Rescue of a biologically active Epstein-Barr virus from nonproducer cells.

abstract：:Inactivation of the tumor suppressor p53 through somatic mutations, observed in 50% of human cancers, is one of the leading causes of tumorigenesis. Clinical and experimental evidence also reveals that p53 mutations sometimes occur in tumor-associated fibroblasts, which correlate with an increased rate of metastases a...

journal_title：Cancer research

authors： Guo G,Marrero L,Rodriguez P,Del Valle L,Ochoa A,Cui Y

更新日期：2013-03-15 00:00:00

abstract：:The glutathione transferase P (GST-P) gene is known for its specific expression during chemical hepatocarcinogenesis of the rat and is used as a tumor marker for hepatocellular carcinoma. We have shown recently that the upstream 2.9-kb region of the GST-P gene is sufficient for conferring tumor-specific expression of ...

journal_title：Cancer research

authors： Suzuki T,Imagawa M,Hirabayashi M,Yuki A,Hisatake K,Nomura K,Kitagawa T,Muramatsu M

更新日期：1995-06-15 00:00:00

abstract：:Monoclonal antibodies (MAbs) 123C3 and 123A8 generated against a membrane preparation of a small cell lung carcinoma (SCLC) specimen recognize not only SCLC and bronchial carcinoids but also a significant portion of non-small cell lung carcinomas (non-SCLC) of various histological types. Together with 13 other monoclo...

journal_title：Cancer research

authors： Moolenaar CE,Muller EJ,Schol DJ,Figdor CG,Bock E,Bitter-Suermann D,Michalides RJ

更新日期：1990-02-15 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:The reason for estrogen independence of C3H mouse mammary tumors has been sought in the initial steps of estradiol action. The characteristics of the estrogen receptors were similar to those observed in estrogen-responsive tissues: high affinity and binding specificity, DNA binding and 8S sedimentation constant as sho...

journal_title：Cancer research

authors： Vignon F,Rochefort H

更新日期：1978-06-01 00:00:00

abstract：:Obesity is associated with increased cancer incidence and mortality. We have previously found that obesity in children is associated with a 50% increased recurrence of acute lymphoblastic leukemia (ALL) in high-risk patients. We have therefore developed novel in vivo and in vitro preclinical models to study the mechan...

journal_title：Cancer research

authors： Behan JW,Yun JP,Proektor MP,Ehsanipour EA,Arutyunyan A,Moses AS,Avramis VI,Louie SG,Butturini A,Heisterkamp N,Mittelman SD

更新日期：2009-10-01 00:00:00

abstract：:Fifty-nine colonic adenomas and 6 hyperplastic colonic polyps were analyzed by single-strand conformation polymorphism analysis for mutations in the adenomatous polyposis coli gene (APC). Frameshifts and premature stop codons in at least one copy of APC were detected in 25 of these adenomas. Five adenomas carried 2 AP...

journal_title：Cancer research

authors： De Benedetti L,Sciallero S,Gismondi V,James R,Bafico A,Biticchi R,Masetti E,Bonelli L,Heouaine A,Picasso M

更新日期：1994-07-01 00:00:00

abstract：:2-Phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) is classified as a relatively nontoxic selenium compound, probably because of its bound selenium moiety. In thiol-rich tissues, such as the kidneys, ebselen is converted into selenol intermediates. Selenols are nucleophilic agents which might be able to react with plat...

journal_title：Cancer research

authors： Baldew GS,McVie JG,van der Valk MA,Los G,de Goeij JJ,Vermeulen NP

更新日期：1990-11-01 00:00:00

abstract：:Aldophosphamide (NSC 254), a putative key metabolite of cyclophosphamide, has now been isolated as a cyanohydrin derivative from an incubation mixture of cyclophosphamide with mouse liver microsomes in vitro and from the plasma of a cyclophosphamide-treated patient. The cyanohydrin has been shown to be identical with ...

journal_title：Cancer research

authors： Fenselau C,Kan MN,Rao SS,Myles A,Friedman OM,Colvin M

更新日期：1977-08-01 00:00:00

abstract：:Eighty-five antibodies recognizing breast cancer-selective antigens were conjugated to ricin toxin A-chain using a disulfide linkage. The cytotoxicities of the resulting immunotoxins were determined on breast cancer cells and normal human fibroblasts. Twenty-four antibodies formed immunotoxins that were toxic to at le...

