Long non-coding RNAs regulation in adipogenesis and lipid metabolism: Emerging insights in obesity.

abstract：:Ethanol, in millimolar concentrations, significantly modifies different transductive systems in human lymphocyte cultures. In particular, the presence of alcohol in the medium more than doubles the [Ca2+]i (from 70-90 to 200-250 nM), increasing Ca2+ fluxes from outside, and inhibits the active transport carried out by...

journal_title：Cellular signalling

authors： Fanò G,Belia S,Mariggiò MA,Antonica A,Agea E,Spinozzi F

更新日期：1993-03-01 00:00:00

abstract：:The implication of protein kinase C in the phenomenon of pancreatic acinar cell desensitization to carbamylcholine, caerulein and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated using a potent PKC inhibitor, staurosporine. At a concentration of 1 microM, staurosporine caused a maximum 64%...

journal_title：Cellular signalling

authors： Morisset J,Paquette B,Benrezzak O

更新日期：1991-01-01 00:00:00

abstract：:In Galpha(z)-deficient mice, survival of sympathetic neurons is significantly attenuated in the presence of pertussis toxin (PTX). This suggests that G(i/o) proteins may have distinct roles in neuronal survival. Here, we investigated the possible involvement of G(i/o) proteins in nerve growth factor (NGF)-induced pro-...

journal_title：Cellular signalling

authors： Wu EH,Wong YH

更新日期：2005-07-01 00:00:00

abstract：:Zfra is a small size 31-amino-acid C2H2 zinc finger-like protein, which is known to interact with c-Jun N-terminal kinase 1 (JNK1), WW domain-containing oxidoreductase (WWOX, FOR or WOX1), TNF receptor-associated death domain protein (TRADD) and nuclear factor kappaB (NF-kappaB) during stress response. Here, we show t...

journal_title：Cellular signalling

authors： Hsu LJ,Hong Q,Schultz L,Kuo E,Lin SR,Lee MH,Lin YS,Chang NS

更新日期：2008-07-01 00:00:00

abstract：:The strong inhibition of thrombin-induced platelet functions induced by okadaic acid is not correlated with the partial modification of pleckstrin phosphorylation, which remains still phosphorylated two min after stimulation, indicating that protein kinase C is not affected by okadaic acid. We then investigated the ef...

journal_title：Cellular signalling

authors： Mauco G,Artçanuthurry V,Pidard D,Grelac F,Maclouf J,Lévy-Tolédano S

更新日期：1997-01-01 00:00:00

abstract：:p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function. The Cas family of ...

journal_title：Cellular signalling

authors： Barrett A,Pellet-Many C,Zachary IC,Evans IM,Frankel P

更新日期：2013-04-01 00:00:00

abstract：:Interleukin 1 (IL-1) triggers the internalization of its cognate receptor from the plasma membrane. We recently demonstrated that this internalization is of critical importance for the IL-1-induced gene expression. In this study we report that the IL-1-induced activation of the small GTPase Rac1 requires receptor endo...

journal_title：Cellular signalling

authors： Windheim M,Hansen B

更新日期：2014-01-01 00:00:00

abstract：:Phospholipase D (PLD) is involved in diverse cellular processes including cell movement, adhesion, and vesicle trafficking through cytoskeletal rearrangements. However, the mechanism by which PLD induces cytoskeletal reorganization is still not fully understood. Here, we describe a new link to cytoskeletal changes tha...

journal_title：Cellular signalling

authors： Jeon H,Kwak D,Noh J,Lee MN,Lee CS,Suh PG,Ryu SH

更新日期：2011-08-01 00:00:00

abstract：:The activation of corticotrophin-releasing hormone receptor (CRHR) 1 is implicated in neuronal injury in experimental stroke. However, little is known about the relationship between CRHR1 activation and brain endothelial barrier impairment after ischemia and reperfusion (I/R). Recently we have demonstrated that the ac...

journal_title：Cellular signalling

authors： Cao C,Zhou J,Wu X,Qian Y,Hong Y,Mu J,Jin L,Zhu C,Li S

更新日期：2020-02-01 00:00:00

abstract：:We have compared a new commercially available non-radioactive protein kinase C (PKC) activity assay based on the fluorescent [A9,10K11]glycogen synthase1-11 analogue C1-peptide with a classical radioactive assay based on myelin basic protein4-14 (MBP4-14) and other substrates. The C1-peptide had lower affinity for PKC...

