Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation?

Abstract:

:Gut microbiota is known to have a relevant role in our health, and is also related to both gastrointestinal and extradigestive diseases. Therefore, restoring the alteration of gut microbiota represents an outstanding clinical target for the treatment of gut microbiota-related diseases. The modulation of gut microbiota is perhaps an ancestral, innate concept for human beings. At this time, the restoration of gut microbiota impairment is a well-established concept in mainstream medicine, and several therapeutic approaches have been developed in this regard. Antibiotics, prebiotics and probiotics are the best known and commercially available options to overcome gastrointestinal dysbiosis. Fecal microbiota transplantation is an old procedure that has recently become popular again. It has shown a clear effectiveness in the treatment of C. difficile infection, and now represents a cutting-edge option for the restoration of gut microbiota. Nevertheless, such weapons should be used with caution. Antibiotics can indeed harm and alter gut microbiota composition. Probiotics, instead, are not at all the same thing, and thinking in terms of different strains is probably the only way to improve clinical outcomes. Moreover, fecal microbiota transplantation has shown promising results, but stronger proofs are needed. Considerable efforts are needed to increase our knowledge in the field of gut microbiota, especially with regard to the future use in its modulation for therapeutic purposes.

journal_name

Intern Emerg Med

authors

Cammarota G,Ianiro G,Bibbò S,Gasbarrini A

doi

10.1007/s11739-014-1069-4

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

365-73

issue

4

eissn

1828-0447

issn

1970-9366

journal_volume

9

pub_type

杂志文章,评审
  • Prevention of anthracycline-induced cardiotoxicity: a systematic review and meta-analysis.

    abstract::Anthracyclines are extensively used in oncologic patients, in particular for breast cancer and hematological malignancies. Cardiac injury is a potentially dangerous side effect of these drugs. In this systematic review, we analyzed published randomized controlled trials (RCTs) to assess if potential cardioprotective d...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-020-02508-8

    authors: Caspani F,Tralongo AC,Campiotti L,Asteggiano R,Guasti L,Squizzato A

    更新日期:2020-10-03 00:00:00

  • Inadequate cancer pain management in Italian clinical trials.

    abstract::Pain treatment in Italy is far from being optimal. In order to improve this situation, the reporting of a complete assessment of pain in the clinical record became compulsory by law. Pain-related cancer protocols (143) were selected from the National Monitoring Centre of Clinical Trials Database and reviewed. Our data...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0658-8

    authors: Lucenteforte E,Maggini V,Maione R,Fabbroni V,Tomino C,Mugelli A

    更新日期:2013-10-01 00:00:00

  • Is echocardiography mandatory for patients with chronic kidney disease?

    abstract::This study aims at evaluating the prevalence of left ventricular diastolic dysfunction in a group of 319 hypertensive patients with stage 3b-4-5 chronic kidney disease (according to Kidney Disease Improving Global Outcomes classification), compared with 216 patients with essential hypertension and normal renal functio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02028-0

    authors: Nardi E,Mulè G,Nardi C,Geraci G,Giammanco A,Bentivegna R,Averna M

    更新日期:2019-09-01 00:00:00

  • Validation of the Italian version of a new coma scale: the FOUR score.

    abstract::The Glasgow Coma Scale (GCS) is the most widely accepted tool for the evaluation of consciousness, despite several reported shortcomings. A new coma scale, named Full Outline of UnResponsiveness (FOUR) score, is now available. The aim of the present study is to provide and validate the Italian version of the FOUR scor...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0583-x

    authors: Marcati E,Ricci S,Casalena A,Toni D,Carolei A,Sacco S

    更新日期:2012-04-01 00:00:00

  • The role of the combination of echo-HRCT score as a tool to evaluate the presence of pulmonary hypertension in idiopathic pulmonary fibrosis.

    abstract::Pulmonary hypertension (PH) is defined as an elevated mean pulmonary artery pressure at rest (mPAP ≥ 25 mmHg), evaluated by right heart catheterization (RHC). The aim of the present study was to evaluate HRCT findings in relation to transthoracic echocardiographic data to better characterize PH in IPF patients and to ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02539-1

    authors: Refini RM,Bettini G,Kacerja E,Cameli P,d'Alessandro M,Bergantini L,De Negri F,Rottoli P,Sestini P,Bargagli E,Mazzei MA

    更新日期:2020-11-05 00:00:00

  • Treatment outcome in a cohort of young patients with polycythemia vera.

