Abstract：
BACKGROUND:Application of functional Near InfraRed Spectroscopy (fNIRS) in neurology is still limited as a good optical coupling and optimized optode coverage of specific brain regions remains challenging, notably for prolonged monitoring. METHODS:We propose to evaluate a new procedure allowing accurate investigation of specific brain regions. The procedure consists in: (i) A priori maximization of spatial sensitivity of fNIRS measurements targeting specific brain regions, while reducing the number of applied optodes in order to decrease installation time and improve subject comfort. (ii) Utilization of a 3D neuronavigation device and usage of collodion to glue optodes on the scalp, ensuring good optical contact for prolonged investigations. (iii) Local reconstruction of the hemodynamic activity along the cortical surface using inverse modelling. RESULTS:Using realistic simulations, we demonstrated that maps derived from optimal montage acquisitions showed, after reconstruction, spatial resolution only slightly lower to that of ultra high density montages while significantly reducing the number of optodes. The optimal montages provided overall good quantitative accuracy especially at the peak of the spatially reconstructed map. We also evaluated real motor responses in two healthy subjects and obtained reproducible motor responses over different sessions. COMPARISON WITH EXISTING METHODS:We are among the first to propose a mathematical optimization strategy, allowing high sensitivity measurements. CONCLUSIONS:Our results support that using personalized optimal montages should allow to conduct accurate fNIRS studies in clinical settings and realistic lifestyle conditions.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Machado A,Cai Z,Pellegrino G,Marcotte O,Vincent T,Lina JM,Kobayashi E,Grova Cdoi
10.1016/j.jneumeth.2018.08.006subject
Has Abstractpub_date
2018-11-01 00:00:00pages
91-108eissn
0165-0270issn
1872-678Xpii
S0165-0270(18)30242-5journal_volume
309pub_type
杂志文章abstract：BACKGROUND:Zebrafish larvae have a high potential as model system to replace rodents, especially in screening and drug discovery applications. However, an experimental setup to deliver mild electrical stimuli with simultaneous high throughput behavioural tracking has not yet been described. NEW METHOD:A new tool was d...
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