journal_title：Cellular signalling

authors： Erdbrügger W,Strohm P,Michel MC

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Our previous study showed that human omental adipose-derived stem cells (ADSCs) promote ovarian cancer growth and metastasis. In this study, the role of autophagy in the ovarian cancer-promoting effects of omental ADSCs was further determined. METHODS:The growth and invasion of ovarian cancer cells were det...

journal_title：Cellular signalling

authors： Chu Y,Wang Y,Li K,Liu M,Zhang Y,Li Y,Hu X,Liu C,Zhou H,Zuo J,Peng W

更新日期：2020-05-01 00:00:00

abstract：:Tamoxifen resistance represents a daunting challenge to the successful treatment for breast cancer. Krüppel-like factor 4 has critical roles in the development and progression of breast cancer, but its expression, function and regulation in the efficacy of TAM therapy in breast cancer have yet to be investigated. Here...

journal_title：Cellular signalling

authors： Jia Y,Zhou J,Luo X,Chen M,Chen Y,Wang J,Xiong H,Ying X,Hu W,Zhao W,Deng W,Wang L

更新日期：2018-01-01 00:00:00

abstract：:The present study was designed to investigate (i) the role of AMPK activation in inducing autophagy in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia, and (ii) whether autophagy offers a survival advantage under these harsh conditions. Low androgen and low oxygen are two co-exis...

journal_title：Cellular signalling

authors： Chhipa RR,Wu Y,Ip C

更新日期：2011-09-01 00:00:00

abstract：:The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is not yet completely understood. In this study, we obse...

journal_title：Cellular signalling

authors： Kim J,Kim SY,Kang S,Yoon HR,Sun BK,Kang D,Kim JH,Song JJ

更新日期：2012-07-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative multifactorial disease characterized, like other diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) or frontotemporal dementia (FTD), by the degeneration of specific neuronal cell populations. Motor neuron loss is distinctive of ALS. However, ...

journal_title：Cellular signalling

authors： Cova E,Ghiroldi A,Guareschi S,Mazzini G,Gagliardi S,Davin A,Bianchi M,Ceroni M,Cereda C

更新日期：2010-10-01 00:00:00

abstract：:SCF induces autophosphorylation of Kit and activates a variety of signaling components including Jnks, Erks, PI 3 Kinase, the JAK-Stat pathway and members of the Src family. Previously we showed that Lyn is activated at multiple points during SCF-induced cell cycle progression and contributes to SCF-mediated growth, c...

journal_title：Cellular signalling

authors： Shivakrupa R,Linnekin D

更新日期：2005-01-01 00:00:00

abstract：:TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed in pancreatic, thyroid, colon, and other cancer tissues. Previously, we demonstrated that TMPRSS4 mediates tumor cell invasion, migration, and metastasis. However, the mechanisms by which TMPRSS4 contributes to invasion are not fully und...

journal_title：Cellular signalling

authors： Min HJ,Lee Y,Zhao XF,Park YK,Lee MK,Lee JW,Kim S

更新日期：2014-02-01 00:00:00

abstract：:To understand how a signaling molecule's activities are regulated, we need insight into the processes controlling the dynamic balance between its synthesis and degradation. For the Ins(1,3,4,5,6)P5 signal, this information is woefully inadequate. For example, the only known cytosolic enzyme with the capacity to degrad...

journal_title：Cellular signalling

authors： Deleu S,Choi K,Pesesse X,Cho J,Sulis ML,Parsons R,Shears SB

更新日期：2006-04-01 00:00:00

abstract：:By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the...

journal_title：Cellular signalling

authors： Hoa L,Kulaberoglu Y,Gundogdu R,Cook D,Mavis M,Gomez M,Gomez V,Hergovich A

更新日期：2016-05-01 00:00:00

abstract：:Oxidative stress is an increase in the reduction potential or a large decrease in the reducing capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is the production of reactive oxygen species (ROS), which include free radicals and peroxides. Some of the less reactive of these ...

journal_title：Cellular signalling

authors： Genestra M

更新日期：2007-09-01 00:00:00

abstract：:Staphylococcal alpha-toxin at subcytotoxic concentrations stimulated phosphatidylinositol turnover and arachidonic acid release in undifferentiated cultures of pheochromocytoma PC12 cells. Stimulation of phospholipase A2 but not C was dependent on extracellular calcium. Addition of staphylococcal alpha-toxin to PC12 c...