journal_title：Cancer research

authors： Bjorn MJ,Ring D,Frankel A

更新日期：1985-03-01 00:00:00

abstract：:The metabolites, transporters, and enzymes involved in choline metabolism are regarded as biomarkers for disease progression in a variety of cancers, but their in vivo detection is not ideal. Both magnetic resonance spectroscopy [MRS using chemical shift imaging (CSI) total choline (tCho)] and C-choline positron emiss...

journal_title：Cancer research

authors： Wehrl HF,Schwab J,Hasenbach K,Reischl G,Tabatabai G,Quintanilla-Martinez L,Jiru F,Chughtai K,Kiss A,Cay F,Bukala D,Heeren RM,Pichler BJ,Sauter AW

更新日期：2013-03-01 00:00:00

abstract：:Five different lipid conjugates of 1-beta-D-arabinofuranosylcytosine (ara-C) were tested for their therapeutic activity on the growth and metastasis of Lewis lung carcinoma (3-LL). Among 1 ester-linked lipid conjugate (Ara-CDP-L-dipalmitin), 3 1-O-alkyl-lipid conjugates (ara-CDP-D,L-PBA, ara-CDP-D,L-PCA, ara-CDP-D,L-M...

journal_title：Cancer research

authors： Berdel WE,Danhauser S,Hong CI,Schick HD,Reichert A,Busch R,Rastetter J,Vogler WR

更新日期：1988-02-15 00:00:00

abstract：:B7-H4 (VTCN1, B7x, B7s) is a ligand for inhibitory coreceptors on T cells implicated in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated macrophages (TAM), but its potential contributions to tumoral immune escape and therapeutic targeting have been less studied. To interrogate B7-H4 expre...

journal_title：Cancer research

authors： Dangaj D,Lanitis E,Zhao A,Joshi S,Cheng Y,Sandaltzopoulos R,Ra HJ,Danet-Desnoyers G,Powell DJ Jr,Scholler N

更新日期：2013-08-01 00:00:00

abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

journal_title：Cancer research

authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

更新日期：1996-08-15 00:00:00

abstract：:After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified ad...

journal_title：Cancer research

authors： Amundson SA,Grace MB,McLeland CB,Epperly MW,Yeager A,Zhan Q,Greenberger JS,Fornace AJ Jr

更新日期：2004-09-15 00:00:00

abstract：:Our goal is to develop peptide vaccines that stimulate tumor antigen-specific T-cell responses against frequently found cancers. Previous work has shown that to generate effective T-cell responses, peptides have to be administered in combination with strong adjuvants such as Toll-like receptor agonists. However, most ...

journal_title：Cancer research

authors： Nava-Parada P,Forni G,Knutson KL,Pease LR,Celis E

更新日期：2007-02-01 00:00:00

abstract：:The mechanisms underlying the progression of prostate cancer to a state of resistance to hormone ablation remain poorly understood. Here, we have investigated the relationship between androgen receptor (AR) and Her-2/neu in prostate cancer cells. Overexpression of Her-2/neu (c-ErbB2) activates the AR pathway and confe...

journal_title：Cancer research

authors： Berger R,Lin DI,Nieto M,Sicinska E,Garraway LA,Adams H,Signoretti S,Hahn WC,Loda M

更新日期：2006-06-01 00:00:00

abstract：:Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelia] cells (MECs) constitutively produce interleukin (IL) 6, IL8, and a nonsecreted form of tumor necrosis factor. MEC transformation by different oncogenes is frequently a...

journal_title：Cancer research

authors： Basolo F,Fiore L,Fontanini G,Conaldi PG,Calvo S,Falcone V,Toniolo A

更新日期：1996-07-01 00:00:00

abstract：:The BCR/ABL fusion protein is a constitutively active tyrosine kinase that is responsible for the pathogenesis of chronic myelogenous leukemia (CML). Clinically, CML is characterized by a chronic phase (CP) that eventually terminates into a blast crisis (BC). BC transformation is associated with accumulation of CD34+ ...

journal_title：Cancer research

authors： Bonati A,Carlo-Stella C,Lunghi P,Albertini R,Pinelli S,Migliaccio E,Sammarelli G,Savoldo B,Tabilio A,Dall'Aglio PP,Pelicci PG

更新日期：2000-02-01 00:00:00

abstract：:The aim of the present study was to establish screening biomarkers of exposure to antineoplastic drugs administered to 11 patients undergoing cancer chemotherapy. Among the anticancer drugs administered were cyclophosphamide (all), Adriamycin (5 of 11), methotrexate (3 of 11), 5-fluorouracil (4 of 11), vincristine (3 ...