    abstract::The treatment of polycythemia vera in young adults is challenging, requiring one to run a balance between the increased risk of vascular complications, if left untreated, versus the potential of promoting secondary leukemia/myelodysplasia or cancer, if actively managed with chemotherapy. We report the results of a 20-...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-010-0429-y

    authors: Ruggeri M,Finotto S,Fortuna S,Rodeghiero F

    更新日期:2010-10-01 00:00:00

  • Effects of cryoablation and radiofrequency ablation on endothelial and blood clotting activation.

    abstract::Cryoablation (CA) emerged as an alternative procedure to radiofrequency (RF). The aim of this study was to compare haemostatic system alterations in patients undergoing RF or CA for atrioventricular nodal reentrant tachycardia ablation. von Willebrand factor (vWF), spontaneous whole blood platelet aggregation, prothro...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-014-1090-7

    authors: Pieragnoli P,Gori AM,Ricciardi G,Carrassa G,Checchi L,Michelucci A,Priora R,Cellai AP,Marcucci R,Padeletti L,Abbate R

    更新日期:2014-12-01 00:00:00

  • Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients.

    abstract::Auto-titrating noninvasive ventilation (NIV) has been developed as a new mode applying variable expiratory-positive airway pressure (EPAP) in addition to variable inspiratory pressures (IPAP), both to deliver targeted tidal volume (VT) and to eliminate upper airway resistance. The purpose of this study is to evaluate ...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1821-2

    authors: Gursel G,Zerman A,Basarik B,Gonderen K,Aydogdu M,Memmedova S

    更新日期:2018-04-01 00:00:00

  • Diagnosis and management of acute aortic syndromes in the emergency department.

    abstract::Acute aortic syndromes (AASs) are deadly cardiovascular emergencies involving the thoracic aorta. AASs are relatively rare conditions, have unspecific signs and symptoms (including truncal pain, syncope, neurologic deficit and limb ischemia) and require contrast-enhanced tomography angiography (CTA) of the chest and a...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-020-02354-8

    authors: Morello F,Santoro M,Fargion AT,Grifoni S,Nazerian P

    更新日期:2021-01-01 00:00:00

  • Cognitive impairment in patients hospitalized for congestive heart failure: data from the RICA Registry.

    abstract::The objective of this study is to determine the prevalence of cognitive impairment (CogI) in patients hospitalized for congestive heart failure, and the influence of CogI on mortality and hospital readmission. This is a multicenter cohort study of patients hospitalized for congestive heart failure enrolled in the RICA...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02400-5

    authors: García Bruñén JM,Povar Echeverria M,Díez-Manglano J,Manzano L,Trullàs JC,Romero Requena JM,Salamanca Bautista MP,González Franco Á,Cepeda Rodrigo JM,Montero-Pérez-Barquero M,RICA Investigators Group.

    更新日期:2021-01-01 00:00:00

  • Impact of gender on short-term and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndromes: a meta-analysis.

    abstract::A meta-analysis to determine the impact of gender on mortality in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS): PubMed, EMBASE, and Cochrane Library, was systematically searched. Two investigators independently reviewed retrieved articles and assessed eligibility. Unadjusted mortality rat...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11739-017-1684-y

    authors: Wang Y,Zhu S,Du R,Zhou J,Chen Y,Zhang Q

    更新日期:2018-03-01 00:00:00

  • Hospital length-of-stay and costs among pulmonary embolism patients treated with rivaroxaban versus parenteral bridging to warfarin.

    abstract::We sought to compare length-of-stay (LOS), total hospital costs, and readmissions among pulmonary embolism (PE) patients treated with rivaroxaban versus parenterally bridged warfarin. We identified adult PE (primary diagnostic code = 415.1x) patients in the Premier Database (11/2012-9/2015), and included those with ≥1...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1552-1

    authors: Weeda ER,Wells PS,Peacock WF,Fermann GJ,Baugh CW,Ashton V,Crivera C,Wildgoose P,Schein JR,Coleman CI

    更新日期:2017-04-01 00:00:00

  • Amiodarone-related thyroid dysfunction.

    abstract::Nowadays, amiodarone is the most commonly used antidysrhythmic drug in clinical practice. It is highly effective in the management of recurrent ventricular dysrhythmias, paroxysmal supraventricular dysrhythmias, including atrial fibrillation and flutter, and in the maintenance of sinus rhythm after electrical cardiove...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-014-1140-1

    authors: Hudzik B,Zubelewicz-Szkodzinska B

    更新日期:2014-12-01 00:00:00

  • Management practices of emergency departments in general hospitals based on blockage of chain of infection during a COVID-19 epidemic.