journal_title：Cellular signalling

authors： Fink D,Contreras ML,Lelkes PI,Lazarovici P

更新日期：1989-01-01 00:00:00

abstract：:The role of the ras oncogene in the signalling pathway triggered by platelet-derived growth factor BB (PDGF-BB) has been investigated in a cell line which normally differentiates into myotubes. Following the activation of the N-ras oncogene, however, the cells proliferate and form foci. PDGF-BB stimulated the phosphor...

journal_title：Cellular signalling

authors： Zeytinoğlu H,Griffiths SL,Dawson AP,Gibson I

更新日期：1995-03-01 00:00:00

abstract：:T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway. The JAK/STAT pathway has recently been shown to be downstream targets of trichothecenes. However, whether there is any crosstalk between JNK and JAK/STAT pathway...

journal_title：Cellular signalling

authors： Wu Q,Wang X,Wan D,Li J,Yuan Z

更新日期：2014-12-01 00:00:00

abstract：:We investigate the mechanisms underlying the intracellular calcium pulse that occurs in response to extracellular adenosine triphosphate (ATP) in osteoclasts. We find that pre-loading of GDP-beta-S abolishes the response in Ca(2+)-free medium, demonstrating an internal release of Ca2+ via a pathway that involves a G p...

journal_title：Cellular signalling

authors： Yu H,Ferrier J

更新日期：1994-11-01 00:00:00

abstract：:In fura-2 loaded isolated mouse pancreatic acinar cells, xanthine oxidase (XOD)-catalyzed reactive oxygen species (ROS) generation caused an increase in the cytosolic Ca(2+) concentration ([Ca(2+)](i)) by release of Ca(2+) from intracellular stores. The ROS-induced Ca(2+) signals showed large variability in shape and ...

journal_title：Cellular signalling

authors： González A,Schmid A,Salido GM,Camello PJ,Pariente JA

更新日期：2002-02-01 00:00:00

abstract：:Neuro-2a (N2a) cells are derived from spontaneous neuroblastoma of mouse and capable to differentiate into neuronal-like cells. Recently, P2X7 receptor has been shown to sustain growth of human neuroblastoma cells but its role during neuronal differentiation remains unexamined.We characterized the role of P2X7 recepto...

journal_title：Cellular signalling

authors： Wu PY,Lin YC,Chang CL,Lu HT,Chin CH,Hsu TT,Chu D,Sun SH

更新日期：2009-06-01 00:00:00

abstract：:This review summarizes some recent findings in human sperm which show that progesterone and 17 alpha hydroxyprogesterone are able rapidly (within seconds) to elevate [Ca2+]i and elicit the acrosome reaction (AR) via a non-genomic cell surface receptor. Progesterone promotes a transient elevation in [Ca2+]i which is bl...

journal_title：Cellular signalling

authors： Blackmore PF

更新日期：1993-09-01 00:00:00

abstract：:SHP1 and SHP2 tyrosine phosphatases have both been implicated in signalling pathways downstream of the interleukin-3 (IL-3) receptor. We have investigated the co-association of SHP1 and SHP2 with tyrosine-phosphorylated proteins in IL-3-dependent BaF/3 cells. We demonstrate that both SHP1 and SHP2 associate with Aic2A...

journal_title：Cellular signalling

authors： Wheadon H,Paling NR,Welham MJ

更新日期：2002-03-01 00:00:00

abstract：:We have previously shown that N18TG2 neuroblastoma cells express the type 6 adenylyl cyclase and that preincubation with nitric oxide (NO) attenuates Gs- and forskolin-stimulated activity. Here we show that this inhibition reflects a direct action of NO on the adenylyl cyclase. Preincubation of N18TG2 cell membranes a...

journal_title：Cellular signalling

authors： Hill J,Howlett A,Klein C

更新日期：2000-04-01 00:00:00

abstract：:We demonstrate the expression of S1P(1,3,4,5) the receptors for sphingosine 1-phosphate (S1P), and LPA(1,2,3) the receptors for lysophosphatidic acid (LPA) in T helper 1 (Th1) and T helper 2 (Th2) cells. S1P and LPA induce the chemotaxis of Th1 and Th2 cells, an activity that is resistant to pertussis toxin (PTX) pret...

journal_title：Cellular signalling

authors： Wang L,Knudsen E,Jin Y,Gessani S,Maghazachi AA

更新日期：2004-09-01 00:00:00