journal_title：Cancer research

authors： Newman MA,Hee SQ,Schoeny R,Lowry L

更新日期：1990-06-01 00:00:00

abstract：:The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9...

journal_title：Cancer research

authors： Dorward AM,Shultz KL,Horton LG,Li R,Churchill GA,Beamer WG

更新日期：2005-02-15 00:00:00

abstract：:The mitochondrial peripheral benzodiazepine receptor (mPBR) is involved in a functional structure designated as the permeability transition pore, which controls apoptosis. Binding of Fas/APO-1/CD95 triggers a prototypic apoptosis-inducing pathway. Using four different human tumor cell lines (T-cell Jurkat, neuroblasto...

journal_title：Cancer research

authors： Decaudin D,Castedo M,Nemati F,Beurdeley-Thomas A,De Pinieux G,Caron A,Pouillart P,Wijdenes J,Rouillard D,Kroemer G,Poupon MF

更新日期：2002-03-01 00:00:00

abstract：:P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intestinal and colonic mucosa. This study aimed to better understand the mechanisms controlling the expres...

journal_title：Cancer research

authors： Milicic A,Harrison LA,Goodlad RA,Hardy RG,Nicholson AM,Presz M,Sieber O,Santander S,Pringle JH,Mandir N,East P,Obszynska J,Sanders S,Piazuelo E,Shaw J,Harrison R,Tomlinson IP,McDonald SA,Wright NA,Jankowski JA

更新日期：2008-10-01 00:00:00

abstract：:A new high-pressure liquid chromatographic method was developed for the simultaneous determination of rubidazone and daunorubicin in human plasma at concentrations as low as 60 ng/ml. Clinical toxicity and the stability of rubidazone were studied in nine patients with advanced solid tumors. Rubidazone was administered...

journal_title：Cancer research

authors： Kovach JS,Ames MM,Sternad ML,O'Connell MJ

更新日期：1979-03-01 00:00:00

abstract：:The lymphoid tissue in the omentum, at the so-called milky spots, is known as an initial place for disseminated cancer cells to develop into solid tumors. In the present study, i.p. macrophages significantly took up oligomannose-coated liposomes (OMLs) that were injected into the peritoneal cavity, and then gradually ...

journal_title：Cancer research

authors： Ikehara Y,Niwa T,Biao L,Ikehara SK,Ohashi N,Kobayashi T,Shimizu Y,Kojima N,Nakanishi H

更新日期：2006-09-01 00:00:00

abstract：:DNA of invasive ductal carcinomas from five women was analyzed for structural alterations in the purine nucleotides using gas chromatography-mass spectrometry with selected ion monitoring. The results were compared to those for a normal DNA control. The carcinoma DNA showed dramatically higher concentrations of the ba...

journal_title：Cancer research

authors： Malins DC,Haimanot R

更新日期：1991-10-01 00:00:00

abstract：:The monoclonal antibodies (MAbs) 323/A3 and 17-1A both recognize a 40-kDa carcinoma-associated epithelial glycoprotein (EGP40). MAb 17-1A has been used in many therapeutic trials as an immunotherapeutic agent to combat advanced colorectal cancer, and about 5-10% overall responses have been observed. It has been shown ...

journal_title：Cancer research

authors： Velders MP,Litvinov SV,Warnaar SO,Gorter A,Fleuren GJ,Zurawski VR Jr,Coney LR

更新日期：1994-04-01 00:00:00

abstract：:DNA-dependent RNA polymerase A (or 1) was purified from murine myeloma MOPC 21 by diethylaminoethyl Sephadex chromatography. Further separation from DNA polymerases, protein kinase and DNA endonuclease was accomplished by polyriboadenylate-Sepharose affinity chromatography followed by gradient centrifugation. Yields f...

journal_title：Cancer research

authors： Hall SH,Smuckler EA

更新日期：1976-03-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is activated to DNA alkylating species via two different alpha-hydroxylation pathways. Methylene hydroxylation leads to DNA methylation, whereas methyl hydroxylation yields DNA pyridyloxobutylation. We have developed a high-pressure liquid chromatography assay utili...

journal_title：Cancer research

authors： Peterson LA,Mathew R,Hecht SS

更新日期：1991-10-15 00:00:00