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Alteration of membrane transductive mechanisms induced by ethanol in human lymphocyte cultures.

Abstract：

:Ethanol, in millimolar concentrations, significantly modifies different transductive systems in human lymphocyte cultures. In particular, the presence of alcohol in the medium more than doubles the [Ca2+]i (from 70-90 to 200-250 nM), increasing Ca2+ fluxes from outside, and inhibits the active transport carried out by the calcium pump. The Ca2+ release from intracellular stores is not involved because 10 mM EGTA in the medium completely abolished the rise of [Ca2+]i. Since IP3 levels and cAMP concentrations are also involved in ethanol events (although with opposite effects), it seems that the alcohol may have a specific target on cell membranes (G-proteins) which influence many transductive pathways.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Fanò G,Belia S,Mariggiò MA,Antonica A,Agea E,Spinozzi F

doi

10.1016/0898-6568(93)90065-t

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

139-43

issue

2

eissn

0898-6568

issn

1873-3913

pii

0898-6568(93)90065-T

journal_volume

5

pub_type

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