence, and young adulthood. Although adolescence and young adulthood are recognizable phase...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2151
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To determine whether upper airway resistance syndrome (UARS) can be recognized and distinguished from obstructive sleep apnea syndrome (OSAS) in prepubertal children based on clinical evaluations, and, in a subgroup of the population, to compare the efficacy of esophageal pressure (Pes) monitoring to that of ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp. Laboratory investigations revealed signs of disseminated intravascular coagulation. An underlying coagulation disorder was suspected, and therapy with recombinant tissue plasminogen activator, fresh-frozen...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2009-2913
更新日期:2011-05-01 00:00:00
abstract::In 1992, the Committee on Infectious Diseases and Committee on Fetus and Newborn of the American Academy of Pediatrics provided guidelines for prevention of early-onset group B streptococcal (GBS) disease through intrapartum chemoprophylaxis of selected maternal GBS carriers. The guidelines were based on demonstrated ...
journal_title:Pediatrics
pub_type: 指南,杂志文章,实务指引
doi:10.1542/peds.99.3.489
更新日期:1997-03-01 00:00:00
abstract::Involvement of the optic nerve, either because of inflammation or increased intracranial pressure, is a rare manifestation of Lyme disease. Of the 4 children reported here with optic nerve abnormalities, 2 had decreased vision months after disease onset attributable to optic neuritis, and 1 had headache and diplopia e...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.2.477
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:This report describes a new fatal syndrome observed in adolescent males at the initial presentation of diabetes mellitus. The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability. DESIGN:Case se...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,评审
doi:10.1542/peds.111.6.1447
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Sleep deprivation is commonly used to enhance the effectiveness of pediatric sedation and to decrease sedation failures. We reviewed our sedation database to evaluate the efficacy of sleep deprivation. METHODS:The entire pediatric sedation unit database (n = 5640) was reviewed retrospectively. Patients witho...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.5.1204
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:Vaccination does not cause sudden infant death syndrome (SIDS). However, SIDS peaks at 2 months of age, when vaccination encounters are frequent. There are no published estimates using population data on age of death and immunization coverage to indicate to practitioners how often coincident vaccination may o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2185
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:We examined the prevalence, persistence, secular and longitudinal trends, and predictors of steroid use in a diverse sample of adolescents. PARTICIPANTS AND METHODS:Data are from Project EAT-II (Eating Among Teens), a 5-year longitudinal study of eating, activity, weight, and related variables in 2516 middle...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-2529
更新日期:2007-03-01 00:00:00
abstract::Advancements in videoconferencing equipment and Internet-based tools for sharing information have resulted in widespread use of telemedicine for providing health care to people who live in remote areas. Given the limited supply of people trained to provide early-intervention services to infants and young children who ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0354J
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to identify important clinical predictors of change in the functional status of children with perinatally acquired human immunodeficiency virus (HIV) infection. METHODS:Children who were perinatally exposed to HIV underwent evaluation of growth, nutritional, and functional statu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.2.e24
更新日期:2000-08-01 00:00:00
abstract:CONTEXT:Hereditary angioedema (HAE) is a rare autosomal-dominant disease characterized by recurrent self-limiting episodes of skin and mucosal edema. Morbidity and mortality are significant, and new and pending therapies are now available to reduce the risk associated with the disease. OBJECTIVE:To update the reader o...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2011-0546
更新日期:2011-12-01 00:00:00
abstract::Delayed initiation of proper therapy for infants with primary infantile glaucoma results in an unnecessarily poor outcome. In an effort to understand why some infants and children had more advanced disease than others, researchers reviewed the records of 24 consecutive infants and children with this problem. The prese...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:Sleep disorders can cause substantial morbidity but often remain undiagnosed among adults. We identified a series of children with sleep-related symptoms and reviewed medical chart notes for the previous 2 years to determine how often sleep problems had been addressed. DESIGN:Observational. Setting. Two univ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.6.1375
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Unintentional injury is the leading cause of death among toddlers in the United States. Toddlers spend the majority of time at home, and the use of recommended safety practices can prevent many injuries. OBJECTIVE:Maternal psychological adjustment and understanding of child development are thought to influe...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1255
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS:Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study populat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-4286
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:High rates of use of child safety seats have been achieved. A remaining challenge in child passenger safety is to reach the Healthy People 2010 objective of child safety seat use to 100%. Several factors have been reported to influence child safety seat use. A child safety seat Hassles Scale was developed to ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2211
更新日期:2006-07-01 00:00:00
abstract::Extensive data available from more than 30 years of research reveal that children raised by gay and lesbian parents have demonstrated resilience with regard to social, psychological, and sexual health despite economic and legal disparities and social stigma. Many studies have demonstrated that children's well-being is...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2013-0377
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of physician-documented sexual histories in female adolescents who presented to an emergency department (ED) with symptoms suggestive of a sexually transmitted infection (STI). Our secondary objectives were to determine if physician-documented sexual history is associated with incr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1775
更新日期:2011-07-01 00:00:00
abstract::Given the pervasive use of screen-based media and the high prevalence of insufficient sleep among American youth and teenagers, this brief report summarizes the literature on electronic media and sleep and provides research recommendations. Recent systematic reviews of the literature reveal that the vast majority of s...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-1758J
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:Public funding for the Low Income Home Energy Assistance Program has never been sufficient to serve more than a small minority of income-eligible households. Low Income Home Energy Assistance Program funding has not increased with recent rapidly rising energy costs, harsh winter conditions, or higher child p...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2943
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVES:The prevalence and identification of hypertriglyceridemia in youths will likely will increase in the future as a consequence of childhood obesity and increased screening for dyslipidemias. We sought to review our clinical experience with hypertriglyceridemia, evaluate factors associated with increased trigly...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0367
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:In 2009, the National Children's Study (NCS) Vanguard Study tested the feasibility of household-based recruitment and participant enrollment using a birth-rate probability sample. In 2010, the NCS Program Office launched 3 additional recruitment approaches. We tested whether provider-based recruitment could i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-4410E
更新日期:2016-06-01 00:00:00
abstract::The role of chloride deficiency in the generation of hypokalemic metabolic alkalosis with elevated plasma renin activity and plasma aldosterone levels, normal blood pressure, and a renal concentrating defect was studied in six infants given a soy formula that was deficient in chloride. A deceleration in linear growth,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::Two instances of metopic craniosynostosis provide dramatic experiments of nature which implicate fetal head constraint as one cause of early sutural fusion. The presumed restriction of growth stretch at the metopic suture in one instance was due to a bicornuate uterus in which the fetal head was markedly constrained. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::The safe sedation of children for procedures requires a systematic approach that includes the following: no administration of sedating medication without the safety net of medical supervision; careful presedation evaluation for underlying medical or surgical conditions that would place the child at increased risk from...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2006-2780
更新日期:2006-12-01 00:00:00
abstract::Using the sample of 1726 special education students from the Collaborative Study of Children With Special Needs, the authors describe the related services being provided to the children and then analyze the relationship between service provision and class placement. Related services are provided in all settings, with ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To identify correlates of objectively measured sedentary behavior in a diverse sample of preschool children. METHODS:A total of 331 children (51% male, 51% black) from a wide range of ethnic and socioeconomic backgrounds in greater Columbia, South Carolina, were recruited for this study. Sedentary behavior (...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0748
更新日期:2011-11-01 00:00:00