    abstract::In a Coronavirus disease 2019 (COVID-19) epidemic, management of the emergency department is a difficult task in terms of prevention and control of the disease in general hospitals. On top of meeting urgent needs of patients for medical treatment, the emergency department also has to devote resources into investigatio...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-020-02499-6

    authors: Hu X,Liu S,Wang B,Xiong H,Wang P

    更新日期:2020-11-01 00:00:00

  • Can C-reactive protein and white blood cell count alone rule out an urgent condition in acute abdominal pain?

    abstract::Up to 10% of all patients at the Emergency Department present for acute abdominal pain. The C-reactive protein (CRP) and white blood cell (WBC) are routinely determined as part of the workup of patients with abdominal pain. Three large prospective cohort studies comprising a total of 2961 adult patients with acute abd...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-015-1333-2

    authors: Paolillo C,Spallino I,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2016-02-01 00:00:00

  • Failure to achieve first attempt success at intubation using video laryngoscopy is associated with increased complications.

    abstract::The purpose of this investigation was to investigate the association between first attempt success and intubation-related complications in the Intensive Care Unit after the widespread adoption of video laryngoscopy. We further sought to characterize and identify the predictors of complications that occur despite first...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-016-1549-9

    authors: Hypes C,Sakles J,Joshi R,Greenberg J,Natt B,Malo J,Bloom J,Chopra H,Mosier J

    更新日期:2017-12-01 00:00:00

  • Etomidate use in severe sepsis and septic shock patients does not contribute to mortality.

    abstract::Use of etomidate in severe sepsis and septic shock has been challenged in recent literature due to its link to adrenal insufficiency and suspected increased mortality. We hypothesized that etomidate does not contribute to mortality in this patient population. A retrospective chart review of 230 intubated, severe sepsi...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0553-3

    authors: Ehrman R,Wira C,Lomax A,Hayward A,Marcelin J,Ellis T,Przyklenk K,Volturo G,Mullen M

    更新日期:2011-06-01 00:00:00

  • Endometriosis, need for a multidisciplinary clinical setting: the internist's point of view.

    abstract::Endometriosis is a common condition characterized by proliferation of endometrial tissue outside the uterus, both in the pelvis and in other extra-pelvic sites. The clinical picture of endometriosis is widely heterogeneous. A correct diagnostic work-up of these patients can sometimes be very difficult, since there are...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-010-0404-7

    authors: Montalto M,Santoro L,D'Onofrio F,Gallo A,Campo S,Campo V,Gasbarrini A,Gasbarrini G

    更新日期:2010-12-01 00:00:00

  • ESC position paper on cardiovascular toxicity of cancer treatments: challenges and expectations.

    abstract::The recent position paper of the European Society of Cardiology (ESC) on cardiovascular toxicity of cancer treatments has attracted considerable interest by healthcare professionals, since it is the first concrete help in the difficult task of monitoring and approaching cardiovascular side effects of anticancer treatm...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-017-1755-0

    authors: Raschi E,Diemberger I,Cosmi B,De Ponti F

    更新日期:2018-01-01 00:00:00

  • Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding.

    abstract::Hypertension and diabetes are known risk factors for obesity-related thrombosis, but several studies have shown that obesity is characterised by a potentially prothrombotic inflammatory state because of activated coagulation and impaired fibrinolysis. In order to verify if obese patients-unaffected by hypertension, di...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-011-0522-x

    authors: Cugno M,Castelli R,Mari D,Mozzi E,Zappa MA,Boscolo-Anzoletti M,Roviaro G,Mannucci PM

    更新日期:2012-06-01 00:00:00

  • Triage in public health emergencies: ethical issues.

    abstract::General concepts about medical disasters, public health and triage are outlined. Triage is described in the context of public health emergencies and disaster settings, and the main ethical values at stake in triage are discussed. Possible conflicts between competing values are outlined. Special attention is given to p...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-010-0362-0

    authors: Petrini C

    更新日期:2010-04-01 00:00:00

  • Therapeutic induced hypothermia does not improve the prognosis of out-of-hospital cardiac arrest patients.

