Interleukin-1-induced activation of the small GTPase Rac1 depends on receptor internalization and regulates gene expression.

Abstract:

:Interleukin 1 (IL-1) triggers the internalization of its cognate receptor from the plasma membrane. We recently demonstrated that this internalization is of critical importance for the IL-1-induced gene expression. In this study we report that the IL-1-induced activation of the small GTPase Rac1 requires receptor endocytosis. We further show that the depletion of Rac1 reduces the IL-1-dependent gene expression without affecting signaling events that are initiated at the plasma membrane. Collectively, we provide evidence for a key role of Rac1 in a pathway that regulates IL-1-induced gene expression depending on receptor endocytosis.

journal_name

Cell Signal

journal_title

Cellular signalling

authors

Windheim M,Hansen B

doi

10.1016/j.cellsig.2013.09.015

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

49-55

issue

1

eissn

0898-6568

issn

1873-3913

pii

S0898-6568(13)00295-7

journal_volume

26

pub_type

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