    abstract::Unconscious patients admitted to critical care units after out-of-hospital cardiac arrest are at high risk for death, and neurologic deficits are common among those who survive. The target temperature management (TTM), 33 vs. 36 °C, after out-of-hospital cardiac arrest trial was conducted to assess the benefits and ha...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11739-014-1100-9

    authors: Granberg B,McGillis E,Solbiati M,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2014-09-01 00:00:00

  • Author Correction: Toxic alcohol diagnosis and management: an emergency medicine review.

    abstract::Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. Th...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11739-018-1833-y

    authors: Ng PC,Long BJ,Davis WT,Sessions DJ,Koyfman A

    更新日期:2018-08-01 00:00:00

  • Colchicine is safe and effective for secondary prevention of recurrent pericarditis.

    abstract::The CORP (COlchicine for Recurrent Pericarditis) trial [7]is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional ant...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s11739-012-0775-z

    authors: Gianni F,Solbiati M,Gruppo di Autoformazione Metodologica (GrAM).

    更新日期:2012-04-01 00:00:00

  • Subclinical hyperthyroidism and cardiovascular manifestations: a reevaluation of the association.

    abstract::Subclinical hyperthyroidism (SH) has been reported associated with atrial fibrillation (AF), heart failure (HF) and coronary heart disease events, including mortality. An expert opinion indicates that AF is the possible link between SH and the other important cardiovascular (CV) manifestations. We analyzed the data of...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-013-0913-2

    authors: Carpi A,Cini G,Russo M,Antonelli A,Gaudio C,Galetta F,Franzoni F,Rossi G

    更新日期:2013-04-01 00:00:00

  • Clinical impact of application of risk assessment models (Padua Prediction Score and Improve Bleeding Score) on venous thromboembolism, major hemorrhage and health expenditure associated with pharmacologic VTE prophylaxis: a "real life" prospective and re

    abstract::International guidelines recommend the use of pharmacological prophylaxis in hospitalized medical patients at high risk of venous thromboembolism (VTE). The same international guidelines suggest the employment of standardized risk assessment models (RAMs) when evaluating the administration of pharmacological prophylax...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-018-1808-z

    authors: Depietri L,Marietta M,Scarlini S,Marcacci M,Corradini E,Pietrangelo A,Ventura P

    更新日期:2018-06-01 00:00:00

  • Cardiometabolic risk prevention strategies: the importance of sharing experiences between Mediterranean countries.

    abstract::According to the Global Burden of Disease Study 2017, between 1990 and 2017, Italy experienced a more attenuate reduction in cardiovascular deaths than Western Europe. When considering risk factors, our Country experienced a reduction in the prevalence of hypertension in the last few decades, especially in women. On t...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-019-02263-5

    authors: Modesti PA,Jarraya F,Mascherini G,Perticone F

    更新日期:2020-06-01 00:00:00

  • Is there a link between venous and arterial thrombosis? A reappraisal.

    abstract::Whether there is a link between venous and arterial thrombotic disorders is still a matter of debate. They share common risk factors, such as old age, male sex and obesity. Endothelial dysfunction and inflammation are likely to play a role in determining the simultaneous involvement of the two vascular compartments. U...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s11739-019-02238-6

    authors: Prandoni P

    更新日期:2020-01-01 00:00:00

  • Predictors of the early outcome in elderly patients with ST elevation myocardial infarction treated with primary angioplasty: a single center experience.

    abstract::Elderly patients are under-represented in trials assessing strategies of early coronary revascularization in acute myocardial infarction, though they are the fastest growing segment of our population. The aims of the present investigation, performed in 357 elderly (≥75 years) patients with ST elevation myocardial infa...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-010-0459-5

    authors: Lazzeri C,Valente S,Chiostri M,Picariello C,Gensini GF

    更新日期:2011-02-01 00:00:00

  • Point-of-care ultrasound modalities in terms of diagnosing acute decompensated heart failure in emergency department; a diagnostic accuracy study.

    abstract::This study aimed to compare the diagnostic accuracy of heart, lung and inferior vena cava (IVC) ultrasonography modalities, alone and combined, for possible added accuracy in diagnosing acute decompensated heart failure (ADHF), in a group of patients with the final diagnosis of ADHF based on plasma level of B-type nat...

    journal_title:Internal and emergency medicine

    pub_type: 杂志文章

    doi:10.1007/s11739-019-02233-x

    authors: Farahmand S,Abdolhoseini A,Aliniagerdroudbari E,Babaniamansour S,Baratloo A,Bagheri-Hariri S

    更新日期:2020-04-01 00:00:00